Development Level

Tbio 2,423 | 10,625
Tdark 499 | 7,003
Tchem 458 | 1,890
Tclin 85 | 602

Collection

Eligible Kinase Proteins 26 | 134
Eligible non-olfactory GPCR Proteins 3 | 145

IMPC Term

preweaning lethality, complete... 220 | 633
preweaning lethality, incomple... 65 | 260
embryonic lethality prior to t... 63 | 187
embryonic lethality prior to o... 60 | 148
abnormal behavior 53 | 226
decreased body weight 51 | 174
decreased total body fat amoun... 43 | 186
decreased lean body mass 42 | 195
abnormal embryo size 37 | 112
abnormal bone structure 33 | 131
decreased body length 33 | 108
decreased bone mineral content 31 | 157
decreased circulating glucose ... 29 | 121
increased or absent threshold ... 29 | 128
abnormal retina morphology 28 | 100
hyperactivity 27 | 108
decreased bone mineral density 26 | 126
increased circulating alkaline... 26 | 119
increased lean body mass 25 | 107
decreased grip strength 24 | 123
enlarged heart 24 | 111
increased bone mineral content 24 | 92
increased grip strength 24 | 83
increased mean corpuscular hem... 23 | 93
decreased circulating choleste... 22 | 85
increased mean corpuscular vol... 22 | 91
abnormal lens morphology 21 | 73
decreased circulating HDL chol... 21 | 77
prenatal lethality prior to he... 21 | 64
increased sacral vertebrae num... 20 | 62
abnormal bone mineralization 19 | 55
decreased lumbar vertebrae num... 18 | 62
decreased rib number 18 | 59
abnormal coat/hair pigmentatio... 17 | 54
decreased leukocyte cell numbe... 17 | 54
short tibia 17 | 82
decreased caudal vertebrae num... 16 | 49
decreased circulating serum al... 16 | 79
decreased circulating triglyce... 16 | 83
decreased hemoglobin content 16 | 53
decreased prepulse inhibition 15 | 52
increased circulating HDL chol... 15 | 63
abnormal retinal pigmentation 14 | 61
hypoactivity 14 | 89
increased bone mineral density 14 | 52
increased circulating sodium l... 14 | 71
increased fasted circulating g... 14 | 68
abnormal eye morphology 13 | 38
abnormal gait 13 | 51
decreased circulating LDL chol... 13 | 37
decreased fasted circulating g... 13 | 49
male infertility 13 | 62
abnormal heart morphology 12 | 51
decreased circulating alanine ... 12 | 53
decreased erythrocyte cell num... 12 | 43
decreased mean corpuscular vol... 12 | 50
corneal opacity 11 | 25
increased circulating choleste... 11 | 53
increased circulating creatini... 11 | 29
thrombocytopenia 11 | 46
abnormal cornea morphology 10 | 24
abnormal locomotor activation 10 | 26
cataract 10 | 26
decreased heart weight 10 | 44
decreased hematocrit 10 | 25
decreased mean corpuscular hem... 10 | 34
embryonic growth retardation 10 | 28
polydactyly 10 | 22
abnormal behavioral response t... 9 | 52
abnormal neural tube closure 9 | 37
anophthalmia 9 | 20
decreased circulating aspartat... 9 | 27
decreased circulating insulin ... 9 | 75
decreased circulating iron lev... 9 | 25
decreased circulating total pr... 9 | 41
decreased startle reflex 9 | 48
decreased threshold for audito... 9 | 32
impaired glucose tolerance 9 | 52
increased circulating chloride... 9 | 43
increased circulating triglyce... 9 | 24
abnormal limb bud morphology 8 | 15
abnormal sleep behavior 8 | 63
abnormal spleen morphology 8 | 36
decreased T cell number 8 | 31
decreased circulating alkaline... 8 | 41
decreased circulating chloride... 8 | 32
decreased circulating free fat... 8 | 39
decreased circulating fructosa... 8 | 31
decreased eosinophil cell numb... 8 | 41
female infertility 8 | 34
improved glucose tolerance 8 | 56
increased blood urea nitrogen ... 8 | 44
increased exploration in new e... 8 | 56
increased heart weight 8 | 37
increased hemoglobin content 8 | 45
increased mean corpuscular hem... 8 | 25
increased startle reflex 8 | 38
increased total body fat amoun... 8 | 57
pale yolk sac 8 | 12
tremors 8 | 34

