Development Level

Tbio 243 | 10,625
Tdark 122 | 7,003
Tclin 60 | 602
Tchem 34 | 1,890

Collection

Eligible Kinase Proteins 1 | 134

IMPC Term

preweaning lethality, complete... 37 | 633
embryonic lethality prior to o... 19 | 148
embryonic lethality prior to t... 13 | 187
abnormal behavior 8 | 226
abnormal embryo size 7 | 112
decreased body weight 6 | 174
prenatal lethality prior to he... 6 | 64
decreased bone mineral content 5 | 157
embryonic growth retardation 5 | 28
preweaning lethality, incomple... 5 | 260
abnormal lens morphology 4 | 73
decreased circulating glucose ... 4 | 121
decreased total body fat amoun... 4 | 186
increased circulating phosphat... 4 | 24
increased circulating sodium l... 4 | 71
increased fasted circulating g... 4 | 68
increased heart weight 4 | 37
abnormal bone structure 3 | 131
abnormal neural tube closure 3 | 37
abnormal retina morphology 3 | 100
decreased circulating choleste... 3 | 85
decreased grip strength 3 | 123
decreased lean body mass 3 | 195
decreased leukocyte cell numbe... 3 | 54
decreased mean platelet volume 3 | 12
hypoactivity 3 | 89
increased lean body mass 3 | 107
pallor 3 | 13
abnormal embryo turning 2 | 15
abnormal heart morphology 2 | 51
abnormal limb bud morphology 2 | 15
abnormal skin coloration 2 | 18
abnormal skin morphology 2 | 23
abnormal tail bud morphology 2 | 6
decreased caudal vertebrae num... 2 | 49
decreased circulating HDL chol... 2 | 77
decreased circulating LDL chol... 2 | 37
decreased circulating alkaline... 2 | 41
decreased circulating chloride... 2 | 32
decreased circulating serum al... 2 | 79
decreased circulating total pr... 2 | 41
decreased circulating triglyce... 2 | 83
decreased eosinophil cell numb... 2 | 41
decreased red blood cell distr... 2 | 11
decreased rib number 2 | 59
decreased startle reflex 2 | 48
decreased total retina thickne... 2 | 20
enlarged heart 2 | 111
hyperactivity 2 | 108
immune system phenotype 2 | 17
increased blood urea nitrogen ... 2 | 44
increased circulating alkaline... 2 | 119
increased circulating chloride... 2 | 43
increased exploration in new e... 2 | 56
increased grip strength 2 | 83
increased leukocyte cell numbe... 2 | 37
increased mean corpuscular vol... 2 | 91
increased startle reflex 2 | 38
persistence of hyaloid vascula... 2 | 22
prenatal lethality 2 | 16
abnormal QRS complex 1 | 25
abnormal coat appearance 1 | 25
abnormal cranium morphology 1 | 32
abnormal kidney morphology 1 | 30
abnormal neural tube morpholog... 1 | 8
abnormal placenta morphology 1 | 4
abnormal retinal blood vessel ... 1 | 18
abnormal skin appearance 1 | 8
abnormal snout morphology 1 | 18
abnormal tail movements 1 | 12
abnormal tooth morphology 1 | 24
abnormal vocalization 1 | 21
absent pinna reflex 1 | 21
absent vibrissae 1 | 14
decreased CD11b-low dendritic ... 1 | 3
decreased blood urea nitrogen ... 1 | 31
decreased body length 1 | 108
decreased circulating creatini... 1 | 31
decreased circulating phosphat... 1 | 15
decreased circulating sodium l... 1 | 18
decreased effector memory CD8-... 1 | 24
decreased follicular B cell nu... 1 | 4
decreased heart weight 1 | 44
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular vol... 1 | 50
decreased monocyte cell number 1 | 28
enlarged heart atrium 1 | 2
enlarged lymph nodes 1 | 27
female infertility 1 | 34
impaired righting response 1 | 19
increased CD4-positive, CD25-p... 1 | 18
increased CD5-positive Ly6C-po... 1 | 4
increased blood uric acid leve... 1 | 5
increased circulating creatini... 1 | 29
increased circulating glucose ... 1 | 16
increased circulating iron lev... 1 | 25
increased granulocyte number 1 | 8
increased mean platelet volume 1 | 19
increased sacral vertebrae num... 1 | 62
thrombocytopenia 1 | 46

