Development Level

Tbio 137 | 11,445
Tclin 50 | 613
Tdark 24 | 6,588
Tchem 14 | 1,598

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 30 | 979
embryonic lethality prior to o... 10 | 239
embryonic lethality prior to t... 8 | 278
abnormal behavior 5 | 298
abnormal embryo size 4 | 220
cataract 4 | 92
decreased bone mineral content 4 | 151
decreased vertical activity 4 | 208
hyperactivity 4 | 148
pallor 4 | 34
increased heart weight 3 | 62
increased lean body mass 3 | 172
increased total body fat amoun... 3 | 134
prenatal lethality prior to he... 3 | 87
preweaning lethality, incomple... 3 | 499
abnormal bone structure 2 | 187
abnormal epididymis morphology 2 | 42
abnormal heart morphology 2 | 162
abnormal lens morphology 2 | 81
abnormal placenta size 2 | 20
abnormal skin coloration 2 | 25
abnormal skin morphology 2 | 50
decreased body weight 2 | 161
decreased circulating chloride... 2 | 30
decreased circulating iron lev... 2 | 32
decreased erythrocyte cell num... 2 | 62
decreased heart weight 2 | 27
decreased lean body mass 2 | 135
decreased mean platelet volume 2 | 25
decreased neutrophil cell numb... 2 | 42
embryonic growth retardation 2 | 106
enlarged epididymis 2 | 31
enlarged heart 2 | 210
hypoactivity 2 | 132
impaired righting response 2 | 26
increased circulating alkaline... 2 | 122
increased circulating calcium ... 2 | 34
increased circulating glucose ... 2 | 24
increased fasted circulating g... 2 | 76
prenatal lethality 2 | 28
abnormal allantois morphology 1 | 8
abnormal chorioallantoic fusio... 1 | 8
abnormal coat appearance 1 | 31
abnormal embryo turning 1 | 31
abnormal gait 1 | 69
abnormal hindbrain development 1 | 16
abnormal limb bud morphology 1 | 17
abnormal liver size 1 | 5
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal neural tube morpholog... 1 | 12
abnormal placenta morphology 1 | 5
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal seminal vesicle morph... 1 | 114
abnormal sensory capabilities-... 1 | 8
abnormal sleep behavior 1 | 70
abnormal tail movements 1 | 12
abnormal vibrissa morphology 1 | 25
abnormal visceral yolk sac mor... 1 | 6
abnormal vitelline vasculature... 1 | 6
absent startle reflex 1 | 24
absent vibrissae 1 | 12
brachydactyly 1 | 19
decreased bone mineral density 1 | 126
decreased circulating LDL chol... 1 | 38
decreased circulating choleste... 1 | 93
decreased circulating creatine... 1 | 4
decreased circulating magnesiu... 1 | 13
decreased circulating phosphat... 1 | 27
decreased circulating triglyce... 1 | 79
decreased food intake 1 | 13
decreased total retina thickne... 1 | 17
enlarged heart atrium 1 | 4
enlarged lymph nodes 1 | 37
enlarged spleen 1 | 41
hemorrhage 1 | 23
increased blood urea nitrogen ... 1 | 48
increased blood uric acid leve... 1 | 5
increased bone mineral content 1 | 108
increased circulating bilirubi... 1 | 16
increased circulating chloride... 1 | 41
increased circulating glycerol... 1 | 9
increased circulating iron lev... 1 | 30
increased circulating phosphat... 1 | 26
increased circulating sodium l... 1 | 71
increased heart rate 1 | 23
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased mean platelet volume 1 | 45
increased prepulse inhibition 1 | 32
long tibia 1 | 25
pale liver 1 | 6
shortened RR interval 1 | 17
small adrenal glands 1 | 16
small seminal vesicle 1 | 10
small superior vagus ganglion 1 | 74
small thymus 1 | 16
syndactyly 1 | 23

