Development Level

Tbio 582 | 10,625
Tdark 296 | 7,003
Tchem 78 | 1,890
Tclin 47 | 602

Collection

Kinase: IDG Consortium (Targets) 5 | 125
Ion Channel: IDG Consortium (Targets) 2 | 102
GPCR: IDG Consortium (Targets) 1 | 127
Kinase: IDG Consortium (Complete/Control) 1 | 37

IMPC Phenotype

preweaning lethality, complete... 58 | 633
embryonic lethality prior to o... 19 | 148
abnormal behavior 18 | 226
embryonic lethality prior to t... 17 | 187
decreased lean body mass 14 | 195
decreased total body fat amoun... 14 | 186
preweaning lethality, incomple... 14 | 260
decreased circulating glucose ... 12 | 121
abnormal bone structure 10 | 131
decreased grip strength 10 | 123
decreased body length 9 | 108
decreased body weight 9 | 174
decreased bone mineral content 9 | 157
decreased bone mineral density 9 | 126
decreased circulating serum al... 9 | 79
increased circulating alkaline... 9 | 119
increased or absent threshold ... 9 | 128
prenatal lethality prior to he... 9 | 64
hyperactivity 8 | 108
increased mean corpuscular hem... 8 | 93
increased mean corpuscular vol... 8 | 91
short tibia 8 | 82
abnormal embryo size 7 | 112
abnormal retina morphology 7 | 100
decreased circulating choleste... 7 | 85
decreased circulating total pr... 7 | 41
decreased circulating triglyce... 7 | 83
hypoactivity 7 | 89
increased bone mineral content 7 | 92
increased lean body mass 7 | 107
abnormal gait 6 | 51
abnormal heart left ventricle ... 6 | 20
abnormal lens morphology 6 | 73
decreased caudal vertebrae num... 6 | 49
decreased circulating HDL chol... 6 | 77
enlarged heart 6 | 111
increased circulating HDL chol... 6 | 63
increased exploration in new e... 6 | 56
increased fasted circulating g... 6 | 68
abnormal sleep behavior 5 | 63
abnormal tibia morphology 5 | 14
decreased circulating alkaline... 5 | 41
decreased circulating insulin ... 5 | 75
decreased heart weight 5 | 44
decreased prepulse inhibition 5 | 52
decreased rib number 5 | 59
increased circulating chloride... 5 | 43
increased circulating choleste... 5 | 53
increased circulating creatini... 5 | 29
increased circulating sodium l... 5 | 71
increased grip strength 5 | 83
increased leukocyte cell numbe... 5 | 37
thrombocytopenia 5 | 46
abnormal maxilla morphology 4 | 16
abnormal rib morphology 4 | 28
decreased circulating alanine ... 4 | 53
decreased circulating fructosa... 4 | 31
decreased erythrocyte cell num... 4 | 43
decreased lumbar vertebrae num... 4 | 62
decreased startle reflex 4 | 48
decreased total retina thickne... 4 | 20
improved glucose tolerance 4 | 56
increased circulating calcium ... 4 | 32
increased heart weight 4 | 37
small testis 4 | 37
straub tail 4 | 26
abnormal bone mineralization 3 | 55
abnormal cranium morphology 3 | 32
abnormal digit morphology 3 | 13
abnormal eye morphology 3 | 38
abnormal heart morphology 3 | 51
abnormal neural tube closure 3 | 37
abnormal retinal pigmentation 3 | 61
abnormal skin coloration 3 | 18
abnormal spleen morphology 3 | 36
abnormal tail morphology 3 | 17
abnormal tail movements 3 | 12
abnormal testis morphology 3 | 30
abnormal tooth morphology 3 | 24
abnormal vertebrae morphology 3 | 14
cardiovascular system phenotyp... 3 | 35
decreased Ly6C low monocyte nu... 3 | 23
decreased NK T cell number 3 | 28
decreased blood urea nitrogen ... 3 | 31
decreased circulating chloride... 3 | 32
decreased circulating creatini... 3 | 31
decreased circulating free fat... 3 | 39
decreased circulating sodium l... 3 | 18
decreased monocyte cell number 3 | 28
embryonic growth retardation 3 | 28
increased body weight 3 | 42
increased circulating free fat... 3 | 17
increased circulating iron lev... 3 | 25
increased circulating phosphat... 3 | 24
pallor 3 | 13
abnormal coat appearance 2 | 25
decreased hemoglobin content 2 | 53
increased cardiac muscle contr... 2 | 5
increased circulating aspartat... 2 | 17
increased circulating bilirubi... 2 | 16

