Development Level

Tbio 277 | 10,625
Tdark 71 | 7,003
Tchem 45 | 1,890
Tclin 15 | 602

Collection

Eligible Ion Channel Proteins 1 | 117
Eligible Kinase Proteins 1 | 134

IMPC Term

preweaning lethality, complete... 16 | 633
preweaning lethality, incomple... 10 | 260
abnormal behavior 7 | 226
decreased bone mineral content 7 | 157
decreased body weight 6 | 174
decreased grip strength 6 | 123
decreased rib number 6 | 59
decreased lean body mass 5 | 195
increased mean corpuscular hem... 5 | 93
abnormal bone structure 4 | 131
decreased circulating choleste... 4 | 85
decreased circulating glucose ... 4 | 121
hypoactivity 4 | 89
increased circulating alkaline... 4 | 119
abnormal sleep behavior 3 | 63
abnormal snout morphology 3 | 18
decreased body length 3 | 108
decreased bone mineral density 3 | 126
decreased circulating HDL chol... 3 | 77
decreased circulating alkaline... 3 | 41
decreased lumbar vertebrae num... 3 | 62
impaired glucose tolerance 3 | 52
increased blood urea nitrogen ... 3 | 44
increased lean body mass 3 | 107
increased mean corpuscular vol... 3 | 91
increased sacral vertebrae num... 3 | 62
small thymus 3 | 11
tremors 3 | 34
abnormal behavioral response t... 2 | 52
abnormal bone mineralization 2 | 55
abnormal coping response 2 | 12
abnormal heart left ventricle ... 2 | 20
abnormal lens morphology 2 | 73
abnormal locomotor activation 2 | 26
abnormal motor coordination/ b... 2 | 4
abnormal retina morphology 2 | 100
decreased basophil cell number 2 | 11
decreased caudal vertebrae num... 2 | 49
decreased circulating aspartat... 2 | 27
decreased circulating glycerol... 2 | 19
decreased fasted circulating g... 2 | 49
decreased hematocrit 2 | 25
decreased hemoglobin content 2 | 53
decreased leukocyte cell numbe... 2 | 54
decreased pulmonary respirator... 2 | 4
enlarged heart 2 | 111
enlarged stomach 2 | 2
hydrops fetalis 2 | 22
hyperactivity 2 | 108
immune system phenotype 2 | 17
increased circulating creatini... 2 | 29
increased circulating triglyce... 2 | 24
increased grip strength 2 | 83
increased or absent threshold ... 2 | 128
lethargy 2 | 5
short tibia 2 | 82
thrombocytopenia 2 | 46
abnormal cornea morphology 1 | 24
abnormal embryo size 1 | 112
abnormal eye morphology 1 | 38
abnormal heart morphology 1 | 51
abnormal iris morphology 1 | 12
abnormal limb bud morphology 1 | 15
abnormal retinal inner nuclear... 1 | 5
abnormal retinal pigmentation 1 | 61
abnormal rib morphology 1 | 28
abnormal skin morphology 1 | 23
abnormal thoracic vertebrae mo... 1 | 16
abnormal tooth morphology 1 | 24
cataract 1 | 26
corneal opacity 1 | 25
cyanosis 1 | 6
decreased CD8-positive, alpha-... 1 | 26
decreased KLRG1-positive NK ce... 1 | 9
decreased T cell number 1 | 31
decreased circulating bilirubi... 1 | 14
decreased circulating calcium ... 1 | 33
decreased circulating magnesiu... 1 | 11
decreased circulating potassiu... 1 | 17
decreased exploration in new e... 1 | 9
decreased heart weight 1 | 44
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular hem... 1 | 19
decreased mean corpuscular vol... 1 | 50
decreased thoracic vertebrae n... 1 | 7
decreased total retina thickne... 1 | 20
decreased vertical activity 1 | 22
female infertility 1 | 34
hemorrhage 1 | 12
impaired righting response 1 | 19
increased CD4-positive, CD25-p... 1 | 18
increased bone mineral density 1 | 52
increased circulating choleste... 1 | 53
increased lactate dehydrogenas... 1 | 3
irregularly shaped pupil 1 | 7
microphthalmia 1 | 15
premature death 1 | 5
shortened PQ interval 1 | 6
small adrenal glands 1 | 15
vertebral fusion 1 | 23