Disease

ovarian cancer 129 | 8,520
osteosarcoma 80 | 7,950
Carcinoma 68 | 11,493
Multiple myeloma 67 | 1,332
lung cancer 66 | 4,740
psoriasis 58 | 6,694
Autosomal recessive predisposition 51 | 1,442
medulloblastoma, large-cell 51 | 6,241
Diabetes mellitus type 2 46 | 69
Treatment Refractory Type 2 Diabetes Mellitus 46 | 53
Cerebellar Ataxia 42 | 304
astrocytic glioma 42 | 2,597
atypical teratoid / rhabdoid tumor 41 | 5,112
pancreatic ductal adenocarcinoma liver metastasis 41 | 1,962
ependymoma 40 | 4,679
glioblastoma 40 | 5,792
Leigh disease 38 | 100
intraductal papillary-mucinous neoplasm (IPMN) 36 | 3,291
Epilepsy 34 | 792
Optic Atrophy 33 | 242
Acidosis, Lactic 32 | 97
Lactic acidemia 32 | 95
Muscle hypotonia 32 | 571
Dystonia 31 | 164
Mitochondrial complex I deficiency 31 | 46
Nystagmus 31 | 317
Breast cancer 30 | 3,578
Blepharoptosis 29 | 231
Cognitive delay 29 | 608
Global developmental delay 29 | 608
Mental and motor retardation 29 | 608
Seizures 29 | 596
Hyperreflexia 28 | 209
Sensorineural Hearing Loss (disorder) 28 | 284
Muscle Spasticity 26 | 195
Pick disease 26 | 1,894
adult high grade glioma 26 | 3,801
diabetes mellitus 26 | 1,728
oligodendroglioma 26 | 2,850
Failure to gain weight 25 | 365
Highly variable clinical phenotype 25 | 150
Highly variable phenotype and severity 25 | 150
Highly variable phenotype, even within families 25 | 150
Muscle Weakness 25 | 170
Pediatric failure to thrive 25 | 365
Phenotypic variability 25 | 150
malignant mesothelioma 25 | 3,232
Dystonic disease 24 | 106
Waldenstrons macroglobulinemia 24 | 765
Cancer 23 | 2,499
Increased serum lactate 23 | 60
Intellectual disability 23 | 1,016
Strabismus 23 | 270
group 4 medulloblastoma 23 | 1,855
Dull intelligence 22 | 645
Low intelligence 22 | 645
Mental Retardation 22 | 645
Mental deficiency 22 | 645
Mitochondrial Complex 1 Deficiency 22 | 28
Poor school performance 22 | 645
intraductal papillary-mucinous carcinoma (IPMC) 22 | 2,989
non-small cell lung cancer 22 | 2,890
Hypertrophic Cardiomyopathy 21 | 117
Respiratory Failure 21 | 104
intraductal papillary-mucinous adenoma (IPMA) 21 | 2,955
CSF lactate increased 20 | 33
Leigh syndrome 20 | 28
Ophthalmoplegia 20 | 106
Babinski Reflex 19 | 100
Developmental regression 19 | 95
Hypoglycemia 19 | 152
Loss of developmental milestones 19 | 95
Mental deterioration in childhood 19 | 95
NADH:Q(1) Oxidoreductase deficiency 19 | 24
Neurodevelopmental regression 19 | 95
Psychomotor regression 19 | 95
Psychomotor regression beginning in infancy 19 | 95
Psychomotor regression in infants 19 | 95
Psychomotor regression, progressive 19 | 95
Schizophrenia 19 | 1,160
group 3 medulloblastoma 19 | 4,104
Abnormal mitochondria in muscle tissue 18 | 20
Atrophy of cerebellum 18 | 103
Cerebellar degeneration 18 | 103
Infratentorial atrophy 18 | 103
Neuropathy 18 | 261
lung adenocarcinoma 18 | 2,716
Dysarthria 17 | 192
Neurodegenerative disease 17 | 414
Neurogenic Muscular Atrophy 17 | 139
Neurogenic muscle atrophy, especially in the lower limbs 17 | 139
Skeletal muscle atrophy 17 | 139
invasive ductal carcinoma 17 | 2,951
muscle degeneration 17 | 139
Astrocytoma, Pilocytic 16 | 3,081
Impaired exercise tolerance 16 | 42
Myopathy 16 | 185
Obesity 16 | 678
Retinitis Pigmentosa 16 | 226
acute myeloid leukemia 16 | 783

Tissue

Blood and immune system 224 | 16,909
Digestive Tract 224 | 17,369
Endocrine System 224 | 18,159
Female tissues 224 | 17,400
Liver and Pancreas 224 | 16,750
Male tissues 224 | 17,142
Skin and soft tissues 224 | 17,230
Urinary Tract 224 | 16,678
Cardiovascular System 223 | 15,192
Nervous System 223 | 16,725
Respiratory system 222 | 16,393

Target Family

Enzyme 135 | 4,145
Non-IDG 74 | 12,091
Transporter 7 | 473
Kinase 5 | 634
GPCR 2 | 408
Ion Channel 1 | 344
Transcription Factor 1 | 1,400

Compartment GO Term

Mitochondrial membrane part 225 | 225
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,784 | 8,784
Membrane 8,531 | 8,531
Nucleus 7,562 | 7,562
Cytosol 6,686 | 6,686
Membrane part 6,554 | 6,554
Plasma membrane 5,830 | 5,830
Macromolecular complex 5,475 | 5,475
Intrinsic component of membran... 5,458 | 5,458
Cell periphery 5,382 | 5,382
Integral component of membrane 5,331 | 5,331
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,975 | 3,975
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,674 | 3,674
Organelle membrane 2,846 | 2,846
Extracellular region 2,732 | 2,732
Plasma membrane part 2,594 | 2,594
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,217 | 2,217
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,932 | 1,932
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,641 | 1,641
Cytoskeletal part 1,637 | 1,637
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 970 | 970
Neuron part 969 | 969
Supramolecular polymer 967 | 967
Supramolecular complex 966 | 966
Cell junction 960 | 960
Supramolecular fiber 959 | 959
Golgi apparatus part 950 | 950
Nucleoli 942 | 942
Endosome 930 | 930
Nucleolus 926 | 926
Chromosomal part 889 | 889
GO:0098796 884 | 884
Ribonucleoprotein complex 865 | 865
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 850 | 850
Transferase complex 849 | 849
Cell surface 842 | 842
Plasma membrane region 841 | 841
Vesicle membrane 801 | 801
Cytoplasmic vesicle membrane 795 | 795
Polymeric cytoskeletal fiber 764 | 764
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 714 | 714
Neuron projection 711 | 711
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

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