Development Level

Tbio 273 | 10,625
Tchem 45 | 1,890
Tdark 29 | 7,003
Tclin 2 | 602

Collection

Kinase: IDG Consortium (Targets) 5 | 125
Kinase: IDG Consortium (Complete/Control) 2 | 37

IMPC Phenotype

preweaning lethality, complete... 28 | 633
preweaning lethality, incomple... 8 | 260
embryonic lethality prior to t... 7 | 187
embryonic lethality prior to o... 6 | 148
decreased body weight 5 | 174
decreased lean body mass 5 | 195
abnormal retina morphology 4 | 100
decreased grip strength 4 | 123
decreased leukocyte cell numbe... 4 | 54
decreased rib number 4 | 59
decreased total body fat amoun... 4 | 186
hyperactivity 4 | 108
prenatal lethality prior to he... 4 | 64
abnormal bone mineralization 3 | 55
abnormal heart morphology 3 | 51
abnormal maxilla morphology 3 | 16
abnormal retinal pigmentation 3 | 61
decreased body length 3 | 108
decreased circulating LDL chol... 3 | 37
decreased circulating glucose ... 3 | 121
decreased circulating iron lev... 3 | 25
decreased hemoglobin content 3 | 53
increased heart weight 3 | 37
increased or absent threshold ... 3 | 128
abnormal behavior 2 | 226
abnormal bone structure 2 | 131
abnormal embryo size 2 | 112
abnormal eye morphology 2 | 38
abnormal locomotor activation 2 | 26
abnormal snout morphology 2 | 18
abnormal startle reflex 2 | 14
abnormal tooth morphology 2 | 24
decreased Ly6C low monocyte nu... 2 | 23
decreased bone mineral content 2 | 157
decreased circulating HDL chol... 2 | 77
decreased circulating alanine ... 2 | 53
decreased circulating calcium ... 2 | 33
decreased circulating chloride... 2 | 32
decreased circulating choleste... 2 | 85
decreased circulating insulin ... 2 | 75
decreased erythrocyte cell num... 2 | 43
decreased hematocrit 2 | 25
decreased monocyte cell number 2 | 28
decreased neutrophil cell numb... 2 | 37
decreased prepulse inhibition 2 | 52
decreased respiratory quotient 2 | 12
enlarged heart 2 | 111
increased blood urea nitrogen ... 2 | 44
increased bone mineral content 2 | 92
increased bone mineral density 2 | 52
increased circulating amylase ... 2 | 13
increased circulating chloride... 2 | 43
increased circulating sodium l... 2 | 71
increased fasted circulating g... 2 | 68
increased grip strength 2 | 83
increased lean body mass 2 | 107
limb grasping 2 | 35
thrombocytosis 2 | 23
tremors 2 | 34
abnormal coat appearance 1 | 25
abnormal epididymis morphology 1 | 31
abnormal gait 1 | 51
abnormal lens morphology 1 | 73
abnormal neural tube morpholog... 1 | 8
abnormal respiratory quotient 1 | 9
abnormal rib morphology 1 | 28
abnormal skin morphology 1 | 23
abnormal vertebrae morphology 1 | 14
decreased KLRG1+ CD4 alpha bet... 1 | 2
decreased Ly6C high monocyte n... 1 | 18
decreased blood urea nitrogen ... 1 | 31
decreased bone mineral density 1 | 126
decreased circulating sodium l... 1 | 18
decreased effector memory CD8-... 1 | 24
decreased eosinophil cell numb... 1 | 41
decreased gamma-delta T cell n... 1 | 18
decreased lumbar vertebrae num... 1 | 62
decreased mean corpuscular hem... 1 | 34
decreased thoracic vertebrae n... 1 | 7
decreased total retina thickne... 1 | 20
hypoactivity 1 | 89
impaired righting response 1 | 19
increased NK T cell number 1 | 11
increased body length 1 | 20
increased body weight 1 | 42
increased circulating HDL chol... 1 | 63
increased circulating choleste... 1 | 53
increased circulating creatini... 1 | 29
increased circulating glycerol... 1 | 11
increased circulating serum al... 1 | 25
increased circulating triglyce... 1 | 24
increased effector memory CD4-... 1 | 15
increased mean corpuscular vol... 1 | 91
increased mean platelet volume 1 | 19
increased sacral vertebrae num... 1 | 62
increased total body fat amoun... 1 | 57
long tibia 1 | 13
oligodactyly 1 | 14
premature death 1 | 5
small thymus 1 | 11