Disease

ovarian cancer 231 | 8,492
osteosarcoma 205 | 7,933
medulloblastoma, large-cell 168 | 6,234
psoriasis 154 | 6,685
lung cancer 145 | 4,473
glioblastoma 134 | 5,572
atypical teratoid / rhabdoid tumor 104 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 91 | 3,289
Breast cancer 88 | 3,099
malignant mesothelioma 87 | 3,163
intraductal papillary-mucinous carcinoma (IPMC) 85 | 2,988
group 3 medulloblastoma 84 | 2,254
invasive ductal carcinoma 79 | 2,950
non-small cell lung cancer 77 | 2,798
primitive neuroectodermal tumor 75 | 3,031
pediatric high grade glioma 73 | 2,712
Cancer 71 | 2,346
intraductal papillary-mucinous adenoma (IPMA) 71 | 2,956
oligodendroglioma 71 | 2,849
pancreatic cancer 62 | 2,300
ependymoma 61 | 2,514
lung adenocarcinoma 60 | 2,714
pilocytic astrocytoma 59 | 3,086
Carcinoma 57 | 2,147
Multiple myeloma 57 | 1,328
subependymal giant cell astrocytoma 57 | 2,287
Pick disease 56 | 1,893
lung carcinoma 51 | 2,844
acute quadriplegic myopathy 49 | 1,157
astrocytic glioma 49 | 2,241
dermatomyositis 49 | 967
colon cancer 48 | 1,475
pancreatic ductal adenocarcinoma liver metastasis 48 | 1,795
group 4 medulloblastoma 45 | 1,875
primary pancreatic ductal adenocarcinoma 45 | 1,271
breast carcinoma 44 | 1,614
ductal carcinoma in situ 43 | 1,745
interstitial cystitis 43 | 2,299
ulcerative colitis 42 | 2,087
adult high grade glioma 41 | 2,148
juvenile dermatomyositis 40 | 1,189
astrocytoma 37 | 1,493
tuberculosis 37 | 1,563
Rheumatoid Arthritis 36 | 1,171
pituitary cancer 36 | 1,972
adrenocortical carcinoma 34 | 1,427
medulloblastoma 34 | 1,524
posterior fossa group A ependymoma 34 | 1,511
Waldenstrons macroglobulinemia 33 | 765
cystic fibrosis 33 | 1,670
nasopharyngeal carcinoma 33 | 1,056
atypical teratoid/rhabdoid tumor 29 | 1,095
cutaneous lupus erythematosus 28 | 1,056
diabetes mellitus 27 | 1,663
primary Sjogren syndrome 26 | 789
sonic hedgehog group medulloblastoma 26 | 1,482
aldosterone-producing adenoma 25 | 664
posterior fossa group B ependymoma 24 | 1,530
Alzheimer's disease 23 | 644
Atopic dermatitis 22 | 944
Neurodegenerative disease 22 | 383
acute myeloid leukemia 22 | 785
non primary Sjogren syndrome sicca 22 | 840
Amyotrophic Lateral Sclerosis 21 | 432
Down syndrome 21 | 548
tuberculosis and treatment for 6 months 21 | 686
Mammary Neoplasms 20 | 410
esophageal adenocarcinoma 20 | 737
gastric carcinoma 20 | 832
progressive supranuclear palsy 20 | 674
Duchenne muscular dystrophy 18 | 602
autosomal dominant Emery-Dreifuss muscular dystrophy 18 | 499
active Crohn's disease 17 | 918
spina bifida 17 | 1,064
Emery-Dreifuss muscular dystrophy 15 | 24
Prostatic Neoplasms 15 | 471
Vascular disease 15 | 281
hereditary spastic paraplegia 15 | 313
Asthma 14 | 349
Endometriosis 14 | 535
Schizophrenia 14 | 503
tuberculosis and treatment for 3 months 14 | 327
IGA Glomerulonephritis 13 | 454
active ulcerative colitis 13 | 477
mucosa-associated lymphoid tissue lymphoma 13 | 480
sarcoidosis 13 | 368
Epilepsy 12 | 346
Intellectual disability 11 | 573
Multiple Sclerosis 11 | 498
Obesity 11 | 616
Parkinson's disease 11 | 364
chronic lymphocytic leukemia 11 | 244
Crohn's disease 10 | 304
HIV Infections 10 | 100
Influenza 10 | 142
inflammatory breast cancer 10 | 404
Diabetes Mellitus, Non-Insulin-Dependent 9 | 161
Stomach Neoplasms 9 | 282
hepatocellular carcinoma 9 | 550
pancreatic carcinoma 9 | 567

