Development Level

Tbio 609 | 10,625
Tdark 175 | 7,003
Tchem 120 | 1,890
Tclin 85 | 602

Collection

Eligible Kinase Proteins 6 | 134

IMPC Term

preweaning lethality, complete... 64 | 633
embryonic lethality prior to o... 27 | 148
embryonic lethality prior to t... 22 | 187
abnormal behavior 13 | 226
decreased body weight 13 | 174
decreased lean body mass 10 | 195
decreased total body fat amoun... 10 | 186
abnormal embryo size 9 | 112
preweaning lethality, incomple... 9 | 260
abnormal lens morphology 8 | 73
decreased bone mineral content 8 | 157
decreased circulating glucose ... 8 | 121
prenatal lethality prior to he... 8 | 64
abnormal retina morphology 7 | 100
decreased circulating choleste... 7 | 85
embryonic growth retardation 7 | 28
hypoactivity 7 | 89
increased mean corpuscular hem... 7 | 93
abnormal bone structure 6 | 131
decreased body length 6 | 108
decreased grip strength 6 | 123
increased circulating choleste... 6 | 53
increased circulating phosphat... 6 | 24
increased circulating sodium l... 6 | 71
increased fasted circulating g... 6 | 68
increased grip strength 6 | 83
increased lean body mass 6 | 107
increased mean corpuscular vol... 6 | 91
decreased circulating HDL chol... 5 | 77
decreased circulating triglyce... 5 | 83
decreased leukocyte cell numbe... 5 | 54
decreased total retina thickne... 5 | 20
hyperactivity 5 | 108
increased circulating HDL chol... 5 | 63
increased circulating alkaline... 5 | 119
increased heart weight 5 | 37
increased or absent threshold ... 5 | 128
increased startle reflex 5 | 38
abnormal gait 4 | 51
abnormal testis morphology 4 | 30
abnormal tooth morphology 4 | 24
decreased bone mineral density 4 | 126
decreased circulating LDL chol... 4 | 37
decreased circulating alkaline... 4 | 41
decreased circulating creatini... 4 | 31
decreased circulating insulin ... 4 | 75
decreased circulating serum al... 4 | 79
decreased circulating total pr... 4 | 41
decreased heart weight 4 | 44
decreased rib number 4 | 59
enlarged heart 4 | 111
small testis 4 | 37
thrombocytopenia 4 | 46
abnormal bone mineralization 3 | 55
abnormal cranium morphology 3 | 32
abnormal epididymis morphology 3 | 31
abnormal neural tube closure 3 | 37
abnormal retinal pigmentation 3 | 61
abnormal skin morphology 3 | 23
decreased T cell number 3 | 31
decreased blood urea nitrogen ... 3 | 31
decreased fasted circulating g... 3 | 49
decreased lumbar vertebrae num... 3 | 62
decreased mean corpuscular vol... 3 | 50
decreased mean platelet volume 3 | 12
decreased red blood cell distr... 3 | 11
decreased startle reflex 3 | 48
enlarged epididymis 3 | 27
female infertility 3 | 34
increased blood urea nitrogen ... 3 | 44
increased circulating aspartat... 3 | 17
increased circulating bilirubi... 3 | 16
increased exploration in new e... 3 | 56
increased total body fat amoun... 3 | 57
male infertility 3 | 62
pallor 3 | 13
persistence of hyaloid vascula... 3 | 22
short tibia 3 | 82
abnormal behavioral response t... 2 | 52
abnormal coat appearance 2 | 25
abnormal embryo turning 2 | 15
abnormal heart left ventricle ... 2 | 20
abnormal heart morphology 2 | 51
abnormal kidney morphology 2 | 30
abnormal locomotor activation 2 | 26
abnormal vertebrae morphology 2 | 14
abnormal vocalization 2 | 21
decreased caudal vertebrae num... 2 | 49
decreased circulating iron lev... 2 | 25
decreased circulating potassiu... 2 | 17
decreased effector memory CD8-... 2 | 24
decreased mean corpuscular hem... 2 | 34
decreased vertical activity 2 | 22
increased bone mineral content 2 | 92
increased circulating calcium ... 2 | 32
increased circulating chloride... 2 | 43
increased circulating iron lev... 2 | 25
increased circulating total pr... 2 | 20
increased erythrocyte cell num... 2 | 26
increased sacral vertebrae num... 2 | 62

