Development Level

Tbio 92 | 11,445
Tchem 18 | 1,598
Tdark 6 | 6,588

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 15 | 979
embryonic lethality prior to o... 8 | 239
embryonic lethality prior to t... 8 | 278
preweaning lethality, incomple... 7 | 499
abnormal embryo size 4 | 220
abnormal retina morphology 4 | 71
abnormal bone structure 3 | 187
decreased bone mineral content 3 | 151
decreased lean body mass 3 | 135
increased mean corpuscular hem... 3 | 96
increased mean corpuscular vol... 3 | 92
abnormal coat-hair pigmentatio... 2 | 64
abnormal cranium morphology 2 | 36
abnormal seminal vesicle morph... 2 | 114
cardiovascular system phenotyp... 2 | 36
cataract 2 | 92
decreased body weight 2 | 161
decreased circulating serum al... 2 | 82
decreased total body fat amoun... 2 | 207
impaired glucose tolerance 2 | 75
increased circulating HDL chol... 2 | 80
increased fasted circulating g... 2 | 76
increased mean platelet volume 2 | 45
increased total body fat amoun... 2 | 134
prolonged QT interval 2 | 38
prolonged ST segment 2 | 36
short tibia 2 | 97
small testis 2 | 58
thrombocytopenia 2 | 56
tremors 2 | 39
abnormal embryo turning 1 | 31
abnormal epididymis morphology 1 | 42
abnormal head morphology 1 | 10
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal optic disc morphology 1 | 10
abnormal retinal inner nuclear... 1 | 8
abnormal skin coloration 1 | 25
abnormal skin morphology 1 | 50
abnormal sleep behavior 1 | 70
abnormal testis morphology 1 | 43
convulsive seizures 1 | 13
cyanosis 1 | 7
decreased body length 1 | 101
decreased bone mineral density 1 | 126
decreased circulating glucose ... 1 | 126
decreased circulating lactate ... 1 | 3
decreased coping response 1 | 8
decreased erythrocyte cell num... 1 | 62
decreased exploration in new e... 1 | 11
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased heart left ventricle... 1 | 28
decreased leukocyte cell numbe... 1 | 73
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular vol... 1 | 79
decreased prepulse inhibition 1 | 82
decreased red blood cell distr... 1 | 41
decreased spleen weight 1 | 10
decreased startle reflex 1 | 75
decreased threshold for audito... 1 | 26
embryonic growth retardation 1 | 106
enlarged epididymis 1 | 31
enlarged kidney 1 | 14
enlarged lymph nodes 1 | 37
enlarged testis 1 | 6
hypoactivity 1 | 132
impaired pupillary reflex 1 | 26
impaired righting response 1 | 26
increased blood urea nitrogen ... 1 | 48
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating alkaline... 1 | 122
increased circulating choleste... 1 | 66
increased circulating glucose ... 1 | 24
increased grip strength 1 | 41
increased heart rate 1 | 23
increased heart weight 1 | 62
increased hematocrit 1 | 46
increased lean body mass 1 | 172
increased neutrophil cell numb... 1 | 46
increased or absent threshold ... 1 | 101
increased spleen weight 1 | 10
increased startle reflex 1 | 112
sclerocornea 1 | 2
shortened RR interval 1 | 17
small kidney 1 | 16
small spleen 1 | 19
urinary bladder obstruction 1 | 4

