Development Level

Tbio 261 | 11,178
Tdark 110 | 6,569
Tclin 62 | 612
Tchem 34 | 1,885

Collection

Kinase: IDG Consortium (Target... 2 | 125

IMPC Phenotype

preweaning lethality, complete... 58 | 979
embryonic lethality prior to o... 20 | 239
embryonic lethality prior to t... 15 | 278
abnormal embryo size 11 | 220
abnormal behavior 9 | 298
embryonic growth retardation 9 | 106
preweaning lethality, incomple... 8 | 499
increased lean body mass 6 | 172
increased total body fat amoun... 6 | 134
pallor 6 | 34
prenatal lethality prior to he... 6 | 87
cataract 5 | 92
abnormal bone structure 4 | 187
abnormal heart morphology 4 | 162
abnormal lens morphology 4 | 81
abnormal neural tube closure 4 | 46
decreased body weight 4 | 161
decreased bone mineral content 4 | 151
decreased vertical activity 4 | 208
enlarged heart 4 | 210
hypoactivity 4 | 132
increased heart weight 4 | 62
abnormal embryo turning 3 | 31
decreased circulating LDL chol... 3 | 38
decreased circulating glucose ... 3 | 126
decreased circulating phosphat... 3 | 27
decreased total body fat amoun... 3 | 207
hyperactivity 3 | 148
increased circulating phosphat... 3 | 26
increased circulating sodium l... 3 | 71
increased fasted circulating g... 3 | 76
increased prepulse inhibition 3 | 32
pale yolk sac 3 | 25
abnormal allantois morphology 2 | 8
abnormal coat-hair pigmentatio... 2 | 64
abnormal hindbrain development 2 | 16
abnormal limb bud morphology 2 | 17
abnormal midbrain development 2 | 20
abnormal neural tube morpholog... 2 | 12
abnormal placenta size 2 | 20
abnormal skin coloration 2 | 25
abnormal spleen morphology 2 | 55
abnormal tail bud morphology 2 | 8
abnormal tail morphology 2 | 25
decreased circulating chloride... 2 | 30
decreased erythrocyte cell num... 2 | 62
decreased food intake 2 | 13
decreased heart weight 2 | 27
decreased lean body mass 2 | 135
decreased leukocyte cell numbe... 2 | 73
decreased mean corpuscular hem... 2 | 50
decreased mean corpuscular vol... 2 | 79
decreased mean platelet volume 2 | 25
decreased neutrophil cell numb... 2 | 42
decreased red blood cell distr... 2 | 41
enlarged spleen 2 | 41
hemorrhage 2 | 23
impaired righting response 2 | 26
improved glucose tolerance 2 | 79
increased anti-nuclear antigen... 2 | 19
increased circulating alkaline... 2 | 122
increased circulating calcium ... 2 | 34
increased circulating glucose ... 2 | 24
increased startle reflex 2 | 112
persistence of hyaloid vascula... 2 | 33
prenatal lethality 2 | 28
prolonged QT interval 2 | 38
thrombocytopenia 2 | 56
abnormal cranium morphology 1 | 36
abnormal gait 1 | 69
abnormal heart looping 1 | 5
abnormal joint morphology 1 | 23
abnormal lung morphology 1 | 26
abnormal tail movements 1 | 12
abnormal tooth morphology 1 | 24
abnormal vertebrae morphology 1 | 18
abnormal vocalization 1 | 21
absent pinna reflex 1 | 23
absent vibrissae 1 | 12
decreased body length 1 | 101
decreased circulating creatine... 1 | 4
decreased circulating potassiu... 1 | 20
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased grip strength 1 | 116
decreased total retina thickne... 1 | 17
enlarged lymph nodes 1 | 37
impaired pupillary reflex 1 | 26
increased blood urea nitrogen ... 1 | 48
increased blood uric acid leve... 1 | 5
increased bone mineral density 1 | 72
increased circulating creatini... 1 | 38
increased circulating iron lev... 1 | 30
increased mean corpuscular vol... 1 | 92
increased red blood cell distr... 1 | 34
long tibia 1 | 25
small superior vagus ganglion 1 | 74
thin ventricular wall 1 | 24
thrombocytosis 1 | 27

