Development Level

Tclin 51 | 613
Tbio 22 | 11,445
Tchem 6 | 1,598
Tdark 1 | 6,588

IMPC Phenotype

preweaning lethality, complete... 10 | 979
cataract 2 | 92
decreased vertical activity 2 | 208
embryonic lethality prior to o... 2 | 239
increased heart weight 2 | 62
abnormal allantois morphology 1 | 8
abnormal behavior 1 | 298
abnormal chorioallantoic fusio... 1 | 8
abnormal digit morphology 1 | 10
abnormal embryo development 1 | 7
abnormal embryo size 1 | 220
abnormal embryo turning 1 | 31
abnormal gait 1 | 69
abnormal heart morphology 1 | 162
abnormal lens morphology 1 | 81
abnormal neural tube morpholog... 1 | 12
abnormal sleep behavior 1 | 70
abnormal tail movements 1 | 12
abnormal visceral yolk sac mor... 1 | 6
abnormal vitelline vasculature... 1 | 6
decreased circulating LDL chol... 1 | 38
decreased circulating choleste... 1 | 93
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased heart weight 1 | 27
decreased lactate dehydrogenas... 1 | 16
decreased mean platelet volume 1 | 25
decreased total retina thickne... 1 | 17
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
hemorrhage 1 | 23
hypoactivity 1 | 132
increased body weight 1 | 25
increased circulating calcium ... 1 | 34
increased circulating phosphat... 1 | 26
increased grip strength 1 | 41
increased lean body mass 1 | 172
male infertility 1 | 123
pale yolk sac 1 | 25
pallor 1 | 34
prenatal lethality prior to he... 1 | 87

Disease

Diabetes mellitus type 2 49 | 69
Treatment Refractory Type 2 Diabetes Mellitus 49 | 53
ovarian cancer 49 | 8,520
Mitochondrial complex I deficiency 39 | 46
Leigh disease 32 | 100
Multiple myeloma 30 | 1,332
osteosarcoma 29 | 7,950
Cerebellar Ataxia 27 | 304
Mitochondrial Complex 1 Deficiency 27 | 28
Acidosis, Lactic 25 | 97
Lactic acidemia 25 | 95
Carcinoma 24 | 11,493
NADH:Q(1) Oxidoreductase deficiency 24 | 24
Autosomal recessive predisposition 23 | 1,442
Blepharoptosis 23 | 231
Sensorineural Hearing Loss (disorder) 23 | 284
Epilepsy 21 | 792
Seizures 21 | 596
Muscle Weakness 20 | 170
Nystagmus 20 | 317
psoriasis 20 | 6,694
Cognitive delay 19 | 608
Developmental regression 19 | 95
Failure to gain weight 19 | 365
Global developmental delay 19 | 608
Hyperreflexia 19 | 209
Leigh syndrome 19 | 28
Loss of developmental milestones 19 | 95
Mental and motor retardation 19 | 608
Mental deterioration in childhood 19 | 95
Muscle hypotonia 19 | 571
Neurodevelopmental regression 19 | 95
Pediatric failure to thrive 19 | 365
Psychomotor regression 19 | 95
Psychomotor regression beginning in infancy 19 | 95
Psychomotor regression in infants 19 | 95
Psychomotor regression, progressive 19 | 95
Strabismus 19 | 270
diabetes mellitus 19 | 1,728
lung cancer 19 | 4,740
pancreatic ductal adenocarcinoma liver metastasis 19 | 1,962
Abnormal mitochondria in muscle tissue 18 | 20
CSF lactate increased 18 | 33
Cancer 18 | 2,499
Dystonia 18 | 164
Highly variable clinical phenotype 18 | 150
Highly variable phenotype and severity 18 | 150
Highly variable phenotype, even within families 18 | 150
Muscle Spasticity 18 | 195
Optic Atrophy 18 | 242
Phenotypic variability 18 | 150
Respiratory Failure 18 | 104
Dystonic disease 17 | 106
glioblastoma 17 | 5,792
medulloblastoma, large-cell 16 | 6,241
Blind Vision 15 | 111
Blindness, Legal 15 | 110
Brain Edema 15 | 50
Cerebral Edema 15 | 30
Hypertrophic Cardiomyopathy 15 | 117
Hypoglycemia 15 | 152
Impaired exercise tolerance 15 | 42
Liver Failure 15 | 73
X-linked dominant 15 | 57
astrocytic glioma 15 | 2,597
Acute necrotizing encephalopathy 14 | 14
Atrophy of cerebellum 14 | 103
Babinski Reflex 14 | 100
Cerebellar degeneration 14 | 103
Comatose 14 | 56
Decreased tendon reflex 14 | 122
Feeding difficulties in infancy 14 | 175
Growth delay 14 | 114
Growth failure 14 | 114
Growth retardation 14 | 115
Infratentorial atrophy 14 | 103
Lethargy 14 | 77
Leukodystrophy 14 | 55
Neurogenic Muscular Atrophy 14 | 139
Neurogenic muscle atrophy, especially in the lower limbs 14 | 139
Pallor of optic disc 14 | 39
Poor growth 14 | 114
Progressive macrocephaly 14 | 18
Skeletal muscle atrophy 14 | 139
Very poor growth 14 | 114
Vomiting 14 | 116
atypical teratoid / rhabdoid tumor 14 | 5,112
ependymoma 14 | 4,679
muscle degeneration 14 | 139
Dementia 13 | 175
Increased serum lactate 13 | 60
Ophthalmoplegia 13 | 106
Myopathy 12 | 185
Parkinson's disease 12 | 392
Alzheimer's disease 11 | 658
Mitochondrial myopathy 11 | 26
Leber hereditary optic neuropathy 10 | 14
Obesity 10 | 678
Retinitis Pigmentosa 10 | 226
Schizophrenia 10 | 1,160

