Development Level

Tbio 655 | 11,178
Tdark 159 | 6,569
Tchem 126 | 1,885
Tclin 87 | 612

Collection

Kinase: IDG Consortium (Target... 3 | 125
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 114 | 979
embryonic lethality prior to o... 33 | 239
embryonic lethality prior to t... 31 | 278
preweaning lethality, incomple... 18 | 499
abnormal behavior 17 | 298
abnormal embryo size 14 | 220
decreased total body fat amoun... 14 | 207
decreased vertical activity 12 | 208
embryonic growth retardation 12 | 106
increased lean body mass 12 | 172
increased total body fat amoun... 12 | 134
decreased body weight 11 | 161
decreased bone mineral content 11 | 151
hyperactivity 11 | 148
cataract 10 | 92
decreased lean body mass 9 | 135
enlarged heart 9 | 210
increased mean corpuscular hem... 9 | 96
prenatal lethality prior to he... 9 | 87
abnormal bone structure 8 | 187
abnormal lens morphology 8 | 81
decreased circulating glucose ... 8 | 126
hypoactivity 7 | 132
abnormal heart morphology 6 | 162
decreased bone mineral density 6 | 126
decreased circulating LDL chol... 6 | 38
decreased circulating alkaline... 6 | 46
decreased circulating total pr... 6 | 49
decreased grip strength 6 | 116
decreased mean corpuscular vol... 6 | 79
increased circulating alkaline... 6 | 122
increased circulating choleste... 6 | 66
increased startle reflex 6 | 112
pallor 6 | 34
abnormal seminal vesicle morph... 5 | 114
abnormal sleep behavior 5 | 70
decreased body length 5 | 101
decreased circulating HDL chol... 5 | 68
decreased circulating choleste... 5 | 93
decreased fasted circulating g... 5 | 65
increased circulating HDL chol... 5 | 80
increased circulating phosphat... 5 | 26
increased circulating sodium l... 5 | 71
increased fasted circulating g... 5 | 76
increased heart weight 5 | 62
persistence of hyaloid vascula... 5 | 33
small testis 5 | 58
thrombocytopenia 5 | 56
abnormal coat-hair pigmentatio... 4 | 64
abnormal cranium morphology 4 | 36
abnormal gait 4 | 69
abnormal neural tube closure 4 | 46
abnormal skin morphology 4 | 50
abnormal testis morphology 4 | 43
decreased circulating creatini... 4 | 39
decreased circulating phosphat... 4 | 27
decreased circulating serum al... 4 | 82
decreased mean platelet volume 4 | 25
decreased red blood cell distr... 4 | 41
decreased startle reflex 4 | 75
decreased total retina thickne... 4 | 17
increased circulating bilirubi... 4 | 16
male infertility 4 | 123
small superior vagus ganglion 4 | 74
abnormal embryo turning 3 | 31
abnormal epididymis morphology 3 | 42
abnormal retina morphology 3 | 71
abnormal tooth morphology 3 | 24
decreased circulating aspartat... 3 | 34
decreased circulating chloride... 3 | 30
decreased circulating insulin ... 3 | 76
decreased erythrocyte cell num... 3 | 62
decreased heart weight 3 | 27
decreased hematocrit 3 | 46
decreased leukocyte cell numbe... 3 | 73
decreased lymphocyte cell numb... 3 | 83
decreased mean corpuscular hem... 3 | 50
enlarged epididymis 3 | 31
impaired righting response 3 | 26
improved glucose tolerance 3 | 79
increased bone mineral content 3 | 108
increased circulating calcium ... 3 | 34
increased circulating serum al... 3 | 22
increased circulating total pr... 3 | 28
increased hemoglobin content 3 | 45
increased mean corpuscular vol... 3 | 92
increased prepulse inhibition 3 | 32
increased red blood cell distr... 3 | 34
pale yolk sac 3 | 25
short tibia 3 | 97
abnormal heart left ventricle ... 2 | 16
abnormal lung morphology 2 | 26
abnormal skin coloration 2 | 25
abnormal spleen morphology 2 | 55
abnormal vertebrae morphology 2 | 18
decreased circulating calcium ... 2 | 36
decreased circulating iron lev... 2 | 32
decreased circulating potassiu... 2 | 20
impaired glucose tolerance 2 | 75
increased monocyte cell number 2 | 63

