Development Level

Tbio 1,014 | 11,445
Tdark 230 | 6,588
Tchem 220 | 1,598
Tclin 112 | 613

Collection

Kinase: IDG Consortium (Target... 6 | 125
RFA-RM-18-021 6 | 328
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 163 | 979
embryonic lethality prior to t... 46 | 278
embryonic lethality prior to o... 45 | 239
preweaning lethality, incomple... 30 | 499
abnormal behavior 27 | 298
abnormal embryo size 26 | 220
increased total body fat amoun... 21 | 134
decreased total body fat amoun... 20 | 207
decreased vertical activity 20 | 208
embryonic growth retardation 18 | 106
decreased bone mineral content 16 | 151
enlarged heart 16 | 210
hyperactivity 16 | 148
increased lean body mass 16 | 172
cataract 15 | 92
decreased body weight 15 | 161
decreased lean body mass 15 | 135
hypoactivity 15 | 132
abnormal lens morphology 14 | 81
increased mean corpuscular hem... 14 | 96
abnormal bone structure 13 | 187
decreased circulating glucose ... 13 | 126
increased startle reflex 13 | 112
abnormal heart morphology 12 | 162
increased circulating choleste... 12 | 66
prenatal lethality prior to he... 11 | 87
decreased grip strength 10 | 116
increased circulating alkaline... 10 | 122
abnormal gait 9 | 69
abnormal seminal vesicle morph... 9 | 114
decreased circulating choleste... 9 | 93
small superior vagus ganglion 9 | 74
thrombocytopenia 9 | 56
abnormal neural tube closure 8 | 46
decreased bone mineral density 8 | 126
decreased circulating alkaline... 8 | 46
decreased erythrocyte cell num... 8 | 62
decreased mean corpuscular vol... 8 | 79
increased bone mineral density 8 | 72
increased circulating HDL chol... 8 | 80
increased fasted circulating g... 8 | 76
increased mean corpuscular vol... 8 | 92
male infertility 8 | 123
abnormal sleep behavior 7 | 70
decreased circulating HDL chol... 7 | 68
decreased circulating triglyce... 7 | 79
decreased fasted circulating g... 7 | 65
decreased leukocyte cell numbe... 7 | 73
decreased prepulse inhibition 7 | 82
increased bone mineral content 7 | 108
increased heart weight 7 | 62
pallor 7 | 34
small testis 7 | 58
abnormal retina morphology 6 | 71
abnormal skin morphology 6 | 50
abnormal testis morphology 6 | 43
decreased circulating LDL chol... 6 | 38
decreased circulating alanine ... 6 | 47
decreased circulating total pr... 6 | 49
decreased lymphocyte cell numb... 6 | 83
increased circulating bilirubi... 6 | 16
increased circulating calcium ... 6 | 34
increased circulating sodium l... 6 | 71
increased hemoglobin content 6 | 45
increased or absent threshold ... 6 | 101
persistence of hyaloid vascula... 6 | 33
abnormal behavioral response t... 5 | 66
abnormal cranium morphology 5 | 36
abnormal embryo turning 5 | 31
abnormal kidney morphology 5 | 65
abnormal tooth morphology 5 | 24
decreased blood urea nitrogen ... 5 | 51
decreased body length 5 | 101
decreased circulating aspartat... 5 | 34
decreased circulating creatini... 5 | 39
decreased circulating insulin ... 5 | 76
decreased circulating phosphat... 5 | 27
decreased circulating serum al... 5 | 82
decreased lactate dehydrogenas... 5 | 16
decreased red blood cell distr... 5 | 41
decreased startle reflex 5 | 75
hydrometra 5 | 53
increased body length 5 | 32
increased circulating phosphat... 5 | 26
increased circulating serum al... 5 | 22
increased grip strength 5 | 41
increased leukocyte cell numbe... 5 | 47
increased monocyte cell number 5 | 63
increased prepulse inhibition 5 | 32
increased red blood cell distr... 5 | 34
short tibia 5 | 97
abnormal coat-hair pigmentatio... 4 | 64
abnormal epididymis morphology 4 | 42
decreased hematocrit 4 | 46
decreased hemoglobin content 4 | 68
improved glucose tolerance 4 | 79
increased circulating chloride... 4 | 41
increased circulating total pr... 4 | 28
pale yolk sac 4 | 25
thrombocytosis 4 | 27

