Development Level

Tbio 113 | 10,625
Tchem 30 | 1,890
Tdark 14 | 7,003
Tclin 7 | 602

Collection

Eligible Kinase Proteins 1 | 134

IMPC Term

decreased body weight 6 | 174
decreased lean body mass 5 | 195
hypoactivity 5 | 89
decreased heart weight 4 | 44
decreased total body fat amoun... 4 | 186
abnormal behavior 3 | 226
decreased body length 3 | 108
decreased bone mineral content 3 | 157
decreased circulating HDL chol... 3 | 77
decreased circulating choleste... 3 | 85
decreased circulating glucose ... 3 | 121
increased heart weight 3 | 37
increased mean corpuscular hem... 3 | 93
increased or absent threshold ... 3 | 128
preweaning lethality, complete... 3 | 633
preweaning lethality, incomple... 3 | 260
abnormal bone structure 2 | 131
abnormal lens morphology 2 | 73
abnormal tibia morphology 2 | 14
decreased bone mineral density 2 | 126
decreased circulating LDL chol... 2 | 37
decreased circulating serum al... 2 | 79
decreased circulating triglyce... 2 | 83
decreased grip strength 2 | 123
decreased startle reflex 2 | 48
decreased total retina thickne... 2 | 20
immune system phenotype 2 | 17
increased circulating bilirubi... 2 | 16
increased fasted circulating g... 2 | 68
increased lean body mass 2 | 107
short tibia 2 | 82
thrombocytopenia 2 | 46
abnormal bone mineralization 1 | 55
abnormal clavicle morphology 1 | 5
abnormal coat appearance 1 | 25
abnormal coat/ hair morphology 1 | 18
abnormal cranium morphology 1 | 32
abnormal femur morphology 1 | 14
abnormal fibula morphology 1 | 2
abnormal glucose homeostasis 1 | 5
abnormal humerus morphology 1 | 11
abnormal joint morphology 1 | 14
abnormal locomotor activation 1 | 26
abnormal pelvic girdle bone mo... 1 | 11
abnormal radius morphology 1 | 8
abnormal retinal outer nuclear... 1 | 5
abnormal rib morphology 1 | 28
abnormal scapula morphology 1 | 3
abnormal ulna morphology 1 | 8
abnormal vertebrae morphology 1 | 14
absent mammary gland 1 | 1
absent vibrissae 1 | 14
aorta dilation 1 | 3
cataract 1 | 26
corneal opacity 1 | 25
decreased blood urea nitrogen ... 1 | 31
decreased circulating alkaline... 1 | 41
decreased circulating calcium ... 1 | 33
decreased circulating creatini... 1 | 31
decreased circulating iron lev... 1 | 25
decreased circulating magnesiu... 1 | 11
decreased circulating potassiu... 1 | 17
decreased circulating total pr... 1 | 41
decreased lumbar vertebrae num... 1 | 62
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular vol... 1 | 50
decreased mean platelet volume 1 | 12
decreased rib number 1 | 59
decreased skeletal muscle mass 1 | 1
decreased vertical activity 1 | 22
enlarged heart 1 | 111
female infertility 1 | 34
hydrometra 1 | 13
hyperactivity 1 | 108
increased bone mineral content 1 | 92
increased circulating LDL chol... 1 | 15
increased circulating alkaline... 1 | 119
increased circulating aspartat... 1 | 17
increased circulating creatini... 1 | 29
increased circulating lipase l... 1 | 1
increased circulating phosphat... 1 | 24
increased circulating serum al... 1 | 25
increased circulating sodium l... 1 | 71
increased erythrocyte cell num... 1 | 26
increased exploration in new e... 1 | 56
increased grip strength 1 | 83
increased mean corpuscular vol... 1 | 91
increased red blood cell distr... 1 | 21
increased respiratory quotient 1 | 12
increased sacral vertebrae num... 1 | 62
increased startle reflex 1 | 38
increased urine magnesium leve... 1 | 1
oligodactyly 1 | 14
persistence of hyaloid vascula... 1 | 22
small heart 1 | 8
small kidney 1 | 10
small ovary 1 | 1
small spleen 1 | 11
small uterus 1 | 1
thin skin 1 | 1

