Development Level

Tbio 42 | 11,445
Tchem 10 | 1,598
Tdark 3 | 6,588

IMPC Phenotype

preweaning lethality, complete... 6 | 979
increased startle reflex 3 | 112
decreased vertical activity 2 | 208
abnormal behavior 1 | 298
abnormal craniofacial morpholo... 1 | 33
abnormal embryo size 1 | 220
abnormal heart morphology 1 | 162
abnormal kidney morphology 1 | 65
abnormal limb morphology 1 | 13
abnormal ovary morphology 1 | 7
abnormal thymus morphology 1 | 7
decreased eosinophil cell numb... 1 | 24
decreased grip strength 1 | 116
decreased prepulse inhibition 1 | 82
edema 1 | 59
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
enlarged thymus 1 | 5
hypoactivity 1 | 132
increased circulating choleste... 1 | 66
increased mean corpuscular hem... 1 | 36
increased mean platelet volume 1 | 45
polycystic kidney 1 | 15
small heart 1 | 10
small kidney 1 | 16
small liver 1 | 8
small lung 1 | 5
small spleen 1 | 19

Disease

Carcinoma 38 | 11,493
ovarian cancer 33 | 8,520
Cancer 26 | 2,499
lung cancer 25 | 4,740
osteosarcoma 25 | 7,950
medulloblastoma, large-cell 23 | 6,241
psoriasis 18 | 6,694
Short stature 17 | 531
group 3 medulloblastoma 17 | 4,104
Breast cancer 16 | 3,578
atypical teratoid / rhabdoid tumor 16 | 5,112
Dull intelligence 15 | 645
Intellectual disability 15 | 1,016
Low intelligence 15 | 645
Mental Retardation 15 | 645
Mental deficiency 15 | 645
Poor school performance 15 | 645
Small head 15 | 374
glioblastoma 15 | 5,792
Cognitive delay 14 | 608
Global developmental delay 14 | 608
Mental and motor retardation 14 | 608
Autosomal recessive predisposition 12 | 1,442
Decreased platelet count 11 | 111
Kidney cancer 11 | 2,613
Thrombocytopenia 11 | 197
malignant mesothelioma 11 | 3,232
Dyskeratosis congenita 10 | 24
Fanconi anemia 10 | 56
non primary Sjogren syndrome sicca 10 | 891
Fetal Growth Retardation 9 | 189
Infant, Small for Gestational Age 9 | 176
Intrauterine retardation 9 | 176
Telangiectasia of the skin 9 | 39
hypopigmented skin patch 9 | 59
Anemia 8 | 365
Bone marrow hypocellularity 8 | 20
Melanoma 8 | 711
Nijmegen breakage syndrome 8 | 24
Sparse scalp hair 8 | 42
Tracheoesophageal Fistula 8 | 36
Xeroderma pigmentosum 8 | 43
pancreatic cancer 8 | 2,398
Aplasia/Hypoplasia of the skin 7 | 16
Ataxia telangiectasia 7 | 34
Cellular immunodeficiency 7 | 17
Dental caries 7 | 164
Hyperhidrosis disorder 7 | 81
Hyperpigmented macules 7 | 42
Increased sweating 7 | 81
Multiple myeloma 7 | 1,332
Osteoporosis 7 | 363
Pick disease 7 | 1,894
Recurrent respiratory infections 7 | 141
Skin Ulcer 7 | 48
Sweating 7 | 81
ependymoma 7 | 4,679
oligodendroglioma 7 | 2,850
Abnormal blistering of the skin 6 | 54
Blister of skin 6 | 54
Blood Coagulation Disorders 6 | 42
Cerebral atrophy 6 | 178
Coagulation abnormalities 6 | 27
Dry skin 6 | 75
Dystrophia unguium 6 | 53
Esophageal Stenosis 6 | 15
Failure to gain weight 6 | 365
Frequent fractures 6 | 53
Gingival Diseases 6 | 19
Glioma 6 | 74
Hemoglobin low 6 | 124
Hemorrhagic Disorders 6 | 30
Highly variable clinical phenotype 6 | 150
Highly variable phenotype and severity 6 | 150
Highly variable phenotype, even within families 6 | 150
Hypodontia 6 | 81
Increased fracture rate 6 | 53
Leukopenia 6 | 72
Leukoplakia, Oral 6 | 20
Malabsorption 6 | 82
Microcephaly 6 | 166
Neutrophil abnormality 6 | 20
Pediatric failure to thrive 6 | 365
Phenotypic variability 6 | 150
Prostatic Neoplasms 6 | 495
Seizures 6 | 596
Skin bulla 6 | 54
Sparse hair 6 | 59
Thin, sparse hair 6 | 59
Varying degree of multiple fractures 6 | 53
Waldenstrons macroglobulinemia 6 | 765
Xerosis 6 | 75
colon cancer 6 | 1,478
diabetes mellitus 6 | 1,728
hepatocellular carcinoma 6 | 547
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,291
lung adenocarcinoma 6 | 2,716
periodontitis 6 | 293
primitive neuroectodermal tumor 6 | 3,035
ulcerative colitis 6 | 1,819

