Development Level

Tbio 2,423 | 10,625
Tdark 499 | 7,003
Tchem 457 | 1,890
Tclin 85 | 602

Collection

Kinase: IDG Consortium (Targets) 23 | 125
Kinase: IDG Consortium (Complete/Control) 8 | 37
GPCR: IDG Consortium (Targets) 3 | 128

IMPC Phenotype

preweaning lethality, complete... 220 | 633
preweaning lethality, incomple... 65 | 260
embryonic lethality prior to t... 63 | 187
embryonic lethality prior to o... 60 | 148
abnormal behavior 53 | 226
decreased body weight 51 | 174
decreased total body fat amoun... 43 | 186
decreased lean body mass 42 | 195
abnormal embryo size 37 | 112
abnormal bone structure 33 | 131
decreased body length 33 | 108
decreased bone mineral content 31 | 157
decreased circulating glucose ... 29 | 121
increased or absent threshold ... 29 | 128
abnormal retina morphology 28 | 100
hyperactivity 27 | 108
decreased bone mineral density 26 | 126
increased circulating alkaline... 26 | 119
increased lean body mass 25 | 107
decreased grip strength 24 | 123
enlarged heart 24 | 111
increased bone mineral content 24 | 92
increased grip strength 24 | 83
increased mean corpuscular hem... 23 | 93
decreased circulating choleste... 22 | 85
increased mean corpuscular vol... 22 | 91
abnormal lens morphology 21 | 73
decreased circulating HDL chol... 21 | 77
prenatal lethality prior to he... 21 | 64
increased sacral vertebrae num... 20 | 62
abnormal bone mineralization 19 | 55
decreased lumbar vertebrae num... 18 | 62
decreased rib number 18 | 59
abnormal coat-hair pigmentatio... 17 | 54
decreased leukocyte cell numbe... 17 | 54
short tibia 17 | 82
decreased caudal vertebrae num... 16 | 49
decreased circulating serum al... 16 | 79
decreased circulating triglyce... 16 | 83
decreased hemoglobin content 16 | 53
decreased prepulse inhibition 15 | 52
increased circulating HDL chol... 15 | 63
abnormal retinal pigmentation 14 | 61
hypoactivity 14 | 89
increased bone mineral density 14 | 52
increased circulating sodium l... 14 | 71
increased fasted circulating g... 14 | 68
abnormal eye morphology 13 | 38
abnormal gait 13 | 51
decreased circulating LDL chol... 13 | 37
decreased fasted circulating g... 13 | 49
male infertility 13 | 62
abnormal heart morphology 12 | 51
decreased circulating alanine ... 12 | 53
decreased erythrocyte cell num... 12 | 43
decreased mean corpuscular vol... 12 | 50
corneal opacity 11 | 25
increased circulating choleste... 11 | 53
increased circulating creatini... 11 | 29
thrombocytopenia 11 | 46
abnormal cornea morphology 10 | 24
abnormal locomotor activation 10 | 26
cataract 10 | 26
decreased heart weight 10 | 44
decreased hematocrit 10 | 25
decreased mean corpuscular hem... 10 | 34
embryonic growth retardation 10 | 28
polydactyly 10 | 22
abnormal behavioral response t... 9 | 52
abnormal neural tube closure 9 | 37
anophthalmia 9 | 20
decreased circulating aspartat... 9 | 27
decreased circulating insulin ... 9 | 75
decreased circulating iron lev... 9 | 25
decreased circulating total pr... 9 | 41
decreased startle reflex 9 | 48
decreased threshold for audito... 9 | 32
impaired glucose tolerance 9 | 52
increased circulating chloride... 9 | 43
increased circulating triglyce... 9 | 24
abnormal limb bud morphology 8 | 15
abnormal sleep behavior 8 | 63
abnormal spleen morphology 8 | 36
decreased T cell number 8 | 31
decreased circulating alkaline... 8 | 41
decreased circulating chloride... 8 | 32
decreased circulating free fat... 8 | 39
decreased circulating fructosa... 8 | 31
decreased eosinophil cell numb... 8 | 41
female infertility 8 | 34
improved glucose tolerance 8 | 56
increased blood urea nitrogen ... 8 | 44
increased exploration in new e... 8 | 56
increased heart weight 8 | 37
increased hemoglobin content 8 | 45
increased mean corpuscular hem... 8 | 25
increased startle reflex 8 | 38
increased total body fat amoun... 8 | 57
pale yolk sac 8 | 12
tremors 8 | 34

