Development Level

Tbio 11 | 11,445

IMPC Phenotype

embryonic lethality prior to o... 3 | 239
preweaning lethality, complete... 3 | 979
embryonic lethality prior to t... 2 | 278
abnormal heart morphology 1 | 162
decreased circulating insulin ... 1 | 76
decreased total body fat amoun... 1 | 207
enlarged heart 1 | 210
increased startle reflex 1 | 112
prenatal lethality prior to he... 1 | 87

Disease

osteosarcoma 9 | 7,950
ovarian cancer 6 | 8,520
group 3 medulloblastoma 5 | 4,104
Pontocerebellar hypoplasia 3 | 36
malignant mesothelioma 3 | 3,232
psoriasis 3 | 6,694
Autosomal recessive predisposition 2 | 1,442
Carcinoma 2 | 11,493
Cerebral atrophy 2 | 178
Cognitive delay 2 | 608
Feeding difficulties 2 | 127
Global developmental delay 2 | 608
Mental and motor retardation 2 | 608
Multiple myeloma 2 | 1,332
Neurodegenerative disease 2 | 414
Pontocerebellar Hypoplasia Type 1 2 | 5
X-linked cerebral adrenoleukodystrophy 2 | 116
astrocytic glioma 2 | 2,597
colon cancer 2 | 1,478
lung cancer 2 | 4,740
medulloblastoma, large-cell 2 | 6,241
non-small cell lung cancer 2 | 2,890
oligodendroglioma 2 | 2,850
Absent speech 1 | 43
Achondroplasia 1 | 21
Alcoholic Intoxication, Chronic 1 | 289
Atrophy of cerebellum 1 | 103
Axial hypotonia 1 | 46
Botulism 1 | 24
Brachydactyly 1 | 156
Breast cancer 1 | 3,578
Cerebellar cyst 1 | 5
Cerebellar degeneration 1 | 103
Charcot-Marie-Tooth disease type 1C 1 | 5
Congenital deafness 1 | 185
Contracture 1 | 96
Contracture of joint 1 | 93
Deafness 1 | 198
Degenerative brain disorder 1 | 100
Disease Progression 1 | 136
Failure to gain weight 1 | 365
Flexion contracture 1 | 93
Flexion contractures of joints 1 | 93
Foot Deformities 1 | 30
Gastric antral vascular ectasia 1 | 10
Growth delay 1 | 114
Growth failure 1 | 114
Growth retardation 1 | 115
Hearing Loss, Partial 1 | 185
Hemophagocytic lymphohistiocytosis 1 | 30
Highly variable severity 1 | 157
Hyperreflexia 1 | 209
Hypoplasia of corpus callosum 1 | 90
Infratentorial atrophy 1 | 103
Kidney cancer 1 | 2,613
Leukemia 1 | 104
Liver neoplasms 1 | 130
Low Vision 1 | 174
Microvillus inclusion disease 1 | 8
Muscle Spasticity 1 | 195
Muscle Weakness 1 | 170
Myositis 1 | 30
Neurogenic Muscular Atrophy 1 | 139
Neurogenic muscle atrophy, especially in the lower limbs 1 | 139
Pediatric failure to thrive 1 | 365
Polyhydramnios 1 | 108
Poor growth 1 | 114
Poor head control 1 | 14
Precancerous Conditions 1 | 80
Prenatal onset 1 | 139
Progressive microcephaly 1 | 32
Respiratory Failure 1 | 104
Respiratory Insufficiency 1 | 132
Respiratory function loss 1 | 121
Skeletal muscle atrophy 1 | 139
Spinal muscular atrophy 1 | 34
Stomach Neoplasms 1 | 300
Strabismus 1 | 270
Supratentorial atrophy 1 | 94
Systemic scleroderma 1 | 60
Variable expressivity 1 | 157
Very poor growth 1 | 114
Visual Impairment 1 | 174
Waldenstrons macroglobulinemia 1 | 765
acute myeloid leukemia 1 | 783
cat-scratch disease 1 | 9
dermatomyositis 1 | 966
diabetes mellitus 1 | 1,728
gastric cancer 1 | 459
glioblastoma multiforme 1 | 142
hearing impairment 1 | 199
hepatocellular carcinoma 1 | 547
intraductal papillary-mucinous adenoma (IPMA) 1 | 2,955
invasive ductal carcinoma 1 | 2,951
muscle degeneration 1 | 139
nonverbal 1 | 43
pancreatic cancer 1 | 2,398
pancreatic carcinoma 1 | 562
subependymal giant cell astrocytoma 1 | 2,287
tuberculosis 1 | 2,010

