Development Level

Tbio 922 | 10,625
Tdark 259 | 7,003
Tchem 243 | 1,890
Tclin 106 | 602

Collection

Eligible Kinase Proteins 8 | 134

IMPC Term

preweaning lethality, complete... 97 | 633
embryonic lethality prior to o... 36 | 148
embryonic lethality prior to t... 35 | 187
abnormal behavior 21 | 226
abnormal embryo size 18 | 112
decreased body weight 18 | 174
preweaning lethality, incomple... 17 | 260
decreased total body fat amoun... 16 | 186
decreased lean body mass 15 | 195
prenatal lethality prior to he... 13 | 64
hypoactivity 12 | 89
increased mean corpuscular vol... 12 | 91
abnormal lens morphology 11 | 73
abnormal retina morphology 11 | 100
decreased bone mineral content 11 | 157
decreased circulating glucose ... 11 | 121
decreased grip strength 11 | 123
increased circulating choleste... 11 | 53
increased grip strength 11 | 83
increased mean corpuscular hem... 11 | 93
increased circulating alkaline... 10 | 119
abnormal bone structure 9 | 131
embryonic growth retardation 9 | 28
hyperactivity 9 | 108
increased lean body mass 9 | 107
decreased circulating choleste... 8 | 85
enlarged heart 8 | 111
increased circulating HDL chol... 8 | 63
abnormal gait 7 | 51
decreased circulating insulin ... 7 | 75
decreased circulating triglyce... 7 | 83
decreased leukocyte cell numbe... 7 | 54
increased circulating sodium l... 7 | 71
increased heart weight 7 | 37
increased startle reflex 7 | 38
abnormal retinal pigmentation 6 | 61
abnormal testis morphology 6 | 30
abnormal tooth morphology 6 | 24
decreased body length 6 | 108
decreased bone mineral density 6 | 126
decreased circulating HDL chol... 6 | 77
decreased circulating alanine ... 6 | 53
decreased circulating alkaline... 6 | 41
decreased circulating serum al... 6 | 79
increased bone mineral density 6 | 52
increased circulating phosphat... 6 | 24
increased fasted circulating g... 6 | 68
increased or absent threshold ... 6 | 128
male infertility 6 | 62
small testis 6 | 37
thrombocytopenia 6 | 46
abnormal behavioral response t... 5 | 52
abnormal neural tube closure 5 | 37
decreased blood urea nitrogen ... 5 | 31
decreased caudal vertebrae num... 5 | 49
decreased circulating creatini... 5 | 31
decreased prepulse inhibition 5 | 52
decreased rib number 5 | 59
decreased startle reflex 5 | 48
decreased total retina thickne... 5 | 20
increased blood urea nitrogen ... 5 | 44
increased circulating bilirubi... 5 | 16
increased erythrocyte cell num... 5 | 26
increased exploration in new e... 5 | 56
increased leukocyte cell numbe... 5 | 37
short tibia 5 | 82
abnormal bone mineralization 4 | 55
abnormal cranium morphology 4 | 32
abnormal epididymis morphology 4 | 31
abnormal limb bud morphology 4 | 15
abnormal maxilla morphology 4 | 16
abnormal rib morphology 4 | 28
abnormal snout morphology 4 | 18
decreased T cell number 4 | 31
decreased circulating LDL chol... 4 | 37
decreased circulating total pr... 4 | 41
decreased erythrocyte cell num... 4 | 43
decreased heart weight 4 | 44
decreased lumbar vertebrae num... 4 | 62
decreased mean corpuscular vol... 4 | 50
enlarged epididymis 4 | 27
female infertility 4 | 34
hemorrhage 4 | 12
improved glucose tolerance 4 | 56
increased NK cell number 4 | 19
increased body length 4 | 20
increased bone mineral content 4 | 92
increased circulating aspartat... 4 | 17
increased circulating chloride... 4 | 43
increased circulating free fat... 4 | 17
increased red blood cell distr... 4 | 21
increased total body fat amoun... 4 | 57
pallor 4 | 13
polydactyly 4 | 22
abnormal heart left ventricle ... 3 | 20
abnormal vertebrae morphology 3 | 14
decreased circulating iron lev... 3 | 25
increased circulating calcium ... 3 | 32
persistence of hyaloid vascula... 3 | 22
thrombocytosis 3 | 23