Disease

ovarian cancer 91 | 8,484
osteosarcoma 73 | 7,933
medulloblastoma, large-cell 69 | 6,234
lung cancer 63 | 4,466
glioblastoma 58 | 5,572
psoriasis 58 | 6,685
atypical teratoid / rhabdoid tumor 50 | 4,369
malignant mesothelioma 37 | 3,162
Cancer 36 | 2,346
invasive ductal carcinoma 36 | 2,950
pilocytic astrocytoma 30 | 3,086
non-small cell lung cancer 28 | 2,798
Pick disease 27 | 1,893
ependymoma 27 | 2,514
intraductal papillary-mucinous neoplasm (IPMN) 27 | 3,289
oligodendroglioma 27 | 2,849
astrocytic glioma 26 | 2,241
pediatric high grade glioma 26 | 2,712
ulcerative colitis 26 | 2,087
lung carcinoma 25 | 2,844
pancreatic cancer 25 | 2,300
pancreatic ductal adenocarcinoma liver metastasis 25 | 1,795
primitive neuroectodermal tumor 25 | 3,031
Breast cancer 24 | 3,094
Multiple myeloma 23 | 1,327
ductal carcinoma in situ 23 | 1,745
lung adenocarcinoma 23 | 2,713
adult high grade glioma 22 | 2,148
Alzheimer's disease 21 | 644
group 4 medulloblastoma 21 | 1,875
intraductal papillary-mucinous adenoma (IPMA) 21 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 21 | 2,988
diabetes mellitus 20 | 1,663
pituitary cancer 20 | 1,972
Neurodegenerative disease 18 | 383
interstitial cystitis 18 | 2,299
sonic hedgehog group medulloblastoma 18 | 1,482
tuberculosis 18 | 1,557
breast carcinoma 17 | 1,614
dermatomyositis 17 | 933
Obesity 16 | 616
colon cancer 16 | 1,475
medulloblastoma 16 | 1,524
group 3 medulloblastoma 15 | 2,254
astrocytoma 14 | 1,493
posterior fossa group A ependymoma 14 | 1,511
posterior fossa group B ependymoma 14 | 1,530
Parkinson's disease 13 | 364
Rheumatoid Arthritis 13 | 1,160
subependymal giant cell astrocytoma 13 | 2,287
acute quadriplegic myopathy 12 | 1,157
aldosterone-producing adenoma 12 | 664
primary pancreatic ductal adenocarcinoma 12 | 1,271
Waldenstrons macroglobulinemia 11 | 765
active Crohn's disease 11 | 918
esophageal adenocarcinoma 11 | 737
juvenile dermatomyositis 11 | 1,189
tuberculosis and treatment for 6 months 11 | 686
adrenocortical carcinoma 10 | 1,427
cutaneous lupus erythematosus 10 | 1,056
cystic fibrosis 10 | 1,665
hereditary spastic paraplegia 10 | 313
primary Sjogren syndrome 10 | 789
Carcinoma 9 | 2,147
Chronic Lymphocytic Leukemia 9 | 242
Optic atrophy 9 | 43
Polycystic Ovary Syndrome 9 | 332
Toxic encephalopathy 9 | 131
acute myeloid leukemia 9 | 780
gastric carcinoma 9 | 832
nasopharyngeal carcinoma 9 | 1,056
non primary Sjogren syndrome sicca 9 | 840
progressive supranuclear palsy 9 | 674
Diabetes Mellitus, Experimental 8 | 106
Mammary Neoplasms 8 | 410
Vascular disease 8 | 281
atypical teratoid/rhabdoid tumor 8 | 1,095
Atopic dermatitis 7 | 944
Endometriosis 7 | 535
Multiple Sclerosis 7 | 498
gastric cancer 7 | 430
spina bifida 7 | 1,064
Autistic Disorder 6 | 320
COPD 6 | 113
Liver carcinoma 6 | 217
Myocardial Ischemia 6 | 169
Prostatic Neoplasms 6 | 471
autosomal dominant Emery-Dreifuss muscular dystrophy 6 | 499
chronic rhinosinusitis 6 | 512
pancreatic carcinoma 6 | 567
Attention deficit hyperactivity disorder 5 | 156
Brain Ischemia 5 | 87
Cerebrovascular disease 5 | 231
Diabetes Mellitus, Non-Insulin-Dependent 5 | 157
Duchenne muscular dystrophy 5 | 602
IGA Glomerulonephritis 5 | 454
Peripheral Neuropathy 5 | 303
mucosa-associated lymphoid tissue lymphoma 5 | 480
nephrosclerosis 5 | 329
tuberculosis and treatment for 3 months 5 | 327