Tissue

Nervous System 402 | 18,561
Blood and immune system 401 | 17,995
Endocrine System 401 | 18,512
Female tissues 401 | 18,647
Liver and Pancreas 400 | 18,136
Male tissues 400 | 17,969
Urinary Tract 400 | 18,444
Digestive Tract 399 | 18,473
Cardiovascular System 397 | 17,958
Skin and soft tissues 396 | 18,115
Respiratory system 394 | 17,484

Target Family

Non-IDG 254 | 11,969
Enzyme 82 | 4,146
Transcription Factor 20 | 1,400
Ion Channel 15 | 341
Kinase 15 | 634
Transporter 8 | 473
Epigenetic 6 | 242
GPCR 6 | 408
Nuclear Receptor 1 | 48
TF/Epigenetic 1 | 38

Compartment GO Term

Nuclear envelope 408 | 408
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,612 | 13,612
Intracellular part 13,475 | 13,475
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,353 | 10,353
Membrane 8,871 | 8,871
Organelle part 8,169 | 8,169
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,831 | 7,831
Nucleus 7,577 | 7,577
Membrane part 6,469 | 6,469
Cytosol 6,034 | 6,034
Plasma membrane 5,673 | 5,673
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,171 | 5,171
Cell periphery 5,146 | 5,146
Nucleoplasm 4,930 | 4,930
Extracellular region 4,607 | 4,607
Protein complex 4,439 | 4,439
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,874 | 3,874
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,592 | 2,592
Plasma membrane part 2,564 | 2,564
Cytoskeleton 2,046 | 2,046
Golgi apparatus 1,946 | 1,946
Endoplasmic reticulum 1,872 | 1,872
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Vesicles 1,625 | 1,625
Cytoskeletal part 1,568 | 1,568
Mitochondrion 1,530 | 1,530
Cell projection 1,425 | 1,425
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,234 | 1,234
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,092 | 1,092
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,084 | 1,084
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Mitochondria 1,003 | 1,003
Chromosome 999 | 999
Mitochondrial part 988 | 988
Nucleoli 950 | 950
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 815 | 815
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 781 | 781
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 739 | 739
Plasma membrane protein comple... 721 | 721
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Microtubule organizing center 680 | 680
Centrosome 676 | 676
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 656 | 656
Extracellular matrix 633 | 633
Synapse 594 | 594
Lytic vacuole 571 | 571

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Putative peripheral benzodiazepine receptor-related protein TSPO Tbio Non-IDG -3.04986 2078.3 186
Microsomal glutathione S-transferase 2 MGST2 Tchem Enzyme -1.10891 12.3 89
Retinal guanylyl cyclase 1 GUCY2D Tbio Kinase -2.18888 178.4 196
Probable E3 ubiquitin-protein ligase DTX2 DTX2 Tbio Enzyme -1.74631 56.9 103
ATP-dependent RNA helicase DDX19A DDX19A Tdark Enzyme 0.02 0.99 53
Short transient receptor potential channel 7 TRPC7 Tbio Ion Channel -2.43795 198.9 193
1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon AGPAT5 Tbio Enzyme -0.69820 4.42 156
Gamma-taxilin TXLNG Tbio Non-IDG -1.67769 52.5 62
Charged multivesicular body protein 7 CHMP7 Tbio Non-IDG -0.48812 3.63 20
Leucine-rich PPR motif-containing protein, mitochondrial LRPPRC Tbio Non-IDG -1.64747 48.2 76