Tissue

Blood and immune system 11 | 16,909
Cardiovascular System 11 | 15,192
Digestive Tract 11 | 17,369
Endocrine System 11 | 18,159
Female tissues 11 | 17,400
Liver and Pancreas 11 | 16,750
Male tissues 11 | 17,142
Nervous System 11 | 16,725
Respiratory system 11 | 16,393
Skin and soft tissues 11 | 17,230
Urinary Tract 11 | 16,678

Target Family

Enzyme 7 | 4,145
Non-IDG 4 | 12,091

Compartment GO Term

Nuclear exosome (RNase complex... 11 | 11
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,784 | 8,784
Membrane 8,531 | 8,531
Nucleus 7,562 | 7,562
Cytosol 6,686 | 6,686
Membrane part 6,554 | 6,554
Plasma membrane 5,830 | 5,830
Macromolecular complex 5,475 | 5,475
Intrinsic component of membran... 5,458 | 5,458
Cell periphery 5,382 | 5,382
Integral component of membrane 5,331 | 5,331
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,975 | 3,975
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,674 | 3,674
Organelle membrane 2,846 | 2,846
Extracellular region 2,732 | 2,732
Plasma membrane part 2,594 | 2,594
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,217 | 2,217
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,932 | 1,932
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,641 | 1,641
Cytoskeletal part 1,637 | 1,637
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 970 | 970
Neuron part 969 | 969
Supramolecular polymer 967 | 967
Supramolecular complex 966 | 966
Cell junction 960 | 960
Supramolecular fiber 959 | 959
Golgi apparatus part 950 | 950
Nucleoli 942 | 942
Endosome 930 | 930
Nucleolus 926 | 926
Chromosomal part 889 | 889
GO:0098796 884 | 884
Ribonucleoprotein complex 865 | 865
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 850 | 850
Transferase complex 849 | 849
Cell surface 842 | 842
Plasma membrane region 841 | 841
Vesicle membrane 801 | 801
Cytoplasmic vesicle membrane 795 | 795
Polymeric cytoskeletal fiber 764 | 764
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 714 | 714
Neuron projection 711 | 711
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Exosome complex exonuclease RRP44 DIS3 Tbio Enzyme -1.80730 64.2 141
Exosome complex component RRP4 EXOSC2 Tbio Non-IDG -0.28065 2.13 121
Exosome complex component MTR3 EXOSC6 Tbio Enzyme -0.78888 5.11 84
Exosome complex component RRP41 EXOSC4 Tbio Enzyme -1.96200 85.3 113
Exosome complex component RRP45 EXOSC9 Tbio Enzyme -1.17714 13.5 92
Exosome complex component RRP46 EXOSC5 Tbio Enzyme -1.31759 21.1 114
Exosome complex component CSL4 EXOSC1 Tbio Non-IDG -2.07438 110.2 129
Nuclear nucleic acid-binding protein C1D C1D Tbio Non-IDG -1.81349 69.3 176
Exosome complex component RRP42 EXOSC7 Tbio Enzyme -0.83091 5.93 161
Exosome complex component RRP43 EXOSC8 Tbio Enzyme -1.44056 25.6 87