Development Level

Tbio 457 | 11,651
Tdark 137 | 6,593
Tchem 78 | 1,388
Tclin 74 | 612

Collection

Kinase: IDG Consortium (Target... 2 | 125
RFA-RM-18-021 2 | 328

IMPC Phenotype

preweaning lethality, complete... 75 | 979
embryonic lethality prior to o... 24 | 239
embryonic lethality prior to t... 22 | 278
abnormal behavior 16 | 298
preweaning lethality, incomple... 14 | 499
abnormal embryo size 12 | 220
decreased total body fat amoun... 11 | 207
decreased vertical activity 11 | 208
increased lean body mass 11 | 172
decreased body weight 10 | 161
decreased bone mineral content 10 | 151
embryonic growth retardation 10 | 106
hyperactivity 10 | 148
increased total body fat amoun... 10 | 134
abnormal bone structure 8 | 187
decreased lean body mass 8 | 135
enlarged heart 8 | 210
abnormal lens morphology 7 | 81
cataract 7 | 92
hypoactivity 7 | 132
prenatal lethality prior to he... 7 | 87
decreased circulating glucose ... 6 | 126
decreased mean corpuscular vol... 6 | 79
pallor 6 | 34
abnormal heart morphology 5 | 162
abnormal neural tube closure 5 | 46
decreased body length 5 | 101
decreased circulating LDL chol... 5 | 38
increased circulating phosphat... 5 | 26
increased circulating sodium l... 5 | 71
increased heart weight 5 | 62
increased mean corpuscular hem... 5 | 96
increased startle reflex 5 | 112
abnormal skin morphology 4 | 50
abnormal sleep behavior 4 | 70
decreased circulating HDL chol... 4 | 68
decreased circulating choleste... 4 | 93
decreased circulating phosphat... 4 | 27
decreased circulating serum al... 4 | 82
decreased circulating total pr... 4 | 49
decreased total retina thickne... 4 | 17
increased circulating HDL chol... 4 | 80
small superior vagus ganglion 4 | 74
thrombocytopenia 4 | 56
abnormal coat-hair pigmentatio... 3 | 64
abnormal cranium morphology 3 | 36
abnormal embryo turning 3 | 31
abnormal gait 3 | 69
abnormal midbrain development 3 | 20
abnormal seminal vesicle morph... 3 | 114
decreased bone mineral density 3 | 126
decreased circulating aspartat... 3 | 34
decreased circulating chloride... 3 | 30
decreased circulating creatini... 3 | 39
decreased grip strength 3 | 116
decreased heart weight 3 | 27
decreased hematocrit 3 | 46
decreased mean corpuscular hem... 3 | 50
decreased red blood cell distr... 3 | 41
decreased startle reflex 3 | 75
improved glucose tolerance 3 | 79
increased bone mineral content 3 | 108
increased circulating alkaline... 3 | 122
increased circulating bilirubi... 3 | 16
increased circulating calcium ... 3 | 34
increased circulating choleste... 3 | 66
increased fasted circulating g... 3 | 76
increased mean corpuscular vol... 3 | 92
increased prepulse inhibition 3 | 32
increased red blood cell distr... 3 | 34
pale yolk sac 3 | 25
persistence of hyaloid vascula... 3 | 33
short tibia 3 | 97
abnormal heart left ventricle ... 2 | 16
abnormal limb bud morphology 2 | 17
abnormal lung morphology 2 | 26
abnormal neural tube morpholog... 2 | 12
abnormal placenta size 2 | 20
abnormal skin coloration 2 | 25
abnormal spleen morphology 2 | 55
abnormal tooth morphology 2 | 24
abnormal vertebrae morphology 2 | 18
abnormal vocalization 2 | 21
decreased circulating insulin ... 2 | 76
decreased circulating iron lev... 2 | 32
decreased circulating potassiu... 2 | 20
decreased circulating triglyce... 2 | 79
decreased erythrocyte cell num... 2 | 62
decreased food intake 2 | 13
decreased hemoglobin content 2 | 68
decreased prepulse inhibition 2 | 82
enlarged spleen 2 | 41
impaired righting response 2 | 26
increased anti-nuclear antigen... 2 | 19
increased hemoglobin content 2 | 45
increased monocyte cell number 2 | 63
increased or absent threshold ... 2 | 101
male infertility 2 | 123
prenatal lethality 2 | 28
small testis 2 | 58

