Development Level

Tbio 305 | 10,625
Tchem 70 | 1,890
Tdark 55 | 7,003
Tclin 19 | 602

IMPC Term

preweaning lethality, complete... 36 | 633
embryonic lethality prior to o... 14 | 148
preweaning lethality, incomple... 13 | 260
embryonic lethality prior to t... 12 | 187
abnormal behavior 7 | 226
decreased lean body mass 7 | 195
decreased body weight 6 | 174
decreased total body fat amoun... 6 | 186
increased circulating sodium l... 6 | 71
abnormal bone structure 5 | 131
decreased body length 5 | 108
decreased bone mineral content 5 | 157
increased bone mineral density 5 | 52
prenatal lethality prior to he... 5 | 64
abnormal embryo size 4 | 112
decreased grip strength 4 | 123
decreased leukocyte cell numbe... 4 | 54
decreased mean corpuscular hem... 4 | 34
decreased rib number 4 | 59
enlarged heart 4 | 111
hydrops fetalis 4 | 22
increased bone mineral content 4 | 92
increased grip strength 4 | 83
increased mean corpuscular hem... 4 | 93
small testis 4 | 37
abnormal coat/hair pigmentatio... 3 | 54
abnormal cornea morphology 3 | 24
abnormal eye morphology 3 | 38
abnormal seminal vesicle morph... 3 | 47
abnormal spleen morphology 3 | 36
decreased blood urea nitrogen ... 3 | 31
decreased bone mineral density 3 | 126
decreased caudal vertebrae num... 3 | 49
decreased circulating alkaline... 3 | 41
decreased circulating glucose ... 3 | 121
decreased eosinophil cell numb... 3 | 41
decreased hemoglobin content 3 | 53
decreased mean corpuscular vol... 3 | 50
increased circulating alkaline... 3 | 119
increased circulating choleste... 3 | 53
increased circulating triglyce... 3 | 24
increased lean body mass 3 | 107
increased mean corpuscular vol... 3 | 91
increased sacral vertebrae num... 3 | 62
male infertility 3 | 62
abnormal behavioral response t... 2 | 52
abnormal coat appearance 2 | 25
abnormal coping response 2 | 12
abnormal gait 2 | 51
abnormal placement of pupils 2 | 4
abnormal retina morphology 2 | 100
abnormal rib morphology 2 | 28
abnormal tail morphology 2 | 17
abnormal tooth morphology 2 | 24
absent pinna reflex 2 | 21
cardiovascular system phenotyp... 2 | 35
corneal opacity 2 | 25
craniofacial phenotype 2 | 9
decreased B cell number 2 | 30
decreased Ly6C high monocyte n... 2 | 18
decreased circulating alanine ... 2 | 53
decreased circulating choleste... 2 | 85
decreased circulating fructosa... 2 | 31
decreased circulating serum al... 2 | 79
decreased circulating triglyce... 2 | 83
decreased fasted circulating g... 2 | 49
decreased heart weight 2 | 44
decreased lumbar vertebrae num... 2 | 62
decreased prepulse inhibition 2 | 52
embryonic growth retardation 2 | 28
female infertility 2 | 34
hyperactivity 2 | 108
hypoactivity 2 | 89
impaired glucose tolerance 2 | 52
increased body weight 2 | 42
increased circulating chloride... 2 | 43
increased circulating iron lev... 2 | 25
increased exploration in new e... 2 | 56
increased heart weight 2 | 37
increased mean corpuscular hem... 2 | 25
increased or absent threshold ... 2 | 128
narrow eye opening 2 | 15
short tibia 2 | 82
small spleen 2 | 11
vertebral fusion 2 | 23
abnormal embryo turning 1 | 15
abnormal heart morphology 1 | 51
abnormal kidney morphology 1 | 30
abnormal locomotor activation 1 | 26
abnormal neural tube closure 1 | 37
abnormal neural tube morpholog... 1 | 8
abnormal thoracic vertebrae mo... 1 | 16
decreased NK cell number 1 | 16
decreased circulating chloride... 1 | 32
decreased circulating sodium l... 1 | 18
increased CD4-positive, CD25-p... 1 | 18
increased NK cell number 1 | 19
increased circulating HDL chol... 1 | 63
increased circulating magnesiu... 1 | 10
long tibia 1 | 13

