Development Level

Tbio 128 | 11,178
Tchem 34 | 1,885
Tdark 12 | 6,569
Tclin 9 | 612

IMPC Phenotype

preweaning lethality, complete... 11 | 979
abnormal behavior 7 | 298
hyperactivity 7 | 148
decreased body weight 6 | 161
decreased vertical activity 6 | 208
decreased bone mineral content 5 | 151
hypoactivity 5 | 132
abnormal bone structure 4 | 187
decreased lean body mass 4 | 135
decreased total body fat amoun... 4 | 207
increased lean body mass 4 | 172
increased mean corpuscular hem... 4 | 96
preweaning lethality, incomple... 4 | 499
abnormal lens morphology 3 | 81
cataract 3 | 92
decreased body length 3 | 101
decreased bone mineral density 3 | 126
decreased circulating HDL chol... 3 | 68
decreased circulating LDL chol... 3 | 38
decreased circulating choleste... 3 | 93
decreased circulating glucose ... 3 | 126
decreased circulating serum al... 3 | 82
decreased circulating total pr... 3 | 49
decreased mean corpuscular vol... 3 | 79
decreased startle reflex 3 | 75
enlarged heart 3 | 210
increased circulating bilirubi... 3 | 16
abnormal cranium morphology 2 | 36
abnormal epididymis morphology 2 | 42
abnormal skin morphology 2 | 50
abnormal sleep behavior 2 | 70
abnormal tibia morphology 2 | 14
decreased circulating aspartat... 2 | 34
decreased grip strength 2 | 116
decreased heart weight 2 | 27
embryonic lethality prior to t... 2 | 278
enlarged epididymis 2 | 31
increased heart rate 2 | 23
increased heart weight 2 | 62
increased hemoglobin content 2 | 45
increased mean corpuscular hem... 2 | 36
increased or absent threshold ... 2 | 101
increased startle reflex 2 | 112
increased total body fat amoun... 2 | 134
short tibia 2 | 97
small superior vagus ganglion 2 | 74
thrombocytopenia 2 | 56
abnormal coat appearance 1 | 31
abnormal coat- hair morphology 1 | 19
abnormal femur morphology 1 | 14
abnormal gait 1 | 69
abnormal joint morphology 1 | 23
abnormal pelvic girdle bone mo... 1 | 12
abnormal rib morphology 1 | 10
abnormal seminal vesicle morph... 1 | 114
abnormal snout morphology 1 | 23
abnormal thymus morphology 1 | 7
abnormal tooth morphology 1 | 24
abnormal vertebrae morphology 1 | 18
abnormal vibrissa morphology 1 | 25
abnormal vitreous body morphol... 1 | 10
absent startle reflex 1 | 24
brachydactyly 1 | 19
corneal opacity 1 | 32
decreased blood urea nitrogen ... 1 | 51
decreased circulating calcium ... 1 | 36
decreased circulating iron lev... 1 | 32
decreased circulating magnesiu... 1 | 13
decreased circulating phosphat... 1 | 27
decreased circulating potassiu... 1 | 20
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased mean platelet volume 1 | 25
decreased prepulse inhibition 1 | 82
decreased total retina thickne... 1 | 17
edema 1 | 59
embryonic lethality prior to o... 1 | 239
female infertility 1 | 60
hydrometra 1 | 53
increased anti-nuclear antigen... 1 | 19
increased bone mineral content 1 | 108
increased circulating alkaline... 1 | 122
increased circulating glycerol... 1 | 9
increased circulating lipase l... 1 | 3
increased circulating phosphat... 1 | 26
increased circulating serum al... 1 | 22
increased circulating sodium l... 1 | 71
increased mean corpuscular vol... 1 | 92
increased red blood cell distr... 1 | 34
mammalian phenotype 1 | 17
persistence of hyaloid vascula... 1 | 33
prenatal lethality prior to he... 1 | 87
shortened RR interval 1 | 17
small adrenal glands 1 | 16
small kidney 1 | 16
small spleen 1 | 19
small thymus 1 | 16
syndactyly 1 | 23