Disease

Carcinoma 90 | 11,493
ovarian cancer 83 | 8,520
medulloblastoma, large-cell 70 | 6,241
lung cancer 66 | 4,740
glioblastoma 65 | 5,792
group 3 medulloblastoma 65 | 4,104
Breast cancer 63 | 3,578
psoriasis 60 | 6,694
osteosarcoma 59 | 7,950
atypical teratoid / rhabdoid tumor 57 | 5,112
primitive neuroectodermal tumor 51 | 3,035
adult high grade glioma 50 | 3,801
intraductal papillary-mucinous carcinoma (IPMC) 50 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 49 | 3,291
non-small cell lung cancer 49 | 2,890
adrenocortical carcinoma 46 | 1,428
ependymoma 44 | 4,679
invasive ductal carcinoma 41 | 2,951
malignant mesothelioma 41 | 3,232
Cancer 37 | 2,499
lung adenocarcinoma 35 | 2,716
Atopic dermatitis 33 | 952
Endometriosis 33 | 540
breast carcinoma 32 | 1,638
ductal carcinoma in situ 32 | 1,745
pancreatic cancer 30 | 2,398
Kidney cancer 28 | 2,613
nasopharyngeal carcinoma 27 | 1,058
oligodendroglioma 27 | 2,850
colon cancer 26 | 1,478
Astrocytoma, Pilocytic 24 | 3,081
interstitial cystitis 23 | 2,312
Intellectual disability 21 | 1,016
intraductal papillary-mucinous adenoma (IPMA) 21 | 2,955
astrocytic glioma 20 | 2,597
Pick disease 16 | 1,894
primary Sjogren syndrome 15 | 735
ulcerative colitis 15 | 1,819
Autosomal recessive predisposition 14 | 1,442
pituitary cancer 14 | 1,972
Dull intelligence 13 | 645
Low intelligence 13 | 645
Mental Retardation 13 | 645
Mental deficiency 13 | 645
Poor school performance 13 | 645
Short stature 13 | 531
Small head 13 | 374
pediatric high grade glioma 12 | 1,064
subependymal giant cell astrocytoma 12 | 2,287
tuberculosis 12 | 2,010
Epilepsy 11 | 792
Cognitive delay 10 | 608
Global developmental delay 10 | 608
Mental and motor retardation 10 | 608
Microcephaly 10 | 166
Multiple myeloma 10 | 1,332
Rheumatoid arthritis 10 | 1,191
esophageal adenocarcinoma 10 | 737
lung carcinoma 10 | 2,843
Liver cancer 9 | 604
Polycystic ovary syndrome 9 | 360
Waldenstrons macroglobulinemia 9 | 765
active Crohn's disease 9 | 922
acute quadriplegic myopathy 9 | 1,158
juvenile dermatomyositis 9 | 1,187
Cataract 8 | 297
Endometrial cancer 8 | 311
Glaucoma 8 | 239
Hypoplastic mandible condyle 8 | 275
Mandibular hypoplasia 8 | 275
Micrognathism 8 | 275
Schizophrenia 8 | 1,160
Seizures 8 | 596
chronic rhinosinusitis 8 | 512
group 4 medulloblastoma 8 | 1,855
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,962
spina bifida 8 | 1,074
Anteverted nostril 7 | 191
Fetal Growth Retardation 7 | 189
Infant, Small for Gestational Age 7 | 176
Intrauterine retardation 7 | 176
Lens Opacities 7 | 231
Melanoma 7 | 711
Sensorineural Hearing Loss (disorder) 7 | 284
astrocytoma 7 | 1,146
cystic fibrosis 7 | 1,696
diabetes mellitus 7 | 1,728
posterior fossa group A ependymoma 7 | 468
tuberculosis and treatment for 6 months 7 | 409
Microcephalic osteodysplastic primordial dwarfism type II 6 | 13
Seckel syndrome 6 | 34
cystic fibrosis and chronic rhinosinusitis 6 | 214
gastric cancer 6 | 459
hepatocellular carcinoma 6 | 547
non primary Sjogren syndrome sicca 6 | 891
Congenital hypoplasia of penis 5 | 176
Optic Atrophy 5 | 242
Prostatic Neoplasms 5 | 495
Retinitis Pigmentosa 5 | 226
cutaneous lupus erythematosus 5 | 1,057

Tissue

Digestive Tract 114 | 17,369
Endocrine System 114 | 18,159
Urinary Tract 114 | 16,678
Liver and Pancreas 113 | 16,750
Skin and soft tissues 113 | 17,230
Blood and immune system 112 | 16,909
Female tissues 112 | 17,400
Male tissues 112 | 17,142
Respiratory system 112 | 16,393
Nervous System 111 | 16,725
Cardiovascular System 104 | 15,192

Target Family

Non-IDG 80 | 12,091
Enzyme 15 | 4,145
Kinase 12 | 634
Transcription Factor 4 | 1,400
Epigenetic 2 | 242
Ion Channel 1 | 344
Transporter 1 | 473
oGPCR 1 | 421

Compartment GO Term

Mitotic spindle 116 | 116
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,784 | 8,784
Membrane 8,531 | 8,531
Nucleus 7,562 | 7,562
Cytosol 6,686 | 6,686
Membrane part 6,554 | 6,554
Plasma membrane 5,830 | 5,830
Macromolecular complex 5,475 | 5,475
Intrinsic component of membran... 5,458 | 5,458
Cell periphery 5,382 | 5,382
Integral component of membrane 5,331 | 5,331
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,975 | 3,975
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,674 | 3,674
Organelle membrane 2,846 | 2,846
Extracellular region 2,732 | 2,732
Plasma membrane part 2,594 | 2,594
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,217 | 2,217
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,932 | 1,932
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,641 | 1,641
Cytoskeletal part 1,637 | 1,637
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 970 | 970
Neuron part 969 | 969
Supramolecular polymer 967 | 967
Supramolecular complex 966 | 966
Cell junction 960 | 960
Supramolecular fiber 959 | 959
Golgi apparatus part 950 | 950
Nucleoli 942 | 942
Endosome 930 | 930
Nucleolus 926 | 926
Chromosomal part 889 | 889
GO:0098796 884 | 884
Ribonucleoprotein complex 865 | 865
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 850 | 850
Transferase complex 849 | 849
Cell surface 842 | 842
Plasma membrane region 841 | 841
Vesicle membrane 801 | 801
Cytoplasmic vesicle membrane 795 | 795
Polymeric cytoskeletal fiber 764 | 764
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 714 | 714
Neuron projection 711 | 711
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Transforming acidic coiled-coil-containing protein 3 TACC3 Tbio Non-IDG -1.99617 101.2 222
Mitotic spindle assembly checkpoint protein MAD1 MAD1L1 Tbio Non-IDG -1.17500 13.6 283
Dual specificity protein phosphatase CDC14C CDC14C Tdark Enzyme -0.37414 4.05 0
Kinesin-like protein KIF20B KIF20B Tbio Non-IDG -1.04680 12.5 48
Centlein CNTLN Tbio Non-IDG -2.28518 122.3 76
Sperm-associated antigen 5 SPAG5 Tbio Non-IDG -1.72743 51.4 136
Nuclear mitotic apparatus protein 1 NUMA1 Tbio Non-IDG -2.76544 575.8 235
Cohesin subunit SA-1 STAG1 Tbio Non-IDG -2.47449 292.2 200
Small kinetochore-associated protein KNSTRN Tbio Non-IDG -1.28291 21.4 32
Kinesin-like protein KIF2C KIF2C Tbio Non-IDG -2.12404 136.3 256