Development Level

Tbio 57 | 11,445
Tdark 10 | 6,588
Tchem 6 | 1,598
Tclin 5 | 613

IMPC Phenotype

preweaning lethality, complete... 6 | 979
abnormal behavior 3 | 298
cataract 3 | 92
abnormal skin morphology 2 | 50
decreased mean platelet volume 2 | 25
hypoactivity 2 | 132
abnormal clavicle morphology 1 | 6
abnormal coat-hair pigmentatio... 1 | 64
abnormal lens morphology 1 | 81
abnormal lung morphology 1 | 26
abnormal rib morphology 1 | 10
abnormal seminal vesicle morph... 1 | 114
abnormal testis morphology 1 | 43
absent startle reflex 1 | 24
decreased circulating alkaline... 1 | 46
decreased circulating creatini... 1 | 39
decreased circulating phosphat... 1 | 27
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased fasted circulating g... 1 | 65
decreased food intake 1 | 13
decreased grip strength 1 | 116
decreased heart left ventricle... 1 | 28
decreased heart weight 1 | 27
decreased leukocyte cell numbe... 1 | 73
decreased neutrophil cell numb... 1 | 42
decreased prepulse inhibition 1 | 82
decreased red blood cell distr... 1 | 41
decreased respiratory quotient 1 | 16
decreased startle reflex 1 | 75
decreased total retina thickne... 1 | 17
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
enlarged lymph nodes 1 | 37
enlarged spleen 1 | 41
enlarged testis 1 | 6
hyperactivity 1 | 148
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased circulating phosphat... 1 | 26
increased circulating potassiu... 1 | 29
increased grip strength 1 | 41
increased heart weight 1 | 62
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
long tibia 1 | 25
preweaning lethality, incomple... 1 | 499
small seminal vesicle 1 | 10
small testis 1 | 58
thin ventricular wall 1 | 24
thrombocytopenia 1 | 56

Disease

ovarian cancer 43 | 8,520
osteosarcoma 38 | 7,950
lung cancer 27 | 4,740
Carcinoma 23 | 11,493
medulloblastoma, large-cell 22 | 6,241
atypical teratoid / rhabdoid tumor 18 | 5,112
adult high grade glioma 17 | 3,801
glioblastoma 17 | 5,792
Breast cancer 16 | 3,578
ependymoma 16 | 4,679
psoriasis 15 | 6,694
Autosomal recessive predisposition 13 | 1,442
astrocytic glioma 12 | 2,597
Multiple myeloma 11 | 1,332
group 3 medulloblastoma 11 | 4,104
Cancer 10 | 2,499
malignant mesothelioma 10 | 3,232
non primary Sjogren syndrome sicca 10 | 891
pancreatic ductal adenocarcinoma liver metastasis 10 | 1,962
Neurodegenerative disease 9 | 414
Waldenstrons macroglobulinemia 9 | 765
group 4 medulloblastoma 9 | 1,855
Astrocytoma, Pilocytic 8 | 3,081
Schizophrenia 8 | 1,160
intraductal papillary-mucinous neoplasm (IPMN) 8 | 3,291
lung adenocarcinoma 8 | 2,716
non-small cell lung cancer 8 | 2,890
primitive neuroectodermal tumor 8 | 3,035
Deafness dystonia syndrome 7 | 21
Dystonia 7 | 164
Parkinson's disease 7 | 392
diabetes mellitus 7 | 1,728
oligodendroglioma 7 | 2,850
Cognitive delay 6 | 608
Global developmental delay 6 | 608
Intellectual disability 6 | 1,016
Leigh disease 6 | 100
Mental and motor retardation 6 | 608
invasive ductal carcinoma 6 | 2,951
tuberculosis 6 | 2,010
Alzheimer's disease 5 | 658
Dull intelligence 5 | 645
Epilepsy 5 | 792
Failure to gain weight 5 | 365
Low intelligence 5 | 645
Mental Retardation 5 | 645
Mental deficiency 5 | 645
Neuropathy 5 | 261
Optic Atrophy 5 | 242
Pediatric failure to thrive 5 | 365
Poor school performance 5 | 645
Sensorineural Hearing Loss (disorder) 5 | 284
acute myeloid leukemia 5 | 783
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
subependymal giant cell astrocytoma 5 | 2,287
ulcerative colitis 5 | 1,819
Cerebellar Ataxia 4 | 304
Diabetes mellitus type 2 4 | 69
Hyperreflexia 4 | 209
Kidney disease 4 | 430
Major Depressive Disorder 4 | 301
Muscle Spasticity 4 | 195
Neurogenic Muscular Atrophy 4 | 139
Neurogenic muscle atrophy, especially in the lower limbs 4 | 139
Obesity 4 | 678
Pick disease 4 | 1,894
Polycystic ovary syndrome 4 | 360
Rheumatoid arthritis 4 | 1,191
Seizures 4 | 596
Skeletal muscle atrophy 4 | 139
Treatment Refractory Type 2 Diabetes Mellitus 4 | 53
Vomiting 4 | 116
aldosterone-producing adenoma 4 | 665
cutaneous lupus erythematosus 4 | 1,057
dermatomyositis 4 | 966
interstitial cystitis 4 | 2,312
muscle degeneration 4 | 139
Acidosis, Lactic 3 | 97
Anemia 3 | 365
Barth syndrome 3 | 23
Bipolar Disorder 3 | 666
Brain Ischemia 3 | 110
Carcinoma, Hepatocellular 3 | 228
Dementia 3 | 175
Highly variable clinical phenotype 3 | 150
Highly variable phenotype and severity 3 | 150
Highly variable phenotype, even within families 3 | 150
Hyperandrogenism 3 | 34
Lactic acidemia 3 | 95
Liver carcinoma 3 | 240
Myopathy 3 | 185
Phenotypic variability 3 | 150
Prostatic Neoplasms 3 | 495
Psychotic Disorders 3 | 151
colon cancer 3 | 1,478
nasopharyngeal carcinoma 3 | 1,058
pancreatic cancer 3 | 2,398
pituitary cancer 3 | 1,972
progressive supranuclear palsy 3 | 676

