Development Level

Tbio 138 | 11,651
Tchem 27 | 1,388
Tdark 12 | 6,593
Tclin 9 | 612

Collection

Kinase: IDG Consortium (Target... 1 | 125
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 11 | 979
hyperactivity 8 | 148
abnormal behavior 7 | 298
decreased body weight 6 | 161
decreased vertical activity 6 | 208
decreased bone mineral content 5 | 151
hypoactivity 5 | 132
abnormal bone structure 4 | 187
decreased lean body mass 4 | 135
decreased total body fat amoun... 4 | 207
increased lean body mass 4 | 172
increased mean corpuscular hem... 4 | 96
preweaning lethality, incomple... 4 | 499
abnormal lens morphology 3 | 81
cataract 3 | 92
decreased body length 3 | 101
decreased bone mineral density 3 | 126
decreased circulating HDL chol... 3 | 68
decreased circulating LDL chol... 3 | 38
decreased circulating choleste... 3 | 93
decreased circulating glucose ... 3 | 126
decreased circulating serum al... 3 | 82
decreased circulating total pr... 3 | 49
decreased mean corpuscular vol... 3 | 79
decreased startle reflex 3 | 75
enlarged heart 3 | 210
increased circulating bilirubi... 3 | 16
abnormal cranium morphology 2 | 36
abnormal epididymis morphology 2 | 42
abnormal skin morphology 2 | 50
abnormal sleep behavior 2 | 70
abnormal tibia morphology 2 | 14
decreased circulating aspartat... 2 | 34
decreased grip strength 2 | 116
decreased heart weight 2 | 27
embryonic lethality prior to t... 2 | 278
enlarged epididymis 2 | 31
increased heart rate 2 | 23
increased heart weight 2 | 62
increased hemoglobin content 2 | 45
increased mean corpuscular hem... 2 | 36
increased or absent threshold ... 2 | 101
increased startle reflex 2 | 112
increased total body fat amoun... 2 | 134
short tibia 2 | 97
small superior vagus ganglion 2 | 74
thrombocytopenia 2 | 56
abnormal coat appearance 1 | 31
abnormal coat- hair morphology 1 | 19
abnormal femur morphology 1 | 14
abnormal gait 1 | 69
abnormal joint morphology 1 | 23
abnormal pelvic girdle bone mo... 1 | 12
abnormal rib morphology 1 | 10
abnormal seminal vesicle morph... 1 | 114
abnormal snout morphology 1 | 23
abnormal thymus morphology 1 | 7
abnormal tooth morphology 1 | 24
abnormal vertebrae morphology 1 | 18
abnormal vibrissa morphology 1 | 25
abnormal vitreous body morphol... 1 | 10
absent startle reflex 1 | 24
brachydactyly 1 | 19
corneal opacity 1 | 32
decreased blood urea nitrogen ... 1 | 51
decreased circulating calcium ... 1 | 36
decreased circulating iron lev... 1 | 32
decreased circulating magnesiu... 1 | 13
decreased circulating phosphat... 1 | 27
decreased circulating potassiu... 1 | 20
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased mean platelet volume 1 | 25
decreased prepulse inhibition 1 | 82
decreased total retina thickne... 1 | 17
edema 1 | 59
embryonic lethality prior to o... 1 | 239
female infertility 1 | 60
hydrometra 1 | 53
increased anti-nuclear antigen... 1 | 19
increased bone mineral content 1 | 108
increased circulating alkaline... 1 | 122
increased circulating glycerol... 1 | 9
increased circulating lipase l... 1 | 3
increased circulating phosphat... 1 | 26
increased circulating serum al... 1 | 22
increased circulating sodium l... 1 | 71
increased mean corpuscular vol... 1 | 92
increased red blood cell distr... 1 | 34
mammalian phenotype 1 | 17
persistence of hyaloid vascula... 1 | 33
prenatal lethality prior to he... 1 | 87
shortened RR interval 1 | 17
small adrenal glands 1 | 16
small kidney 1 | 16
small spleen 1 | 19
small thymus 1 | 16
syndactyly 1 | 23

