Development Level

Tbio 922 | 10,625
Tdark 259 | 7,003
Tchem 243 | 1,890
Tclin 106 | 602

Collection

Eligible Kinase Proteins 8 | 134

IMPC Term

preweaning lethality, complete... 97 | 633
embryonic lethality prior to o... 36 | 148
embryonic lethality prior to t... 35 | 187
abnormal behavior 21 | 226
abnormal embryo size 18 | 112
decreased body weight 18 | 174
preweaning lethality, incomple... 17 | 260
decreased total body fat amoun... 16 | 186
decreased lean body mass 15 | 195
prenatal lethality prior to he... 13 | 64
hypoactivity 12 | 89
increased mean corpuscular vol... 12 | 91
abnormal lens morphology 11 | 73
abnormal retina morphology 11 | 100
decreased bone mineral content 11 | 157
decreased circulating glucose ... 11 | 121
decreased grip strength 11 | 123
increased circulating choleste... 11 | 53
increased grip strength 11 | 83
increased mean corpuscular hem... 11 | 93
increased circulating alkaline... 10 | 119
abnormal bone structure 9 | 131
embryonic growth retardation 9 | 28
hyperactivity 9 | 108
increased lean body mass 9 | 107
decreased circulating choleste... 8 | 85
enlarged heart 8 | 111
increased circulating HDL chol... 8 | 63
abnormal gait 7 | 51
decreased circulating insulin ... 7 | 75
decreased circulating triglyce... 7 | 83
decreased leukocyte cell numbe... 7 | 54
increased circulating sodium l... 7 | 71
increased heart weight 7 | 37
increased startle reflex 7 | 38
abnormal retinal pigmentation 6 | 61
abnormal testis morphology 6 | 30
abnormal tooth morphology 6 | 24
decreased body length 6 | 108
decreased bone mineral density 6 | 126
decreased circulating HDL chol... 6 | 77
decreased circulating alanine ... 6 | 53
decreased circulating alkaline... 6 | 41
decreased circulating serum al... 6 | 79
increased bone mineral density 6 | 52
increased circulating phosphat... 6 | 24
increased fasted circulating g... 6 | 68
increased or absent threshold ... 6 | 128
male infertility 6 | 62
small testis 6 | 37
thrombocytopenia 6 | 46
abnormal behavioral response t... 5 | 52
abnormal neural tube closure 5 | 37
decreased blood urea nitrogen ... 5 | 31
decreased caudal vertebrae num... 5 | 49
decreased circulating creatini... 5 | 31
decreased prepulse inhibition 5 | 52
decreased rib number 5 | 59
decreased startle reflex 5 | 48
decreased total retina thickne... 5 | 20
increased blood urea nitrogen ... 5 | 44
increased circulating bilirubi... 5 | 16
increased circulating chloride... 5 | 43
increased erythrocyte cell num... 5 | 26
increased exploration in new e... 5 | 56
increased leukocyte cell numbe... 5 | 37
short tibia 5 | 82
abnormal bone mineralization 4 | 55
abnormal cranium morphology 4 | 32
abnormal epididymis morphology 4 | 31
abnormal limb bud morphology 4 | 15
abnormal maxilla morphology 4 | 16
abnormal rib morphology 4 | 28
abnormal snout morphology 4 | 18
decreased T cell number 4 | 31
decreased circulating LDL chol... 4 | 37
decreased circulating total pr... 4 | 41
decreased erythrocyte cell num... 4 | 43
decreased heart weight 4 | 44
decreased lumbar vertebrae num... 4 | 62
decreased mean corpuscular vol... 4 | 50
enlarged epididymis 4 | 27
female infertility 4 | 34
hemorrhage 4 | 12
improved glucose tolerance 4 | 56
increased NK cell number 4 | 19
increased body length 4 | 20
increased bone mineral content 4 | 92
increased circulating aspartat... 4 | 17
increased circulating free fat... 4 | 17
increased red blood cell distr... 4 | 21
increased total body fat amoun... 4 | 57
pallor 4 | 13
polydactyly 4 | 22
abnormal heart left ventricle ... 3 | 20
abnormal vertebrae morphology 3 | 14
decreased circulating iron lev... 3 | 25
increased circulating calcium ... 3 | 32
persistence of hyaloid vascula... 3 | 22
thrombocytosis 3 | 23

