Development Level

Tbio 177 | 11,651
Tchem 31 | 1,388
Tdark 25 | 6,593
Tclin 16 | 612

IMPC Phenotype

preweaning lethality, complete... 22 | 979
preweaning lethality, incomple... 11 | 499
embryonic lethality prior to t... 9 | 278
abnormal behavior 7 | 298
increased startle reflex 7 | 112
embryonic lethality prior to o... 6 | 239
decreased total body fat amoun... 5 | 207
decreased vertical activity 5 | 208
abnormal bone structure 4 | 187
increased bone mineral content 4 | 108
abnormal seminal vesicle morph... 3 | 114
decreased body weight 3 | 161
decreased mean corpuscular vol... 3 | 79
hyperactivity 3 | 148
increased bone mineral density 3 | 72
increased circulating alkaline... 3 | 122
increased circulating choleste... 3 | 66
increased lean body mass 3 | 172
small spleen 3 | 19
abnormal embryo size 2 | 220
abnormal eye morphology 2 | 68
abnormal gait 2 | 69
abnormal kidney morphology 2 | 65
abnormal retina morphology 2 | 71
abnormal spleen morphology 2 | 55
cardiovascular system phenotyp... 2 | 36
decreased blood urea nitrogen ... 2 | 51
decreased body length 2 | 101
decreased bone mineral content 2 | 151
decreased bone mineral density 2 | 126
decreased caudal vertebrae num... 2 | 53
decreased circulating alkaline... 2 | 46
decreased circulating choleste... 2 | 93
decreased circulating serum al... 2 | 82
decreased grip strength 2 | 116
decreased leukocyte cell numbe... 2 | 73
decreased prepulse inhibition 2 | 82
embryonic growth retardation 2 | 106
enlarged heart 2 | 210
hypoactivity 2 | 132
increased body weight 2 | 25
increased circulating HDL chol... 2 | 80
increased circulating triglyce... 2 | 42
increased hemoglobin content 2 | 45
increased mean corpuscular hem... 2 | 96
increased total body fat amoun... 2 | 134
short tibia 2 | 97
small testis 2 | 58
abnormal coat appearance 1 | 31
abnormal coat-hair pigmentatio... 1 | 64
abnormal cornea morphology 1 | 31
abnormal craniofacial morpholo... 1 | 33
abnormal cranium morphology 1 | 36
abnormal ear morphology 1 | 9
abnormal embryo turning 1 | 31
abnormal head morphology 1 | 10
abnormal heart left ventricle ... 1 | 16
abnormal lens morphology 1 | 81
abnormal locomotor behavior 1 | 24
abnormal neural tube closure 1 | 46
abnormal neural tube morpholog... 1 | 12
abnormal pancreas morphology 1 | 13
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal startle reflex 1 | 15
abnormal testis morphology 1 | 43
abnormal tooth morphology 1 | 24
abnormal vocalization 1 | 21
absent pinna reflex 1 | 23
cataract 1 | 92
decreased circulating LDL chol... 1 | 38
decreased circulating creatine... 1 | 4
decreased circulating insulin ... 1 | 76
decreased fasted circulating g... 1 | 65
decreased fluid intake 1 | 3
decreased lean body mass 1 | 135
edema 1 | 59
enlarged lymph nodes 1 | 37
hemorrhage 1 | 23
hydrometra 1 | 53
impaired glucose tolerance 1 | 75
impaired righting response 1 | 26
increased body length 1 | 32
increased circulating alanine ... 1 | 13
increased circulating aspartat... 1 | 15
increased circulating chloride... 1 | 41
increased circulating creatine... 1 | 5
increased circulating glycerol... 1 | 9
increased circulating magnesiu... 1 | 10
increased circulating sodium l... 1 | 71
increased lactate dehydrogenas... 1 | 3
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular vol... 1 | 92
increased prepulse inhibition 1 | 32
persistence of hyaloid vascula... 1 | 33
polycystic kidney 1 | 15
prenatal lethality prior to he... 1 | 87
small kidney 1 | 16
thin ventricular wall 1 | 24
vertebral fusion 1 | 23