Disease

ovarian cancer 254 | 8,492
osteosarcoma 220 | 7,933
psoriasis 185 | 6,685
medulloblastoma, large-cell 182 | 6,234
lung cancer 180 | 4,473
glioblastoma 170 | 5,572
Cancer 153 | 2,346
atypical teratoid / rhabdoid tumor 131 | 4,369
malignant mesothelioma 124 | 3,163
Breast cancer 122 | 3,099
primitive neuroectodermal tumor 115 | 3,031
non-small cell lung cancer 105 | 2,798
group 3 medulloblastoma 101 | 2,254
lung adenocarcinoma 101 | 2,714
pediatric high grade glioma 93 | 2,712
intraductal papillary-mucinous neoplasm (IPMN) 85 | 3,289
invasive ductal carcinoma 84 | 2,950
intraductal papillary-mucinous carcinoma (IPMC) 75 | 2,988
Carcinoma 72 | 2,147
Multiple myeloma 64 | 1,328
colon cancer 62 | 1,475
ductal carcinoma in situ 60 | 1,745
breast carcinoma 59 | 1,614
oligodendroglioma 58 | 2,849
adrenocortical carcinoma 54 | 1,427
astrocytoma 54 | 1,493
pancreatic cancer 53 | 2,300
posterior fossa group A ependymoma 53 | 1,511
ependymoma 48 | 2,514
group 4 medulloblastoma 48 | 1,875
intraductal papillary-mucinous adenoma (IPMA) 48 | 2,956
Waldenstrons macroglobulinemia 45 | 765
nasopharyngeal carcinoma 45 | 1,056
sonic hedgehog group medulloblastoma 45 | 1,482
pituitary cancer 44 | 1,972
Rheumatoid Arthritis 43 | 1,171
Pick disease 42 | 1,893
pilocytic astrocytoma 42 | 3,086
diabetes mellitus 41 | 1,663
astrocytic glioma 39 | 2,241
subependymal giant cell astrocytoma 39 | 2,287
ulcerative colitis 39 | 2,087
Intellectual disability 37 | 573
atypical teratoid/rhabdoid tumor 37 | 1,095
dermatomyositis 37 | 967
Mammary Neoplasms 36 | 410
acute quadriplegic myopathy 36 | 1,157
juvenile dermatomyositis 36 | 1,189
Endometriosis 34 | 535
adult high grade glioma 33 | 2,148
lung carcinoma 33 | 2,844
medulloblastoma 32 | 1,524
Prostatic Neoplasms 31 | 471
interstitial cystitis 30 | 2,299
Atopic dermatitis 29 | 944
acute myeloid leukemia 29 | 785
pancreatic ductal adenocarcinoma liver metastasis 28 | 1,795
pancreatic carcinoma 26 | 567
tuberculosis 26 | 1,563
hepatocellular carcinoma 25 | 550
non primary Sjogren syndrome sicca 24 | 840
cystic fibrosis 23 | 1,670
Fanconi's anemia 22 | 50
gastric cancer 22 | 436
non-small cell lung carcinoma 22 | 413
spina bifida 22 | 1,064
cutaneous lupus erythematosus 21 | 1,056
primary Sjogren syndrome 21 | 789
IGA Glomerulonephritis 20 | 454
Melanoma 20 | 261
Peripheral Neuropathy 20 | 303
primary pancreatic ductal adenocarcinoma 20 | 1,271
aldosterone-producing adenoma 19 | 664
progressive supranuclear palsy 18 | 674
tuberculosis and treatment for 6 months 18 | 686
Ataxia telangiectasia 17 | 32
Colorectal Neoplasms 17 | 217
Male infertility 17 | 170
Microcephaly 17 | 149
Obesity 17 | 616
Stomach Neoplasms 17 | 282
inflammatory breast cancer 17 | 404
Adenoid Cystic Carcinoma 16 | 99
Liver carcinoma 16 | 217
Lung Neoplasms 16 | 171
Nijmegen breakage syndrome 16 | 23
gastric carcinoma 16 | 832
Alzheimer's disease 15 | 644
Bloom syndrome 15 | 30
Neoplastic Syndromes, Hereditary 15 | 48
esophageal adenocarcinoma 15 | 737
Adenocarcinoma 14 | 115
Adenoma 14 | 165
Bladder Neoplasm 14 | 109
Cockayne syndrome 14 | 54
Schizophrenia 14 | 503
posterior fossa group B ependymoma 14 | 1,530
Primary cutaneous T-cell lymphoma 13 | 29
active Crohn's disease 13 | 918
ovarian neoplasm 13 | 97