Disease

ovarian cancer 101 | 8,297
Carcinoma 98 | 11,192
osteosarcoma 81 | 7,766
lung cancer 75 | 4,607
medulloblastoma, large-cell 74 | 6,086
glioblastoma 64 | 5,635
psoriasis 64 | 6,514
atypical teratoid / rhabdoid tumor 60 | 4,971
ependymoma 51 | 4,559
malignant mesothelioma 45 | 3,135
Cancer 42 | 2,388
invasive ductal carcinoma 41 | 2,867
adult high grade glioma 40 | 3,701
group 3 medulloblastoma 35 | 4,002
astrocytic glioma 34 | 2,530
non-small cell lung cancer 34 | 2,799
Astrocytoma, Pilocytic 33 | 3,006
intraductal papillary-mucinous neoplasm (IPMN) 33 | 3,204
Breast cancer 32 | 3,469
oligodendroglioma 32 | 2,768
tuberculosis 30 | 1,963
lung adenocarcinoma 29 | 2,627
pancreatic cancer 29 | 2,322
pancreatic ductal adenocarcinoma liver metastasis 29 | 1,911
Pick disease 28 | 1,856
ductal carcinoma in situ 27 | 1,686
intraductal papillary-mucinous carcinoma (IPMC) 27 | 2,902
lung carcinoma 26 | 2,755
Multiple myeloma 25 | 1,296
intraductal papillary-mucinous adenoma (IPMA) 25 | 2,872
primitive neuroectodermal tumor 25 | 2,957
ulcerative colitis 24 | 1,765
Alzheimer's disease 22 | 640
diabetes mellitus 22 | 1,683
group 4 medulloblastoma 22 | 1,806
pituitary cancer 22 | 1,915
breast carcinoma 20 | 1,589
colon cancer 20 | 1,428
dermatomyositis 20 | 941
Autosomal recessive predisposition 19 | 1,407
interstitial cystitis 19 | 2,237
Neurodegenerative disease 18 | 402
Schizophrenia 18 | 1,136
Kidney cancer 17 | 2,548
Obesity 17 | 655
Rheumatoid arthritis 16 | 1,156
subependymal giant cell astrocytoma 16 | 2,230
Parkinson's disease 14 | 378
cystic fibrosis 14 | 1,629
juvenile dermatomyositis 14 | 1,147
Waldenstrons macroglobulinemia 13 | 742
active Crohn's disease 13 | 882
acute quadriplegic myopathy 13 | 1,133
aldosterone-producing adenoma 13 | 646
medulloblastoma 13 | 702
pediatric high grade glioma 13 | 1,035
Toxic encephalopathy 12 | 139
acute myeloid leukemia 12 | 760
astrocytoma 12 | 1,113
Multiple Sclerosis 11 | 527
Optic Atrophy 11 | 239
cutaneous lupus erythematosus 11 | 1,016
esophageal adenocarcinoma 11 | 696
primary Sjogren syndrome 11 | 710
primary pancreatic ductal adenocarcinoma 11 | 1,071
progressive supranuclear palsy 11 | 656
Bipolar Disorder 10 | 646
Breast Neoplasms 10 | 423
Liver Cirrhosis, Experimental 10 | 733
Mammary Neoplasms 10 | 403
Muscle hypotonia 10 | 562
adrenocortical carcinoma 10 | 1,385
hereditary spastic paraplegia 10 | 313
Atopic dermatitis 9 | 915
Intellectual disability 9 | 998
Polycystic ovary syndrome 9 | 348
Vascular disease 9 | 294
active ulcerative colitis 9 | 736
nasopharyngeal carcinoma 9 | 1,024
non primary Sjogren syndrome sicca 9 | 861
Chronic Lymphocytic Leukemia 8 | 254
Diabetes Mellitus, Experimental 8 | 101
Endometriosis 8 | 521
Epilepsy 8 | 775
Melanoma 8 | 689
Neuropathy 8 | 254
gastric cancer 8 | 445
gastric carcinoma 8 | 781
Cerebrovascular disease 7 | 223
Diabetes Mellitus, Type 2 7 | 136
Dull intelligence 7 | 634
Liver carcinoma 7 | 229
Low intelligence 7 | 634
Major Depressive Disorder 7 | 293
Mental Retardation 7 | 634
Mental deficiency 7 | 634
Poor school performance 7 | 634
Seizures 7 | 584
Unipolar Depression 7 | 244
spina bifida 7 | 1,053

Tissue

Endocrine System 180 | 18,159
Blood and immune system 178 | 16,909
Female tissues 178 | 17,400
Male tissues 178 | 17,142
Digestive Tract 177 | 17,369
Skin and soft tissues 177 | 17,230
Liver and Pancreas 176 | 16,750
Nervous System 176 | 16,725
Respiratory system 176 | 16,393
Urinary Tract 176 | 16,678
Cardiovascular System 174 | 15,192

Target Family

Non-IDG 110 | 12,091
Enzyme 48 | 4,145
Kinase 14 | 634
Transporter 6 | 473
Epigenetic 2 | 242
GPCR 1 | 408
Nuclear Receptor 1 | 48
Transcription Factor 1 | 1,400

