Development Level

Tbio 271 | 11,445
Tdark 111 | 6,588
Tclin 62 | 613
Tchem 28 | 1,598

Collection

Kinase: IDG Consortium (Target... 2 | 125
RFA-RM-18-021 2 | 328

IMPC Phenotype

preweaning lethality, complete... 59 | 979
embryonic lethality prior to o... 20 | 239
embryonic lethality prior to t... 15 | 278
abnormal embryo size 11 | 220
abnormal behavior 9 | 298
embryonic growth retardation 9 | 106
preweaning lethality, incomple... 8 | 499
cataract 6 | 92
increased lean body mass 6 | 172
increased total body fat amoun... 6 | 134
pallor 6 | 34
prenatal lethality prior to he... 6 | 87
abnormal bone structure 4 | 187
abnormal heart morphology 4 | 162
abnormal lens morphology 4 | 81
abnormal neural tube closure 4 | 46
decreased body weight 4 | 161
decreased bone mineral content 4 | 151
decreased vertical activity 4 | 208
enlarged heart 4 | 210
hypoactivity 4 | 132
increased heart weight 4 | 62
abnormal embryo turning 3 | 31
decreased circulating LDL chol... 3 | 38
decreased circulating glucose ... 3 | 126
decreased circulating phosphat... 3 | 27
decreased total body fat amoun... 3 | 207
hyperactivity 3 | 148
increased circulating phosphat... 3 | 26
increased circulating sodium l... 3 | 71
increased fasted circulating g... 3 | 76
increased prepulse inhibition 3 | 32
pale yolk sac 3 | 25
abnormal allantois morphology 2 | 8
abnormal coat-hair pigmentatio... 2 | 64
abnormal hindbrain development 2 | 16
abnormal limb bud morphology 2 | 17
abnormal midbrain development 2 | 20
abnormal neural tube morpholog... 2 | 12
abnormal placenta size 2 | 20
abnormal skin coloration 2 | 25
abnormal spleen morphology 2 | 55
abnormal tail bud morphology 2 | 8
abnormal tail morphology 2 | 25
decreased circulating chloride... 2 | 30
decreased erythrocyte cell num... 2 | 62
decreased food intake 2 | 13
decreased heart weight 2 | 27
decreased lean body mass 2 | 135
decreased leukocyte cell numbe... 2 | 73
decreased mean corpuscular hem... 2 | 50
decreased mean corpuscular vol... 2 | 79
decreased mean platelet volume 2 | 25
decreased neutrophil cell numb... 2 | 42
decreased red blood cell distr... 2 | 41
enlarged spleen 2 | 41
hemorrhage 2 | 23
impaired righting response 2 | 26
improved glucose tolerance 2 | 79
increased anti-nuclear antigen... 2 | 19
increased circulating alkaline... 2 | 122
increased circulating calcium ... 2 | 34
increased circulating glucose ... 2 | 24
increased startle reflex 2 | 112
persistence of hyaloid vascula... 2 | 33
prenatal lethality 2 | 28
prolonged QT interval 2 | 38
thrombocytopenia 2 | 56
abnormal cranium morphology 1 | 36
abnormal gait 1 | 69
abnormal heart looping 1 | 5
abnormal joint morphology 1 | 23
abnormal lung morphology 1 | 26
abnormal retina morphology 1 | 71
abnormal tail movements 1 | 12
abnormal tooth morphology 1 | 24
abnormal vertebrae morphology 1 | 18
abnormal vocalization 1 | 21
absent pinna reflex 1 | 23
absent vibrissae 1 | 12
decreased body length 1 | 101
decreased circulating creatine... 1 | 4
decreased circulating potassiu... 1 | 20
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased grip strength 1 | 116
decreased total retina thickne... 1 | 17
enlarged lymph nodes 1 | 37
impaired pupillary reflex 1 | 26
increased blood urea nitrogen ... 1 | 48
increased blood uric acid leve... 1 | 5
increased bone mineral density 1 | 72
increased circulating creatini... 1 | 38
increased circulating iron lev... 1 | 30
increased mean corpuscular vol... 1 | 92
increased red blood cell distr... 1 | 34
long tibia 1 | 25
small superior vagus ganglion 1 | 74
thin ventricular wall 1 | 24