Tissue

Blood and immune system 80 | 16,909
Digestive Tract 80 | 17,369
Endocrine System 80 | 18,159
Male tissues 80 | 17,142
Urinary Tract 80 | 16,678
Female tissues 79 | 17,400
Liver and Pancreas 79 | 16,750
Nervous System 79 | 16,725
Respiratory system 79 | 16,393
Skin and soft tissues 79 | 17,230
Cardiovascular System 78 | 15,192

Target Family

Enzyme 63 | 4,145
Non-IDG 11 | 12,091
Kinase 2 | 634
Transporter 2 | 473
Epigenetic 1 | 242
Transcription Factor 1 | 1,400

Compartment GO Term

NADH dehydrogenase complex 80 | 80
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,784 | 8,784
Membrane 8,531 | 8,531
Nucleus 7,562 | 7,562
Cytosol 6,686 | 6,686
Membrane part 6,554 | 6,554
Plasma membrane 5,830 | 5,830
Macromolecular complex 5,475 | 5,475
Intrinsic component of membran... 5,458 | 5,458
Cell periphery 5,382 | 5,382
Integral component of membrane 5,331 | 5,331
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,975 | 3,975
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,674 | 3,674
Organelle membrane 2,846 | 2,846
Extracellular region 2,732 | 2,732
Plasma membrane part 2,594 | 2,594
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,217 | 2,217
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,932 | 1,932
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,641 | 1,641
Cytoskeletal part 1,637 | 1,637
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 970 | 970
Neuron part 969 | 969
Supramolecular polymer 967 | 967
Supramolecular complex 966 | 966
Cell junction 960 | 960
Supramolecular fiber 959 | 959
Golgi apparatus part 950 | 950
Nucleoli 942 | 942
Endosome 930 | 930
Nucleolus 926 | 926
Chromosomal part 889 | 889
GO:0098796 884 | 884
Ribonucleoprotein complex 865 | 865
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 850 | 850
Transferase complex 849 | 849
Cell surface 842 | 842
Plasma membrane region 841 | 841
Vesicle membrane 801 | 801
Cytoplasmic vesicle membrane 795 | 795
Polymeric cytoskeletal fiber 764 | 764
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 714 | 714
Neuron projection 711 | 711
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 NDUFA11 Tclin Enzyme -0.62794 3.79 65
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 NDUFB9 Tclin Enzyme -2.43529 263.5 165
NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial NDUFS4 Tclin Enzyme -2.97252 871.7 197
Membrane progestin receptor alpha PAQR7 Tbio Non-IDG -1.89212 76.1 122
Cytochrome b MT-CYB Tbio Non-IDG -3.77047 5856.5 134
Amine oxidase [flavin-containing] B MAOB Tclin Enzyme -3.40865 2530.3 252
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial NDUFS1 Tclin Enzyme -1.42734 26.2 214
ATP-dependent RNA helicase A DHX9 Tbio Enzyme -2.85807 734.3 204
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial NDUFV1 Tclin Enzyme -1.42801 26.4 177
NADH-ubiquinone oxidoreductase chain 4L MT-ND4L Tclin Enzyme -1.94310 80.5 57