Tissue

Endocrine System 55 | 18,159
Blood and immune system 54 | 16,909
Digestive Tract 54 | 17,369
Female tissues 54 | 17,400
Liver and Pancreas 54 | 16,750
Male tissues 54 | 17,142
Respiratory system 53 | 16,393
Skin and soft tissues 53 | 17,230
Urinary Tract 53 | 16,678
Nervous System 52 | 16,725
Cardiovascular System 51 | 15,192

Target Family

Non-IDG 34 | 12,091
Enzyme 11 | 4,145
Transcription Factor 6 | 1,400
Epigenetic 3 | 242
Kinase 1 | 634

Compartment GO Term

Nuclear chromosome, telomeric ... 55 | 55
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,784 | 8,784
Membrane 8,531 | 8,531
Nucleus 7,562 | 7,562
Cytosol 6,686 | 6,686
Membrane part 6,554 | 6,554
Plasma membrane 5,830 | 5,830
Macromolecular complex 5,475 | 5,475
Intrinsic component of membran... 5,458 | 5,458
Cell periphery 5,382 | 5,382
Integral component of membrane 5,331 | 5,331
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,975 | 3,975
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,674 | 3,674
Organelle membrane 2,846 | 2,846
Extracellular region 2,732 | 2,732
Plasma membrane part 2,594 | 2,594
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,217 | 2,217
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,932 | 1,932
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,641 | 1,641
Cytoskeletal part 1,637 | 1,637
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 970 | 970
Neuron part 969 | 969
Supramolecular polymer 967 | 967
Supramolecular complex 966 | 966
Cell junction 960 | 960
Supramolecular fiber 959 | 959
Golgi apparatus part 950 | 950
Nucleoli 942 | 942
Endosome 930 | 930
Nucleolus 926 | 926
Chromosomal part 889 | 889
GO:0098796 884 | 884
Ribonucleoprotein complex 865 | 865
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 850 | 850
Transferase complex 849 | 849
Cell surface 842 | 842
Plasma membrane region 841 | 841
Vesicle membrane 801 | 801
Cytoplasmic vesicle membrane 795 | 795
Polymeric cytoskeletal fiber 764 | 764
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 714 | 714
Neuron projection 711 | 711
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
TP53-binding protein 1 TP53BP1 Tbio Epigenetic -2.69485 464.8 577
DNA repair protein XRCC3 XRCC3 Tbio Non-IDG -2.50791 314.0 414
Telomere repeats-binding bouquet formation protein 1 TERB1 Tdark Transcription Factor -0.45230 3.56 26
Transcriptional activator protein Pur-alpha PURA Tbio Non-IDG -2.17708 158.7 170
Regulator of telomere elongation helicase 1 RTEL1 Tbio Enzyme -2.66156 233.0 85
Telomeric repeat-binding factor 2-interacting protein 1 TERF2IP Tchem Non-IDG -0.75509 5.75 308
H/ACA ribonucleoprotein complex subunit 2 NHP2 Tbio Non-IDG -1.51951 28.7 54
Breast cancer type 2 susceptibility protein BRCA2 Tbio Non-IDG -3.46139 2647.6 209
CST complex subunit CTC1 CTC1 Tbio Non-IDG -1.74818 54.2 49
Telomere repeats-binding bouquet formation protein 2 TERB2 Tdark Non-IDG 0.60 0.26 6