Disease

ovarian cancer 866 | 8,520
Carcinoma 809 | 11,493
osteosarcoma 705 | 7,950
psoriasis 537 | 6,694
lung cancer 527 | 4,740
medulloblastoma, large-cell 526 | 6,241
glioblastoma 462 | 5,792
atypical teratoid / rhabdoid tumor 405 | 5,112
ependymoma 353 | 4,679
pancreatic ductal adenocarcinoma liver metastasis 339 | 1,962
Cancer 327 | 2,499
group 3 medulloblastoma 318 | 4,104
Breast cancer 306 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 301 | 3,291
malignant mesothelioma 288 | 3,232
adult high grade glioma 284 | 3,801
Autosomal recessive predisposition 256 | 1,442
non-small cell lung cancer 250 | 2,890
invasive ductal carcinoma 249 | 2,951
Multiple myeloma 241 | 1,332
astrocytic glioma 236 | 2,597
lung adenocarcinoma 236 | 2,716
oligodendroglioma 223 | 2,850
primitive neuroectodermal tumor 222 | 3,035
diabetes mellitus 217 | 1,728
intraductal papillary-mucinous adenoma (IPMA) 217 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 217 | 2,989
Astrocytoma, Pilocytic 213 | 3,081
tuberculosis 198 | 2,010
pancreatic cancer 194 | 2,398
lung carcinoma 190 | 2,843
subependymal giant cell astrocytoma 178 | 2,287
ulcerative colitis 173 | 1,819
Pick disease 172 | 1,894
breast carcinoma 167 | 1,638
Schizophrenia 157 | 1,160
ductal carcinoma in situ 155 | 1,745
Epilepsy 154 | 792
interstitial cystitis 151 | 2,312
group 4 medulloblastoma 146 | 1,855
Cognitive delay 137 | 608
Global developmental delay 137 | 608
Mental and motor retardation 137 | 608
Obesity 137 | 678
Muscle hypotonia 135 | 571
pituitary cancer 135 | 1,972
cystic fibrosis 134 | 1,696
Seizures 133 | 596
adrenocortical carcinoma 133 | 1,428
colon cancer 132 | 1,478
Kidney cancer 130 | 2,613
Intellectual disability 127 | 1,016
Neurodegenerative disease 116 | 414
acute quadriplegic myopathy 111 | 1,158
Alzheimer's disease 110 | 658
Waldenstrons macroglobulinemia 110 | 765
non primary Sjogren syndrome sicca 110 | 891
astrocytoma 108 | 1,146
Rheumatoid arthritis 107 | 1,191
Liver Cirrhosis, Experimental 103 | 769
Dull intelligence 101 | 645
Low intelligence 101 | 645
Mental Retardation 101 | 645
Mental deficiency 101 | 645
Poor school performance 101 | 645
Cerebellar Ataxia 100 | 304
acute myeloid leukemia 99 | 783
dermatomyositis 97 | 966
juvenile dermatomyositis 97 | 1,187
Breast Neoplasms 95 | 445
Leigh disease 95 | 100
Mammary Neoplasms 94 | 425
Failure to gain weight 90 | 365
Pediatric failure to thrive 90 | 365
Vascular disease 88 | 319
Acidosis, Lactic 86 | 97
Bipolar Disorder 86 | 666
Lactic acidemia 85 | 95
Atopic dermatitis 84 | 952
cutaneous lupus erythematosus 84 | 1,057
Prostatic Neoplasms 83 | 495
Parkinson's disease 81 | 392
nasopharyngeal carcinoma 81 | 1,058
pediatric high grade glioma 80 | 1,064
active ulcerative colitis 79 | 764
primary pancreatic ductal adenocarcinoma 79 | 1,109
Anemia 77 | 365
Stomach Neoplasms 76 | 300
active Crohn's disease 76 | 922
Depressive disorder 75 | 409
Hypoglycemia 75 | 152
aldosterone-producing adenoma 75 | 665
Neuropathy 74 | 261
Optic Atrophy 73 | 242
Dystonia 72 | 164
gastric carcinoma 72 | 807
Heart disease 70 | 306
Toxic encephalopathy 70 | 141
Hypertension 69 | 396
Kidney disease 68 | 430