Tissue

Digestive Tract 76 | 17,369
Endocrine System 76 | 18,159
Female tissues 76 | 17,400
Liver and Pancreas 76 | 16,750
Male tissues 76 | 17,142
Nervous System 76 | 16,725
Skin and soft tissues 76 | 17,230
Blood and immune system 75 | 16,909
Respiratory system 75 | 16,393
Urinary Tract 75 | 16,678
Cardiovascular System 73 | 15,192

Target Family

Enzyme 38 | 4,145
Non-IDG 34 | 12,091
Kinase 5 | 634
Epigenetic 1 | 242

Compartment GO Term

Mitochondrial intermembrane sp... 78 | 78
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,784 | 8,784
Membrane 8,531 | 8,531
Nucleus 7,562 | 7,562
Cytosol 6,686 | 6,686
Membrane part 6,554 | 6,554
Plasma membrane 5,830 | 5,830
Macromolecular complex 5,475 | 5,475
Intrinsic component of membran... 5,458 | 5,458
Cell periphery 5,382 | 5,382
Integral component of membrane 5,331 | 5,331
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,975 | 3,975
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,674 | 3,674
Organelle membrane 2,846 | 2,846
Extracellular region 2,732 | 2,732
Plasma membrane part 2,594 | 2,594
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,217 | 2,217
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,932 | 1,932
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,641 | 1,641
Cytoskeletal part 1,637 | 1,637
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 970 | 970
Neuron part 969 | 969
Supramolecular polymer 967 | 967
Supramolecular complex 966 | 966
Cell junction 960 | 960
Supramolecular fiber 959 | 959
Golgi apparatus part 950 | 950
Nucleoli 942 | 942
Endosome 930 | 930
Nucleolus 926 | 926
Chromosomal part 889 | 889
GO:0098796 884 | 884
Ribonucleoprotein complex 865 | 865
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 850 | 850
Transferase complex 849 | 849
Cell surface 842 | 842
Plasma membrane region 841 | 841
Vesicle membrane 801 | 801
Cytoplasmic vesicle membrane 795 | 795
Polymeric cytoskeletal fiber 764 | 764
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 714 | 714
Neuron projection 711 | 711
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Adenylate kinase 2, mitochondrial AK2 Tbio Kinase -2.00007 98.7 330
NAD-dependent protein deacylase sirtuin-5, mitochondrial SIRT5 Tchem Epigenetic -2.36015 219.3 427
Myocilin MYOC Tbio Non-IDG -2.65916 482.8 169
MICOS complex subunit MIC19 CHCHD3 Tbio Non-IDG -1.16714 14.1 178
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 HSD3B1 Tchem Enzyme -2.62147 370.7 267
Mitochondrial import inner membrane translocase subunit Tim9 TIMM9 Tbio Enzyme -1.31703 21.3 72
Mitochondrial import inner membrane translocase subunit Tim8 B TIMM8B Tbio Enzyme -1.46649 28.6 54
Mitochondrial import inner membrane translocase subunit Tim13 TIMM13 Tbio Enzyme -1.90930 75.7 32
Ubiquinol-cytochrome-c reductase complex assembly factor 2 UQCC2 Tbio Enzyme -1.53008 34.4 21
Oligoribonuclease, mitochondrial REXO2 Tbio Enzyme -2.15502 143.8 115