Disease

ovarian cancer 566 | 8,491
osteosarcoma 462 | 7,933
medulloblastoma, large-cell 324 | 6,234
psoriasis 323 | 6,685
lung cancer 294 | 4,473
glioblastoma 277 | 5,572
atypical teratoid / rhabdoid tumor 216 | 4,369
pancreatic ductal adenocarcinoma liver metastasis 183 | 1,795
malignant mesothelioma 171 | 3,163
intraductal papillary-mucinous neoplasm (IPMN) 166 | 3,289
oligodendroglioma 162 | 2,849
Breast cancer 159 | 3,098
astrocytic glioma 151 | 2,241
ependymoma 150 | 2,514
primitive neuroectodermal tumor 146 | 3,031
intraductal papillary-mucinous adenoma (IPMA) 144 | 2,956
non-small cell lung cancer 144 | 2,798
Multiple myeloma 142 | 1,327
invasive ductal carcinoma 139 | 2,950
intraductal papillary-mucinous carcinoma (IPMC) 133 | 2,988
group 3 medulloblastoma 130 | 2,254
lung adenocarcinoma 127 | 2,714
pilocytic astrocytoma 127 | 3,086
subependymal giant cell astrocytoma 123 | 2,287
ulcerative colitis 122 | 2,087
pediatric high grade glioma 119 | 2,712
lung carcinoma 116 | 2,844
Pick disease 110 | 1,893
adult high grade glioma 109 | 2,148
interstitial cystitis 100 | 2,299
pancreatic cancer 97 | 2,300
medulloblastoma 95 | 1,524
group 4 medulloblastoma 94 | 1,875
tuberculosis 92 | 1,563
pituitary cancer 90 | 1,972
cystic fibrosis 86 | 1,670
ductal carcinoma in situ 81 | 1,745
Cancer 76 | 2,346
breast carcinoma 76 | 1,614
colon cancer 73 | 1,475
posterior fossa group B ependymoma 70 | 1,530
non primary Sjogren syndrome sicca 68 | 840
adrenocortical carcinoma 67 | 1,427
Waldenstrons macroglobulinemia 66 | 764
astrocytoma 65 | 1,493
atypical teratoid/rhabdoid tumor 61 | 1,095
sonic hedgehog group medulloblastoma 60 | 1,482
acute myeloid leukemia 59 | 785
diabetes mellitus 59 | 1,663
Carcinoma 55 | 2,147
acute quadriplegic myopathy 55 | 1,157
primary pancreatic ductal adenocarcinoma 54 | 1,271
Rheumatoid Arthritis 53 | 1,170
juvenile dermatomyositis 53 | 1,189
posterior fossa group A ependymoma 53 | 1,511
nasopharyngeal carcinoma 50 | 1,056
active Crohn's disease 49 | 918
Obesity 46 | 616
aldosterone-producing adenoma 45 | 664
cutaneous lupus erythematosus 45 | 1,056
spina bifida 45 | 1,064
dermatomyositis 44 | 966
Leigh disease 43 | 81
Atopic dermatitis 41 | 944
Alzheimer's disease 38 | 644
primary Sjogren syndrome 36 | 788
gastric carcinoma 35 | 832
tuberculosis and treatment for 6 months 34 | 686
progressive supranuclear palsy 33 | 674
esophageal adenocarcinoma 32 | 737
Diabetes mellitus type 2 30 | 69
Neurodegenerative disease 30 | 383
Treatment Refractory Type 2 Diabetes Mellitus 30 | 53
hepatocellular carcinoma 30 | 550
Parkinson's disease 29 | 364
Down syndrome 27 | 548
IGA Glomerulonephritis 25 | 454
Mammary Neoplasms 25 | 410
fibroadenoma 25 | 557
Duchenne muscular dystrophy 24 | 602
Endometriosis 24 | 535
Multiple Sclerosis 24 | 498
hereditary spastic paraplegia 24 | 313
pancreatic carcinoma 24 | 567
Cardiomyopathy 22 | 110
active ulcerative colitis 22 | 477
non-small cell lung carcinoma 22 | 413
Prostatic Neoplasms 21 | 471
sarcoidosis 21 | 368
Intellectual disability 20 | 573
Stomach Neoplasms 20 | 282
Autistic Disorder 19 | 320
Degenerative polyarthritis 19 | 93
Lactic acidosis 19 | 43
Crohn's disease 18 | 304
Neuropathy 18 | 210
Polycystic Ovary Syndrome 18 | 334
chronic rhinosinusitis 18 | 512
gastric cancer 18 | 436
nephrosclerosis 18 | 329