Tissue

Endocrine System 1,555 | 18,159
Digestive Tract 1,543 | 17,369
Skin and soft tissues 1,538 | 17,230
Female tissues 1,537 | 17,400
Blood and immune system 1,529 | 16,909
Male tissues 1,529 | 17,142
Urinary Tract 1,529 | 16,678
Liver and Pancreas 1,528 | 16,750
Nervous System 1,523 | 16,725
Respiratory system 1,504 | 16,393
Cardiovascular System 1,480 | 15,192

Target Family

Enzyme 710 | 4,145
Non-IDG 637 | 12,091
Kinase 84 | 634
Transporter 74 | 473
Transcription Factor 35 | 1,400
Epigenetic 15 | 242
Nuclear Receptor 8 | 48
GPCR 5 | 408
Ion Channel 5 | 344
TF/Epigenetic 3 | 38

Compartment GO Term

Mitochondrion 1,576 | 1,576
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,109 | 14,109
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,975 | 8,975
Intracellular organelle part 8,783 | 8,783
Membrane 8,531 | 8,531
Nucleus 7,562 | 7,562
Cytosol 6,686 | 6,686
Membrane part 6,554 | 6,554
Plasma membrane 5,830 | 5,830
Macromolecular complex 5,475 | 5,475
Intrinsic component of membran... 5,458 | 5,458
Cell periphery 5,382 | 5,382
Integral component of membrane 5,331 | 5,331
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,975 | 3,975
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,674 | 3,674
Organelle membrane 2,846 | 2,846
Extracellular region 2,732 | 2,732
Plasma membrane part 2,594 | 2,594
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,217 | 2,217
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,637 | 1,637
Extracellular region part 1,628 | 1,628
Vesicles 1,613 | 1,613
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 967 | 967
Supramolecular complex 966 | 966
Cell junction 960 | 960
Supramolecular fiber 959 | 959
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 930 | 930
Nucleolus 926 | 926
Chromosomal part 889 | 889
GO:0098796 884 | 884
Ribonucleoprotein complex 865 | 865
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 850 | 850
Transferase complex 849 | 849
Cell surface 842 | 842
Plasma membrane region 841 | 841
Vesicle membrane 801 | 801
Cytoplasmic vesicle membrane 795 | 795
Polymeric cytoskeletal fiber 764 | 764
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 714 | 714
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 663 | 663
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitochondrial coenzyme A transporter SLC25A42 SLC25A42 Tbio Transporter -0.53750 4.06 29
Mitochondrial uncoupling protein 3 UCP3 Tbio Non-IDG -2.74050 585.4 181
E3 ubiquitin-protein ligase TRIM39 TRIM39 Tbio Enzyme -1.24729 16.2 194
Caspase-14 CASP14 Tchem Enzyme -1.81937 73.7 348
Protein NipSnap homolog 3B NIPSNAP3B Tbio Non-IDG -1.06487 11.0 103
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial NDUFS1 Tclin Enzyme -1.42734 26.2 214
Mitochondrial import inner membrane translocase subunit Tim13 TIMM13 Tbio Enzyme -1.90930 75.7 32
Unconventional prefoldin RPB5 interactor 1 URI1 Tbio Enzyme -2.15409 134.8 150
Phosphate carrier protein, mitochondrial SLC25A3 Tbio Transporter -2.85426 703.4 33
Succinate dehydrogenase assembly factor 2, mitochondrial SDHAF2 Tbio Enzyme -1.86465 69.5 34