Development Level

Tbio 608 | 10,625
Tdark 175 | 7,003
Tchem 120 | 1,890
Tclin 85 | 602

Collection

Eligible Kinase Proteins 6 | 134

IMPC Term

preweaning lethality, complete... 64 | 633
embryonic lethality prior to o... 27 | 148
embryonic lethality prior to t... 22 | 187
abnormal behavior 13 | 226
decreased body weight 13 | 174
decreased lean body mass 10 | 195
decreased total body fat amoun... 10 | 186
abnormal embryo size 9 | 112
preweaning lethality, incomple... 9 | 260
abnormal lens morphology 8 | 73
decreased bone mineral content 8 | 157
decreased circulating glucose ... 8 | 121
prenatal lethality prior to he... 8 | 64
abnormal retina morphology 7 | 100
decreased circulating choleste... 7 | 85
embryonic growth retardation 7 | 28
hypoactivity 7 | 89
increased mean corpuscular hem... 7 | 93
abnormal bone structure 6 | 131
decreased body length 6 | 108
decreased grip strength 6 | 123
increased circulating choleste... 6 | 53
increased circulating phosphat... 6 | 24
increased circulating sodium l... 6 | 71
increased fasted circulating g... 6 | 68
increased grip strength 6 | 83
increased lean body mass 6 | 107
increased mean corpuscular vol... 6 | 91
decreased circulating HDL chol... 5 | 77
decreased circulating triglyce... 5 | 83
decreased leukocyte cell numbe... 5 | 54
decreased total retina thickne... 5 | 20
hyperactivity 5 | 108
increased circulating HDL chol... 5 | 63
increased circulating alkaline... 5 | 119
increased heart weight 5 | 37
increased or absent threshold ... 5 | 128
increased startle reflex 5 | 38
abnormal gait 4 | 51
abnormal testis morphology 4 | 30
abnormal tooth morphology 4 | 24
decreased bone mineral density 4 | 126
decreased circulating LDL chol... 4 | 37
decreased circulating alkaline... 4 | 41
decreased circulating creatini... 4 | 31
decreased circulating insulin ... 4 | 75
decreased circulating serum al... 4 | 79
decreased circulating total pr... 4 | 41
decreased heart weight 4 | 44
decreased rib number 4 | 59
enlarged heart 4 | 111
small testis 4 | 37
thrombocytopenia 4 | 46
abnormal bone mineralization 3 | 55
abnormal cranium morphology 3 | 32
abnormal epididymis morphology 3 | 31
abnormal neural tube closure 3 | 37
abnormal retinal pigmentation 3 | 61
abnormal skin morphology 3 | 23
decreased T cell number 3 | 31
decreased blood urea nitrogen ... 3 | 31
decreased fasted circulating g... 3 | 49
decreased lumbar vertebrae num... 3 | 62
decreased mean corpuscular vol... 3 | 50
decreased mean platelet volume 3 | 12
decreased red blood cell distr... 3 | 11
decreased startle reflex 3 | 48
enlarged epididymis 3 | 27
female infertility 3 | 34
increased blood urea nitrogen ... 3 | 44
increased circulating aspartat... 3 | 17
increased circulating bilirubi... 3 | 16
increased exploration in new e... 3 | 56
increased total body fat amoun... 3 | 57
male infertility 3 | 62
pallor 3 | 13
persistence of hyaloid vascula... 3 | 22
short tibia 3 | 82
abnormal behavioral response t... 2 | 52
abnormal coat appearance 2 | 25
abnormal embryo turning 2 | 15
abnormal heart left ventricle ... 2 | 20
abnormal heart morphology 2 | 51
abnormal kidney morphology 2 | 30
abnormal locomotor activation 2 | 26
abnormal tail movements 2 | 12
abnormal vertebrae morphology 2 | 14
abnormal vocalization 2 | 21
decreased caudal vertebrae num... 2 | 49
decreased circulating iron lev... 2 | 25
decreased circulating potassiu... 2 | 17
decreased effector memory CD8-... 2 | 24
decreased mean corpuscular hem... 2 | 34
decreased vertical activity 2 | 22
increased bone mineral content 2 | 92
increased circulating calcium ... 2 | 32
increased circulating iron lev... 2 | 25
increased circulating total pr... 2 | 20
increased erythrocyte cell num... 2 | 26
increased sacral vertebrae num... 2 | 62