Tissue

Female tissues 446 | 18,647
Blood and immune system 443 | 17,995
Endocrine System 443 | 18,512
Male tissues 443 | 17,969
Nervous System 443 | 18,561
Urinary Tract 443 | 18,444
Digestive Tract 441 | 18,473
Liver and Pancreas 441 | 18,136
Cardiovascular System 440 | 17,958
Respiratory system 434 | 17,484
Skin and soft tissues 431 | 18,115

Target Family

Non-IDG 246 | 11,969
Transcription Factor 71 | 1,400
Enzyme 54 | 4,146
Epigenetic 50 | 242
Kinase 15 | 634
Nuclear Receptor 8 | 48
TF/Epigenetic 4 | 38
Transporter 1 | 473

Compartment GO Term

Nuclear chromosome 449 | 449
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,612 | 13,612
Intracellular part 13,475 | 13,475
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,353 | 10,353
Membrane 8,871 | 8,871
Organelle part 8,169 | 8,169
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,831 | 7,831
Nucleus 7,577 | 7,577
Membrane part 6,469 | 6,469
Cytosol 6,034 | 6,034
Plasma membrane 5,673 | 5,673
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,171 | 5,171
Cell periphery 5,146 | 5,146
Nucleoplasm 4,930 | 4,930
Extracellular region 4,607 | 4,607
Protein complex 4,439 | 4,439
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,874 | 3,874
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,592 | 2,592
Plasma membrane part 2,564 | 2,564
Cytoskeleton 2,046 | 2,046
Golgi apparatus 1,946 | 1,946
Endoplasmic reticulum 1,872 | 1,872
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Vesicles 1,625 | 1,625
Cytoskeletal part 1,568 | 1,568
Mitochondrion 1,530 | 1,530
Cell projection 1,425 | 1,425
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,234 | 1,234
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,092 | 1,092
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,084 | 1,084
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Mitochondria 1,003 | 1,003
Chromosome 999 | 999
Mitochondrial part 988 | 988
Nucleoli 950 | 950
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 815 | 815
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 781 | 781
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 739 | 739
Plasma membrane protein comple... 721 | 721
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Microtubule organizing center 680 | 680
Centrosome 676 | 676
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 656 | 656
Extracellular matrix 633 | 633
Synapse 594 | 594
Lytic vacuole 571 | 571

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA polymerase delta catalytic subunit POLD1 Tclin Enzyme -2.02098 96.6 198
DNA replication complex GINS protein SLD5 GINS4 Tdark Non-IDG -1.25647 17.0 45
Protection of telomeres protein 1 POT1 Tbio Non-IDG -1.79851 58.3 169
Chromodomain-helicase-DNA-binding protein 4 CHD4 Tbio Epigenetic -2.19846 145.8 170
Breast cancer metastasis-suppressor 1-like protein BRMS1L Tbio Non-IDG -1.66955 52.7 94
TERF1-interacting nuclear factor 2 TINF2 Tbio Non-IDG -1.98986 89.8 128
Histone chaperone ASF1B ASF1B Tbio Non-IDG -0.98695 10.4 108
Leucine-rich PPR motif-containing protein, mitochondrial LRPPRC Tbio Non-IDG -1.64747 48.2 76
Mothers against decapentaplegic homolog 4 SMAD4 Tbio Transcription Factor -3.12904 1149.7 572
Crossover junction endonuclease MUS81 MUS81 Tbio Enzyme -2.03597 106.6 73