Disease

Carcinoma 153 | 11,493
ovarian cancer 143 | 8,520
osteosarcoma 130 | 7,950
psoriasis 109 | 6,694
glioblastoma 106 | 5,792
lung cancer 104 | 4,740
Cancer 102 | 2,499
medulloblastoma, large-cell 99 | 6,241
atypical teratoid / rhabdoid tumor 95 | 5,112
group 3 medulloblastoma 83 | 4,104
Breast cancer 81 | 3,578
malignant mesothelioma 76 | 3,232
ependymoma 63 | 4,679
primitive neuroectodermal tumor 63 | 3,035
adult high grade glioma 56 | 3,801
invasive ductal carcinoma 56 | 2,951
lung adenocarcinoma 56 | 2,716
non-small cell lung cancer 52 | 2,890
Multiple myeloma 49 | 1,332
Kidney cancer 48 | 2,613
intraductal papillary-mucinous neoplasm (IPMN) 46 | 3,291
intraductal papillary-mucinous carcinoma (IPMC) 42 | 2,989
breast carcinoma 41 | 1,638
pancreatic cancer 38 | 2,398
oligodendroglioma 37 | 2,850
Intellectual disability 35 | 1,016
intraductal papillary-mucinous adenoma (IPMA) 35 | 2,955
ductal carcinoma in situ 34 | 1,745
Schizophrenia 33 | 1,160
astrocytoma 33 | 1,146
Astrocytoma, Pilocytic 32 | 3,081
colon cancer 32 | 1,478
subependymal giant cell astrocytoma 32 | 2,287
diabetes mellitus 31 | 1,728
Rheumatoid arthritis 30 | 1,191
astrocytic glioma 30 | 2,597
Pick disease 28 | 1,894
group 4 medulloblastoma 28 | 1,855
lung carcinoma 28 | 2,843
pancreatic ductal adenocarcinoma liver metastasis 28 | 1,962
dermatomyositis 27 | 966
juvenile dermatomyositis 27 | 1,187
pituitary cancer 27 | 1,972
tuberculosis 27 | 2,010
acute quadriplegic myopathy 26 | 1,158
interstitial cystitis 26 | 2,312
ulcerative colitis 26 | 1,819
Breast Neoplasms 23 | 445
Mammary Neoplasms 23 | 425
Waldenstrons macroglobulinemia 23 | 765
acute myeloid leukemia 23 | 783
adrenocortical carcinoma 23 | 1,428
pediatric high grade glioma 22 | 1,064
Dull intelligence 21 | 645
Low intelligence 21 | 645
Mental Retardation 21 | 645
Mental deficiency 21 | 645
Poor school performance 21 | 645
Obesity 20 | 678
Short stature 20 | 531
Muscle hypotonia 19 | 571
Epilepsy 18 | 792
nasopharyngeal carcinoma 18 | 1,058
spina bifida 18 | 1,074
Cryptorchidism 17 | 296
Endometriosis 17 | 540
Prostatic Neoplasms 17 | 495
aldosterone-producing adenoma 17 | 665
hepatocellular carcinoma 17 | 547
Bipolar Disorder 16 | 666
Cognitive delay 16 | 608
Global developmental delay 16 | 608
Liver cancer 16 | 604
Mental and motor retardation 16 | 608
Small head 16 | 374
cystic fibrosis 16 | 1,696
gastric cancer 16 | 459
pancreatic carcinoma 16 | 562
Atopic dermatitis 15 | 952
Seizures 15 | 596
non primary Sjogren syndrome sicca 15 | 891
Autosomal recessive predisposition 14 | 1,442
Lymphoid leukemia 14 | 160
Melanoma 14 | 711
Primary cutaneous T-cell lymphoma 14 | 29
medulloblastoma 14 | 720
non-small cell lung carcinoma 14 | 317
Acquired scoliosis 13 | 281
Carcinoma, Hepatocellular 13 | 228
Craniofacial Abnormalities 13 | 151
Curvature of spine 13 | 282
Immune system cancer 13 | 140
Neoplasm Metastasis 13 | 168
Peripheral T-cell lymphoma 13 | 25
Stomach Neoplasms 13 | 300
primary Sjogren syndrome 13 | 735
primary pancreatic ductal adenocarcinoma 13 | 1,109
Cleft Palate 12 | 271
Vascular disease 12 | 319
cutaneous lupus erythematosus 12 | 1,057

Tissue

Endocrine System 245 | 18,159
Digestive Tract 242 | 17,369
Skin and soft tissues 242 | 17,230
Female tissues 240 | 17,400
Male tissues 238 | 17,142
Blood and immune system 237 | 16,909
Liver and Pancreas 235 | 16,750
Nervous System 234 | 16,725
Urinary Tract 234 | 16,678
Respiratory system 232 | 16,393
Cardiovascular System 229 | 15,192

Target Family

Non-IDG 115 | 12,091
Transcription Factor 59 | 1,400
Epigenetic 47 | 242
Enzyme 19 | 4,145
Nuclear Receptor 8 | 48
Kinase 1 | 634

Compartment GO Term

Nuclear chromatin 249 | 249
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,783 | 8,783
Membrane 8,530 | 8,530
Nucleus 7,563 | 7,563
Cytosol 6,686 | 6,686
Membrane part 6,553 | 6,553
Plasma membrane 5,829 | 5,829
Macromolecular complex 5,476 | 5,476
Intrinsic component of membran... 5,457 | 5,457
Cell periphery 5,381 | 5,381
Integral component of membrane 5,330 | 5,330
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,974 | 3,974
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,673 | 3,673
Organelle membrane 2,846 | 2,846
Extracellular region 2,731 | 2,731
Plasma membrane part 2,593 | 2,593
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,216 | 2,216
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,638 | 1,638
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 968 | 968
Supramolecular complex 967 | 967
Cell junction 960 | 960
Supramolecular fiber 960 | 960
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 931 | 931
Nucleolus 927 | 927
Chromosomal part 889 | 889
GO:0098796 883 | 883
Ribonucleoprotein complex 864 | 864
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 849 | 849
Transferase complex 849 | 849
Cell surface 841 | 841
Plasma membrane region 841 | 841
Vesicle membrane 800 | 800
Cytoplasmic vesicle membrane 794 | 794
Polymeric cytoskeletal fiber 765 | 765
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 713 | 713
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
COP9 signalosome complex subunit 9 COPS9 Tbio Non-IDG 0.21 0.92 14
Transcriptional repressor scratch 2 SCRT2 Tdark Transcription Factor 0.22 1.09 25
INO80 complex subunit B INO80B Tbio Non-IDG -1.16370 15.1 53
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 PLCB1 Tbio Enzyme -2.50444 332.8 190
E1A-binding protein p400 EP400 Tbio Non-IDG -1.47248 27.6 69
Chromobox protein homolog 3 CBX3 Tbio Epigenetic -2.00023 90.5 366
Chromatin assembly factor 1 subunit A CHAF1A Tbio Non-IDG -1.60312 40.7 157
Chromatin assembly factor 1 subunit B CHAF1B Tbio Non-IDG -1.02167 9.99 181
NAD-dependent protein deacetylase sirtuin-7 SIRT7 Tbio Epigenetic -2.22094 153.0 348
Estrogen receptor ESR1 Tclin Nuclear Receptor -4.00480 8421.6 2610