Development Level

Tbio 334 | 11,445
Tdark 84 | 6,588
Tchem 43 | 1,598
Tclin 37 | 613

Collection

Kinase: IDG Consortium (Comple... 1 | 37
Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 72 | 979
embryonic lethality prior to o... 19 | 239
embryonic lethality prior to t... 18 | 278
abnormal embryo size 8 | 220
embryonic growth retardation 7 | 106
prenatal lethality prior to he... 6 | 87
abnormal behavior 5 | 298
decreased fasted circulating g... 5 | 65
decreased total body fat amoun... 5 | 207
enlarged heart 5 | 210
increased lean body mass 5 | 172
preweaning lethality, incomple... 5 | 499
abnormal bone structure 4 | 187
abnormal gait 4 | 69
abnormal heart morphology 4 | 162
cataract 4 | 92
decreased circulating alkaline... 4 | 46
increased circulating alkaline... 4 | 122
increased circulating choleste... 4 | 66
increased fasted circulating g... 4 | 76
increased mean corpuscular hem... 4 | 96
increased total body fat amoun... 4 | 134
abnormal coat-hair pigmentatio... 3 | 64
abnormal lens morphology 3 | 81
abnormal retina morphology 3 | 71
abnormal testis morphology 3 | 43
decreased bone mineral density 3 | 126
decreased circulating glucose ... 3 | 126
decreased grip strength 3 | 116
decreased mean platelet volume 3 | 25
decreased vertical activity 3 | 208
improved glucose tolerance 3 | 79
increased circulating total pr... 3 | 28
increased heart weight 3 | 62
small testis 3 | 58
abnormal behavioral response t... 2 | 66
abnormal bone mineralization 2 | 38
abnormal epididymis morphology 2 | 42
abnormal seminal vesicle morph... 2 | 114
abnormal tail movements 2 | 12
decreased body weight 2 | 161
decreased bone mineral content 2 | 151
decreased circulating LDL chol... 2 | 38
decreased circulating choleste... 2 | 93
decreased circulating creatini... 2 | 39
decreased circulating insulin ... 2 | 76
decreased circulating total pr... 2 | 49
decreased erythrocyte cell num... 2 | 62
enlarged epididymis 2 | 31
hyperactivity 2 | 148
hypoactivity 2 | 132
impaired glucose tolerance 2 | 75
increased blood urea nitrogen ... 2 | 48
increased circulating HDL chol... 2 | 80
increased circulating calcium ... 2 | 34
increased circulating serum al... 2 | 22
male infertility 2 | 123
pallor 2 | 34
persistence of hyaloid vascula... 2 | 33
prolonged QT interval 2 | 38
abnormal craniofacial morpholo... 1 | 33
abnormal cranium morphology 1 | 36
abnormal embryo turning 1 | 31
abnormal heart left ventricle ... 1 | 16
abnormal neural tube closure 1 | 46
abnormal neural tube morpholog... 1 | 12
abnormal retinal vasculature m... 1 | 27
abnormal sleep behavior 1 | 70
abnormal spleen morphology 1 | 55
abnormal tooth morphology 1 | 24
abnormal vocalization 1 | 21
decreased T cell number 1 | 15
decreased circulating calcium ... 1 | 36
decreased circulating chloride... 1 | 30
decreased circulating iron lev... 1 | 32
decreased circulating triglyce... 1 | 79
decreased eosinophil cell numb... 1 | 24
decreased lean body mass 1 | 135
decreased red blood cell distr... 1 | 41
enlarged spleen 1 | 41
hydrometra 1 | 53
impaired pupillary reflex 1 | 26
impaired righting response 1 | 26
increased anti-nuclear antigen... 1 | 19
increased circulating amylase ... 1 | 25
increased circulating aspartat... 1 | 15
increased circulating bilirubi... 1 | 16
increased circulating fructosa... 1 | 13
increased circulating iron lev... 1 | 30
increased circulating phosphat... 1 | 26
increased exploration in new e... 1 | 8
increased hemoglobin content 1 | 45
increased prepulse inhibition 1 | 32
increased startle reflex 1 | 112
long tibia 1 | 25
prenatal lethality 1 | 28
small superior vagus ganglion 1 | 74
thin ventricular wall 1 | 24
tremors 1 | 39
vertebral fusion 1 | 23