Disease

ovarian cancer 247 | 8,492
osteosarcoma 177 | 7,933
psoriasis 120 | 6,685
lung cancer 116 | 4,473
medulloblastoma, large-cell 114 | 6,234
pancreatic ductal adenocarcinoma liver metastasis 103 | 1,795
glioblastoma 99 | 5,572
Multiple myeloma 94 | 1,328
atypical teratoid / rhabdoid tumor 83 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 74 | 3,289
Breast cancer 66 | 3,099
astrocytic glioma 65 | 2,241
ependymoma 61 | 2,514
oligodendroglioma 54 | 2,849
Diabetes mellitus type 2 51 | 69
malignant mesothelioma 51 | 3,163
pediatric high grade glioma 51 | 2,712
Treatment Refractory Type 2 Diabetes Mellitus 50 | 53
intraductal papillary-mucinous carcinoma (IPMC) 49 | 2,988
invasive ductal carcinoma 48 | 2,950
intraductal papillary-mucinous adenoma (IPMA) 46 | 2,956
non-small cell lung cancer 46 | 2,798
Pick disease 45 | 1,893
lung adenocarcinoma 45 | 2,714
Leigh disease 43 | 81
non primary Sjogren syndrome sicca 40 | 840
diabetes mellitus 39 | 1,663
pilocytic astrocytoma 39 | 3,086
medulloblastoma 38 | 1,524
subependymal giant cell astrocytoma 38 | 2,287
primitive neuroectodermal tumor 37 | 3,031
Cancer 35 | 2,346
Waldenstrons macroglobulinemia 34 | 765
acute myeloid leukemia 34 | 785
adult high grade glioma 34 | 2,148
lung carcinoma 34 | 2,844
pancreatic cancer 33 | 2,300
Mitochondrial complex I deficiency 32 | 37
breast carcinoma 32 | 1,614
group 3 medulloblastoma 32 | 2,254
ulcerative colitis 30 | 2,087
astrocytoma 29 | 1,493
Leigh syndrome 27 | 34
Mitochondrial Complex 1 Deficiency 26 | 28
group 4 medulloblastoma 26 | 1,875
tuberculosis 26 | 1,563
colon cancer 23 | 1,475
pituitary cancer 23 | 1,972
Neurodegenerative disease 22 | 383
Rheumatoid Arthritis 22 | 1,171
cystic fibrosis 22 | 1,670
sonic hedgehog group medulloblastoma 22 | 1,482
Alzheimer's disease 21 | 644
ductal carcinoma in situ 21 | 1,745
adrenocortical carcinoma 20 | 1,427
posterior fossa group A ependymoma 20 | 1,511
NADH:Q(1) Oxidoreductase deficiency 19 | 20
acute quadriplegic myopathy 19 | 1,157
hereditary spastic paraplegia 19 | 313
Obesity 18 | 616
posterior fossa group B ependymoma 18 | 1,530
atypical teratoid/rhabdoid tumor 17 | 1,095
interstitial cystitis 17 | 2,299
Mammary Neoplasms 16 | 410
Myopathy 16 | 128
aldosterone-producing adenoma 16 | 664
nasopharyngeal carcinoma 16 | 1,056
Kidney disease 15 | 397
Leber hereditary optic neuropathy 15 | 17
Schizophrenia 15 | 503
primary pancreatic ductal adenocarcinoma 15 | 1,271
tuberculosis and treatment for 6 months 15 | 686
Anemia 14 | 252
Neuropathy 14 | 210
Parkinson's disease 14 | 364
dermatomyositis 14 | 967
Cardiomyopathy 13 | 110
Down syndrome 13 | 548
Heart disease 13 | 279
LEIGH SYNDROME DUE TO MITOCHONDRIAL COMPLEX I DEFICIENCY 13 | 14
juvenile dermatomyositis 13 | 1,189
3-methylglutaconic aciduria 12 | 29
Cerebrovascular disease 12 | 231
Lactic acidosis 12 | 43
Mitochondrial myopathy 12 | 24
Multiple acyl-CoA dehydrogenase deficiency 12 | 26
Polycystic Ovary Syndrome 12 | 335
Stomach Neoplasms 12 | 282
Dystonia 11 | 77
Epilepsy 11 | 346
Multiple Sclerosis 11 | 498
hepatocellular carcinoma 11 | 550
Duchenne muscular dystrophy 10 | 602
Hypertension 10 | 293
Optic atrophy 10 | 43
cutaneous lupus erythematosus 10 | 1,056
inflammatory breast cancer 10 | 404
pancreatic carcinoma 10 | 567
progressive supranuclear palsy 10 | 674
spina bifida 10 | 1,064

