Development Level

Tbio 632 | 11,445
Tdark 258 | 6,588
Tchem 60 | 1,598
Tclin 48 | 613

Collection

RFA-RM-18-021 8 | 328
Kinase: IDG Consortium (Target... 5 | 125
Ion Channel: IDG Consortium (T... 2 | 99
GPCR: IDG Consortium (Targets) 1 | 126
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 97 | 979
embryonic lethality prior to o... 26 | 239
preweaning lethality, incomple... 24 | 499
embryonic lethality prior to t... 22 | 278
abnormal behavior 18 | 298
decreased circulating glucose ... 15 | 126
decreased total body fat amoun... 15 | 207
enlarged heart 15 | 210
abnormal bone structure 14 | 187
abnormal embryo size 14 | 220
increased lean body mass 13 | 172
abnormal heart morphology 11 | 162
cataract 10 | 92
prenatal lethality prior to he... 10 | 87
decreased bone mineral density 9 | 126
decreased vertical activity 9 | 208
embryonic growth retardation 9 | 106
hyperactivity 9 | 148
increased circulating alkaline... 9 | 122
increased circulating choleste... 9 | 66
abnormal seminal vesicle morph... 8 | 114
decreased bone mineral content 8 | 151
decreased circulating total pr... 8 | 49
decreased prepulse inhibition 8 | 82
hypoactivity 8 | 132
increased bone mineral content 8 | 108
increased mean corpuscular vol... 8 | 92
increased total body fat amoun... 8 | 134
small superior vagus ganglion 8 | 74
abnormal lens morphology 7 | 81
decreased body weight 7 | 161
decreased circulating choleste... 7 | 93
decreased circulating serum al... 7 | 82
decreased lean body mass 7 | 135
increased circulating HDL chol... 7 | 80
increased mean corpuscular hem... 7 | 96
short tibia 7 | 97
decreased body length 6 | 101
decreased caudal vertebrae num... 6 | 53
decreased circulating HDL chol... 6 | 68
decreased erythrocyte cell num... 6 | 62
decreased startle reflex 6 | 75
hydrometra 6 | 53
improved glucose tolerance 6 | 79
increased circulating calcium ... 6 | 34
increased startle reflex 6 | 112
thrombocytopenia 6 | 56
abnormal heart left ventricle ... 5 | 16
abnormal tibia morphology 5 | 14
decreased circulating alkaline... 5 | 46
decreased circulating insulin ... 5 | 76
decreased circulating triglyce... 5 | 79
decreased grip strength 5 | 116
decreased lymphocyte cell numb... 5 | 83
decreased red blood cell distr... 5 | 41
decreased total retina thickne... 5 | 17
increased circulating creatini... 5 | 38
increased heart weight 5 | 62
increased leukocyte cell numbe... 5 | 47
increased monocyte cell number 5 | 63
pallor 5 | 34
small testis 5 | 58
abnormal cranium morphology 4 | 36
abnormal gait 4 | 69
abnormal neural tube closure 4 | 46
abnormal skin morphology 4 | 50
abnormal vertebrae morphology 4 | 18
cardiovascular system phenotyp... 4 | 36
increased blood urea nitrogen ... 4 | 48
increased bone mineral density 4 | 72
increased circulating sodium l... 4 | 71
increased erythrocyte cell num... 4 | 39
increased or absent threshold ... 4 | 101
persistence of hyaloid vascula... 4 | 33
abnormal behavioral response t... 3 | 66
abnormal epididymis morphology 3 | 42
abnormal eye morphology 3 | 68
abnormal locomotor behavior 3 | 24
abnormal retina morphology 3 | 71
abnormal sleep behavior 3 | 70
abnormal spleen morphology 3 | 55
abnormal tail movements 3 | 12
absent startle reflex 3 | 24
decreased circulating fructosa... 3 | 30
decreased circulating sodium l... 3 | 22
decreased fasted circulating g... 3 | 65
decreased food intake 3 | 13
decreased hemoglobin content 3 | 68
decreased lactate dehydrogenas... 3 | 16
increased circulating bilirubi... 3 | 16
increased circulating chloride... 3 | 41
increased circulating iron lev... 3 | 30
increased circulating potassiu... 3 | 29
increased circulating serum al... 3 | 22
increased hematocrit 3 | 46
increased hemoglobin content 3 | 45
increased prepulse inhibition 3 | 32
increased red blood cell distr... 3 | 34
male infertility 3 | 123
prenatal lethality 3 | 28