Disease

ovarian cancer 275 | 8,520
Carcinoma 255 | 11,493
osteosarcoma 213 | 7,950
lung cancer 149 | 4,740
psoriasis 149 | 6,694
medulloblastoma, large-cell 140 | 6,241
pancreatic ductal adenocarcinoma liver metastasis 130 | 1,962
Autosomal recessive predisposition 120 | 1,442
glioblastoma 109 | 5,792
group 3 medulloblastoma 99 | 4,104
atypical teratoid / rhabdoid tumor 95 | 5,112
Multiple myeloma 81 | 1,332
ependymoma 77 | 4,679
intraductal papillary-mucinous neoplasm (IPMN) 77 | 3,291
Muscle hypotonia 73 | 571
Breast cancer 70 | 3,578
Epilepsy 70 | 792
non-small cell lung cancer 70 | 2,890
Cognitive delay 68 | 608
Global developmental delay 68 | 608
Mental and motor retardation 68 | 608
adult high grade glioma 64 | 3,801
malignant mesothelioma 61 | 3,232
lung adenocarcinoma 60 | 2,716
Seizures 59 | 596
diabetes mellitus 59 | 1,728
Cancer 58 | 2,499
Acidosis, Lactic 57 | 97
Lactic acidemia 56 | 95
invasive ductal carcinoma 55 | 2,951
astrocytic glioma 54 | 2,597
intraductal papillary-mucinous adenoma (IPMA) 53 | 2,955
primitive neuroectodermal tumor 53 | 3,035
Cerebellar Ataxia 52 | 304
Leigh disease 52 | 100
intraductal papillary-mucinous carcinoma (IPMC) 51 | 2,989
Intellectual disability 47 | 1,016
ulcerative colitis 47 | 1,819
oligodendroglioma 46 | 2,850
Dull intelligence 45 | 645
Low intelligence 45 | 645
Mental Retardation 45 | 645
Mental deficiency 45 | 645
Poor school performance 45 | 645
interstitial cystitis 45 | 2,312
Pick disease 44 | 1,894
non primary Sjogren syndrome sicca 42 | 891
pancreatic cancer 40 | 2,398
subependymal giant cell astrocytoma 39 | 2,287
Failure to gain weight 38 | 365
Hypoglycemia 38 | 152
Obesity 38 | 678
Pediatric failure to thrive 38 | 365
Schizophrenia 38 | 1,160
lung carcinoma 38 | 2,843
tuberculosis 38 | 2,010
Astrocytoma, Pilocytic 36 | 3,081
Neurodegenerative disease 36 | 414
colon cancer 36 | 1,478
breast carcinoma 35 | 1,638
Optic Atrophy 34 | 242
cystic fibrosis 33 | 1,696
group 4 medulloblastoma 33 | 1,855
Dystonia 32 | 164
Increased serum lactate 32 | 60
Neuropathy 32 | 261
Sensorineural Hearing Loss (disorder) 32 | 284
Waldenstrons macroglobulinemia 32 | 765
ductal carcinoma in situ 32 | 1,745
Vomiting 31 | 116
Nystagmus 30 | 317
adrenocortical carcinoma 30 | 1,428
Dystonic disease 29 | 106
Infantile onset 29 | 238
Kidney cancer 29 | 2,613
Lactic acidosis 29 | 51
Blepharoptosis 28 | 231
acute myeloid leukemia 28 | 783
Lethargy 27 | 77
Liver Cirrhosis, Experimental 27 | 769
Hepatomegaly 26 | 285
Muscle Weakness 25 | 170
pituitary cancer 25 | 1,972
Short stature 24 | 531
Highly variable clinical phenotype 23 | 150
Highly variable phenotype and severity 23 | 150
Highly variable phenotype, even within families 23 | 150
Myopathy 23 | 185
Phenotypic variability 23 | 150
Small head 23 | 374
Stomach Neoplasms 23 | 300
Breast Neoplasms 22 | 445
Hyperreflexia 22 | 209
Mammary Neoplasms 22 | 425
Mitochondrial myopathy 22 | 26
aldosterone-producing adenoma 22 | 665
Anemia 21 | 365
Cerebral atrophy 21 | 178
Prostatic Neoplasms 21 | 495
acute quadriplegic myopathy 21 | 1,158

