Development Level

Tbio 368 | 10,625
Tdark 143 | 7,003
Tchem 84 | 1,890
Tclin 68 | 602

Collection

Kinase: IDG Consortium (Targets) 2 | 125

IMPC Phenotype

preweaning lethality, complete... 45 | 633
embryonic lethality prior to o... 21 | 148
embryonic lethality prior to t... 18 | 187
decreased body weight 12 | 174
abnormal behavior 11 | 226
decreased lean body mass 9 | 195
decreased total body fat amoun... 9 | 186
abnormal embryo size 8 | 112
decreased bone mineral content 8 | 157
preweaning lethality, incomple... 8 | 260
decreased circulating glucose ... 7 | 121
hypoactivity 7 | 89
decreased grip strength 6 | 123
increased grip strength 6 | 83
increased lean body mass 6 | 107
prenatal lethality prior to he... 6 | 64
abnormal bone structure 5 | 131
abnormal lens morphology 5 | 73
decreased circulating choleste... 5 | 85
decreased total retina thickne... 5 | 20
embryonic growth retardation 5 | 28
increased circulating phosphat... 5 | 24
increased circulating sodium l... 5 | 71
increased heart weight 5 | 37
increased or absent threshold ... 5 | 128
abnormal neural tube closure 4 | 37
decreased body length 4 | 108
decreased circulating HDL chol... 4 | 77
decreased circulating serum al... 4 | 79
decreased circulating triglyce... 4 | 83
decreased heart weight 4 | 44
decreased leukocyte cell numbe... 4 | 54
increased fasted circulating g... 4 | 68
increased mean corpuscular vol... 4 | 91
abnormal retina morphology 3 | 100
abnormal skin morphology 3 | 23
decreased blood urea nitrogen ... 3 | 31
decreased circulating LDL chol... 3 | 37
decreased circulating creatini... 3 | 31
decreased circulating insulin ... 3 | 75
decreased circulating total pr... 3 | 41
decreased mean corpuscular vol... 3 | 50
decreased mean platelet volume 3 | 12
decreased rib number 3 | 59
decreased startle reflex 3 | 48
enlarged heart 3 | 111
hyperactivity 3 | 108
increased circulating HDL chol... 3 | 63
increased circulating alkaline... 3 | 119
increased circulating aspartat... 3 | 17
increased circulating choleste... 3 | 53
increased exploration in new e... 3 | 56
increased mean corpuscular hem... 3 | 93
increased startle reflex 3 | 38
increased total body fat amoun... 3 | 57
pallor 3 | 13
persistence of hyaloid vascula... 3 | 22
short tibia 3 | 82
thrombocytopenia 3 | 46
abnormal QRS complex 2 | 25
abnormal bone mineralization 2 | 55
abnormal coat appearance 2 | 25
abnormal coat- hair morphology 2 | 18
abnormal coat-hair pigmentatio... 2 | 54
abnormal cranium morphology 2 | 32
abnormal embryo turning 2 | 15
abnormal femur morphology 2 | 14
abnormal gait 2 | 51
abnormal heart morphology 2 | 51
abnormal joint morphology 2 | 14
abnormal limb bud morphology 2 | 15
abnormal locomotor activation 2 | 26
abnormal skin coloration 2 | 18
abnormal snout morphology 2 | 18
abnormal tail bud morphology 2 | 6
abnormal tooth morphology 2 | 24
abnormal vertebrae morphology 2 | 14
abnormal vocalization 2 | 21
decreased bone mineral density 2 | 126
decreased caudal vertebrae num... 2 | 49
decreased circulating alkaline... 2 | 41
decreased circulating chloride... 2 | 32
decreased circulating iron lev... 2 | 25
decreased circulating potassiu... 2 | 17
decreased lumbar vertebrae num... 2 | 62
decreased mean corpuscular hem... 2 | 34
decreased red blood cell distr... 2 | 11
female infertility 2 | 34
improved glucose tolerance 2 | 56
increased blood urea nitrogen ... 2 | 44
increased bone mineral content 2 | 92
increased circulating bilirubi... 2 | 16
increased circulating calcium ... 2 | 32
increased circulating chloride... 2 | 43
increased circulating creatini... 2 | 29
increased erythrocyte cell num... 2 | 26
increased leukocyte cell numbe... 2 | 37
increased red blood cell distr... 2 | 21
increased sacral vertebrae num... 2 | 62
prenatal lethality 2 | 16