Tissue

Blood and immune system 1,001 | 17,994
Nervous System 1,000 | 18,560
Female tissues 999 | 18,646
Liver and Pancreas 999 | 18,135
Digestive Tract 998 | 18,472
Cardiovascular System 997 | 17,957
Male tissues 997 | 17,968
Endocrine System 996 | 18,511
Urinary Tract 994 | 18,443
Respiratory system 990 | 17,483
Skin and soft tissues 988 | 18,114

Target Family

Non-IDG 458 | 11,969
Enzyme 402 | 4,146
Transcription Factor 48 | 1,400
Transporter 39 | 473
Kinase 28 | 634
Epigenetic 15 | 242
Ion Channel 6 | 341
GPCR 3 | 408
Nuclear Receptor 2 | 48
TF/Epigenetic 2 | 38

Compartment GO Term

Mitochondria 1,003 | 1,003
cellular_component 18,237 | 18,237
Cell 15,806 | 15,806
Cell part 15,806 | 15,806
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,648 | 12,648
membrane-bounded organelle 11,793 | 11,793
Intracellular organelle 11,617 | 11,617
Intracellular membrane-bounded... 10,618 | 10,618
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,169 | 8,169
Intracellular organelle part 8,011 | 8,011
Cytoplasmic part 7,830 | 7,830
Nucleus 7,577 | 7,577
Membrane part 6,470 | 6,470
Cytosol 6,035 | 6,035
Plasma membrane 5,673 | 5,673
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,171 | 5,171
Cell periphery 5,146 | 5,146
Nucleoplasm 4,929 | 4,929
Extracellular region 4,606 | 4,606
Protein complex 4,439 | 4,439
Intracellular organelle lumen 4,330 | 4,330
Organelle lumen 4,330 | 4,330
membrane-enclosed lumen 4,330 | 4,330
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,839 | 3,839
non-membrane-bounded organelle 3,838 | 3,838
Nuclear part 3,807 | 3,807
Endomembrane system 3,720 | 3,720
Vesicle 3,666 | 3,666
membrane-bounded vesicle 3,494 | 3,494
Nuclear lumen 3,464 | 3,464
Extracellular organelle 2,849 | 2,849
Extracellular vesicle 2,848 | 2,848
Extracellular exosome 2,828 | 2,828
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,564 | 2,564
Cytoskeleton 2,046 | 2,046
Golgi apparatus 1,946 | 1,946
Endoplasmic reticulum 1,872 | 1,872
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Vesicles 1,625 | 1,625
Cytoskeletal part 1,568 | 1,568
Mitochondrion 1,531 | 1,531
Cell projection 1,426 | 1,426
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,305 | 1,305
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,234 | 1,234
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Chromosome 999 | 999
Mitochondrial part 989 | 989
Nucleoli 952 | 952
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 793 | 793
Intracellular ribonucleoprotei... 789 | 789
Nucleoplasm part 781 | 781
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 739 | 739
Plasma membrane protein comple... 721 | 721
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Microtubule organizing center 680 | 680
Centrosome 676 | 676
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Synapse 594 | 594
Lytic vacuole 571 | 571

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Hydroxymethylglutaryl-CoA synthase, mitochondrial HMGCS2 Tbio Enzyme -1.69372 46.6 95
Neuron-specific protein family member 1 NSG1 Tbio Non-IDG -1.10592 14.0 156
Cerebral cavernous malformations 2 protein CCM2 Tbio Non-IDG -1.85660 65.6 146
Zinc finger ZZ-type and EF-hand domain-containing protein 1 ZZEF1 Tdark Non-IDG 0.19 0.86 20
Forkhead box protein B1 FOXB1 Tbio Transcription Factor -1.13586 14.6 100
ATP synthase subunit s-like protein ATP5SL Tdark Enzyme 0.24 0.57 23
WD repeat-containing protein 70 WDR70 Tdark Non-IDG 0.90 0.28 20
Butyrophilin subfamily 2 member A2 BTN2A2 Tdark Non-IDG -0.20596 2.49 73
CCA tRNA nucleotidyltransferase 1, mitochondrial TRNT1 Tbio Enzyme -1.33746 60.4 26
Low-density lipoprotein receptor-related protein 12 LRP12 Tdark Non-IDG -0.53997 3.72 131