Tissue

Endocrine System 493 | 18,159
Digestive Tract 491 | 17,369
Skin and soft tissues 491 | 17,230
Female tissues 490 | 17,400
Urinary Tract 490 | 16,678
Liver and Pancreas 489 | 16,750
Blood and immune system 488 | 16,909
Nervous System 487 | 16,725
Male tissues 485 | 17,142
Respiratory system 482 | 16,393
Cardiovascular System 476 | 15,192

Target Family

Enzyme 301 | 4,145
Non-IDG 165 | 12,091
Kinase 17 | 634
Epigenetic 4 | 242
Transporter 4 | 473
Transcription Factor 3 | 1,400
Ion Channel 2 | 344
Nuclear Receptor 2 | 48

Compartment GO Term

Mitochondrial matrix 498 | 498
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,784 | 8,784
Membrane 8,531 | 8,531
Nucleus 7,562 | 7,562
Cytosol 6,686 | 6,686
Membrane part 6,554 | 6,554
Plasma membrane 5,830 | 5,830
Macromolecular complex 5,475 | 5,475
Intrinsic component of membran... 5,458 | 5,458
Cell periphery 5,382 | 5,382
Integral component of membrane 5,331 | 5,331
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,975 | 3,975
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,674 | 3,674
Organelle membrane 2,846 | 2,846
Extracellular region 2,732 | 2,732
Plasma membrane part 2,594 | 2,594
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,217 | 2,217
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,932 | 1,932
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,641 | 1,641
Cytoskeletal part 1,637 | 1,637
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 970 | 970
Neuron part 969 | 969
Supramolecular polymer 967 | 967
Supramolecular complex 966 | 966
Cell junction 960 | 960
Supramolecular fiber 959 | 959
Golgi apparatus part 950 | 950
Nucleoli 942 | 942
Endosome 930 | 930
Nucleolus 926 | 926
Chromosomal part 889 | 889
GO:0098796 884 | 884
Ribonucleoprotein complex 865 | 865
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 850 | 850
Transferase complex 849 | 849
Cell surface 842 | 842
Plasma membrane region 841 | 841
Vesicle membrane 801 | 801
Cytoplasmic vesicle membrane 795 | 795
Polymeric cytoskeletal fiber 764 | 764
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 714 | 714
Neuron projection 711 | 711
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Iron-sulfur cluster assembly 1 homolog, mitochondrial ISCA1 Tbio Non-IDG -1.68100 45.7 44
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial MCCC1 Tbio Enzyme -1.91194 82.4 102
Sarcosine dehydrogenase, mitochondrial SARDH Tbio Enzyme -1.78290 56.5 35
Isobutyryl-CoA dehydrogenase, mitochondrial ACAD8 Tbio Enzyme -1.14784 13.9 150
Hydroxymethylglutaryl-CoA synthase, mitochondrial HMGCS2 Tbio Enzyme -1.74279 54.0 126
NAD-dependent protein deacylase sirtuin-5, mitochondrial SIRT5 Tchem Epigenetic -2.36015 219.3 427
2-oxoglutarate dehydrogenase-like, mitochondrial OGDHL Tbio Enzyme -0.59292 3.63 46
Elongation factor G, mitochondrial GFM1 Tbio Non-IDG -2.39993 250.5 121
Cysteine desulfurase, mitochondrial NFS1 Tbio Enzyme -1.70267 46.3 131
39S ribosomal protein L22, mitochondrial MRPL22 Tdark Non-IDG 0.70 0.21 64