Disease

ovarian cancer 2,069 | 8,492
osteosarcoma 1,744 | 7,933
medulloblastoma, large-cell 1,325 | 6,234
psoriasis 1,300 | 6,685
glioblastoma 1,167 | 5,572
lung cancer 1,137 | 4,473
atypical teratoid / rhabdoid tumor 898 | 4,369
Cancer 795 | 2,346
malignant mesothelioma 781 | 3,163
Breast cancer 720 | 3,099
primitive neuroectodermal tumor 687 | 3,031
intraductal papillary-mucinous neoplasm (IPMN) 678 | 3,289
group 3 medulloblastoma 636 | 2,254
oligodendroglioma 605 | 2,849
pediatric high grade glioma 592 | 2,712
intraductal papillary-mucinous carcinoma (IPMC) 585 | 2,988
non-small cell lung cancer 578 | 2,798
invasive ductal carcinoma 558 | 2,950
ependymoma 535 | 2,514
lung adenocarcinoma 517 | 2,714
intraductal papillary-mucinous adenoma (IPMA) 505 | 2,956
Multiple myeloma 482 | 1,328
Carcinoma 451 | 2,147
pilocytic astrocytoma 448 | 3,086
astrocytic glioma 436 | 2,241
pancreatic cancer 429 | 2,300
subependymal giant cell astrocytoma 422 | 2,287
Pick disease 419 | 1,893
astrocytoma 381 | 1,493
group 4 medulloblastoma 372 | 1,875
adult high grade glioma 351 | 2,148
pancreatic ductal adenocarcinoma liver metastasis 350 | 1,795
acute quadriplegic myopathy 344 | 1,157
colon cancer 341 | 1,475
lung carcinoma 339 | 2,844
diabetes mellitus 338 | 1,663
ductal carcinoma in situ 328 | 1,745
ulcerative colitis 327 | 2,087
breast carcinoma 324 | 1,614
pituitary cancer 324 | 1,972
sonic hedgehog group medulloblastoma 323 | 1,482
juvenile dermatomyositis 317 | 1,189
adrenocortical carcinoma 313 | 1,427
Waldenstrons macroglobulinemia 309 | 765
medulloblastoma 299 | 1,524
dermatomyositis 295 | 967
Rheumatoid Arthritis 285 | 1,171
interstitial cystitis 282 | 2,299
posterior fossa group A ependymoma 268 | 1,511
tuberculosis 266 | 1,563
acute myeloid leukemia 241 | 785
spina bifida 240 | 1,064
atypical teratoid/rhabdoid tumor 238 | 1,095
primary pancreatic ductal adenocarcinoma 236 | 1,271
cystic fibrosis 223 | 1,670
nasopharyngeal carcinoma 221 | 1,056
posterior fossa group B ependymoma 195 | 1,530
tuberculosis and treatment for 6 months 185 | 686
non primary Sjogren syndrome sicca 184 | 840
Intellectual disability 176 | 573
cutaneous lupus erythematosus 174 | 1,056
progressive supranuclear palsy 166 | 674
Atopic dermatitis 165 | 944
Endometriosis 165 | 535
Mammary Neoplasms 161 | 410
primary Sjogren syndrome 155 | 789
hepatocellular carcinoma 151 | 550
Alzheimer's disease 146 | 644
aldosterone-producing adenoma 143 | 664
gastric carcinoma 138 | 832
Amyotrophic Lateral Sclerosis 135 | 432
active Crohn's disease 135 | 918
Prostatic Neoplasms 124 | 471
esophageal adenocarcinoma 124 | 737
pancreatic carcinoma 122 | 567
IGA Glomerulonephritis 116 | 454
Down syndrome 111 | 548
Stomach Neoplasms 105 | 282
gastric cancer 105 | 436
Obesity 102 | 616
inflammatory breast cancer 96 | 404
autosomal dominant Emery-Dreifuss muscular dystrophy 95 | 499
Neurodegenerative disease 86 | 383
Polycystic Ovary Syndrome 83 | 335
Schizophrenia 79 | 503
non-small cell lung carcinoma 77 | 413
Liver carcinoma 76 | 217
Peripheral Neuropathy 76 | 303
Parkinson's disease 74 | 364
chronic rhinosinusitis 74 | 512
Crohn's disease 73 | 304
glioblastoma multiforme 73 | 347
hereditary spastic paraplegia 72 | 313
Duchenne muscular dystrophy 71 | 602
Vascular disease 71 | 281
active ulcerative colitis 71 | 477
Melanoma 69 | 261
Multiple Sclerosis 69 | 498
mucosa-associated lymphoid tissue lymphoma 69 | 480
Lung Neoplasms 67 | 171