Disease

ovarian cancer 536 | 8,492
osteosarcoma 422 | 7,933
psoriasis 311 | 6,685
lung cancer 302 | 4,473
medulloblastoma, large-cell 299 | 6,234
glioblastoma 251 | 5,572
pancreatic ductal adenocarcinoma liver metastasis 218 | 1,795
atypical teratoid / rhabdoid tumor 190 | 4,369
Multiple myeloma 166 | 1,328
intraductal papillary-mucinous neoplasm (IPMN) 164 | 3,289
Breast cancer 150 | 3,099
malignant mesothelioma 139 | 3,163
Cancer 138 | 2,346
non-small cell lung cancer 137 | 2,798
invasive ductal carcinoma 130 | 2,950
ependymoma 129 | 2,514
astrocytic glioma 127 | 2,241
lung adenocarcinoma 122 | 2,714
oligodendroglioma 122 | 2,849
intraductal papillary-mucinous adenoma (IPMA) 116 | 2,956
pediatric high grade glioma 116 | 2,712
primitive neuroectodermal tumor 113 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 112 | 2,988
ulcerative colitis 112 | 2,087
diabetes mellitus 107 | 1,663
pilocytic astrocytoma 102 | 3,086
Pick disease 101 | 1,893
lung carcinoma 100 | 2,844
group 3 medulloblastoma 98 | 2,254
pancreatic cancer 93 | 2,300
adult high grade glioma 87 | 2,148
group 4 medulloblastoma 85 | 1,875
breast carcinoma 81 | 1,614
interstitial cystitis 81 | 2,299
subependymal giant cell astrocytoma 81 | 2,287
non primary Sjogren syndrome sicca 79 | 840
tuberculosis 78 | 1,563
medulloblastoma 74 | 1,524
Obesity 73 | 616
ductal carcinoma in situ 73 | 1,745
Waldenstrons macroglobulinemia 72 | 765
Leigh disease 69 | 81
Neurodegenerative disease 69 | 383
astrocytoma 67 | 1,493
adrenocortical carcinoma 66 | 1,427
acute myeloid leukemia 64 | 785
colon cancer 63 | 1,475
Alzheimer's disease 62 | 644
pituitary cancer 62 | 1,972
sonic hedgehog group medulloblastoma 61 | 1,482
cystic fibrosis 59 | 1,670
posterior fossa group B ependymoma 57 | 1,530
Rheumatoid Arthritis 53 | 1,171
Diabetes mellitus type 2 52 | 69
Parkinson's disease 52 | 364
Treatment Refractory Type 2 Diabetes Mellitus 51 | 53
acute quadriplegic myopathy 51 | 1,157
dermatomyositis 50 | 967
posterior fossa group A ependymoma 48 | 1,511
aldosterone-producing adenoma 46 | 664
atypical teratoid/rhabdoid tumor 46 | 1,095
primary pancreatic ductal adenocarcinoma 45 | 1,271
Mammary Neoplasms 44 | 410
Neuropathy 41 | 210
tuberculosis and treatment for 6 months 41 | 686
Kidney disease 40 | 397
Toxic encephalopathy 40 | 131
Prostatic Neoplasms 39 | 471
Vascular disease 39 | 281
hereditary spastic paraplegia 39 | 313
Stomach Neoplasms 38 | 282
gastric carcinoma 38 | 832
nasopharyngeal carcinoma 38 | 1,056
juvenile dermatomyositis 37 | 1,189
active Crohn's disease 36 | 918
Mitochondrial complex I deficiency 34 | 37
pancreatic carcinoma 34 | 567
cutaneous lupus erythematosus 33 | 1,056
Heart disease 32 | 279
Lactic acidosis 32 | 43
Leigh syndrome 32 | 34
Atopic dermatitis 31 | 944
Schizophrenia 31 | 503
hepatocellular carcinoma 31 | 550
Anemia 30 | 252
Diabetes Mellitus, Experimental 30 | 106
Liver carcinoma 28 | 217
Osteoporosis 28 | 259
Polycystic Ovary Syndrome 28 | 335
Amyotrophic Lateral Sclerosis 27 | 432
Brain disease 27 | 84
Carcinoma 27 | 2,147
Epilepsy 27 | 346
Hyperglycemia 27 | 120
Mitochondrial Complex 1 Deficiency 27 | 28
nephrosclerosis 27 | 329
primary Sjogren syndrome 27 | 789
esophageal adenocarcinoma 26 | 737
fibroadenoma 26 | 557
spina bifida 26 | 1,064