Disease

ovarian cancer 840 | 8,492
osteosarcoma 691 | 7,933
psoriasis 527 | 6,685
medulloblastoma, large-cell 505 | 6,234
lung cancer 496 | 4,473
glioblastoma 436 | 5,572
atypical teratoid / rhabdoid tumor 321 | 4,369
pancreatic ductal adenocarcinoma liver metastasis 315 | 1,795
Cancer 300 | 2,346
intraductal papillary-mucinous neoplasm (IPMN) 295 | 3,289
malignant mesothelioma 277 | 3,163
Breast cancer 263 | 3,099
Multiple myeloma 239 | 1,328
non-small cell lung cancer 237 | 2,798
invasive ductal carcinoma 232 | 2,950
lung adenocarcinoma 232 | 2,714
ependymoma 217 | 2,514
primitive neuroectodermal tumor 217 | 3,031
oligodendroglioma 213 | 2,849
intraductal papillary-mucinous adenoma (IPMA) 211 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 209 | 2,988
pediatric high grade glioma 208 | 2,712
pilocytic astrocytoma 202 | 3,086
astrocytic glioma 201 | 2,241
ulcerative colitis 199 | 2,087
diabetes mellitus 194 | 1,663
lung carcinoma 186 | 2,844
pancreatic cancer 185 | 2,300
group 3 medulloblastoma 170 | 2,254
subependymal giant cell astrocytoma 167 | 2,287
Pick disease 161 | 1,893
tuberculosis 152 | 1,563
breast carcinoma 151 | 1,614
interstitial cystitis 148 | 2,299
adult high grade glioma 146 | 2,148
group 4 medulloblastoma 145 | 1,875
ductal carcinoma in situ 142 | 1,745
medulloblastoma 132 | 1,524
adrenocortical carcinoma 131 | 1,427
cystic fibrosis 127 | 1,670
astrocytoma 126 | 1,493
colon cancer 126 | 1,475
pituitary cancer 123 | 1,972
Obesity 122 | 616
Waldenstrons macroglobulinemia 108 | 765
Neurodegenerative disease 106 | 383
Rheumatoid Arthritis 104 | 1,171
acute quadriplegic myopathy 104 | 1,157
non primary Sjogren syndrome sicca 104 | 840
Alzheimer's disease 102 | 644
posterior fossa group A ependymoma 100 | 1,511
primary pancreatic ductal adenocarcinoma 98 | 1,271
sonic hedgehog group medulloblastoma 97 | 1,482
dermatomyositis 95 | 967
juvenile dermatomyositis 95 | 1,189
Carcinoma 92 | 2,147
acute myeloid leukemia 92 | 785
atypical teratoid/rhabdoid tumor 92 | 1,095
posterior fossa group B ependymoma 87 | 1,530
Mammary Neoplasms 86 | 410
Atopic dermatitis 80 | 944
Vascular disease 79 | 281
nasopharyngeal carcinoma 79 | 1,056
Leigh disease 76 | 81
Prostatic Neoplasms 76 | 471
active Crohn's disease 76 | 918
Parkinson's disease 75 | 364
cutaneous lupus erythematosus 75 | 1,056
gastric carcinoma 75 | 832
aldosterone-producing adenoma 72 | 664
Kidney disease 67 | 397
Stomach Neoplasms 65 | 282
Toxic encephalopathy 59 | 131
primary Sjogren syndrome 59 | 789
hepatocellular carcinoma 58 | 550
spina bifida 57 | 1,064
tuberculosis and treatment for 6 months 57 | 686
Heart disease 56 | 279
Liver carcinoma 55 | 217
Neuropathy 54 | 210
Schizophrenia 54 | 503
Amyotrophic Lateral Sclerosis 53 | 432
hereditary spastic paraplegia 53 | 313
pancreatic carcinoma 53 | 567
Diabetes mellitus type 2 52 | 69
Multiple Sclerosis 52 | 498
esophageal adenocarcinoma 52 | 737
Treatment Refractory Type 2 Diabetes Mellitus 51 | 53
Diabetes Mellitus, Experimental 50 | 106
Hyperglycemia 50 | 120
Anemia 49 | 252
Cerebrovascular disease 49 | 231
Down syndrome 49 | 548
Duchenne muscular dystrophy 48 | 602
Intellectual disability 48 | 573
Endometriosis 47 | 535
Liver disease 47 | 219
progressive supranuclear palsy 47 | 674
Hypertension 46 | 293
Asthma 45 | 349