Tissue

Female tissues 3,431 | 18,647
Nervous System 3,426 | 18,561
Digestive Tract 3,421 | 18,473
Male tissues 3,420 | 17,969
Endocrine System 3,418 | 18,512
Blood and immune system 3,414 | 17,995
Liver and Pancreas 3,414 | 18,136
Urinary Tract 3,414 | 18,444
Cardiovascular System 3,406 | 17,958
Respiratory system 3,380 | 17,484
Skin and soft tissues 3,380 | 18,115

Target Family

Non-IDG 1,864 | 11,969
Enzyme 739 | 4,146
Transcription Factor 433 | 1,400
Epigenetic 167 | 242
Kinase 164 | 634
Nuclear Receptor 46 | 48
TF/Epigenetic 26 | 38
Transporter 15 | 473
GPCR 7 | 408
Ion Channel 4 | 341

Compartment GO Term

Nuclear lumen 3,465 | 3,465
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,612 | 13,612
Intracellular part 13,475 | 13,475
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,353 | 10,353
Membrane 8,871 | 8,871
Organelle part 8,169 | 8,169
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,831 | 7,831
Nucleus 7,577 | 7,577
Membrane part 6,469 | 6,469
Cytosol 6,034 | 6,034
Plasma membrane 5,673 | 5,673
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,171 | 5,171
Cell periphery 5,146 | 5,146
Nucleoplasm 4,930 | 4,930
Extracellular region 4,607 | 4,607
Protein complex 4,439 | 4,439
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,874 | 3,874
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,592 | 2,592
Plasma membrane part 2,564 | 2,564
Cytoskeleton 2,046 | 2,046
Golgi apparatus 1,946 | 1,946
Endoplasmic reticulum 1,872 | 1,872
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Vesicles 1,625 | 1,625
Cytoskeletal part 1,568 | 1,568
Mitochondrion 1,530 | 1,530
Cell projection 1,425 | 1,425
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,234 | 1,234
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,092 | 1,092
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,084 | 1,084
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Mitochondria 1,003 | 1,003
Chromosome 999 | 999
Mitochondrial part 988 | 988
Nucleoli 950 | 950
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 815 | 815
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 781 | 781
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 739 | 739
Plasma membrane protein comple... 721 | 721
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Microtubule organizing center 680 | 680
Centrosome 676 | 676
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 656 | 656
Extracellular matrix 633 | 633
Synapse 594 | 594
Lytic vacuole 571 | 571

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA polymerase delta catalytic subunit POLD1 Tclin Enzyme -2.02098 96.6 198
cAMP-dependent protein kinase catalytic subunit alpha PRKACA Tchem Kinase -1.02404 9.59 274
Lysyl oxidase homolog 2 LOXL2 Tbio Enzyme -2.17984 142.0 237
Thioredoxin domain-containing protein 2 TXNDC2 Tbio Non-IDG -0.71996 6.88 13
Metal-response element-binding transcription factor 2 MTF2 Tbio Epigenetic -1.74028 52.0 101
Serine/threonine-protein kinase RIO1 RIOK1 Tchem Kinase -0.72835 5.14 142
ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 Tbio Transporter -0.85002 7.01 82
Cullin-associated NEDD8-dissociated protein 1 CAND1 Tbio Non-IDG -1.85520 69.1 156
SH3 domain-binding glutamic acid-rich-like protein 2 SH3BGRL2 Tbio Non-IDG 0.08 0.71 6
tRNA-splicing endonuclease subunit Sen15 TSEN15 Tdark Enzyme -0.33090 2.16 47