Development Level

Tbio 431 | 10,625
Tchem 126 | 1,890
Tclin 82 | 602
Tdark 42 | 7,003

Collection

Eligible Ion Channel Proteins 9 | 117
Eligible non-olfactory GPCR Proteins 7 | 143
Eligible Kinase Proteins 2 | 134

IMPC Term

preweaning lethality, complete... 27 | 633
abnormal behavior 17 | 226
preweaning lethality, incomple... 16 | 260
decreased total body fat amoun... 15 | 186
decreased lean body mass 12 | 195
abnormal bone structure 11 | 131
decreased grip strength 11 | 123
embryonic lethality prior to t... 11 | 187
increased lean body mass 9 | 107
decreased bone mineral content 8 | 157
embryonic lethality prior to o... 8 | 148
hyperactivity 8 | 108
increased circulating sodium l... 8 | 71
increased or absent threshold ... 8 | 128
decreased body weight 7 | 174
decreased circulating HDL chol... 7 | 77
decreased circulating alanine ... 7 | 53
decreased circulating alkaline... 7 | 41
decreased fasted circulating g... 7 | 49
enlarged heart 7 | 111
increased circulating alkaline... 7 | 119
tremors 7 | 34
abnormal embryo size 6 | 112
abnormal gait 6 | 51
abnormal sleep behavior 6 | 63
decreased circulating choleste... 6 | 85
increased mean corpuscular hem... 6 | 93
decreased bone mineral density 5 | 126
decreased circulating serum al... 5 | 79
decreased circulating total pr... 5 | 41
increased circulating chloride... 5 | 43
increased fasted circulating g... 5 | 68
increased mean corpuscular vol... 5 | 91
male infertility 5 | 62
short tibia 5 | 82
abnormal behavioral response t... 4 | 52
abnormal retina morphology 4 | 100
decreased circulating LDL chol... 4 | 37
decreased circulating aspartat... 4 | 27
decreased circulating glucose ... 4 | 121
decreased circulating insulin ... 4 | 75
hypoactivity 4 | 89
impaired glucose tolerance 4 | 52
improved glucose tolerance 4 | 56
increased blood urea nitrogen ... 4 | 44
increased body weight 4 | 42
increased bone mineral content 4 | 92
increased heart weight 4 | 37
limb grasping 4 | 35
prenatal lethality prior to he... 4 | 64
abnormal coat/hair pigmentatio... 3 | 54
abnormal heart morphology 3 | 51
abnormal hindbrain development 3 | 24
abnormal locomotor activation 3 | 26
abnormal neural tube closure 3 | 37
decreased mean corpuscular vol... 3 | 50
decreased pulmonary respirator... 3 | 4
decreased rib number 3 | 59
decreased total retina thickne... 3 | 20
hemorrhage 3 | 12
increased circulating calcium ... 3 | 32
increased circulating iron lev... 3 | 25
increased exploration in new e... 3 | 56
increased grip strength 3 | 83
increased startle reflex 3 | 38
increased total body fat amoun... 3 | 57
persistence of hyaloid vascula... 3 | 22
straub tail 3 | 26
abnormal coping response 2 | 12
abnormal epididymis morphology 2 | 31
abnormal heart left ventricle ... 2 | 20
abnormal retinal pigmentation 2 | 61
abnormal skin morphology 2 | 23
abnormal testis morphology 2 | 30
abnormal tooth morphology 2 | 24
decreased T cell number 2 | 31
decreased body length 2 | 108
decreased circulating chloride... 2 | 32
decreased circulating triglyce... 2 | 83
decreased effector memory CD8-... 2 | 24
decreased exploration in new e... 2 | 9
decreased heart weight 2 | 44
decreased hemoglobin content 2 | 53
decreased lumbar vertebrae num... 2 | 62
decreased prepulse inhibition 2 | 52
decreased vertical activity 2 | 22
enlarged stomach 2 | 2
increased circulating bilirubi... 2 | 16
increased circulating choleste... 2 | 53
increased circulating free fat... 2 | 17
increased circulating potassiu... 2 | 31
increased circulating serum al... 2 | 25
increased circulating triglyce... 2 | 24
increased erythrocyte cell num... 2 | 26
increased mean corpuscular hem... 2 | 25
lethargy 2 | 5
polycystic kidney 2 | 9
small testis 2 | 37
small thymus 2 | 11
thrombocytosis 2 | 23

