Development Level

Tbio 118 | 11,445
Tchem 10 | 1,598
Tdark 9 | 6,588
Tclin 8 | 613

Collection

Kinase: IDG Consortium (Comple... 2 | 37

IMPC Phenotype

preweaning lethality, complete... 11 | 979
preweaning lethality, incomple... 7 | 499
embryonic lethality prior to t... 6 | 278
abnormal behavior 4 | 298
abnormal embryo size 4 | 220
decreased grip strength 4 | 116
embryonic growth retardation 4 | 106
increased or absent threshold ... 4 | 101
abnormal bone structure 3 | 187
abnormal placenta size 3 | 20
abnormal retina morphology 3 | 71
decreased body weight 3 | 161
decreased circulating amylase ... 3 | 28
hyperactivity 3 | 148
increased circulating sodium l... 3 | 71
pallor 3 | 34
abnormal behavioral response t... 2 | 66
abnormal coat-hair pigmentatio... 2 | 64
abnormal seminal vesicle morph... 2 | 114
abnormal vocalization 2 | 21
absent pinna reflex 2 | 23
convulsive seizures 2 | 13
decreased circulating triglyce... 2 | 79
decreased lean body mass 2 | 135
decreased leukocyte cell numbe... 2 | 73
decreased prepulse inhibition 2 | 82
decreased vertical activity 2 | 208
edema 2 | 59
impaired righting response 2 | 26
improved glucose tolerance 2 | 79
increased body length 2 | 32
increased circulating chloride... 2 | 41
increased heart weight 2 | 62
increased lean body mass 2 | 172
increased total body fat amoun... 2 | 134
persistence of hyaloid vascula... 2 | 33
prenatal lethality prior to he... 2 | 87
stereotypic behavior 2 | 3
trunk curl 2 | 16
abnormal cornea morphology 1 | 31
abnormal cranium morphology 1 | 36
abnormal digit morphology 1 | 10
abnormal eye morphology 1 | 68
abnormal femur morphology 1 | 14
abnormal limb bud morphology 1 | 17
abnormal locomotor activation 1 | 16
abnormal pericardium morpholog... 1 | 26
abnormal response to new envir... 1 | 10
abnormal sensory capabilities-... 1 | 8
abnormal skin coloration 1 | 25
abnormal sleep behavior 1 | 70
abnormal whole-body plethysmog... 1 | 4
absent startle reflex 1 | 24
cardiovascular system phenotyp... 1 | 36
corneal opacity 1 | 32
decreased anxiety-related resp... 1 | 12
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating LDL chol... 1 | 38
decreased circulating alkaline... 1 | 46
decreased circulating creatini... 1 | 39
decreased circulating fructosa... 1 | 30
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased circulating potassiu... 1 | 20
decreased circulating serum al... 1 | 82
decreased eosinophil cell numb... 1 | 24
decreased exploration in new e... 1 | 11
decreased fluid intake 1 | 3
decreased hematocrit 1 | 46
decreased mean platelet volume 1 | 25
decreased spleen weight 1 | 10
decreased startle reflex 1 | 75
embryonic lethality prior to o... 1 | 239
female infertility 1 | 60
fused cornea and lens 1 | 5
fused phalanges 1 | 1
hemorrhage 1 | 23
hypoactivity 1 | 132
impaired pupillary reflex 1 | 26
increased blood urea nitrogen ... 1 | 48
increased bone mineral content 1 | 108
increased circulating alkaline... 1 | 122
increased circulating iron lev... 1 | 30
increased circulating triglyce... 1 | 42
increased heart rate variabili... 1 | 7
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased spleen weight 1 | 10
increased startle reflex 1 | 112
increased vertical activity 1 | 24
limb grasping 1 | 41
pale liver 1 | 6
pale yolk sac 1 | 25
short tibia 1 | 97
thrombocytosis 1 | 27
tremors 1 | 39