Disease

ovarian cancer 102 | 8,520
Carcinoma 99 | 11,493
osteosarcoma 82 | 7,950
lung cancer 75 | 4,740
medulloblastoma, large-cell 75 | 6,241
psoriasis 65 | 6,694
glioblastoma 64 | 5,792
atypical teratoid / rhabdoid tumor 61 | 5,112
ependymoma 52 | 4,679
malignant mesothelioma 45 | 3,232
Cancer 43 | 2,499
invasive ductal carcinoma 41 | 2,951
adult high grade glioma 40 | 3,801
group 3 medulloblastoma 35 | 4,104
Astrocytoma, Pilocytic 34 | 3,081
astrocytic glioma 34 | 2,597
non-small cell lung cancer 34 | 2,890
intraductal papillary-mucinous neoplasm (IPMN) 33 | 3,291
Breast cancer 32 | 3,578
oligodendroglioma 32 | 2,850
pancreatic ductal adenocarcinoma liver metastasis 30 | 1,962
tuberculosis 30 | 2,010
lung adenocarcinoma 29 | 2,716
pancreatic cancer 29 | 2,398
Pick disease 28 | 1,894
ductal carcinoma in situ 27 | 1,745
intraductal papillary-mucinous carcinoma (IPMC) 27 | 2,989
lung carcinoma 26 | 2,843
Multiple myeloma 25 | 1,332
intraductal papillary-mucinous adenoma (IPMA) 25 | 2,955
primitive neuroectodermal tumor 25 | 3,035
ulcerative colitis 24 | 1,819
diabetes mellitus 23 | 1,728
group 4 medulloblastoma 23 | 1,855
Alzheimer's disease 22 | 658
pituitary cancer 22 | 1,972
breast carcinoma 20 | 1,638
colon cancer 20 | 1,478
dermatomyositis 20 | 966
Autosomal recessive predisposition 19 | 1,442
interstitial cystitis 19 | 2,312
Neurodegenerative disease 18 | 414
Schizophrenia 18 | 1,160
Kidney cancer 17 | 2,613
Obesity 17 | 678
Rheumatoid arthritis 16 | 1,191
subependymal giant cell astrocytoma 16 | 2,287
Parkinson's disease 14 | 392
cystic fibrosis 14 | 1,696
juvenile dermatomyositis 14 | 1,187
pediatric high grade glioma 14 | 1,064
Waldenstrons macroglobulinemia 13 | 765
active Crohn's disease 13 | 922
acute quadriplegic myopathy 13 | 1,158
aldosterone-producing adenoma 13 | 665
medulloblastoma 13 | 720
Toxic encephalopathy 12 | 141
acute myeloid leukemia 12 | 783
astrocytoma 12 | 1,146
Multiple Sclerosis 11 | 540
Optic Atrophy 11 | 242
cutaneous lupus erythematosus 11 | 1,057
esophageal adenocarcinoma 11 | 737
primary Sjogren syndrome 11 | 735
primary pancreatic ductal adenocarcinoma 11 | 1,109
progressive supranuclear palsy 11 | 676
Bipolar Disorder 10 | 666
Breast Neoplasms 10 | 445
Liver Cirrhosis, Experimental 10 | 769
Mammary Neoplasms 10 | 425
Muscle hypotonia 10 | 571
adrenocortical carcinoma 10 | 1,428
hereditary spastic paraplegia 10 | 318
Atopic dermatitis 9 | 952
Intellectual disability 9 | 1,016
Polycystic ovary syndrome 9 | 360
Vascular disease 9 | 319
active ulcerative colitis 9 | 764
nasopharyngeal carcinoma 9 | 1,058
non primary Sjogren syndrome sicca 9 | 891
Chronic Lymphocytic Leukemia 8 | 262
Diabetes Mellitus, Experimental 8 | 108
Endometriosis 8 | 540
Epilepsy 8 | 792
Melanoma 8 | 711
Neuropathy 8 | 261
gastric cancer 8 | 459
gastric carcinoma 8 | 807
Cerebrovascular disease 7 | 238
Diabetes Mellitus, Type 2 7 | 142
Dull intelligence 7 | 645
Liver carcinoma 7 | 240
Low intelligence 7 | 645
Major Depressive Disorder 7 | 301
Mental Retardation 7 | 645
Mental deficiency 7 | 645
Poor school performance 7 | 645
Seizures 7 | 596
Unipolar Depression 7 | 250
spina bifida 7 | 1,074

