Development Level

Tbio 299 | 10,625
Tdark 85 | 7,003
Tchem 49 | 1,890
Tclin 34 | 602

Collection

Eligible Kinase Proteins 3 | 134

IMPC Term

preweaning lethality, complete... 38 | 633
embryonic lethality prior to o... 14 | 148
embryonic lethality prior to t... 12 | 187
prenatal lethality prior to he... 7 | 64
abnormal embryo size 5 | 112
abnormal retina morphology 5 | 100
abnormal behavior 4 | 226
abnormal lens morphology 4 | 73
embryonic growth retardation 4 | 28
abnormal gait 3 | 51
abnormal retinal pigmentation 3 | 61
abnormal testis morphology 3 | 30
decreased body weight 3 | 174
decreased circulating choleste... 3 | 85
decreased fasted circulating g... 3 | 49
decreased rib number 3 | 59
hyperactivity 3 | 108
increased circulating alkaline... 3 | 119
increased circulating choleste... 3 | 53
increased fasted circulating g... 3 | 68
increased grip strength 3 | 83
increased heart weight 3 | 37
increased mean corpuscular hem... 3 | 93
increased startle reflex 3 | 38
small testis 3 | 37
abnormal behavioral response t... 2 | 52
abnormal bone mineralization 2 | 55
abnormal bone structure 2 | 131
abnormal epididymis morphology 2 | 31
abnormal seminal vesicle morph... 2 | 47
abnormal tail movements 2 | 12
abnormal tooth morphology 2 | 24
decreased CD4-positive, alpha ... 2 | 19
decreased Ly6C low monocyte nu... 2 | 23
decreased T cell number 2 | 31
decreased body length 2 | 108
decreased bone mineral density 2 | 126
decreased circulating HDL chol... 2 | 77
decreased circulating LDL chol... 2 | 37
decreased circulating alkaline... 2 | 41
decreased circulating creatini... 2 | 31
decreased circulating glucose ... 2 | 121
decreased circulating insulin ... 2 | 75
decreased circulating triglyce... 2 | 83
decreased effector memory CD8-... 2 | 24
decreased total body fat amoun... 2 | 186
enlarged epididymis 2 | 27
enlarged heart 2 | 111
improved glucose tolerance 2 | 56
increased circulating HDL chol... 2 | 63
increased circulating total pr... 2 | 20
increased lean body mass 2 | 107
increased mean corpuscular vol... 2 | 91
increased or absent threshold ... 2 | 128
male infertility 2 | 62
preweaning lethality, incomple... 2 | 260
abnormal coping response 1 | 12
abnormal craniofacial morpholo... 1 | 12
abnormal cranium morphology 1 | 32
abnormal embryo turning 1 | 15
abnormal heart left ventricle ... 1 | 20
abnormal heart morphology 1 | 51
abnormal kidney morphology 1 | 30
abnormal neural tube closure 1 | 37
abnormal retinal blood vessel ... 1 | 18
abnormal skin appearance 1 | 8
abnormal skin morphology 1 | 23
abnormal snout morphology 1 | 18
abnormal startle reflex 1 | 14
abnormal vocalization 1 | 21
decreased CD11b-low dendritic ... 1 | 3
decreased CD8-positive, alpha-... 1 | 26
decreased alpha-beta T cell nu... 1 | 12
decreased caudal vertebrae num... 1 | 49
decreased circulating chloride... 1 | 32
decreased circulating iron lev... 1 | 25
decreased eosinophil cell numb... 1 | 41
decreased exploration in new e... 1 | 9
decreased follicular B cell nu... 1 | 4
decreased gamma-delta T cell n... 1 | 18
decreased grip strength 1 | 123
decreased heart rate 1 | 10
decreased heart weight 1 | 44
decreased lumbar vertebrae num... 1 | 62
decreased red blood cell distr... 1 | 11
decreased vertical activity 1 | 22
female infertility 1 | 34
increased NK cell number 1 | 19
increased blood urea nitrogen ... 1 | 44
increased circulating aspartat... 1 | 17
increased circulating bilirubi... 1 | 16
increased circulating creatini... 1 | 29
increased circulating fructosa... 1 | 11
increased circulating iron lev... 1 | 25
increased effector memory CD4-... 1 | 15
increased eosinophil cell numb... 1 | 9
short tibia 1 | 82
thrombocytopenia 1 | 46
tremors 1 | 34
vertebral fusion 1 | 23