Disease

ovarian cancer 403 | 8,520
osteosarcoma 313 | 7,950
Carcinoma 309 | 11,493
lung cancer 231 | 4,740
medulloblastoma, large-cell 222 | 6,241
psoriasis 222 | 6,694
glioblastoma 202 | 5,792
atypical teratoid / rhabdoid tumor 177 | 5,112
ependymoma 163 | 4,679
pancreatic ductal adenocarcinoma liver metastasis 158 | 1,962
Multiple myeloma 134 | 1,332
adult high grade glioma 130 | 3,801
Breast cancer 127 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 127 | 3,291
Cancer 124 | 2,499
malignant mesothelioma 116 | 3,232
astrocytic glioma 114 | 2,597
group 3 medulloblastoma 114 | 4,104
Autosomal recessive predisposition 110 | 1,442
invasive ductal carcinoma 105 | 2,951
non-small cell lung cancer 103 | 2,890
diabetes mellitus 98 | 1,728
oligodendroglioma 96 | 2,850
lung adenocarcinoma 94 | 2,716
intraductal papillary-mucinous carcinoma (IPMC) 92 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 86 | 2,955
Astrocytoma, Pilocytic 83 | 3,081
primitive neuroectodermal tumor 82 | 3,035
lung carcinoma 80 | 2,843
tuberculosis 79 | 2,010
group 4 medulloblastoma 78 | 1,855
Schizophrenia 75 | 1,160
Pick disease 72 | 1,894
pancreatic cancer 69 | 2,398
ulcerative colitis 69 | 1,819
Epilepsy 68 | 792
breast carcinoma 65 | 1,638
Obesity 64 | 678
subependymal giant cell astrocytoma 64 | 2,287
Alzheimer's disease 63 | 658
non primary Sjogren syndrome sicca 62 | 891
Muscle hypotonia 61 | 571
Seizures 61 | 596
Cognitive delay 59 | 608
Global developmental delay 59 | 608
Mental and motor retardation 59 | 608
ductal carcinoma in situ 59 | 1,745
Cerebellar Ataxia 58 | 304
Neurodegenerative disease 55 | 414
acute myeloid leukemia 55 | 783
Leigh disease 54 | 100
Waldenstrons macroglobulinemia 54 | 765
Rheumatoid arthritis 53 | 1,191
Diabetes mellitus type 2 52 | 69
Intellectual disability 52 | 1,016
Optic Atrophy 52 | 242
Treatment Refractory Type 2 Diabetes Mellitus 51 | 53
pituitary cancer 51 | 1,972
Parkinson's disease 50 | 392
astrocytoma 50 | 1,146
colon cancer 49 | 1,478
Failure to gain weight 48 | 365
Pediatric failure to thrive 48 | 365
cystic fibrosis 48 | 1,696
adrenocortical carcinoma 47 | 1,428
Acidosis, Lactic 46 | 97
Dystonia 46 | 164
Lactic acidemia 46 | 95
Toxic encephalopathy 46 | 141
interstitial cystitis 46 | 2,312
Blepharoptosis 45 | 231
Breast Neoplasms 43 | 445
Mammary Neoplasms 43 | 425
dermatomyositis 43 | 966
Dull intelligence 40 | 645
Hyperreflexia 40 | 209
Low intelligence 40 | 645
Mental Retardation 40 | 645
Mental deficiency 40 | 645
Nystagmus 40 | 317
Poor school performance 40 | 645
acute quadriplegic myopathy 40 | 1,158
Bipolar Disorder 39 | 666
Liver Cirrhosis, Experimental 39 | 769
Mitochondrial complex I deficiency 39 | 46
Muscle Weakness 38 | 170
Neuropathy 38 | 261
Sensorineural Hearing Loss (disorder) 38 | 284
Vascular disease 38 | 319
aldosterone-producing adenoma 38 | 665
Anemia 37 | 365
Hypertrophic Cardiomyopathy 36 | 117
Stomach Neoplasms 36 | 300
pediatric high grade glioma 36 | 1,064
Kidney disease 35 | 430
Depressive disorder 34 | 409
Heart failure 34 | 162
Increased serum lactate 34 | 60
Kidney cancer 34 | 2,613
juvenile dermatomyositis 33 | 1,187