Disease

ovarian cancer 2,068 | 8,491
osteosarcoma 1,744 | 7,933
medulloblastoma, large-cell 1,325 | 6,234
psoriasis 1,300 | 6,685
glioblastoma 1,167 | 5,572
lung cancer 1,137 | 4,473
atypical teratoid / rhabdoid tumor 898 | 4,369
Cancer 795 | 2,346
malignant mesothelioma 781 | 3,163
Breast cancer 719 | 3,098
primitive neuroectodermal tumor 687 | 3,031
intraductal papillary-mucinous neoplasm (IPMN) 678 | 3,289
group 3 medulloblastoma 636 | 2,254
oligodendroglioma 605 | 2,849
pediatric high grade glioma 592 | 2,712
intraductal papillary-mucinous carcinoma (IPMC) 585 | 2,988
non-small cell lung cancer 578 | 2,798
invasive ductal carcinoma 558 | 2,950
ependymoma 535 | 2,514
lung adenocarcinoma 517 | 2,714
intraductal papillary-mucinous adenoma (IPMA) 505 | 2,956
Multiple myeloma 481 | 1,327
Carcinoma 451 | 2,147
pilocytic astrocytoma 448 | 3,086
astrocytic glioma 436 | 2,241
pancreatic cancer 429 | 2,300
subependymal giant cell astrocytoma 422 | 2,287
Pick disease 419 | 1,893
astrocytoma 381 | 1,493
group 4 medulloblastoma 372 | 1,875
adult high grade glioma 351 | 2,148
pancreatic ductal adenocarcinoma liver metastasis 350 | 1,795
acute quadriplegic myopathy 344 | 1,157
colon cancer 341 | 1,475
lung carcinoma 339 | 2,844
diabetes mellitus 338 | 1,663
ductal carcinoma in situ 328 | 1,745
ulcerative colitis 327 | 2,087
breast carcinoma 324 | 1,614
pituitary cancer 324 | 1,972
sonic hedgehog group medulloblastoma 323 | 1,482
juvenile dermatomyositis 317 | 1,189
adrenocortical carcinoma 313 | 1,427
Waldenstrons macroglobulinemia 308 | 764
medulloblastoma 299 | 1,524
dermatomyositis 294 | 966
Rheumatoid Arthritis 284 | 1,170
interstitial cystitis 282 | 2,299
posterior fossa group A ependymoma 268 | 1,511
tuberculosis 266 | 1,563
acute myeloid leukemia 241 | 785
spina bifida 240 | 1,064
atypical teratoid/rhabdoid tumor 238 | 1,095
primary pancreatic ductal adenocarcinoma 236 | 1,271
cystic fibrosis 223 | 1,670
nasopharyngeal carcinoma 221 | 1,056
posterior fossa group B ependymoma 195 | 1,530
tuberculosis and treatment for 6 months 185 | 686
non primary Sjogren syndrome sicca 184 | 840
Intellectual disability 176 | 573
cutaneous lupus erythematosus 174 | 1,056
progressive supranuclear palsy 166 | 674
Atopic dermatitis 165 | 944
Endometriosis 165 | 535
Mammary Neoplasms 161 | 410
primary Sjogren syndrome 154 | 788
hepatocellular carcinoma 151 | 550
Alzheimer's disease 146 | 644
aldosterone-producing adenoma 143 | 664
gastric carcinoma 138 | 832
Amyotrophic Lateral Sclerosis 135 | 432
active Crohn's disease 135 | 918
Prostatic Neoplasms 124 | 471
esophageal adenocarcinoma 124 | 737
pancreatic carcinoma 122 | 567
IGA Glomerulonephritis 116 | 454
Down syndrome 111 | 548
Stomach Neoplasms 105 | 282
gastric cancer 105 | 436
Obesity 102 | 616
inflammatory breast cancer 96 | 404
autosomal dominant Emery-Dreifuss muscular dystrophy 95 | 499
Neurodegenerative disease 86 | 383
Polycystic Ovary Syndrome 82 | 334
Schizophrenia 79 | 503
non-small cell lung carcinoma 77 | 413
Liver carcinoma 76 | 217
Peripheral Neuropathy 76 | 303
Parkinson's disease 74 | 364
chronic rhinosinusitis 74 | 512
Crohn's disease 73 | 304
glioblastoma multiforme 73 | 347
hereditary spastic paraplegia 72 | 313
Duchenne muscular dystrophy 71 | 602
Vascular disease 71 | 281
active ulcerative colitis 71 | 477
Melanoma 69 | 261
Multiple Sclerosis 69 | 498
mucosa-associated lymphoid tissue lymphoma 69 | 480
Lung Neoplasms 67 | 171