Disease

ovarian cancer 261 | 8,484
osteosarcoma 202 | 7,933
lung cancer 145 | 4,466
psoriasis 144 | 6,685
medulloblastoma, large-cell 136 | 6,234
pancreatic ductal adenocarcinoma liver metastasis 118 | 1,795
glioblastoma 100 | 5,572
Multiple myeloma 79 | 1,327
atypical teratoid / rhabdoid tumor 77 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 72 | 3,289
Breast cancer 67 | 3,094
non-small cell lung cancer 66 | 2,798
malignant mesothelioma 58 | 3,162
ulcerative colitis 58 | 2,087
lung adenocarcinoma 56 | 2,713
group 3 medulloblastoma 55 | 2,254
Cancer 54 | 2,346
invasive ductal carcinoma 52 | 2,950
intraductal papillary-mucinous adenoma (IPMA) 50 | 2,956
primitive neuroectodermal tumor 50 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 48 | 2,988
diabetes mellitus 47 | 1,663
pediatric high grade glioma 47 | 2,712
ependymoma 46 | 2,514
oligodendroglioma 46 | 2,849
astrocytic glioma 45 | 2,241
interstitial cystitis 44 | 2,299
Pick disease 43 | 1,893
Leigh disease 42 | 81
non primary Sjogren syndrome sicca 42 | 840
lung carcinoma 38 | 2,844
pancreatic cancer 38 | 2,300
group 4 medulloblastoma 36 | 1,875
Obesity 35 | 616
colon cancer 35 | 1,475
subependymal giant cell astrocytoma 35 | 2,287
Neurodegenerative disease 34 | 383
breast carcinoma 34 | 1,614
Waldenstrons macroglobulinemia 32 | 765
medulloblastoma 32 | 1,524
pilocytic astrocytoma 32 | 3,086
tuberculosis 32 | 1,557
adrenocortical carcinoma 31 | 1,427
adult high grade glioma 31 | 2,148
cystic fibrosis 29 | 1,665
ductal carcinoma in situ 29 | 1,745
posterior fossa group B ependymoma 29 | 1,530
sonic hedgehog group medulloblastoma 27 | 1,482
Lactic acidosis 26 | 42
acute myeloid leukemia 26 | 780
pituitary cancer 25 | 1,972
Neuropathy 23 | 210
Stomach Neoplasms 23 | 282
astrocytoma 23 | 1,493
Mammary Neoplasms 22 | 410
acute quadriplegic myopathy 22 | 1,157
Mitochondrial myopathy 20 | 23
primary pancreatic ductal adenocarcinoma 20 | 1,271
Prostatic Neoplasms 19 | 471
aldosterone-producing adenoma 19 | 664
atypical teratoid/rhabdoid tumor 19 | 1,095
dermatomyositis 19 | 933
nasopharyngeal carcinoma 19 | 1,056
tuberculosis and treatment for 6 months 19 | 686
Diabetes mellitus type 2 18 | 69
Methylmalonic acidemia 18 | 39
Treatment Refractory Type 2 Diabetes Mellitus 18 | 53
gastric carcinoma 18 | 832
Alzheimer's disease 17 | 644
Maple syrup urine disease 17 | 25
active Crohn's disease 17 | 918
nephrosclerosis 17 | 329
posterior fossa group A ependymoma 17 | 1,511
Disease Progression 16 | 125
Epilepsy 16 | 346
MITOCHONDRIAL COMPLEX I DEFICIENCY 16 | 37
Vascular disease 16 | 281
pancreatic carcinoma 16 | 567
Atopic dermatitis 15 | 944
Parkinson's disease 15 | 364
Degenerative polyarthritis 14 | 93
Leber hereditary optic neuropathy 14 | 17
Rheumatoid Arthritis 14 | 1,160
juvenile dermatomyositis 14 | 1,189
Diabetes Mellitus, Experimental 13 | 106
Hypoglycemia 13 | 81
Osteoporosis 13 | 257
esophageal adenocarcinoma 13 | 737
hereditary spastic paraplegia 13 | 313
Anemia 12 | 252
Atherosclerosis 12 | 275
Chronic progressive external ophthalmoplegia 12 | 18
Glycine encephalopathy 12 | 28
IGA Glomerulonephritis 12 | 454
Multiple acyl-CoA dehydrogenase deficiency 12 | 26
Propionic acidemia 12 | 20
Schizophrenia 12 | 501
hepatocellular carcinoma 12 | 532
inflammatory breast cancer 12 | 404
cutaneous lupus erythematosus 11 | 1,056