Tissue

Blood and immune system 457 | 17,995
Cardiovascular System 456 | 17,958
Digestive Tract 456 | 18,473
Endocrine System 456 | 18,512
Female tissues 456 | 18,647
Male tissues 456 | 17,969
Nervous System 456 | 18,561
Urinary Tract 456 | 18,444
Liver and Pancreas 455 | 18,136
Respiratory system 453 | 17,484
Skin and soft tissues 451 | 18,115

Target Family

Enzyme 209 | 4,146
Non-IDG 184 | 11,969
Transporter 54 | 473
Kinase 9 | 634
GPCR 1 | 408
Ion Channel 1 | 341
Transcription Factor 1 | 1,400

Compartment GO Term

Mitochondrial inner membrane 459 | 459
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,612 | 13,612
Intracellular part 13,475 | 13,475
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,353 | 10,353
Membrane 8,871 | 8,871
Organelle part 8,169 | 8,169
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,831 | 7,831
Nucleus 7,577 | 7,577
Membrane part 6,469 | 6,469
Cytosol 6,034 | 6,034
Plasma membrane 5,673 | 5,673
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,171 | 5,171
Cell periphery 5,146 | 5,146
Nucleoplasm 4,930 | 4,930
Extracellular region 4,607 | 4,607
Protein complex 4,439 | 4,439
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,874 | 3,874
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,592 | 2,592
Plasma membrane part 2,564 | 2,564
Cytoskeleton 2,046 | 2,046
Golgi apparatus 1,946 | 1,946
Endoplasmic reticulum 1,872 | 1,872
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Vesicles 1,625 | 1,625
Cytoskeletal part 1,568 | 1,568
Mitochondrion 1,530 | 1,530
Cell projection 1,425 | 1,425
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,234 | 1,234
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,092 | 1,092
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,084 | 1,084
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Mitochondria 1,003 | 1,003
Chromosome 999 | 999
Mitochondrial part 988 | 988
Nucleoli 950 | 950
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 815 | 815
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 781 | 781
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 739 | 739
Plasma membrane protein comple... 721 | 721
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Microtubule organizing center 680 | 680
Centrosome 676 | 676
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 656 | 656
Extracellular matrix 633 | 633
Synapse 594 | 594
Lytic vacuole 571 | 571

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitochondrial coenzyme A transporter SLC25A42 SLC25A42 Tbio Transporter -0.38872 3.06 24
Solute carrier family 25 member 33 SLC25A33 Tbio Transporter -0.28165 1.49 35
ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 Tbio Transporter -0.85002 7.01 82
Ubiquitin-associated domain-containing protein 1 UBAC1 Tbio Non-IDG -2.56341 358.4 116
Ubiquinol-cytochrome-c reductase complex assembly factor 2 UQCC2 Tbio Enzyme -1.50813 29.9 15
Mitochondrial uncoupling protein 3 UCP3 Tbio Non-IDG -2.72649 574.1 155
MICOS complex subunit MIC25 CHCHD6 Tbio Non-IDG -1.52785 31.8 140
Cardiolipin synthase (CMP-forming) CRLS1 Tbio Enzyme -0.80844 6.24 93
Cytochrome b-c1 complex subunit 1, mitochondrial UQCRC1 Tbio Enzyme -1.42607 27.2 143
Putative peripheral benzodiazepine receptor-related protein TSPO Tbio Non-IDG -3.04986 2078.3 186