Disease

ovarian cancer 838 | 8,484
osteosarcoma 691 | 7,933
psoriasis 526 | 6,685
medulloblastoma, large-cell 505 | 6,234
lung cancer 494 | 4,466
glioblastoma 436 | 5,572
atypical teratoid / rhabdoid tumor 322 | 4,369
pancreatic ductal adenocarcinoma liver metastasis 314 | 1,795
Cancer 300 | 2,346
intraductal papillary-mucinous neoplasm (IPMN) 295 | 3,289
malignant mesothelioma 275 | 3,162
Breast cancer 261 | 3,094
Multiple myeloma 239 | 1,327
non-small cell lung cancer 236 | 2,798
invasive ductal carcinoma 232 | 2,950
lung adenocarcinoma 231 | 2,713
primitive neuroectodermal tumor 218 | 3,031
ependymoma 216 | 2,514
oligodendroglioma 213 | 2,849
intraductal papillary-mucinous adenoma (IPMA) 212 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 210 | 2,988
pediatric high grade glioma 209 | 2,712
pilocytic astrocytoma 203 | 3,086
astrocytic glioma 201 | 2,241
ulcerative colitis 200 | 2,087
diabetes mellitus 194 | 1,663
lung carcinoma 187 | 2,844
pancreatic cancer 186 | 2,300
group 3 medulloblastoma 170 | 2,254
subependymal giant cell astrocytoma 168 | 2,287
Pick disease 161 | 1,893
tuberculosis 152 | 1,557
breast carcinoma 150 | 1,614
interstitial cystitis 148 | 2,299
adult high grade glioma 146 | 2,148
group 4 medulloblastoma 145 | 1,875
ductal carcinoma in situ 141 | 1,745
medulloblastoma 132 | 1,524
adrenocortical carcinoma 131 | 1,427
astrocytoma 127 | 1,493
cystic fibrosis 127 | 1,665
colon cancer 126 | 1,475
pituitary cancer 124 | 1,972
Obesity 122 | 616
Waldenstrons macroglobulinemia 108 | 765
Neurodegenerative disease 106 | 383
acute quadriplegic myopathy 105 | 1,157
non primary Sjogren syndrome sicca 105 | 840
Rheumatoid Arthritis 104 | 1,160
Alzheimer's disease 102 | 644
posterior fossa group A ependymoma 101 | 1,511
primary pancreatic ductal adenocarcinoma 99 | 1,271
sonic hedgehog group medulloblastoma 98 | 1,482
juvenile dermatomyositis 96 | 1,189
dermatomyositis 95 | 933
Carcinoma 92 | 2,147
atypical teratoid/rhabdoid tumor 92 | 1,095
acute myeloid leukemia 91 | 780
posterior fossa group B ependymoma 87 | 1,530
Mammary Neoplasms 86 | 410
Atopic dermatitis 79 | 944
Vascular disease 79 | 281
nasopharyngeal carcinoma 79 | 1,056
Prostatic Neoplasms 77 | 471
Leigh disease 76 | 81
Parkinson's disease 76 | 364
active Crohn's disease 76 | 918
gastric carcinoma 76 | 832
cutaneous lupus erythematosus 75 | 1,056
aldosterone-producing adenoma 72 | 664
Kidney disease 67 | 396
Stomach Neoplasms 65 | 282
Toxic encephalopathy 59 | 131
primary Sjogren syndrome 59 | 789
spina bifida 57 | 1,064
tuberculosis and treatment for 6 months 57 | 686
Heart disease 56 | 279
Liver carcinoma 55 | 217
Neuropathy 54 | 210
Schizophrenia 54 | 501
Amyotrophic Lateral Sclerosis 53 | 431
hepatocellular carcinoma 53 | 532
hereditary spastic paraplegia 53 | 313
pancreatic carcinoma 53 | 567
Diabetes mellitus type 2 52 | 69
Multiple Sclerosis 52 | 498
esophageal adenocarcinoma 52 | 737
Treatment Refractory Type 2 Diabetes Mellitus 51 | 53
Diabetes Mellitus, Experimental 50 | 106
Down syndrome 50 | 548
Hyperglycemia 50 | 120
Anemia 49 | 252
Cerebrovascular disease 49 | 231
Duchenne muscular dystrophy 49 | 602
Intellectual disability 48 | 573
Liver disease 47 | 219
progressive supranuclear palsy 47 | 674
Endometriosis 46 | 535
Asthma 45 | 349
fibroadenoma 45 | 557