Disease

ovarian cancer 564 | 8,520
Carcinoma 514 | 11,493
osteosarcoma 459 | 7,950
medulloblastoma, large-cell 323 | 6,241
psoriasis 321 | 6,694
lung cancer 297 | 4,740
glioblastoma 283 | 5,792
atypical teratoid / rhabdoid tumor 258 | 5,112
ependymoma 226 | 4,679
group 3 medulloblastoma 216 | 4,104
pancreatic ductal adenocarcinoma liver metastasis 193 | 1,962
adult high grade glioma 181 | 3,801
Breast cancer 171 | 3,578
malignant mesothelioma 170 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 166 | 3,291
astrocytic glioma 165 | 2,597
oligodendroglioma 162 | 2,850
non-small cell lung cancer 155 | 2,890
primitive neuroectodermal tumor 145 | 3,035
intraductal papillary-mucinous adenoma (IPMA) 143 | 2,955
Multiple myeloma 142 | 1,332
invasive ductal carcinoma 139 | 2,951
Autosomal recessive predisposition 132 | 1,442
intraductal papillary-mucinous carcinoma (IPMC) 132 | 2,989
Astrocytoma, Pilocytic 128 | 3,081
lung adenocarcinoma 127 | 2,716
subependymal giant cell astrocytoma 122 | 2,287
lung carcinoma 116 | 2,843
Pick disease 110 | 1,894
tuberculosis 107 | 2,010
ulcerative colitis 103 | 1,819
interstitial cystitis 100 | 2,312
pancreatic cancer 96 | 2,398
Kidney cancer 91 | 2,613
pituitary cancer 90 | 1,972
group 4 medulloblastoma 88 | 1,855
cystic fibrosis 85 | 1,696
Muscle hypotonia 84 | 571
ductal carcinoma in situ 81 | 1,745
Cancer 80 | 2,499
Epilepsy 77 | 792
breast carcinoma 77 | 1,638
Cognitive delay 75 | 608
Global developmental delay 75 | 608
Mental and motor retardation 75 | 608
colon cancer 73 | 1,478
non primary Sjogren syndrome sicca 70 | 891
adrenocortical carcinoma 67 | 1,428
Seizures 66 | 596
Waldenstrons macroglobulinemia 65 | 765
Intellectual disability 61 | 1,016
diabetes mellitus 61 | 1,728
acute myeloid leukemia 59 | 783
Leigh disease 56 | 100
acute quadriplegic myopathy 55 | 1,158
Rheumatoid arthritis 53 | 1,191
juvenile dermatomyositis 53 | 1,187
Schizophrenia 52 | 1,160
Cerebellar Ataxia 51 | 304
Dull intelligence 51 | 645
Low intelligence 51 | 645
Mental Retardation 51 | 645
Mental deficiency 51 | 645
Poor school performance 51 | 645
medulloblastoma 51 | 720
Acidosis, Lactic 50 | 97
astrocytoma 50 | 1,146
nasopharyngeal carcinoma 50 | 1,058
Failure to gain weight 49 | 365
Lactic acidemia 49 | 95
Pediatric failure to thrive 49 | 365
active Crohn's disease 49 | 922
pediatric high grade glioma 46 | 1,064
aldosterone-producing adenoma 45 | 665
cutaneous lupus erythematosus 45 | 1,057
spina bifida 45 | 1,074
Obesity 44 | 678
dermatomyositis 44 | 966
active ulcerative colitis 43 | 764
primary pancreatic ductal adenocarcinoma 43 | 1,109
Atopic dermatitis 41 | 952
Nystagmus 41 | 317
Alzheimer's disease 39 | 658
Optic Atrophy 38 | 242
Hypoglycemia 37 | 152
Liver Cirrhosis, Experimental 36 | 769
primary Sjogren syndrome 34 | 735
Blepharoptosis 33 | 231
Increased serum lactate 33 | 60
progressive supranuclear palsy 33 | 676
Dystonia 32 | 164
Hypertrophic Cardiomyopathy 32 | 117
Small head 32 | 374
esophageal adenocarcinoma 32 | 737
gastric carcinoma 32 | 807
Infantile onset 31 | 238
Hyperreflexia 30 | 209
Lethargy 30 | 77
Neurodegenerative disease 30 | 414
Sensorineural Hearing Loss (disorder) 30 | 284