Disease

ovarian cancer 535 | 8,484
osteosarcoma 423 | 7,933
psoriasis 311 | 6,685
lung cancer 301 | 4,466
medulloblastoma, large-cell 299 | 6,234
glioblastoma 252 | 5,572
pancreatic ductal adenocarcinoma liver metastasis 218 | 1,795
atypical teratoid / rhabdoid tumor 191 | 4,369
Multiple myeloma 166 | 1,327
intraductal papillary-mucinous neoplasm (IPMN) 165 | 3,289
Breast cancer 150 | 3,094
Cancer 139 | 2,346
malignant mesothelioma 139 | 3,162
non-small cell lung cancer 137 | 2,798
invasive ductal carcinoma 131 | 2,950
ependymoma 129 | 2,514
astrocytic glioma 127 | 2,241
lung adenocarcinoma 122 | 2,713
oligodendroglioma 122 | 2,849
intraductal papillary-mucinous adenoma (IPMA) 117 | 2,956
pediatric high grade glioma 117 | 2,712
primitive neuroectodermal tumor 114 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 113 | 2,988
ulcerative colitis 113 | 2,087
diabetes mellitus 107 | 1,663
pilocytic astrocytoma 103 | 3,086
Pick disease 101 | 1,893
lung carcinoma 101 | 2,844
group 3 medulloblastoma 98 | 2,254
pancreatic cancer 94 | 2,300
adult high grade glioma 87 | 2,148
group 4 medulloblastoma 85 | 1,875
subependymal giant cell astrocytoma 82 | 2,287
breast carcinoma 81 | 1,614
interstitial cystitis 81 | 2,299
non primary Sjogren syndrome sicca 80 | 840
tuberculosis 78 | 1,557
medulloblastoma 74 | 1,524
Obesity 73 | 616
ductal carcinoma in situ 73 | 1,745
Waldenstrons macroglobulinemia 72 | 765
Leigh disease 69 | 81
Neurodegenerative disease 69 | 383
astrocytoma 68 | 1,493
adrenocortical carcinoma 66 | 1,427
acute myeloid leukemia 64 | 780
colon cancer 63 | 1,475
pituitary cancer 63 | 1,972
Alzheimer's disease 62 | 644
sonic hedgehog group medulloblastoma 62 | 1,482
cystic fibrosis 59 | 1,665
posterior fossa group B ependymoma 57 | 1,530
Parkinson's disease 53 | 364
Rheumatoid Arthritis 53 | 1,160
Diabetes mellitus type 2 52 | 69
acute quadriplegic myopathy 52 | 1,157
Treatment Refractory Type 2 Diabetes Mellitus 51 | 53
dermatomyositis 50 | 933
posterior fossa group A ependymoma 49 | 1,511
aldosterone-producing adenoma 46 | 664
atypical teratoid/rhabdoid tumor 46 | 1,095
primary pancreatic ductal adenocarcinoma 46 | 1,271
Mammary Neoplasms 45 | 410
Neuropathy 41 | 210
tuberculosis and treatment for 6 months 41 | 686
Kidney disease 40 | 396
Prostatic Neoplasms 40 | 471
Toxic encephalopathy 40 | 131
Vascular disease 39 | 281
gastric carcinoma 39 | 832
hereditary spastic paraplegia 39 | 313
Stomach Neoplasms 38 | 282
juvenile dermatomyositis 38 | 1,189
nasopharyngeal carcinoma 38 | 1,056
active Crohn's disease 36 | 918
MITOCHONDRIAL COMPLEX I DEFICIENCY 34 | 37
pancreatic carcinoma 34 | 567
cutaneous lupus erythematosus 33 | 1,056
Heart disease 32 | 279
Atopic dermatitis 31 | 944
Lactic acidosis 31 | 42
Schizophrenia 31 | 501
Anemia 30 | 252
Diabetes Mellitus, Experimental 30 | 106
hepatocellular carcinoma 29 | 532
Liver carcinoma 28 | 217
Osteoporosis 28 | 257
Polycystic Ovary Syndrome 28 | 332
Amyotrophic Lateral Sclerosis 27 | 431
Carcinoma 27 | 2,147
Epilepsy 27 | 346
Hyperglycemia 27 | 120
fibroadenoma 27 | 557
nephrosclerosis 27 | 329
primary Sjogren syndrome 27 | 789
Down syndrome 26 | 548
IGA Glomerulonephritis 26 | 454
esophageal adenocarcinoma 26 | 737
progressive supranuclear palsy 26 | 674
spina bifida 26 | 1,064