Disease

ovarian cancer 221 | 8,491
osteosarcoma 175 | 7,933
psoriasis 138 | 6,685
medulloblastoma, large-cell 136 | 6,234
lung cancer 114 | 4,473
glioblastoma 108 | 5,572
atypical teratoid / rhabdoid tumor 91 | 4,369
Cancer 87 | 2,346
malignant mesothelioma 79 | 3,163
Multiple myeloma 68 | 1,327
group 3 medulloblastoma 68 | 2,254
Breast cancer 66 | 3,098
oligodendroglioma 66 | 2,849
Carcinoma 63 | 2,147
intraductal papillary-mucinous neoplasm (IPMN) 62 | 3,289
primitive neuroectodermal tumor 62 | 3,031
ependymoma 60 | 2,514
Pick disease 56 | 1,893
Waldenstrons macroglobulinemia 54 | 764
intraductal papillary-mucinous adenoma (IPMA) 54 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 54 | 2,988
acute quadriplegic myopathy 51 | 1,157
dermatomyositis 49 | 966
adult high grade glioma 47 | 2,148
astrocytic glioma 47 | 2,241
juvenile dermatomyositis 47 | 1,189
non-small cell lung cancer 44 | 2,798
pediatric high grade glioma 44 | 2,712
subependymal giant cell astrocytoma 44 | 2,287
astrocytoma 42 | 1,493
diabetes mellitus 42 | 1,663
pilocytic astrocytoma 41 | 3,086
invasive ductal carcinoma 40 | 2,950
group 4 medulloblastoma 39 | 1,875
Rheumatoid Arthritis 38 | 1,170
pancreatic cancer 38 | 2,300
progressive supranuclear palsy 34 | 674
acute myeloid leukemia 33 | 785
pancreatic ductal adenocarcinoma liver metastasis 33 | 1,795
lung adenocarcinoma 32 | 2,714
pituitary cancer 31 | 1,972
ulcerative colitis 31 | 2,087
sonic hedgehog group medulloblastoma 30 | 1,482
Intellectual disability 28 | 573
tuberculosis 27 | 1,563
tuberculosis and treatment for 6 months 27 | 686
lung carcinoma 25 | 2,844
breast carcinoma 24 | 1,614
colon cancer 24 | 1,475
primary Sjogren syndrome 24 | 788
ductal carcinoma in situ 22 | 1,745
medulloblastoma 22 | 1,524
primary pancreatic ductal adenocarcinoma 22 | 1,271
adrenocortical carcinoma 21 | 1,427
Amyotrophic Lateral Sclerosis 20 | 432
non primary Sjogren syndrome sicca 20 | 840
cutaneous lupus erythematosus 19 | 1,056
interstitial cystitis 19 | 2,299
posterior fossa group B ependymoma 19 | 1,530
autosomal dominant Emery-Dreifuss muscular dystrophy 18 | 499
posterior fossa group A ependymoma 18 | 1,511
spina bifida 18 | 1,064
Mammary Neoplasms 16 | 410
atypical teratoid/rhabdoid tumor 16 | 1,095
hepatocellular carcinoma 15 | 550
Alzheimer's disease 14 | 644
Prostatic Neoplasms 14 | 471
aldosterone-producing adenoma 14 | 664
glioblastoma multiforme 14 | 347
Down syndrome 13 | 548
Muscular atrophy 13 | 67
cystic fibrosis 13 | 1,670
gastric carcinoma 13 | 832
Neurodegenerative disease 12 | 383
nasopharyngeal carcinoma 12 | 1,056
pancreatic carcinoma 12 | 567
IGA Glomerulonephritis 11 | 454
Parkinson's disease 11 | 364
Renal Cell Carcinoma 11 | 199
inflammatory breast cancer 11 | 404
Gaucher disease type 1 10 | 171
Microcephaly 10 | 149
Vascular disease 10 | 281
Diabetes Mellitus, Non-Insulin-Dependent 9 | 161
Duchenne muscular dystrophy 9 | 602
HIV Infections 9 | 99
Kidney cancer 9 | 121
Leukemia 9 | 88
Liver carcinoma 9 | 217
Melanoma 9 | 261
Obesity 9 | 616
Prostate cancer 9 | 172
Schizophrenia 9 | 503
active Crohn's disease 9 | 918
gastric cancer 9 | 436
tuberculosis and treatment for 3 months 9 | 327
Kidney disease 8 | 397
Multiple Sclerosis 8 | 498
Polycystic Ovary Syndrome 8 | 334
mucosa-associated lymphoid tissue lymphoma 8 | 480