Compartment GO Term

Mitochondrial outer membrane 183 | 183
cellular_component 17,863 | 17,863
Cell 15,779 | 15,779
Cell part 15,778 | 15,778
Intracellular 13,764 | 13,764
Intracellular part 13,630 | 13,630
Organelle 11,921 | 11,921
Intracellular organelle 11,712 | 11,712
membrane-bounded organelle 10,823 | 10,823
Cytoplasm 10,720 | 10,720
Intracellular membrane-bounded... 10,057 | 10,057
Cytoplasmic part 9,029 | 9,029
Organelle part 8,755 | 8,755
Intracellular organelle part 8,566 | 8,566
Membrane 8,335 | 8,335
Nucleus 7,336 | 7,336
Cytosol 6,551 | 6,551
Membrane part 6,403 | 6,403
Plasma membrane 5,682 | 5,682
Macromolecular complex 5,345 | 5,345
Intrinsic component of membran... 5,320 | 5,320
Cell periphery 5,248 | 5,248
Integral component of membrane 5,197 | 5,197
Nucleoplasm 4,931 | 4,931
Intracellular organelle lumen 4,923 | 4,923
Organelle lumen 4,923 | 4,923
membrane-enclosed lumen 4,923 | 4,923
Nuclear part 4,169 | 4,169
Endomembrane system 4,108 | 4,108
Intracellular non-membrane-bou... 3,917 | 3,917
non-membrane-bounded organelle 3,917 | 3,917
Nuclear lumen 3,851 | 3,851
Protein complex 3,565 | 3,565
Organelle membrane 2,798 | 2,798
Extracellular region 2,600 | 2,600
Plasma membrane part 2,531 | 2,531
Vesicle 2,280 | 2,280
Cytoplasmic vesicle 2,158 | 2,158
Intracellular vesicle 2,157 | 2,157
Cytoskeleton 2,084 | 2,084
Bounding membrane of organelle 1,924 | 1,924
Endoplasmic reticulum 1,922 | 1,922
Golgi apparatus 1,884 | 1,884
Intrinsic component of plasma ... 1,701 | 1,701
Integral component of plasma m... 1,647 | 1,647
Cytoskeletal part 1,613 | 1,613
Catalytic complex 1,592 | 1,592
Vesicles 1,566 | 1,566
Mitochondrion 1,557 | 1,557
Extracellular region part 1,533 | 1,533
Cell projection 1,524 | 1,524
Whole membrane 1,521 | 1,521
Cytoplasmic vesicle part 1,468 | 1,468
Endoplasmic reticulum part 1,315 | 1,315
GO:0031975 1,139 | 1,139
Organelle envelope 1,131 | 1,131
Microtubule cytoskeleton 1,127 | 1,127
Nucleoplasm part 1,100 | 1,100
Nuclear outer membrane-endopla... 1,094 | 1,094
Endoplasmic reticulum membrane 1,076 | 1,076
Extracellular space 1,059 | 1,059
Mitochondrial part 1,027 | 1,027
Chromosome 1,020 | 1,020
Mitochondria 985 | 985
Neuron part 958 | 958
Supramolecular polymer 950 | 950
Cell junction 949 | 949
Supramolecular complex 949 | 949
Supramolecular fiber 942 | 942
Secretory vesicle 930 | 930
Golgi apparatus part 923 | 923
Nucleoli 923 | 923
Nucleolus 916 | 916
Endosome 915 | 915
Chromosomal part 872 | 872
GO:0098796 868 | 868
Ribonucleoprotein complex 845 | 845
Cell projection part 838 | 838
Transferase complex 837 | 837
Intracellular ribonucleoprotei... 830 | 830
Plasma membrane region 826 | 826
Secretory granule 810 | 810
Cell surface 805 | 805
Vesicle membrane 786 | 786
Cytoplasmic vesicle membrane 780 | 780
Polymeric cytoskeletal fiber 753 | 753
Mitochondrial envelope 739 | 739
Golgi membrane 715 | 715
Microtubule organizing center 712 | 712
Nuclear body 708 | 708
Vacuole 708 | 708
Neuron projection 701 | 701
Mitochondrial membrane 689 | 689
Centrosome 685 | 685
Extracellular matrix 670 | 670
Receptor complex 670 | 670
Synapse 656 | 656
Lysosome 600 | 600
Lytic vacuole 600 | 600
Endosomal part 554 | 554
Chromatin 552 | 552

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Bcl-2 homologous antagonist/killer BAK1 Tchem Non-IDG -2.29199 175.9 554
Dynamin-like 120 kDa protein, mitochondrial OPA1 Tbio Non-IDG -2.51554 307.1 210
Mitochondria-eating protein SPATA18 Tbio Non-IDG -0.96526 11.0 92
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like BNIP3L Tbio Non-IDG -2.20837 153.7 355
ATP-dependent RNA helicase DDX3X DDX3X Tchem Enzyme -2.32036 221.7 479
Armadillo repeat-containing X-linked protein 1 ARMCX1 Tbio Non-IDG -0.95377 9.83 180
Serine/threonine-protein phosphatase PGAM5, mitochondrial PGAM5 Tbio Enzyme -1.40119 21.5 27
Protein Tob2 TOB2 Tbio Non-IDG -1.58444 34.4 108
Armadillo repeat-containing X-linked protein 2 ARMCX2 Tbio Non-IDG -0.68585 5.02 96
Tripartite motif-containing protein 14 TRIM14 Tbio Non-IDG -0.97373 8.40 93