Disease

ovarian cancer 360 | 8,491
osteosarcoma 274 | 7,933
psoriasis 202 | 6,685
medulloblastoma, large-cell 201 | 6,234
lung cancer 198 | 4,473
glioblastoma 176 | 5,572
atypical teratoid / rhabdoid tumor 139 | 4,369
pancreatic ductal adenocarcinoma liver metastasis 138 | 1,795
Multiple myeloma 116 | 1,327
intraductal papillary-mucinous neoplasm (IPMN) 114 | 3,289
Cancer 102 | 2,346
Breast cancer 100 | 3,098
malignant mesothelioma 95 | 3,163
astrocytic glioma 94 | 2,241
ependymoma 91 | 2,514
invasive ductal carcinoma 89 | 2,950
non-small cell lung cancer 89 | 2,798
pediatric high grade glioma 89 | 2,712
oligodendroglioma 88 | 2,849
intraductal papillary-mucinous carcinoma (IPMC) 85 | 2,988
lung adenocarcinoma 82 | 2,714
intraductal papillary-mucinous adenoma (IPMA) 78 | 2,956
diabetes mellitus 77 | 1,663
pilocytic astrocytoma 76 | 3,086
lung carcinoma 75 | 2,844
primitive neuroectodermal tumor 75 | 3,031
Pick disease 69 | 1,893
pancreatic cancer 66 | 2,300
ulcerative colitis 65 | 2,087
adult high grade glioma 60 | 2,148
subependymal giant cell astrocytoma 59 | 2,287
group 3 medulloblastoma 57 | 2,254
group 4 medulloblastoma 55 | 1,875
non primary Sjogren syndrome sicca 55 | 840
breast carcinoma 54 | 1,614
ductal carcinoma in situ 53 | 1,745
Diabetes mellitus type 2 52 | 69
Treatment Refractory Type 2 Diabetes Mellitus 51 | 53
astrocytoma 51 | 1,493
medulloblastoma 51 | 1,524
Alzheimer's disease 50 | 644
acute myeloid leukemia 50 | 785
tuberculosis 50 | 1,563
pituitary cancer 46 | 1,972
Waldenstrons macroglobulinemia 45 | 764
colon cancer 45 | 1,475
sonic hedgehog group medulloblastoma 45 | 1,482
Leigh disease 44 | 81
Neurodegenerative disease 44 | 383
Obesity 43 | 616
Rheumatoid Arthritis 43 | 1,170
adrenocortical carcinoma 43 | 1,427
posterior fossa group A ependymoma 41 | 1,511
interstitial cystitis 39 | 2,299
Parkinson's disease 37 | 364
acute quadriplegic myopathy 37 | 1,157
cystic fibrosis 37 | 1,670
Mammary Neoplasms 35 | 410
posterior fossa group B ependymoma 35 | 1,530
dermatomyositis 34 | 966
Mitochondrial complex I deficiency 32 | 37
Toxic encephalopathy 32 | 131
aldosterone-producing adenoma 32 | 664
atypical teratoid/rhabdoid tumor 32 | 1,095
primary pancreatic ductal adenocarcinoma 32 | 1,271
Vascular disease 31 | 281
hereditary spastic paraplegia 31 | 313
Kidney disease 30 | 397
nasopharyngeal carcinoma 30 | 1,056
tuberculosis and treatment for 6 months 28 | 686
Leigh syndrome 27 | 34
juvenile dermatomyositis 27 | 1,189
Mitochondrial Complex 1 Deficiency 26 | 28
Heart disease 24 | 279
Prostatic Neoplasms 24 | 471
gastric carcinoma 24 | 832
Neuropathy 23 | 210
Stomach Neoplasms 23 | 282
active Crohn's disease 23 | 918
Anemia 22 | 252
Diabetes Mellitus, Experimental 22 | 106
Polycystic Ovary Syndrome 22 | 334
pancreatic carcinoma 22 | 567
Schizophrenia 21 | 503
cutaneous lupus erythematosus 21 | 1,056
hepatocellular carcinoma 21 | 550
progressive supranuclear palsy 21 | 674
Down syndrome 20 | 548
esophageal adenocarcinoma 20 | 737
spina bifida 20 | 1,064
Atopic dermatitis 19 | 944
Multiple Sclerosis 19 | 498
NADH:Q(1) Oxidoreductase deficiency 19 | 20
Optic atrophy 19 | 43
primary Sjogren syndrome 19 | 788
Carcinoma 18 | 2,147
IGA Glomerulonephritis 18 | 454
Myopathy 18 | 128
Diabetes Mellitus, Non-Insulin-Dependent 17 | 161
fibroadenoma 17 | 557