Tissue

Female tissues 1,515 | 18,647
Nervous System 1,515 | 18,561
Endocrine System 1,513 | 18,512
Blood and immune system 1,512 | 17,995
Urinary Tract 1,512 | 18,444
Digestive Tract 1,511 | 18,473
Liver and Pancreas 1,510 | 18,136
Cardiovascular System 1,506 | 17,958
Male tissues 1,506 | 17,969
Skin and soft tissues 1,499 | 18,115
Respiratory system 1,494 | 17,484

Target Family

Enzyme 703 | 4,146
Non-IDG 616 | 11,969
Kinase 82 | 634
Transporter 72 | 473
Transcription Factor 26 | 1,400
Epigenetic 13 | 242
Nuclear Receptor 8 | 48
Ion Channel 5 | 341
TF/Epigenetic 3 | 38
GPCR 2 | 408

Compartment GO Term

Mitochondrion 1,530 | 1,530
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,612 | 13,612
Intracellular part 13,475 | 13,475
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,353 | 10,353
Membrane 8,871 | 8,871
Organelle part 8,169 | 8,169
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,831 | 7,831
Nucleus 7,577 | 7,577
Membrane part 6,469 | 6,469
Cytosol 6,034 | 6,034
Plasma membrane 5,673 | 5,673
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,171 | 5,171
Cell periphery 5,146 | 5,146
Nucleoplasm 4,930 | 4,930
Extracellular region 4,607 | 4,607
Protein complex 4,439 | 4,439
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,874 | 3,874
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,592 | 2,592
Plasma membrane part 2,564 | 2,564
Cytoskeleton 2,046 | 2,046
Golgi apparatus 1,946 | 1,946
Endoplasmic reticulum 1,872 | 1,872
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Vesicles 1,625 | 1,625
Cytoskeletal part 1,568 | 1,568
Cell projection 1,425 | 1,425
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,234 | 1,234
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,092 | 1,092
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,084 | 1,084
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Mitochondria 1,003 | 1,003
Chromosome 999 | 999
Mitochondrial part 988 | 988
Nucleoli 950 | 950
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 815 | 815
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 781 | 781
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 739 | 739
Plasma membrane protein comple... 721 | 721
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Microtubule organizing center 680 | 680
Centrosome 676 | 676
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 656 | 656
Extracellular matrix 633 | 633
Synapse 594 | 594
Lytic vacuole 571 | 571

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
cAMP-dependent protein kinase catalytic subunit alpha PRKACA Tchem Kinase -1.02404 9.59 274
Mitochondrial coenzyme A transporter SLC25A42 SLC25A42 Tbio Transporter -0.38872 3.06 24
Solute carrier family 25 member 33 SLC25A33 Tbio Transporter -0.28165 1.49 35
ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 Tbio Transporter -0.85002 7.01 82
Thioredoxin reductase 3 TXNRD3 Tchem Enzyme -1.69637 55.1 0
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial MCCC2 Tbio Enzyme -1.23140 15.5 156
NACHT, LRR and PYD domains-containing protein 3 NLRP3 Tchem Non-IDG -3.22772 1655.7 459
Ubiquinol-cytochrome-c reductase complex assembly factor 2 UQCC2 Tbio Enzyme -1.50813 29.9 15
GPN-loop GTPase 1 GPN1 Tbio Enzyme -1.00563 10.8 120
Mitochondrial uncoupling protein 3 UCP3 Tbio Non-IDG -2.72649 574.1 155