Disease

Carcinoma 109 | 11,493
ovarian cancer 70 | 8,520
psoriasis 63 | 6,694
osteosarcoma 61 | 7,950
Kidney cancer 52 | 2,613
glioblastoma 46 | 5,792
Breast cancer 45 | 3,578
lung cancer 45 | 4,740
medulloblastoma, large-cell 44 | 6,241
Cancer 42 | 2,499
atypical teratoid / rhabdoid tumor 40 | 5,112
ependymoma 39 | 4,679
intraductal papillary-mucinous carcinoma (IPMC) 39 | 2,989
acute quadriplegic myopathy 36 | 1,158
intraductal papillary-mucinous adenoma (IPMA) 36 | 2,955
invasive ductal carcinoma 36 | 2,951
malignant mesothelioma 36 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 35 | 3,291
adult high grade glioma 34 | 3,801
diabetes mellitus 34 | 1,728
lung carcinoma 31 | 2,843
pancreatic cancer 31 | 2,398
Autosomal recessive predisposition 30 | 1,442
lung adenocarcinoma 30 | 2,716
non-small cell lung cancer 29 | 2,890
breast carcinoma 27 | 1,638
primitive neuroectodermal tumor 27 | 3,035
colon cancer 26 | 1,478
group 3 medulloblastoma 25 | 4,104
group 4 medulloblastoma 25 | 1,855
Heart disease 23 | 306
ductal carcinoma in situ 23 | 1,745
Astrocytoma, Pilocytic 22 | 3,081
Duchenne muscular dystrophy 22 | 601
Myopathy 22 | 185
subependymal giant cell astrocytoma 22 | 2,287
oligodendroglioma 21 | 2,850
Liver cancer 20 | 604
ulcerative colitis 20 | 1,819
Hypertrophic Cardiomyopathy 18 | 117
astrocytic glioma 18 | 2,597
cystic fibrosis 18 | 1,696
pancreatic ductal adenocarcinoma liver metastasis 18 | 1,962
Cardiomyopathy 17 | 116
Hypertension 17 | 396
Schizophrenia 17 | 1,160
pituitary cancer 17 | 1,972
Cerebrovascular disease 16 | 238
autosomal dominant Emery-Dreifuss muscular dystrophy 16 | 510
interstitial cystitis 16 | 2,312
juvenile dermatomyositis 16 | 1,187
Liver Cirrhosis, Experimental 15 | 769
Melanoma 15 | 711
Skin cancer 15 | 469
Cardiomegaly 14 | 116
Epilepsy 14 | 792
Dilated cardiomyopathy 13 | 56
Endometrial cancer 13 | 311
Heart failure 13 | 162
Kidney disease 13 | 430
dermatomyositis 13 | 966
Becker muscular dystrophy 12 | 191
Cardiomyopathy, Dilated 12 | 83
Coronary artery disease 12 | 268
Intellectual disability 12 | 1,016
Multiple myeloma 12 | 1,332
Nonsyndromic deafness 12 | 142
Pick disease 12 | 1,894
primary pancreatic ductal adenocarcinoma 12 | 1,109
Alzheimer's disease 11 | 658
Amyotrophic lateral sclerosis 11 | 451
Congestive heart failure 11 | 113
Myocardial Infarction 11 | 151
Osteoporosis 11 | 363
Rheumatoid arthritis 11 | 1,191
Sensorineural hearing loss 11 | 106
adrenocortical carcinoma 11 | 1,428
pediatric high grade glioma 11 | 1,064
Distal arthrogryposis 10 | 42
Familial isolated dilated cardiomyopathy 10 | 41
LEFT VENTRICULAR NONCOMPACTION 10 10 | 40
LEFT VENTRICULAR NONCOMPACTION 8 10 | 40
Polycystic ovary syndrome 10 | 360
Primary cutaneous amyloidosis 10 | 29
Seizures 10 | 596
tuberculosis 10 | 2,010
Acquired scoliosis 9 | 281
Atherosclerosis 9 | 291
Cognitive delay 9 | 608
Curvature of spine 9 | 282
Global developmental delay 9 | 608
Hypertensive disease 9 | 292
Hypoplastic mandible condyle 9 | 275
Mandibular hypoplasia 9 | 275
Mental and motor retardation 9 | 608
Micrognathism 9 | 275
Neoplasm Invasiveness 9 | 161
Short stature 9 | 531
active ulcerative colitis 9 | 764
limb girdle muscular dystrophy 2A 9 | 213

Tissue

Digestive Tract 142 | 17,369
Endocrine System 142 | 18,159
Skin and soft tissues 142 | 17,230
Male tissues 139 | 17,142
Blood and immune system 136 | 16,909
Female tissues 136 | 17,400
Urinary Tract 132 | 16,678
Nervous System 131 | 16,725
Liver and Pancreas 130 | 16,750
Cardiovascular System 129 | 15,192
Respiratory system 125 | 16,393

Target Family

Non-IDG 106 | 12,091
Enzyme 13 | 4,145
Kinase 13 | 634
Transcription Factor 10 | 1,400
Transporter 2 | 473
GPCR 1 | 408

Compartment GO Term

Myosin complex 145 | 145
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,784 | 8,784
Membrane 8,531 | 8,531
Nucleus 7,562 | 7,562
Cytosol 6,686 | 6,686
Membrane part 6,554 | 6,554
Plasma membrane 5,830 | 5,830
Macromolecular complex 5,475 | 5,475
Intrinsic component of membran... 5,458 | 5,458
Cell periphery 5,382 | 5,382
Integral component of membrane 5,331 | 5,331
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,975 | 3,975
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,674 | 3,674
Organelle membrane 2,846 | 2,846
Extracellular region 2,732 | 2,732
Plasma membrane part 2,594 | 2,594
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,217 | 2,217
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,932 | 1,932
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,641 | 1,641
Cytoskeletal part 1,637 | 1,637
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 970 | 970
Neuron part 969 | 969
Supramolecular polymer 967 | 967
Supramolecular complex 966 | 966
Cell junction 960 | 960
Supramolecular fiber 959 | 959
Golgi apparatus part 950 | 950
Nucleoli 942 | 942
Endosome 930 | 930
Nucleolus 926 | 926
Chromosomal part 889 | 889
GO:0098796 884 | 884
Ribonucleoprotein complex 865 | 865
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 850 | 850
Transferase complex 849 | 849
Cell surface 842 | 842
Plasma membrane region 841 | 841
Vesicle membrane 801 | 801
Cytoplasmic vesicle membrane 795 | 795
Polymeric cytoskeletal fiber 764 | 764
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 714 | 714
Neuron projection 711 | 711
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Unconventional myosin-XV MYO15A Tbio Non-IDG -1.64094 42.8 15
Myomesin-1 MYOM1 Tbio Non-IDG -1.21420 16.8 127
Myosin-13 MYH13 Tbio Non-IDG -1.26079 16.6 12
Myosin-2 MYH2 Tbio Non-IDG -2.14128 114.9 63
Harmonin USH1C Tbio Non-IDG -2.10689 124.7 188
Myosin-4 MYH4 Tbio Non-IDG -1.81214 51.8 52
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 ATP2A2 Tbio Transporter -2.87498 737.3 295
Moesin MSN Tbio Non-IDG -2.61389 361.7 550
Myosin light chain 1/3, skeletal muscle isoform MYL1 Tbio Non-IDG -2.11698 129.3 109
Myosin-IIIb MYO3B Tbio Kinase -0.73450 5.14 127