Tissue

Blood and immune system 659 | 17,994
Female tissues 659 | 18,646
Male tissues 659 | 17,968
Nervous System 659 | 18,560
Digestive Tract 658 | 18,472
Urinary Tract 658 | 18,443
Cardiovascular System 657 | 17,957
Liver and Pancreas 657 | 18,135
Endocrine System 656 | 18,511
Respiratory system 652 | 17,483
Skin and soft tissues 650 | 18,114

Target Family

Non-IDG 291 | 11,969
Enzyme 272 | 4,146
Transporter 60 | 473
Kinase 25 | 634
Transcription Factor 7 | 1,400
Epigenetic 3 | 242
GPCR 2 | 408
Nuclear Receptor 2 | 48
Ion Channel 1 | 341

Compartment GO Term

Mitochondrial membrane 663 | 663
cellular_component 18,237 | 18,237
Cell 15,806 | 15,806
Cell part 15,806 | 15,806
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,648 | 12,648
membrane-bounded organelle 11,793 | 11,793
Intracellular organelle 11,617 | 11,617
Intracellular membrane-bounded... 10,618 | 10,618
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,169 | 8,169
Intracellular organelle part 8,011 | 8,011
Cytoplasmic part 7,830 | 7,830
Nucleus 7,577 | 7,577
Membrane part 6,470 | 6,470
Cytosol 6,035 | 6,035
Plasma membrane 5,673 | 5,673
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,171 | 5,171
Cell periphery 5,146 | 5,146
Nucleoplasm 4,929 | 4,929
Extracellular region 4,606 | 4,606
Protein complex 4,439 | 4,439
Intracellular organelle lumen 4,330 | 4,330
Organelle lumen 4,330 | 4,330
membrane-enclosed lumen 4,330 | 4,330
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,839 | 3,839
non-membrane-bounded organelle 3,838 | 3,838
Nuclear part 3,807 | 3,807
Endomembrane system 3,720 | 3,720
Vesicle 3,666 | 3,666
membrane-bounded vesicle 3,494 | 3,494
Nuclear lumen 3,464 | 3,464
Extracellular organelle 2,849 | 2,849
Extracellular vesicle 2,848 | 2,848
Extracellular exosome 2,828 | 2,828
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,564 | 2,564
Cytoskeleton 2,046 | 2,046
Golgi apparatus 1,946 | 1,946
Endoplasmic reticulum 1,872 | 1,872
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Vesicles 1,625 | 1,625
Cytoskeletal part 1,568 | 1,568
Mitochondrion 1,531 | 1,531
Cell projection 1,426 | 1,426
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,305 | 1,305
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,234 | 1,234
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Mitochondria 1,003 | 1,003
Chromosome 999 | 999
Mitochondrial part 989 | 989
Nucleoli 952 | 952
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 793 | 793
Intracellular ribonucleoprotei... 789 | 789
Nucleoplasm part 781 | 781
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 739 | 739
Plasma membrane protein comple... 721 | 721
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Microtubule organizing center 680 | 680
Centrosome 676 | 676
Vacuolar membrane 667 | 667
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Synapse 594 | 594
Lytic vacuole 571 | 571

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.29593 203.1 88
Protein Mpv17 MPV17 Tbio Non-IDG -1.63162 40.5 114
Long-chain-fatty-acid--CoA ligase 6 ACSL6 Tbio Enzyme -1.84683 72.3 120
Galectin-3 LGALS3 Tchem Non-IDG -3.33005 2249.5 911
Mitochondrial 2-oxoglutarate/malate carrier protein SLC25A11 Tbio Transporter -1.36706 24.8 148
28S ribosomal protein S18a, mitochondrial MRPS18A Tdark Non-IDG 0.32 0.72 46
Mitochondrial ribosome-associated GTPase 1 MTG1 Tdark Enzyme -0.54103 1.85 75
Cytochrome b5 type B CYB5B Tbio Non-IDG -0.89834 7.51 36
Protoheme IX farnesyltransferase, mitochondrial COX10 Tbio Enzyme -1.58383 36.7 127
Maltase-glucoamylase, intestinal MGAM Tclin Enzyme -4.50018 27956.4 30