Tissue

Female tissues 163 | 18,647
Nervous System 163 | 18,561
Blood and immune system 162 | 17,995
Cardiovascular System 162 | 17,958
Digestive Tract 162 | 18,473
Liver and Pancreas 162 | 18,136
Male tissues 162 | 17,969
Urinary Tract 162 | 18,444
Endocrine System 161 | 18,512
Respiratory system 161 | 17,484
Skin and soft tissues 160 | 18,115

Target Family

Non-IDG 95 | 11,971
Enzyme 47 | 4,146
Kinase 12 | 634
Transporter 5 | 473
Epigenetic 2 | 242
Transcription Factor 2 | 1,400
Nuclear Receptor 1 | 48

Compartment GO Term

Mitochondrial outer membrane 164 | 164
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,170 | 8,170
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,830 | 7,830
Nucleus 6,897 | 6,897
Membrane part 6,469 | 6,469
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,172 | 5,172
Cell periphery 5,145 | 5,145
Plasma membrane 5,059 | 5,059
Extracellular region 4,606 | 4,606
Protein complex 4,438 | 4,438
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Cytosol 3,352 | 3,352
Nucleoplasm 2,938 | 2,938
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,563 | 2,563
Cytoskeleton 2,045 | 2,045
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Endoplasmic reticulum 1,663 | 1,663
Cytoskeletal part 1,567 | 1,567
Mitochondrion 1,530 | 1,530
Cell projection 1,426 | 1,426
Golgi apparatus 1,402 | 1,402
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,233 | 1,233
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Chromosome 999 | 999
Mitochondrial part 989 | 989
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 780 | 780
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 738 | 738
Plasma membrane protein comple... 720 | 720
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Microtubule organizing center 617 | 617
Synapse 594 | 594
Lysosome 571 | 571
Lytic vacuole 571 | 571
Vesicle membrane 559 | 559
cell-cell junction 557 | 557
Cytoplasmic vesicle membrane 552 | 552

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
ATP synthase F(0) complex subunit C3, mitochondrial ATP5G3 Tdark Enzyme -1.10871 11.9 27
Cytochrome b5 CYB5A Tchem Non-IDG -3.24788 1711.2 249
Mitofusin-1 MFN1 Tbio Non-IDG -1.99234 91.2 0
Carnitine O-palmitoyltransferase 1, liver isoform CPT1A Tchem Enzyme -2.30451 203.2 252
ATP synthase F(0) complex subunit C2, mitochondrial ATP5G2 Tbio Enzyme -1.03087 9.31 110
Protein Tob1 TOB1 Tbio Non-IDG -1.56387 42.5 170
Steroidogenic acute regulatory protein, mitochondrial STAR Tbio Non-IDG -2.80784 708.8 168
Cytochrome c CYCS Tbio Non-IDG -3.73952 4771.4 630
NADH-cytochrome b5 reductase 3 CYB5R3 Tchem Enzyme -1.93440 89.2 241
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 Tchem Enzyme -2.65191 464.3 66