Disease

medulloblastoma, large-cell 379 | 6,234
glioblastoma 349 | 5,572
ovarian cancer 305 | 8,484
atypical teratoid / rhabdoid tumor 289 | 4,369
osteosarcoma 284 | 7,933
psoriasis 279 | 6,685
pilocytic astrocytoma 261 | 3,086
oligodendroglioma 254 | 2,849
pediatric high grade glioma 213 | 2,712
primitive neuroectodermal tumor 213 | 3,031
lung cancer 197 | 4,466
lung carcinoma 172 | 2,844
Carcinoma 170 | 2,147
astrocytic glioma 168 | 2,241
malignant mesothelioma 165 | 3,162
ependymoma 162 | 2,514
Cancer 158 | 2,346
subependymal giant cell astrocytoma 153 | 2,287
Pick disease 146 | 1,893
Breast cancer 142 | 3,094
adult high grade glioma 133 | 2,148
intraductal papillary-mucinous adenoma (IPMA) 132 | 2,956
intraductal papillary-mucinous neoplasm (IPMN) 128 | 3,289
invasive ductal carcinoma 126 | 2,950
intraductal papillary-mucinous carcinoma (IPMC) 125 | 2,988
pituitary cancer 125 | 1,972
Alzheimer's disease 124 | 644
Schizophrenia 123 | 501
astrocytoma 116 | 1,493
non-small cell lung cancer 112 | 2,798
posterior fossa group A ependymoma 112 | 1,511
medulloblastoma 111 | 1,524
lung adenocarcinoma 110 | 2,713
group 4 medulloblastoma 102 | 1,875
interstitial cystitis 100 | 2,299
Epilepsy 97 | 346
group 3 medulloblastoma 96 | 2,254
sonic hedgehog group medulloblastoma 94 | 1,482
Parkinson's disease 93 | 364
colon cancer 91 | 1,475
pancreatic cancer 91 | 2,300
Neurodegenerative disease 85 | 383
cystic fibrosis 85 | 1,665
diabetes mellitus 84 | 1,663
ulcerative colitis 81 | 2,087
breast carcinoma 79 | 1,614
posterior fossa group B ependymoma 79 | 1,530
Obesity 75 | 616
ductal carcinoma in situ 74 | 1,745
Intellectual disability 68 | 573
Toxic encephalopathy 68 | 131
atypical teratoid/rhabdoid tumor 65 | 1,095
Autistic Disorder 64 | 320
tuberculosis 62 | 1,557
adrenocortical carcinoma 60 | 1,427
Bipolar Disorder 57 | 266
Amyotrophic Lateral Sclerosis 55 | 431
Down syndrome 54 | 548
Neuropathy 52 | 210
Dementia 51 | 129
cutaneous lupus erythematosus 50 | 1,056
acute quadriplegic myopathy 48 | 1,157
pancreatic ductal adenocarcinoma liver metastasis 48 | 1,795
Seizures 47 | 95
juvenile dermatomyositis 47 | 1,189
primary pancreatic ductal adenocarcinoma 47 | 1,271
Atopic dermatitis 46 | 944
Cerebrovascular disease 46 | 231
Multiple myeloma 46 | 1,327
Multiple Sclerosis 44 | 498
Rheumatoid Arthritis 44 | 1,160
Cocaine-Related Disorders 43 | 88
Pain agnosia 43 | 99
aldosterone-producing adenoma 42 | 664
nasopharyngeal carcinoma 42 | 1,056
Alcohol dependence 40 | 107
Hypertension 40 | 287
dermatomyositis 40 | 933
spina bifida 40 | 1,064
gastric carcinoma 38 | 832
progressive supranuclear palsy 38 | 674
Migraine 37 | 79
Vascular disease 37 | 281
Major Depressive Disorder 36 | 106
Brain disease 35 | 83
Kidney disease 34 | 396
non primary Sjogren syndrome sicca 34 | 840
Asthma 33 | 349
Duchenne muscular dystrophy 33 | 602
Hyperalgesia 33 | 71
Pain 32 | 70
Status Epilepticus 32 | 85
Adenoma 31 | 165
Attention deficit hyperactivity disorder 31 | 156
Heart disease 31 | 279
Endometriosis 30 | 535
Huntington's disease 29 | 72
Waldenstrons macroglobulinemia 29 | 765
autosomal dominant Emery-Dreifuss muscular dystrophy 29 | 499
fibroadenoma 29 | 557

Tissue

Female tissues 675 | 18,647
Nervous System 674 | 18,561
Digestive Tract 672 | 18,473
Endocrine System 672 | 18,512
Urinary Tract 670 | 18,444
Liver and Pancreas 665 | 18,136
Skin and soft tissues 662 | 18,115
Cardiovascular System 658 | 17,958
Blood and immune system 651 | 17,995
Male tissues 648 | 17,969
Respiratory system 638 | 17,484

Target Family

Non-IDG 394 | 11,971
Enzyme 93 | 4,146
Ion Channel 55 | 341
GPCR 46 | 406
Kinase 37 | 634
Transporter 26 | 473
Transcription Factor 12 | 1,400
oGPCR 10 | 421
Epigenetic 7 | 242
Nuclear Receptor 1 | 48

Compartment GO Term

Neuron projection 681 | 681
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,170 | 8,170
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,830 | 7,830
Nucleus 6,897 | 6,897
Membrane part 6,469 | 6,469
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,172 | 5,172
Cell periphery 5,145 | 5,145
Plasma membrane 5,059 | 5,059
Extracellular region 4,606 | 4,606
Protein complex 4,438 | 4,438
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Cytosol 3,352 | 3,352
Nucleoplasm 2,938 | 2,938
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,563 | 2,563
Cytoskeleton 2,045 | 2,045
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Endoplasmic reticulum 1,663 | 1,663
Cytoskeletal part 1,567 | 1,567
Mitochondrion 1,530 | 1,530
Cell projection 1,426 | 1,426
Golgi apparatus 1,402 | 1,402
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,233 | 1,233
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Chromosome 999 | 999
Mitochondrial part 989 | 989
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 780 | 780
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 738 | 738
Plasma membrane protein comple... 720 | 720
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Microtubule organizing center 617 | 617
Synapse 594 | 594
Lysosome 571 | 571
Lytic vacuole 571 | 571
Vesicle membrane 559 | 559
cell-cell junction 557 | 557
Cytoplasmic vesicle membrane 552 | 552

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
D(2) dopamine receptor DRD2 Tclin GPCR -3.24474 1775.2 248
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
Apolipoprotein E APOE Tbio Non-IDG -4.17470 15380.4 788
Glial cell line-derived neurotrophic factor GDNF Tbio Non-IDG -3.30206 2301.5 303
Protein Smaug homolog 1 SAMD4A Tbio Non-IDG 16.8 58
Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 Tchem Ion Channel -1.68717 47.7 33
Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B Tclin Ion Channel -2.21210 162.9 67
Epidermal growth factor receptor kinase substrate 8 EPS8 Tbio Enzyme -1.80380 77.2 248
Neurofilament heavy polypeptide NEFH Tbio Non-IDG -2.73883 563.3 681