Tissue

Blood and immune system 981 | 17,995
Female tissues 981 | 18,647
Nervous System 981 | 18,561
Digestive Tract 980 | 18,473
Urinary Tract 980 | 18,444
Cardiovascular System 978 | 17,958
Endocrine System 978 | 18,512
Liver and Pancreas 978 | 18,136
Male tissues 978 | 17,969
Respiratory system 971 | 17,484
Skin and soft tissues 971 | 18,115

Target Family

Enzyme 494 | 4,146
Non-IDG 369 | 11,969
Transporter 65 | 473
Kinase 39 | 634
Transcription Factor 8 | 1,400
Epigenetic 6 | 242
Nuclear Receptor 3 | 48
GPCR 2 | 408
Ion Channel 2 | 341

Compartment GO Term

Mitochondrial part 988 | 988
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,612 | 13,612
Intracellular part 13,475 | 13,475
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,353 | 10,353
Membrane 8,871 | 8,871
Organelle part 8,169 | 8,169
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,831 | 7,831
Nucleus 7,577 | 7,577
Membrane part 6,469 | 6,469
Cytosol 6,034 | 6,034
Plasma membrane 5,673 | 5,673
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,171 | 5,171
Cell periphery 5,146 | 5,146
Nucleoplasm 4,930 | 4,930
Extracellular region 4,607 | 4,607
Protein complex 4,439 | 4,439
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,874 | 3,874
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,592 | 2,592
Plasma membrane part 2,564 | 2,564
Cytoskeleton 2,046 | 2,046
Golgi apparatus 1,946 | 1,946
Endoplasmic reticulum 1,872 | 1,872
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Vesicles 1,625 | 1,625
Cytoskeletal part 1,568 | 1,568
Mitochondrion 1,530 | 1,530
Cell projection 1,425 | 1,425
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,234 | 1,234
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,092 | 1,092
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,084 | 1,084
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Mitochondria 1,003 | 1,003
Chromosome 999 | 999
Nucleoli 950 | 950
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 815 | 815
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 781 | 781
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 739 | 739
Plasma membrane protein comple... 721 | 721
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Microtubule organizing center 680 | 680
Centrosome 676 | 676
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 656 | 656
Extracellular matrix 633 | 633
Synapse 594 | 594
Lytic vacuole 571 | 571

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitochondrial coenzyme A transporter SLC25A42 SLC25A42 Tbio Transporter -0.38872 3.06 24
Solute carrier family 25 member 33 SLC25A33 Tbio Transporter -0.28165 1.49 35
ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 Tbio Transporter -0.85002 7.01 82
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial MCCC2 Tbio Enzyme -1.23140 15.5 156
Ubiquinol-cytochrome-c reductase complex assembly factor 2 UQCC2 Tbio Enzyme -1.50813 29.9 15
Mitochondrial uncoupling protein 3 UCP3 Tbio Non-IDG -2.72649 574.1 155
Glycerol-3-phosphate acyltransferase 1, mitochondrial GPAM Tchem Enzyme -1.86960 75.6 147
Thioredoxin, mitochondrial TXN2 Tbio Non-IDG -2.03892 119.3 242
Apoptosis-inducing factor 2 AIFM2 Tbio Non-IDG -1.15514 16.2 195
MICOS complex subunit MIC25 CHCHD6 Tbio Non-IDG -1.52785 31.8 140