Tissue

Female tissues 1,515 | 18,647
Nervous System 1,515 | 18,561
Endocrine System 1,513 | 18,512
Blood and immune system 1,512 | 17,995
Urinary Tract 1,512 | 18,444
Digestive Tract 1,511 | 18,473
Liver and Pancreas 1,510 | 18,136
Cardiovascular System 1,506 | 17,958
Male tissues 1,506 | 17,969
Skin and soft tissues 1,499 | 18,115
Respiratory system 1,494 | 17,484

Target Family

Enzyme 703 | 4,146
Non-IDG 616 | 11,971
Kinase 82 | 634
Transporter 72 | 473
Transcription Factor 26 | 1,400
Epigenetic 13 | 242
Nuclear Receptor 8 | 48
Ion Channel 5 | 341
TF/Epigenetic 3 | 38
GPCR 2 | 406

Compartment GO Term

Mitochondrion 1,530 | 1,530
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,170 | 8,170
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,830 | 7,830
Nucleus 6,897 | 6,897
Membrane part 6,469 | 6,469
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,172 | 5,172
Cell periphery 5,145 | 5,145
Plasma membrane 5,059 | 5,059
Extracellular region 4,606 | 4,606
Protein complex 4,438 | 4,438
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Cytosol 3,352 | 3,352
Nucleoplasm 2,938 | 2,938
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,563 | 2,563
Cytoskeleton 2,045 | 2,045
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Endoplasmic reticulum 1,663 | 1,663
Cytoskeletal part 1,567 | 1,567
Cell projection 1,426 | 1,426
Golgi apparatus 1,402 | 1,402
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,233 | 1,233
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Chromosome 999 | 999
Mitochondrial part 989 | 989
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 780 | 780
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 738 | 738
Plasma membrane protein comple... 720 | 720
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Microtubule organizing center 617 | 617
Synapse 594 | 594
Lysosome 571 | 571
Lytic vacuole 571 | 571
Vesicle membrane 559 | 559
cell-cell junction 557 | 557
Cytoplasmic vesicle membrane 552 | 552

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitochondrial 2-oxodicarboxylate carrier SLC25A21 Tbio Transporter -0.46900 2.68 102
RNA pseudouridylate synthase domain-containing protein 3 RPUSD3 Tdark Enzyme 0.42 34
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
ATP synthase F(0) complex subunit C3, mitochondrial ATP5G3 Tdark Enzyme -1.10871 11.9 27
ADP/ATP translocase 3 SLC25A6 Tbio Transporter -2.06581 118.3 193
ADP/ATP translocase 1 SLC25A4 Tbio Transporter -2.05462 110.8 89
G2/mitotic-specific cyclin-B1 CCNB1 Tchem Non-IDG -3.09727 1121.4 955
Apolipoprotein E APOE Tbio Non-IDG -4.17470 15380.4 788
Forkhead box protein M1 FOXM1 Tbio Transcription Factor -3.09305 1275.4 345
Glial cell line-derived neurotrophic factor GDNF Tbio Non-IDG -3.30206 2301.5 303