Tissue

Female tissues 3,430 | 18,646
Nervous System 3,425 | 18,560
Digestive Tract 3,420 | 18,472
Male tissues 3,419 | 17,968
Endocrine System 3,417 | 18,511
Blood and immune system 3,413 | 17,994
Liver and Pancreas 3,413 | 18,135
Urinary Tract 3,413 | 18,443
Cardiovascular System 3,405 | 17,957
Respiratory system 3,379 | 17,483
Skin and soft tissues 3,379 | 18,114

Target Family

Non-IDG 1,864 | 11,969
Enzyme 738 | 4,146
Transcription Factor 433 | 1,400
Epigenetic 167 | 242
Kinase 164 | 634
Nuclear Receptor 46 | 48
TF/Epigenetic 26 | 38
Transporter 15 | 473
GPCR 7 | 408
Ion Channel 4 | 341

Compartment GO Term

Nuclear lumen 3,464 | 3,464
cellular_component 18,237 | 18,237
Cell 15,806 | 15,806
Cell part 15,806 | 15,806
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,648 | 12,648
membrane-bounded organelle 11,793 | 11,793
Intracellular organelle 11,617 | 11,617
Intracellular membrane-bounded... 10,618 | 10,618
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,169 | 8,169
Intracellular organelle part 8,011 | 8,011
Cytoplasmic part 7,830 | 7,830
Nucleus 7,577 | 7,577
Membrane part 6,470 | 6,470
Cytosol 6,035 | 6,035
Plasma membrane 5,673 | 5,673
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,171 | 5,171
Cell periphery 5,146 | 5,146
Nucleoplasm 4,929 | 4,929
Extracellular region 4,606 | 4,606
Protein complex 4,439 | 4,439
Intracellular organelle lumen 4,330 | 4,330
Organelle lumen 4,330 | 4,330
membrane-enclosed lumen 4,330 | 4,330
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,839 | 3,839
non-membrane-bounded organelle 3,838 | 3,838
Nuclear part 3,807 | 3,807
Endomembrane system 3,720 | 3,720
Vesicle 3,666 | 3,666
membrane-bounded vesicle 3,494 | 3,494
Extracellular organelle 2,849 | 2,849
Extracellular vesicle 2,848 | 2,848
Extracellular exosome 2,828 | 2,828
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,564 | 2,564
Cytoskeleton 2,046 | 2,046
Golgi apparatus 1,946 | 1,946
Endoplasmic reticulum 1,872 | 1,872
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Vesicles 1,625 | 1,625
Cytoskeletal part 1,568 | 1,568
Mitochondrion 1,531 | 1,531
Cell projection 1,426 | 1,426
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,305 | 1,305
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,234 | 1,234
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Mitochondria 1,003 | 1,003
Chromosome 999 | 999
Mitochondrial part 989 | 989
Nucleoli 952 | 952
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 793 | 793
Intracellular ribonucleoprotei... 789 | 789
Nucleoplasm part 781 | 781
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 739 | 739
Plasma membrane protein comple... 721 | 721
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Microtubule organizing center 680 | 680
Centrosome 676 | 676
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Synapse 594 | 594
Lytic vacuole 571 | 571

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Myeloma-overexpressed gene 2 protein COPS9 Tdark Non-IDG 0.21 0.67 12
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 MAGI1 Tbio Enzyme -1.04868 9.00 130
Huntingtin HTT Tchem Non-IDG -3.32908 2140.8 521
Splicing regulatory glutamine/lysine-rich protein 1 SREK1 Tdark Non-IDG -0.37946 3.77 39
DNA-directed RNA polymerase II subunit RPB2 POLR2B Tbio Enzyme -2.47495 286.5 135
WD repeat-containing protein mio MIOS Tdark Non-IDG -1.44864 27.4 14
Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 DHX15 Tbio Enzyme -1.70052 49.6 108
mRNA cap guanine-N7 methyltransferase RNMT Tbio Enzyme -1.91115 79.0 301
Receptor tyrosine-protein kinase erbB-2 ERBB2 Tclin Kinase -4.25806 19000.3 3336
Small cell adhesion glycoprotein SMAGP Tdark Non-IDG 0.00000 1.85 72