Development Level

Tbio 418 | 11,445
Tdark 130 | 6,588
Tchem 78 | 1,598
Tclin 70 | 613

Collection

Kinase: IDG Consortium (Target... 2 | 125
RFA-RM-18-021 2 | 328

IMPC Phenotype

preweaning lethality, complete... 72 | 979
embryonic lethality prior to o... 23 | 239
embryonic lethality prior to t... 21 | 278
abnormal behavior 16 | 298
preweaning lethality, incomple... 13 | 499
abnormal embryo size 12 | 220
decreased total body fat amoun... 11 | 207
decreased vertical activity 11 | 208
increased lean body mass 11 | 172
decreased body weight 10 | 161
decreased bone mineral content 10 | 151
embryonic growth retardation 10 | 106
hyperactivity 10 | 148
increased total body fat amoun... 10 | 134
abnormal bone structure 8 | 187
decreased lean body mass 8 | 135
abnormal lens morphology 7 | 81
cataract 7 | 92
enlarged heart 7 | 210
hypoactivity 7 | 132
prenatal lethality prior to he... 7 | 87
decreased circulating glucose ... 6 | 126
decreased mean corpuscular vol... 6 | 79
pallor 6 | 34
abnormal heart morphology 5 | 162
abnormal neural tube closure 5 | 46
decreased body length 5 | 101
decreased circulating LDL chol... 5 | 38
increased heart weight 5 | 62
increased startle reflex 5 | 112
abnormal sleep behavior 4 | 70
decreased circulating HDL chol... 4 | 68
decreased circulating choleste... 4 | 93
decreased circulating phosphat... 4 | 27
decreased circulating serum al... 4 | 82
decreased circulating total pr... 4 | 49
decreased total retina thickne... 4 | 17
increased circulating phosphat... 4 | 26
increased circulating sodium l... 4 | 71
increased mean corpuscular hem... 4 | 96
small superior vagus ganglion 4 | 74
thrombocytopenia 4 | 56
abnormal coat-hair pigmentatio... 3 | 64
abnormal cranium morphology 3 | 36
abnormal embryo turning 3 | 31
abnormal midbrain development 3 | 20
abnormal seminal vesicle morph... 3 | 114
abnormal skin morphology 3 | 50
decreased bone mineral density 3 | 126
decreased circulating aspartat... 3 | 34
decreased circulating chloride... 3 | 30
decreased grip strength 3 | 116
decreased heart weight 3 | 27
decreased hematocrit 3 | 46
decreased mean corpuscular hem... 3 | 50
decreased red blood cell distr... 3 | 41
decreased startle reflex 3 | 75
improved glucose tolerance 3 | 79
increased bone mineral content 3 | 108
increased circulating HDL chol... 3 | 80
increased circulating alkaline... 3 | 122
increased circulating bilirubi... 3 | 16
increased circulating calcium ... 3 | 34
increased fasted circulating g... 3 | 76
increased prepulse inhibition 3 | 32
increased red blood cell distr... 3 | 34
pale yolk sac 3 | 25
persistence of hyaloid vascula... 3 | 33
short tibia 3 | 97
abnormal gait 2 | 69
abnormal heart left ventricle ... 2 | 16
abnormal limb bud morphology 2 | 17
abnormal neural tube morpholog... 2 | 12
abnormal placenta size 2 | 20
abnormal skin coloration 2 | 25
abnormal spleen morphology 2 | 55
abnormal tooth morphology 2 | 24
abnormal vertebrae morphology 2 | 18
abnormal vocalization 2 | 21
decreased circulating creatini... 2 | 39
decreased circulating insulin ... 2 | 76
decreased circulating iron lev... 2 | 32
decreased circulating potassiu... 2 | 20
decreased circulating triglyce... 2 | 79
decreased erythrocyte cell num... 2 | 62
decreased food intake 2 | 13
decreased hemoglobin content 2 | 68
decreased prepulse inhibition 2 | 82
enlarged spleen 2 | 41
impaired righting response 2 | 26
increased anti-nuclear antigen... 2 | 19
increased circulating choleste... 2 | 66
increased circulating glucose ... 2 | 24
increased hemoglobin content 2 | 45
increased mean corpuscular vol... 2 | 92
increased monocyte cell number 2 | 63
increased or absent threshold ... 2 | 101
male infertility 2 | 123
prenatal lethality 2 | 28
small testis 2 | 58