Disease

ovarian cancer 254 | 8,297
osteosarcoma 180 | 7,766
Carcinoma 164 | 11,192
lung cancer 121 | 4,607
psoriasis 120 | 6,514
medulloblastoma, large-cell 118 | 6,086
pancreatic ductal adenocarcinoma liver metastasis 110 | 1,911
glioblastoma 101 | 5,635
Multiple myeloma 99 | 1,296
atypical teratoid / rhabdoid tumor 95 | 4,971
ependymoma 83 | 4,559
Autosomal recessive predisposition 78 | 1,407
intraductal papillary-mucinous neoplasm (IPMN) 75 | 3,204
Breast cancer 69 | 3,469
astrocytic glioma 68 | 2,530
adult high grade glioma 65 | 3,701
group 3 medulloblastoma 57 | 4,002
Epilepsy 53 | 775
malignant mesothelioma 52 | 3,135
Cerebellar Ataxia 51 | 302
Diabetes mellitus type 2 51 | 69
invasive ductal carcinoma 51 | 2,867
oligodendroglioma 51 | 2,768
Leigh disease 50 | 100
Treatment Refractory Type 2 Diabetes Mellitus 50 | 53
non-small cell lung cancer 50 | 2,799
Muscle hypotonia 49 | 562
Cognitive delay 48 | 596
Global developmental delay 48 | 596
Mental and motor retardation 48 | 596
diabetes mellitus 47 | 1,683
intraductal papillary-mucinous carcinoma (IPMC) 47 | 2,902
lung adenocarcinoma 45 | 2,627
Acidosis, Lactic 44 | 97
Lactic acidemia 44 | 95
Pick disease 44 | 1,856
Seizures 44 | 584
intraductal papillary-mucinous adenoma (IPMA) 44 | 2,872
Failure to gain weight 43 | 359
Pediatric failure to thrive 43 | 359
non primary Sjogren syndrome sicca 43 | 861
group 4 medulloblastoma 41 | 1,806
Mitochondrial complex I deficiency 39 | 46
Astrocytoma, Pilocytic 38 | 3,006
Cancer 38 | 2,388
Nystagmus 37 | 309
Optic Atrophy 37 | 239
primitive neuroectodermal tumor 37 | 2,957
Blepharoptosis 36 | 229
Waldenstrons macroglobulinemia 36 | 742
breast carcinoma 36 | 1,589
subependymal giant cell astrocytoma 36 | 2,230
Dystonia 35 | 163
Sensorineural Hearing Loss (disorder) 35 | 281
Hyperreflexia 34 | 208
acute myeloid leukemia 34 | 760
tuberculosis 34 | 1,963
Hypertrophic Cardiomyopathy 33 | 115
Intellectual disability 33 | 998
Muscle Weakness 33 | 168
lung carcinoma 33 | 2,755
Increased serum lactate 32 | 60
Highly variable clinical phenotype 31 | 147
Highly variable phenotype and severity 31 | 147
Highly variable phenotype, even within families 31 | 147
Phenotypic variability 31 | 147
Schizophrenia 31 | 1,136
pancreatic cancer 31 | 2,322
Dull intelligence 30 | 634
Low intelligence 30 | 634
Mental Retardation 30 | 634
Mental deficiency 30 | 634
Muscle Spasticity 30 | 192
Poor school performance 30 | 634
Strabismus 29 | 265
Dystonic disease 28 | 105
Hypoglycemia 28 | 146
Myopathy 27 | 185
Respiratory Failure 27 | 101
Mitochondrial Complex 1 Deficiency 26 | 28
astrocytoma 26 | 1,113
ulcerative colitis 26 | 1,765
CSF lactate increased 25 | 33
Leigh syndrome 25 | 28
Rheumatoid arthritis 25 | 1,156
Vomiting 25 | 116
Alzheimer's disease 24 | 640
Developmental regression 24 | 94
Loss of developmental milestones 24 | 94
Mental deterioration in childhood 24 | 94
Neurodevelopmental regression 24 | 94
Psychomotor regression 24 | 94
Psychomotor regression beginning in infancy 24 | 94
Psychomotor regression in infants 24 | 94
Psychomotor regression, progressive 24 | 94
Babinski Reflex 23 | 98
Neuropathy 23 | 254
Obesity 23 | 655
colon cancer 23 | 1,428
pituitary cancer 23 | 1,915

Tissue

Endocrine System 461 | 18,159
Digestive Tract 459 | 17,369
Liver and Pancreas 455 | 16,750
Male tissues 455 | 17,142
Female tissues 454 | 17,400
Skin and soft tissues 454 | 17,230
Urinary Tract 454 | 16,678
Blood and immune system 452 | 16,909
Nervous System 451 | 16,725
Respiratory system 449 | 16,393
Cardiovascular System 446 | 15,192

Target Family

Enzyme 211 | 4,145
Non-IDG 190 | 12,091
Transporter 53 | 473
Kinase 9 | 634
GPCR 2 | 408
Ion Channel 1 | 344
Transcription Factor 1 | 1,400