Disease

ovarian cancer 257 | 8,520
osteosarcoma 182 | 7,950
Carcinoma 167 | 11,493
lung cancer 121 | 4,740
psoriasis 121 | 6,694
medulloblastoma, large-cell 119 | 6,241
pancreatic ductal adenocarcinoma liver metastasis 111 | 1,962
glioblastoma 102 | 5,792
Multiple myeloma 100 | 1,332
atypical teratoid / rhabdoid tumor 96 | 5,112
ependymoma 84 | 4,679
Autosomal recessive predisposition 80 | 1,442
intraductal papillary-mucinous neoplasm (IPMN) 75 | 3,291
astrocytic glioma 70 | 2,597
Breast cancer 69 | 3,578
adult high grade glioma 66 | 3,801
group 3 medulloblastoma 57 | 4,104
Cerebellar Ataxia 53 | 304
Epilepsy 53 | 792
malignant mesothelioma 53 | 3,232
oligodendroglioma 53 | 2,850
Diabetes mellitus type 2 51 | 69
invasive ductal carcinoma 51 | 2,951
Leigh disease 50 | 100
Treatment Refractory Type 2 Diabetes Mellitus 50 | 53
non-small cell lung cancer 50 | 2,890
Muscle hypotonia 49 | 571
Cognitive delay 48 | 608
Global developmental delay 48 | 608
Mental and motor retardation 48 | 608
intraductal papillary-mucinous carcinoma (IPMC) 48 | 2,989
diabetes mellitus 47 | 1,728
intraductal papillary-mucinous adenoma (IPMA) 46 | 2,955
Pick disease 45 | 1,894
lung adenocarcinoma 45 | 2,716
Acidosis, Lactic 44 | 97
Lactic acidemia 44 | 95
Seizures 44 | 596
Failure to gain weight 43 | 365
Pediatric failure to thrive 43 | 365
non primary Sjogren syndrome sicca 43 | 891
group 4 medulloblastoma 42 | 1,855
Mitochondrial complex I deficiency 39 | 46
Optic Atrophy 39 | 242
Astrocytoma, Pilocytic 38 | 3,081
Cancer 38 | 2,499
Nystagmus 38 | 317
Blepharoptosis 37 | 231
primitive neuroectodermal tumor 37 | 3,035
subependymal giant cell astrocytoma 37 | 2,287
Dystonia 36 | 164
Waldenstrons macroglobulinemia 36 | 765
breast carcinoma 36 | 1,638
Hyperreflexia 35 | 209
Sensorineural Hearing Loss (disorder) 35 | 284
Muscle Weakness 34 | 170
acute myeloid leukemia 34 | 783
tuberculosis 34 | 2,010
Hypertrophic Cardiomyopathy 33 | 117
Intellectual disability 33 | 1,016
lung carcinoma 33 | 2,843
Increased serum lactate 32 | 60
Highly variable clinical phenotype 31 | 150
Highly variable phenotype and severity 31 | 150
Highly variable phenotype, even within families 31 | 150
Muscle Spasticity 31 | 195
Phenotypic variability 31 | 150
Schizophrenia 31 | 1,160
pancreatic cancer 31 | 2,398
Dull intelligence 30 | 645
Low intelligence 30 | 645
Mental Retardation 30 | 645
Mental deficiency 30 | 645
Poor school performance 30 | 645
Dystonic disease 29 | 106
Strabismus 29 | 270
Hypoglycemia 28 | 152
ulcerative colitis 28 | 1,819
Myopathy 27 | 185
Respiratory Failure 27 | 104
Mitochondrial Complex 1 Deficiency 26 | 28
astrocytoma 26 | 1,146
Babinski Reflex 25 | 100
CSF lactate increased 25 | 33
Leigh syndrome 25 | 28
Rheumatoid arthritis 25 | 1,191
Vomiting 25 | 116
Alzheimer's disease 24 | 658
Developmental regression 24 | 95
Loss of developmental milestones 24 | 95
Mental deterioration in childhood 24 | 95
Neurodegenerative disease 24 | 414
Neurodevelopmental regression 24 | 95
Neuropathy 24 | 261
Psychomotor regression 24 | 95
Psychomotor regression beginning in infancy 24 | 95
Psychomotor regression in infants 24 | 95
Psychomotor regression, progressive 24 | 95
Obesity 23 | 678
pituitary cancer 23 | 1,972

Tissue

Endocrine System 466 | 18,159
Digestive Tract 464 | 17,369
Liver and Pancreas 460 | 16,750
Male tissues 460 | 17,142
Female tissues 459 | 17,400
Skin and soft tissues 459 | 17,230
Urinary Tract 459 | 16,678
Blood and immune system 457 | 16,909
Nervous System 456 | 16,725
Respiratory system 454 | 16,393
Cardiovascular System 451 | 15,192

Target Family

Enzyme 214 | 4,145
Non-IDG 192 | 12,091
Transporter 53 | 473
Kinase 9 | 634
GPCR 2 | 408
Ion Channel 1 | 344
Transcription Factor 1 | 1,400

Compartment GO Term

Mitochondrial inner membrane 472 | 472
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,109 | 14,109
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,975 | 8,975
Intracellular organelle part 8,783 | 8,783
Membrane 8,531 | 8,531
Nucleus 7,562 | 7,562
Cytosol 6,686 | 6,686
Membrane part 6,554 | 6,554
Plasma membrane 5,830 | 5,830
Macromolecular complex 5,475 | 5,475
Intrinsic component of membran... 5,458 | 5,458
Cell periphery 5,382 | 5,382
Integral component of membrane 5,331 | 5,331
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,975 | 3,975
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,674 | 3,674
Organelle membrane 2,846 | 2,846
Extracellular region 2,732 | 2,732
Plasma membrane part 2,594 | 2,594
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,217 | 2,217
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,637 | 1,637
Extracellular region part 1,628 | 1,628
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 967 | 967
Supramolecular complex 966 | 966
Cell junction 960 | 960
Supramolecular fiber 959 | 959
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 930 | 930
Nucleolus 926 | 926
Chromosomal part 889 | 889
GO:0098796 884 | 884
Ribonucleoprotein complex 865 | 865
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 850 | 850
Transferase complex 849 | 849
Cell surface 842 | 842
Plasma membrane region 841 | 841
Vesicle membrane 801 | 801
Cytoplasmic vesicle membrane 795 | 795
Polymeric cytoskeletal fiber 764 | 764
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 714 | 714
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 663 | 663
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

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