Disease

ovarian cancer 380 | 8,520
Carcinoma 294 | 11,493
osteosarcoma 290 | 7,950
lung cancer 215 | 4,740
medulloblastoma, large-cell 210 | 6,241
psoriasis 210 | 6,694
glioblastoma 187 | 5,792
atypical teratoid / rhabdoid tumor 169 | 5,112
pancreatic ductal adenocarcinoma liver metastasis 152 | 1,962
ependymoma 149 | 4,679
Multiple myeloma 127 | 1,332
intraductal papillary-mucinous neoplasm (IPMN) 122 | 3,291
adult high grade glioma 120 | 3,801
Breast cancer 115 | 3,578
Cancer 112 | 2,499
astrocytic glioma 108 | 2,597
group 3 medulloblastoma 108 | 4,104
malignant mesothelioma 108 | 3,232
Autosomal recessive predisposition 101 | 1,442
invasive ductal carcinoma 98 | 2,951
non-small cell lung cancer 96 | 2,890
oligodendroglioma 91 | 2,850
intraductal papillary-mucinous carcinoma (IPMC) 90 | 2,989
diabetes mellitus 89 | 1,728
lung adenocarcinoma 86 | 2,716
intraductal papillary-mucinous adenoma (IPMA) 83 | 2,955
lung carcinoma 78 | 2,843
Astrocytoma, Pilocytic 77 | 3,081
primitive neuroectodermal tumor 76 | 3,035
tuberculosis 73 | 2,010
Pick disease 70 | 1,894
group 4 medulloblastoma 69 | 1,855
pancreatic cancer 68 | 2,398
Epilepsy 65 | 792
Schizophrenia 63 | 1,160
ulcerative colitis 63 | 1,819
breast carcinoma 62 | 1,638
subependymal giant cell astrocytoma 61 | 2,287
Muscle hypotonia 60 | 571
ductal carcinoma in situ 58 | 1,745
non primary Sjogren syndrome sicca 58 | 891
Cerebellar Ataxia 57 | 304
Seizures 56 | 596
Alzheimer's disease 54 | 658
Cognitive delay 54 | 608
Global developmental delay 54 | 608
Mental and motor retardation 54 | 608
acute myeloid leukemia 54 | 783
Diabetes mellitus type 2 52 | 69
Obesity 52 | 678
Leigh disease 51 | 100
Treatment Refractory Type 2 Diabetes Mellitus 51 | 53
Waldenstrons macroglobulinemia 50 | 765
Optic Atrophy 49 | 242
Rheumatoid arthritis 49 | 1,191
colon cancer 49 | 1,478
Intellectual disability 47 | 1,016
Neurodegenerative disease 47 | 414
pituitary cancer 47 | 1,972
Failure to gain weight 46 | 365
Pediatric failure to thrive 46 | 365
astrocytoma 46 | 1,146
Acidosis, Lactic 45 | 97
Lactic acidemia 45 | 95
adrenocortical carcinoma 45 | 1,428
cystic fibrosis 44 | 1,696
Blepharoptosis 42 | 231
Dystonia 42 | 164
acute quadriplegic myopathy 40 | 1,158
interstitial cystitis 40 | 2,312
Breast Neoplasms 39 | 445
Hyperreflexia 39 | 209
Mammary Neoplasms 39 | 425
Mitochondrial complex I deficiency 39 | 46
dermatomyositis 39 | 966
Dull intelligence 38 | 645
Low intelligence 38 | 645
Mental Retardation 38 | 645
Mental deficiency 38 | 645
Nystagmus 38 | 317
Parkinson's disease 38 | 392
Poor school performance 38 | 645
Muscle Weakness 37 | 170
Hypertrophic Cardiomyopathy 36 | 117
Liver Cirrhosis, Experimental 36 | 769
Sensorineural Hearing Loss (disorder) 36 | 284
Toxic encephalopathy 36 | 141
pediatric high grade glioma 36 | 1,064
aldosterone-producing adenoma 35 | 665
Vascular disease 34 | 319
Anemia 33 | 365
Increased serum lactate 33 | 60
Kidney cancer 33 | 2,613
Neuropathy 33 | 261
Dystonic disease 32 | 106
Hypoglycemia 32 | 152
Muscle Spasticity 32 | 195
Strabismus 32 | 270
juvenile dermatomyositis 32 | 1,187
nasopharyngeal carcinoma 31 | 1,058

Tissue

Endocrine System 687 | 18,159
Digestive Tract 682 | 17,369
Male tissues 678 | 17,142
Skin and soft tissues 677 | 17,230
Blood and immune system 676 | 16,909
Female tissues 676 | 17,400
Liver and Pancreas 675 | 16,750
Nervous System 674 | 16,725
Urinary Tract 674 | 16,678
Respiratory system 668 | 16,393
Cardiovascular System 663 | 15,192

Target Family

Non-IDG 315 | 12,091
Enzyme 278 | 4,145
Transporter 60 | 473
Kinase 27 | 634
Transcription Factor 7 | 1,400
Epigenetic 3 | 242
GPCR 3 | 408
Nuclear Receptor 2 | 48
Ion Channel 1 | 344

Compartment GO Term

Mitochondrial membrane 696 | 696
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,109 | 14,109
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,975 | 8,975
Intracellular organelle part 8,783 | 8,783
Membrane 8,531 | 8,531
Nucleus 7,562 | 7,562
Cytosol 6,686 | 6,686
Membrane part 6,554 | 6,554
Plasma membrane 5,830 | 5,830
Macromolecular complex 5,475 | 5,475
Intrinsic component of membran... 5,458 | 5,458
Cell periphery 5,382 | 5,382
Integral component of membrane 5,331 | 5,331
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,975 | 3,975
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,674 | 3,674
Organelle membrane 2,846 | 2,846
Extracellular region 2,732 | 2,732
Plasma membrane part 2,594 | 2,594
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,217 | 2,217
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,637 | 1,637
Extracellular region part 1,628 | 1,628
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 967 | 967
Supramolecular complex 966 | 966
Cell junction 960 | 960
Supramolecular fiber 959 | 959
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 930 | 930
Nucleolus 926 | 926
Chromosomal part 889 | 889
GO:0098796 884 | 884
Ribonucleoprotein complex 865 | 865
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 850 | 850
Transferase complex 849 | 849
Cell surface 842 | 842
Plasma membrane region 841 | 841
Vesicle membrane 801 | 801
Cytoplasmic vesicle membrane 795 | 795
Polymeric cytoskeletal fiber 764 | 764
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 714 | 714
Neuron projection 712 | 712
Centrosome 696 | 696
Receptor complex 686 | 686
Synapse 663 | 663
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

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