Tissue

Blood and immune system 982 | 17,995
Female tissues 982 | 18,647
Nervous System 982 | 18,561
Digestive Tract 981 | 18,473
Urinary Tract 981 | 18,444
Cardiovascular System 979 | 17,958
Endocrine System 979 | 18,512
Liver and Pancreas 979 | 18,136
Male tissues 979 | 17,969
Respiratory system 972 | 17,484
Skin and soft tissues 972 | 18,115

Target Family

Enzyme 494 | 4,146
Non-IDG 370 | 11,971
Transporter 65 | 473
Kinase 39 | 634
Transcription Factor 8 | 1,400
Epigenetic 6 | 242
Nuclear Receptor 3 | 48
GPCR 2 | 406
Ion Channel 2 | 341

Compartment GO Term

Mitochondrial part 989 | 989
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,170 | 8,170
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,830 | 7,830
Nucleus 6,897 | 6,897
Membrane part 6,469 | 6,469
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,172 | 5,172
Cell periphery 5,145 | 5,145
Plasma membrane 5,059 | 5,059
Extracellular region 4,606 | 4,606
Protein complex 4,438 | 4,438
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Cytosol 3,352 | 3,352
Nucleoplasm 2,938 | 2,938
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,563 | 2,563
Cytoskeleton 2,045 | 2,045
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Endoplasmic reticulum 1,663 | 1,663
Cytoskeletal part 1,567 | 1,567
Mitochondrion 1,530 | 1,530
Cell projection 1,426 | 1,426
Golgi apparatus 1,402 | 1,402
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,233 | 1,233
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Chromosome 999 | 999
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 780 | 780
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 738 | 738
Plasma membrane protein comple... 720 | 720
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Microtubule organizing center 617 | 617
Synapse 594 | 594
Lysosome 571 | 571
Lytic vacuole 571 | 571
Vesicle membrane 559 | 559
cell-cell junction 557 | 557
Cytoplasmic vesicle membrane 552 | 552

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitochondrial 2-oxodicarboxylate carrier SLC25A21 Tbio Transporter -0.46900 2.68 102
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
ATP synthase F(0) complex subunit C3, mitochondrial ATP5G3 Tdark Enzyme -1.10871 11.9 27
ADP/ATP translocase 3 SLC25A6 Tbio Transporter -2.06581 118.3 193
ADP/ATP translocase 1 SLC25A4 Tbio Transporter -2.05462 110.8 89
Glial cell line-derived neurotrophic factor GDNF Tbio Non-IDG -3.30206 2301.5 303
Cardiac phospholamban PLN Tbio Non-IDG -1.89899 84.7 326
V(D)J recombination-activating protein 1 RAG1 Tbio Non-IDG -3.00063 1061.1 65
NADH-ubiquinone oxidoreductase chain 6 MT-ND6 Tclin Enzyme -2.74395 585.6 62
ATP synthase protein 8 MT-ATP8 Tbio Enzyme -2.30895 191.4 20