Tissue

Endocrine System 735 | 18,159
Digestive Tract 729 | 17,369
Male tissues 725 | 17,142
Female tissues 724 | 17,400
Skin and soft tissues 724 | 17,230
Blood and immune system 723 | 16,909
Liver and Pancreas 722 | 16,750
Nervous System 721 | 16,725
Urinary Tract 720 | 16,678
Respiratory system 713 | 16,393
Cardiovascular System 709 | 15,192

Target Family

Non-IDG 341 | 12,091
Enzyme 295 | 4,145
Transporter 63 | 473
Kinase 28 | 634
Transcription Factor 8 | 1,400
Epigenetic 5 | 242
GPCR 3 | 408
Nuclear Receptor 2 | 48
Ion Channel 1 | 344

Compartment GO Term

Mitochondrial envelope 746 | 746
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,783 | 8,783
Membrane 8,530 | 8,530
Nucleus 7,563 | 7,563
Cytosol 6,686 | 6,686
Membrane part 6,553 | 6,553
Plasma membrane 5,829 | 5,829
Macromolecular complex 5,476 | 5,476
Intrinsic component of membran... 5,457 | 5,457
Cell periphery 5,381 | 5,381
Integral component of membrane 5,330 | 5,330
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,974 | 3,974
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,673 | 3,673
Organelle membrane 2,846 | 2,846
Extracellular region 2,731 | 2,731
Plasma membrane part 2,593 | 2,593
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,216 | 2,216
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,638 | 1,638
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 968 | 968
Supramolecular complex 967 | 967
Cell junction 960 | 960
Supramolecular fiber 960 | 960
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 931 | 931
Nucleolus 927 | 927
Chromosomal part 889 | 889
GO:0098796 883 | 883
Ribonucleoprotein complex 864 | 864
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 849 | 849
Transferase complex 849 | 849
Cell surface 841 | 841
Plasma membrane region 841 | 841
Vesicle membrane 800 | 800
Cytoplasmic vesicle membrane 794 | 794
Polymeric cytoskeletal fiber 765 | 765
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 713 | 713
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Calcium uptake protein 3, mitochondrial MICU3 Tdark Non-IDG -0.21085 1.14 50
UbiA prenyltransferase domain-containing protein 1 UBIAD1 Tbio Enzyme -1.59893 42.5 50
28S ribosomal protein S14, mitochondrial MRPS14 Tdark Non-IDG 0.30 0.11 22
39S ribosomal protein L40, mitochondrial MRPL40 Tbio Non-IDG -0.92179 8.33 105
Transmembrane protein 11, mitochondrial TMEM11 Tdark Non-IDG -2.44072 252.5 35
Inactive caspase-12 CASP12 Tbio Enzyme -2.64252 415.1 429
Hydroxyproline dehydrogenase PRODH2 Tbio Enzyme -0.72861 5.94 76
Cytochrome b-c1 complex subunit 6-like, mitochondrial UQCRHL Tdark Non-IDG -0.84371 11.5 0
Glycerol kinase 3 GK3P Tdark Kinase -1.84692 109.0 0