Compartment GO Term

Mitochondrial inner membrane 467 | 467
cellular_component 17,863 | 17,863
Cell 15,779 | 15,779
Cell part 15,778 | 15,778
Intracellular 13,764 | 13,764
Intracellular part 13,630 | 13,630
Organelle 11,921 | 11,921
Intracellular organelle 11,712 | 11,712
membrane-bounded organelle 10,823 | 10,823
Cytoplasm 10,720 | 10,720
Intracellular membrane-bounded... 10,057 | 10,057
Cytoplasmic part 9,029 | 9,029
Organelle part 8,755 | 8,755
Intracellular organelle part 8,566 | 8,566
Membrane 8,335 | 8,335
Nucleus 7,336 | 7,336
Cytosol 6,551 | 6,551
Membrane part 6,403 | 6,403
Plasma membrane 5,682 | 5,682
Macromolecular complex 5,345 | 5,345
Intrinsic component of membran... 5,320 | 5,320
Cell periphery 5,248 | 5,248
Integral component of membrane 5,197 | 5,197
Nucleoplasm 4,931 | 4,931
Intracellular organelle lumen 4,923 | 4,923
Organelle lumen 4,923 | 4,923
membrane-enclosed lumen 4,923 | 4,923
Nuclear part 4,169 | 4,169
Endomembrane system 4,108 | 4,108
Intracellular non-membrane-bou... 3,917 | 3,917
non-membrane-bounded organelle 3,917 | 3,917
Nuclear lumen 3,851 | 3,851
Protein complex 3,565 | 3,565
Organelle membrane 2,798 | 2,798
Extracellular region 2,600 | 2,600
Plasma membrane part 2,531 | 2,531
Vesicle 2,280 | 2,280
Cytoplasmic vesicle 2,158 | 2,158
Intracellular vesicle 2,157 | 2,157
Cytoskeleton 2,084 | 2,084
Bounding membrane of organelle 1,924 | 1,924
Endoplasmic reticulum 1,922 | 1,922
Golgi apparatus 1,884 | 1,884
Intrinsic component of plasma ... 1,701 | 1,701
Integral component of plasma m... 1,647 | 1,647
Cytoskeletal part 1,613 | 1,613
Catalytic complex 1,592 | 1,592
Vesicles 1,566 | 1,566
Mitochondrion 1,557 | 1,557
Extracellular region part 1,533 | 1,533
Cell projection 1,524 | 1,524
Whole membrane 1,521 | 1,521
Cytoplasmic vesicle part 1,468 | 1,468
Endoplasmic reticulum part 1,315 | 1,315
GO:0031975 1,139 | 1,139
Organelle envelope 1,131 | 1,131
Microtubule cytoskeleton 1,127 | 1,127
Nucleoplasm part 1,100 | 1,100
Nuclear outer membrane-endopla... 1,094 | 1,094
Endoplasmic reticulum membrane 1,076 | 1,076
Extracellular space 1,059 | 1,059
Mitochondrial part 1,027 | 1,027
Chromosome 1,020 | 1,020
Mitochondria 985 | 985
Neuron part 958 | 958
Supramolecular polymer 950 | 950
Cell junction 949 | 949
Supramolecular complex 949 | 949
Supramolecular fiber 942 | 942
Secretory vesicle 930 | 930
Golgi apparatus part 923 | 923
Nucleoli 923 | 923
Nucleolus 916 | 916
Endosome 915 | 915
Chromosomal part 872 | 872
GO:0098796 868 | 868
Ribonucleoprotein complex 845 | 845
Cell projection part 838 | 838
Transferase complex 837 | 837
Intracellular ribonucleoprotei... 830 | 830
Plasma membrane region 826 | 826
Secretory granule 810 | 810
Cell surface 805 | 805
Vesicle membrane 786 | 786
Cytoplasmic vesicle membrane 780 | 780
Polymeric cytoskeletal fiber 753 | 753
Mitochondrial envelope 739 | 739
Golgi membrane 715 | 715
Microtubule organizing center 712 | 712
Nuclear body 708 | 708
Vacuole 708 | 708
Neuron projection 701 | 701
Mitochondrial membrane 689 | 689
Centrosome 685 | 685
Extracellular matrix 670 | 670
Receptor complex 670 | 670
Synapse 656 | 656
Lysosome 600 | 600
Lytic vacuole 600 | 600
Endosomal part 554 | 554
Chromatin 552 | 552

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Putative cytochrome b-c1 complex subunit Rieske-like protein 1 UQCRFS1P1 Tdark Non-IDG -2.12377 231.9 0
Cytosolic phospholipase A2 beta JMJD7-PLA2G4B Tchem Enzyme -0.60640 3.75 104
Dynamin-like 120 kDa protein, mitochondrial OPA1 Tbio Non-IDG -2.51554 307.1 210
39S ribosomal protein L27, mitochondrial MRPL27 Tdark Non-IDG 0.60 0.05 48
39S ribosomal protein L36, mitochondrial MRPL36 Tdark Non-IDG -1.19524 14.7 33
2,4-dienoyl-CoA reductase, mitochondrial DECR1 Tbio Enzyme -4.22091 15887.9 151
Folylpolyglutamate synthase, mitochondrial FPGS Tchem Enzyme -1.90018 79.8 131
28S ribosomal protein S22, mitochondrial MRPS22 Tbio Non-IDG -2.42971 211.9 107
4-hydroxybenzoate polyprenyltransferase, mitochondrial COQ2 Tbio Enzyme -2.13154 132.2 47
28S ribosomal protein S35, mitochondrial MRPS35 Tdark Non-IDG 0.00000 84