Tissue

Blood and immune system 465 | 17,995
Digestive Tract 465 | 18,473
Endocrine System 465 | 18,512
Female tissues 465 | 18,647
Nervous System 465 | 18,561
Urinary Tract 465 | 18,444
Cardiovascular System 464 | 17,958
Liver and Pancreas 464 | 18,136
Male tissues 462 | 17,969
Skin and soft tissues 462 | 18,115
Respiratory system 461 | 17,484

Target Family

Enzyme 280 | 4,146
Non-IDG 156 | 11,971
Kinase 16 | 634
Epigenetic 4 | 242
Transporter 4 | 473
Transcription Factor 3 | 1,400
Ion Channel 2 | 341
Nuclear Receptor 2 | 48

Compartment GO Term

Mitochondrial matrix 467 | 467
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,170 | 8,170
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,830 | 7,830
Nucleus 6,897 | 6,897
Membrane part 6,469 | 6,469
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,172 | 5,172
Cell periphery 5,145 | 5,145
Plasma membrane 5,059 | 5,059
Extracellular region 4,606 | 4,606
Protein complex 4,438 | 4,438
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Cytosol 3,352 | 3,352
Nucleoplasm 2,938 | 2,938
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,563 | 2,563
Cytoskeleton 2,045 | 2,045
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Endoplasmic reticulum 1,663 | 1,663
Cytoskeletal part 1,567 | 1,567
Mitochondrion 1,530 | 1,530
Cell projection 1,426 | 1,426
Golgi apparatus 1,402 | 1,402
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,233 | 1,233
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Chromosome 999 | 999
Mitochondrial part 989 | 989
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 780 | 780
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 738 | 738
Plasma membrane protein comple... 720 | 720
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Microtubule organizing center 617 | 617
Synapse 594 | 594
Lysosome 571 | 571
Lytic vacuole 571 | 571
Vesicle membrane 559 | 559
cell-cell junction 557 | 557
Cytoplasmic vesicle membrane 552 | 552

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
ADP/ATP translocase 1 SLC25A4 Tbio Transporter -2.05462 110.8 89
V(D)J recombination-activating protein 1 RAG1 Tbio Non-IDG -3.00063 1061.1 65
NADH-ubiquinone oxidoreductase chain 6 MT-ND6 Tclin Enzyme -2.74395 585.6 62
ATP synthase protein 8 MT-ATP8 Tbio Enzyme -2.30895 191.4 20
Malate dehydrogenase, mitochondrial MDH2 Tchem Enzyme -2.21960 180.2 229
39S ribosomal protein L37, mitochondrial MRPL37 Tdark Non-IDG -0.30103 2.00 47
Trifunctional enzyme subunit alpha, mitochondrial HADHA Tbio Non-IDG -2.96515 948.2 132
Heat shock protein 75 kDa, mitochondrial TRAP1 Tchem Non-IDG -1.12188 14.9 328
Insulin INS Tbio Non-IDG -5.14691 141255.4 1549
Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial IDH3B Tbio Enzyme -1.13428 13.6 146