Tissue

Female tissues 345 | 18,646
Blood and immune system 344 | 17,994
Male tissues 344 | 17,968
Nervous System 344 | 18,560
Cardiovascular System 343 | 17,957
Digestive Tract 343 | 18,472
Liver and Pancreas 343 | 18,135
Endocrine System 342 | 18,511
Urinary Tract 340 | 18,443
Respiratory system 339 | 17,483
Skin and soft tissues 337 | 18,114

Target Family

Non-IDG 210 | 11,969
Enzyme 59 | 4,146
Transcription Factor 39 | 1,400
Kinase 22 | 634
Epigenetic 13 | 242
TF/Epigenetic 4 | 38
Nuclear Receptor 2 | 48

Compartment GO Term

Nuclear body 349 | 349
cellular_component 18,237 | 18,237
Cell 15,806 | 15,806
Cell part 15,806 | 15,806
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,648 | 12,648
membrane-bounded organelle 11,793 | 11,793
Intracellular organelle 11,617 | 11,617
Intracellular membrane-bounded... 10,618 | 10,618
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,169 | 8,169
Intracellular organelle part 8,011 | 8,011
Cytoplasmic part 7,830 | 7,830
Nucleus 7,577 | 7,577
Membrane part 6,470 | 6,470
Cytosol 6,035 | 6,035
Plasma membrane 5,673 | 5,673
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,171 | 5,171
Cell periphery 5,146 | 5,146
Nucleoplasm 4,929 | 4,929
Extracellular region 4,606 | 4,606
Protein complex 4,439 | 4,439
Intracellular organelle lumen 4,330 | 4,330
Organelle lumen 4,330 | 4,330
membrane-enclosed lumen 4,330 | 4,330
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,839 | 3,839
non-membrane-bounded organelle 3,838 | 3,838
Nuclear part 3,807 | 3,807
Endomembrane system 3,720 | 3,720
Vesicle 3,666 | 3,666
membrane-bounded vesicle 3,494 | 3,494
Nuclear lumen 3,464 | 3,464
Extracellular organelle 2,849 | 2,849
Extracellular vesicle 2,848 | 2,848
Extracellular exosome 2,828 | 2,828
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,564 | 2,564
Cytoskeleton 2,046 | 2,046
Golgi apparatus 1,946 | 1,946
Endoplasmic reticulum 1,872 | 1,872
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Vesicles 1,625 | 1,625
Cytoskeletal part 1,568 | 1,568
Mitochondrion 1,531 | 1,531
Cell projection 1,426 | 1,426
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,305 | 1,305
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,234 | 1,234
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Mitochondria 1,003 | 1,003
Chromosome 999 | 999
Mitochondrial part 989 | 989
Nucleoli 952 | 952
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 793 | 793
Intracellular ribonucleoprotei... 789 | 789
Nucleoplasm part 781 | 781
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 739 | 739
Plasma membrane protein comple... 721 | 721
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Microtubule organizing center 680 | 680
Centrosome 676 | 676
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Synapse 594 | 594
Lytic vacuole 571 | 571

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
U4/U6 small nuclear ribonucleoprotein Prp4 PRPF4 Tchem Non-IDG -0.55879 7.56 79
THAP domain-containing protein 7 THAP7 Tbio Transcription Factor -0.07311 1.18 14
Tumor suppressor p53-binding protein 1 TP53BP1 Tbio Epigenetic -2.65153 422.5 514
Zinc finger protein RFP TRIM27 Tbio Non-IDG -1.50884 32.8 154
Protein Mis18-beta OIP5 Tbio Non-IDG -1.17135 15.6 42
Trimethylguanosine synthase TGS1 Tbio Enzyme -1.36236 24.4 85
DNA-binding protein SATB1 SATB1 Tbio Transcription Factor -2.24334 197.9 293
Sodium channel modifier 1 SCNM1 Tdark Non-IDG -0.61195 4.75 38
E3 ubiquitin-protein ligase Arkadia RNF111 Tbio Enzyme -1.35799 23.9 89
RNA-binding protein 4 RBM4 Tbio Non-IDG -1.66806 47.5 138