Disease

ovarian cancer 558 | 8,297
Carcinoma 473 | 11,192
osteosarcoma 434 | 7,766
lung cancer 322 | 4,607
psoriasis 316 | 6,514
medulloblastoma, large-cell 308 | 6,086
glioblastoma 265 | 5,635
pancreatic ductal adenocarcinoma liver metastasis 235 | 1,911
atypical teratoid / rhabdoid tumor 232 | 4,971
ependymoma 207 | 4,559
Autosomal recessive predisposition 190 | 1,407
group 3 medulloblastoma 179 | 4,002
intraductal papillary-mucinous neoplasm (IPMN) 175 | 3,204
Multiple myeloma 172 | 1,296
Breast cancer 167 | 3,469
adult high grade glioma 167 | 3,701
malignant mesothelioma 154 | 3,135
Cancer 149 | 2,388
non-small cell lung cancer 148 | 2,799
astrocytic glioma 142 | 2,530
invasive ductal carcinoma 140 | 2,867
lung adenocarcinoma 130 | 2,627
intraductal papillary-mucinous adenoma (IPMA) 122 | 2,872
intraductal papillary-mucinous carcinoma (IPMC) 122 | 2,902
oligodendroglioma 120 | 2,768
diabetes mellitus 119 | 1,683
Epilepsy 116 | 775
primitive neuroectodermal tumor 116 | 2,957
Muscle hypotonia 112 | 562
Cognitive delay 106 | 596
Global developmental delay 106 | 596
Mental and motor retardation 106 | 596
lung carcinoma 106 | 2,755
Astrocytoma, Pilocytic 105 | 3,006
tuberculosis 104 | 1,963
ulcerative colitis 102 | 1,765
Seizures 101 | 584
Pick disease 100 | 1,856
pancreatic cancer 100 | 2,322
group 4 medulloblastoma 93 | 1,806
breast carcinoma 89 | 1,589
Schizophrenia 88 | 1,136
Leigh disease 86 | 100
subependymal giant cell astrocytoma 86 | 2,230
Intellectual disability 85 | 998
Cerebellar Ataxia 83 | 302
interstitial cystitis 83 | 2,237
Acidosis, Lactic 81 | 97
non primary Sjogren syndrome sicca 81 | 861
Lactic acidemia 80 | 95
Obesity 80 | 655
ductal carcinoma in situ 79 | 1,686
Waldenstrons macroglobulinemia 74 | 742
Dull intelligence 73 | 634
Low intelligence 73 | 634
Mental Retardation 73 | 634
Mental deficiency 73 | 634
Poor school performance 73 | 634
Failure to gain weight 72 | 359
Pediatric failure to thrive 72 | 359
Neurodegenerative disease 70 | 402
acute myeloid leukemia 69 | 760
colon cancer 69 | 1,428
Alzheimer's disease 68 | 640
adrenocortical carcinoma 68 | 1,385
cystic fibrosis 67 | 1,629
pituitary cancer 67 | 1,915
Optic Atrophy 63 | 239
Hypoglycemia 61 | 146
Liver Cirrhosis, Experimental 61 | 733
Dystonia 59 | 163
astrocytoma 58 | 1,113
Kidney cancer 56 | 2,548
Rheumatoid arthritis 55 | 1,156
Blepharoptosis 54 | 229
Parkinson's disease 54 | 378
acute quadriplegic myopathy 54 | 1,133
dermatomyositis 54 | 941
Neuropathy 53 | 254
Diabetes mellitus type 2 52 | 69
Nystagmus 52 | 309
Sensorineural Hearing Loss (disorder) 51 | 281
Treatment Refractory Type 2 Diabetes Mellitus 51 | 53
Anemia 50 | 353
Increased serum lactate 50 | 60
Toxic encephalopathy 50 | 139
aldosterone-producing adenoma 50 | 646
Hyperreflexia 48 | 208
Infantile onset 48 | 236
Vomiting 48 | 116
Bipolar Disorder 47 | 646
Breast Neoplasms 47 | 423
Mammary Neoplasms 47 | 403
pediatric high grade glioma 47 | 1,035
Dystonic disease 45 | 105
Hypertrophic Cardiomyopathy 45 | 115
Muscle Weakness 45 | 168
Stomach Neoplasms 45 | 287
Phenotypic variability 44 | 147
juvenile dermatomyositis 44 | 1,147

Tissue

Endocrine System 1,014 | 18,159
Digestive Tract 1,006 | 17,369
Skin and soft tissues 1,001 | 17,230
Female tissues 1,000 | 17,400
Blood and immune system 997 | 16,909
Liver and Pancreas 997 | 16,750
Male tissues 997 | 17,142
Urinary Tract 996 | 16,678
Nervous System 995 | 16,725
Respiratory system 981 | 16,393
Cardiovascular System 975 | 15,192

Target Family

Enzyme 507 | 4,145
Non-IDG 393 | 12,091
Transporter 65 | 473
Kinase 41 | 634
Transcription Factor 7 | 1,400
Epigenetic 6 | 242
GPCR 3 | 408
Nuclear Receptor 3 | 48
Ion Channel 2 | 344