Tissue

Endocrine System 993 | 18,159
Female tissues 991 | 17,400
Digestive Tract 988 | 17,369
Skin and soft tissues 987 | 17,230
Male tissues 986 | 17,142
Liver and Pancreas 982 | 16,750
Nervous System 982 | 16,725
Urinary Tract 982 | 16,678
Blood and immune system 981 | 16,909
Respiratory system 975 | 16,393
Cardiovascular System 955 | 15,192

Target Family

Non-IDG 454 | 12,091
Enzyme 402 | 4,145
Transcription Factor 48 | 1,400
Transporter 38 | 473
Kinase 28 | 634
Epigenetic 15 | 242
Ion Channel 6 | 344
GPCR 3 | 408
Nuclear Receptor 2 | 48
TF/Epigenetic 2 | 38

Compartment GO Term

Mitochondria 998 | 998
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,109 | 14,109
Intracellular part 13,972 | 13,972
Organelle 12,237 | 12,237
Intracellular organelle 12,023 | 12,023
membrane-bounded organelle 11,130 | 11,130
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,340 | 10,340
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,784 | 8,784
Membrane 8,531 | 8,531
Nucleus 7,561 | 7,561
Cytosol 6,686 | 6,686
Membrane part 6,554 | 6,554
Plasma membrane 5,830 | 5,830
Macromolecular complex 5,476 | 5,476
Intrinsic component of membran... 5,458 | 5,458
Cell periphery 5,382 | 5,382
Integral component of membrane 5,331 | 5,331
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,972 | 3,972
non-membrane-bounded organelle 3,972 | 3,972
Nuclear lumen 3,968 | 3,968
Protein complex 3,674 | 3,674
Organelle membrane 2,846 | 2,846
Extracellular region 2,732 | 2,732
Plasma membrane part 2,594 | 2,594
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,217 | 2,217
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,955 | 1,955
Golgi apparatus 1,932 | 1,932
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,641 | 1,641
Cytoskeletal part 1,637 | 1,637
Extracellular region part 1,628 | 1,628
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,547 | 1,547
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,123 | 1,123
Nuclear outer membrane-endopla... 1,121 | 1,121
Nucleoplasm part 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,040 | 1,040
Mitochondrial part 1,036 | 1,036
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 967 | 967
Supramolecular complex 966 | 966
Cell junction 960 | 960
Supramolecular fiber 959 | 959
Golgi apparatus part 949 | 949
Nucleoli 942 | 942
Endosome 931 | 931
Nucleolus 926 | 926
Chromosomal part 889 | 889
GO:0098796 884 | 884
Ribonucleoprotein complex 864 | 864
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 849 | 849
Transferase complex 848 | 848
Cell surface 842 | 842
Plasma membrane region 841 | 841
Vesicle membrane 801 | 801
Cytoplasmic vesicle membrane 795 | 795
Polymeric cytoskeletal fiber 764 | 764
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 714 | 714
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 Tbio Transporter -0.85002 7.18 96
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial MCCC2 Tbio Enzyme -1.24396 15.5 189
Death-associated protein-like 1 DAPL1 Tbio Non-IDG -0.91439 8.29 84
Isovaleryl-CoA dehydrogenase, mitochondrial IVD Tbio Enzyme -3.13592 1365.7 103
ATP synthase mitochondrial F1 complex assembly factor 1 ATPAF1 Tdark Enzyme -1.23958 17.4 47
Serine protease HTRA2, mitochondrial HTRA2 Tbio Enzyme -2.60032 392.5 519
Histone-lysine N-methyltransferase NSD3 NSD3 Tbio Epigenetic -1.36629 23.0 234
Sterol regulatory element-binding protein 2 SREBF2 Tchem Transcription Factor -2.61148 361.0 205
5-aminolevulinate synthase, nonspecific, mitochondrial ALAS1 Tbio Enzyme -1.80580 61.7 153
Transcription factor Sp9 SP9 Tdark Transcription Factor -2.00940 96.9 15