Tissue

Endocrine System 183 | 18,159
Blood and immune system 181 | 16,909
Female tissues 181 | 17,400
Male tissues 181 | 17,142
Digestive Tract 180 | 17,369
Skin and soft tissues 180 | 17,230
Liver and Pancreas 179 | 16,750
Nervous System 179 | 16,725
Respiratory system 179 | 16,393
Urinary Tract 179 | 16,678
Cardiovascular System 177 | 15,192

Target Family

Non-IDG 110 | 12,091
Enzyme 49 | 4,145
Kinase 15 | 634
Transporter 6 | 473
Epigenetic 2 | 242
Transcription Factor 2 | 1,400
GPCR 1 | 408
Nuclear Receptor 1 | 48

Compartment GO Term

Mitochondrial outer membrane 186 | 186
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,783 | 8,783
Membrane 8,530 | 8,530
Nucleus 7,563 | 7,563
Cytosol 6,686 | 6,686
Membrane part 6,553 | 6,553
Plasma membrane 5,829 | 5,829
Macromolecular complex 5,476 | 5,476
Intrinsic component of membran... 5,457 | 5,457
Cell periphery 5,381 | 5,381
Integral component of membrane 5,330 | 5,330
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,974 | 3,974
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,673 | 3,673
Organelle membrane 2,846 | 2,846
Extracellular region 2,731 | 2,731
Plasma membrane part 2,593 | 2,593
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,216 | 2,216
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,638 | 1,638
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 968 | 968
Supramolecular complex 967 | 967
Cell junction 960 | 960
Supramolecular fiber 960 | 960
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 931 | 931
Nucleolus 927 | 927
Chromosomal part 889 | 889
GO:0098796 883 | 883
Ribonucleoprotein complex 864 | 864
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 849 | 849
Transferase complex 849 | 849
Cell surface 841 | 841
Plasma membrane region 841 | 841
Vesicle membrane 800 | 800
Cytoplasmic vesicle membrane 794 | 794
Polymeric cytoskeletal fiber 765 | 765
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 713 | 713
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Glycerol kinase 3 GK3P Tdark Kinase -1.84692 109.0 0
Reticulon-4-interacting protein 1, mitochondrial RTN4IP1 Tbio Enzyme -1.69878 47.3 145
Radical S-adenosyl methionine domain-containing protein 2 RSAD2 Tbio Non-IDG -1.99883 103.3 117
Cyclic AMP-dependent transcription factor ATF-2 ATF2 Tbio Transcription Factor -2.23104 170.7 1819
Stimulator of interferon genes protein TMEM173 Tbio Non-IDG -2.37722 230.3 450
E3 ubiquitin-protein ligase MARCH5 MARCH5 Tbio Epigenetic -1.47833 33.3 156
Ras-related protein Rab-32 RAB32 Tbio Enzyme -1.46660 33.4 127
BH3-interacting domain death agonist BID Tbio Non-IDG -1.85313 58.9 981
Metaxin-1 MTX1 Tbio Non-IDG -1.93920 85.1 64
Apoptosis-inducing factor 2 AIFM2 Tbio Non-IDG -1.22943 14.9 217