Compartment GO Term

Mitochondrial part 1,027 | 1,027
cellular_component 17,863 | 17,863
Cell 15,779 | 15,779
Cell part 15,778 | 15,778
Intracellular 13,764 | 13,764
Intracellular part 13,630 | 13,630
Organelle 11,921 | 11,921
Intracellular organelle 11,712 | 11,712
membrane-bounded organelle 10,823 | 10,823
Cytoplasm 10,720 | 10,720
Intracellular membrane-bounded... 10,057 | 10,057
Cytoplasmic part 9,029 | 9,029
Organelle part 8,755 | 8,755
Intracellular organelle part 8,566 | 8,566
Membrane 8,335 | 8,335
Nucleus 7,336 | 7,336
Cytosol 6,551 | 6,551
Membrane part 6,403 | 6,403
Plasma membrane 5,682 | 5,682
Macromolecular complex 5,345 | 5,345
Intrinsic component of membran... 5,320 | 5,320
Cell periphery 5,248 | 5,248
Integral component of membrane 5,197 | 5,197
Nucleoplasm 4,931 | 4,931
Intracellular organelle lumen 4,923 | 4,923
Organelle lumen 4,923 | 4,923
membrane-enclosed lumen 4,923 | 4,923
Nuclear part 4,169 | 4,169
Endomembrane system 4,108 | 4,108
Intracellular non-membrane-bou... 3,917 | 3,917
non-membrane-bounded organelle 3,917 | 3,917
Nuclear lumen 3,851 | 3,851
Protein complex 3,565 | 3,565
Organelle membrane 2,798 | 2,798
Extracellular region 2,600 | 2,600
Plasma membrane part 2,531 | 2,531
Vesicle 2,280 | 2,280
Cytoplasmic vesicle 2,158 | 2,158
Intracellular vesicle 2,157 | 2,157
Cytoskeleton 2,084 | 2,084
Bounding membrane of organelle 1,924 | 1,924
Endoplasmic reticulum 1,922 | 1,922
Golgi apparatus 1,884 | 1,884
Intrinsic component of plasma ... 1,701 | 1,701
Integral component of plasma m... 1,647 | 1,647
Cytoskeletal part 1,613 | 1,613
Catalytic complex 1,592 | 1,592
Vesicles 1,566 | 1,566
Mitochondrion 1,557 | 1,557
Extracellular region part 1,533 | 1,533
Cell projection 1,524 | 1,524
Whole membrane 1,521 | 1,521
Cytoplasmic vesicle part 1,468 | 1,468
Endoplasmic reticulum part 1,315 | 1,315
GO:0031975 1,139 | 1,139
Organelle envelope 1,131 | 1,131
Microtubule cytoskeleton 1,127 | 1,127
Nucleoplasm part 1,100 | 1,100
Nuclear outer membrane-endopla... 1,094 | 1,094
Endoplasmic reticulum membrane 1,076 | 1,076
Extracellular space 1,059 | 1,059
Chromosome 1,020 | 1,020
Mitochondria 985 | 985
Neuron part 958 | 958
Supramolecular polymer 950 | 950
Cell junction 949 | 949
Supramolecular complex 949 | 949
Supramolecular fiber 942 | 942
Secretory vesicle 930 | 930
Golgi apparatus part 923 | 923
Nucleoli 923 | 923
Nucleolus 916 | 916
Endosome 915 | 915
Chromosomal part 872 | 872
GO:0098796 868 | 868
Ribonucleoprotein complex 845 | 845
Cell projection part 838 | 838
Transferase complex 837 | 837
Intracellular ribonucleoprotei... 830 | 830
Plasma membrane region 826 | 826
Secretory granule 810 | 810
Cell surface 805 | 805
Vesicle membrane 786 | 786
Cytoplasmic vesicle membrane 780 | 780
Polymeric cytoskeletal fiber 753 | 753
Mitochondrial envelope 739 | 739
Golgi membrane 715 | 715
Microtubule organizing center 712 | 712
Nuclear body 708 | 708
Vacuole 708 | 708
Neuron projection 701 | 701
Mitochondrial membrane 689 | 689
Centrosome 685 | 685
Extracellular matrix 670 | 670
Receptor complex 670 | 670
Synapse 656 | 656
Lysosome 600 | 600
Lytic vacuole 600 | 600
Endosomal part 554 | 554
Chromatin 552 | 552

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Hydroxyacylglutathione hydrolase, mitochondrial HAGH Tbio Enzyme -1.95974 82.6 162
Putative cytochrome b-c1 complex subunit Rieske-like protein 1 UQCRFS1P1 Tdark Non-IDG -2.12377 231.9 0
Cytosolic phospholipase A2 beta JMJD7-PLA2G4B Tchem Enzyme -0.60640 3.75 104
2-5A-dependent ribonuclease RNASEL Tchem Kinase -2.71673 525.8 127
Bcl-2 homologous antagonist/killer BAK1 Tchem Non-IDG -2.29199 175.9 554
Dynamin-like 120 kDa protein, mitochondrial OPA1 Tbio Non-IDG -2.51554 307.1 210
39S ribosomal protein L27, mitochondrial MRPL27 Tdark Non-IDG 0.60 0.05 48
Acyl-coenzyme A synthetase ACSM4, mitochondrial ACSM4 Tdark Enzyme 0.00000 1.21 51
Putative transferase CAF17, mitochondrial IBA57 Tbio Enzyme -0.95798 9.91 43
Heat shock 70 kDa protein 4 HSPA4 Tbio Non-IDG -3.92672 8635.1 432