Development Level

Tbio 808 | 11,651
Tdark 182 | 6,593
Tchem 111 | 1,388
Tclin 36 | 612

Collection

Kinase: IDG Consortium (Target... 14 | 125
Kinase: IDG Consortium (Comple... 9 | 37
Ion Channel: IDG Consortium (T... 2 | 99
GPCR: IDG Consortium (Targets) 1 | 126

IMPC Phenotype

preweaning lethality, complete... 100 | 979
preweaning lethality, incomple... 44 | 499
embryonic lethality prior to t... 28 | 278
abnormal embryo size 24 | 220
abnormal behavior 21 | 298
embryonic lethality prior to o... 19 | 239
male infertility 18 | 123
decreased total body fat amoun... 17 | 207
abnormal bone structure 15 | 187
decreased body weight 14 | 161
decreased bone mineral density 13 | 126
increased circulating alkaline... 13 | 122
decreased body length 12 | 101
decreased bone mineral content 12 | 151
decreased lean body mass 12 | 135
hypoactivity 12 | 132
increased fasted circulating g... 12 | 76
abnormal retina morphology 11 | 71
prenatal lethality prior to he... 11 | 87
embryonic growth retardation 10 | 106
increased bone mineral content 10 | 108
decreased circulating glucose ... 9 | 126
decreased circulating serum al... 9 | 82
decreased grip strength 9 | 116
decreased vertical activity 9 | 208
impaired glucose tolerance 9 | 75
increased bone mineral density 9 | 72
increased lean body mass 9 | 172
increased mean corpuscular hem... 9 | 96
increased startle reflex 9 | 112
increased total body fat amoun... 9 | 134
abnormal sleep behavior 8 | 70
cataract 8 | 92
edema 8 | 59
hyperactivity 8 | 148
increased body length 8 | 32
increased circulating HDL chol... 8 | 80
increased or absent threshold ... 8 | 101
short tibia 8 | 97
abnormal heart morphology 7 | 162
decreased red blood cell distr... 7 | 41
improved glucose tolerance 7 | 79
increased blood urea nitrogen ... 7 | 48
increased hematocrit 7 | 46
increased mean corpuscular vol... 7 | 92
abnormal kidney morphology 6 | 65
abnormal lens morphology 6 | 81
abnormal seminal vesicle morph... 6 | 114
decreased circulating choleste... 6 | 93
increased leukocyte cell numbe... 6 | 47
small testis 6 | 58
abnormal behavioral response t... 5 | 66
abnormal cranium morphology 5 | 36
abnormal embryo turning 5 | 31
abnormal spleen morphology 5 | 55
abnormal tail morphology 5 | 25
decreased caudal vertebrae num... 5 | 53
decreased circulating LDL chol... 5 | 38
decreased fasted circulating g... 5 | 65
decreased mean corpuscular vol... 5 | 79
decreased startle reflex 5 | 75
enlarged heart 5 | 210
female infertility 5 | 60
increased circulating chloride... 5 | 41
increased circulating sodium l... 5 | 71
increased grip strength 5 | 41
thrombocytopenia 5 | 56
abnormal coat-hair pigmentatio... 4 | 64
abnormal craniofacial morpholo... 4 | 33
abnormal gait 4 | 69
abnormal head morphology 4 | 10
abnormal limb morphology 4 | 13
abnormal neural tube closure 4 | 46
abnormal pericardium morpholog... 4 | 26
abnormal skin morphology 4 | 50
abnormal testis morphology 4 | 43
decreased blood urea nitrogen ... 4 | 51
decreased circulating calcium ... 4 | 36
decreased leukocyte cell numbe... 4 | 73
hemorrhage 4 | 23
increased circulating creatini... 4 | 38
increased circulating glucose ... 4 | 24
increased lymphocyte cell numb... 4 | 32
increased mean platelet volume 4 | 45
prenatal lethality 4 | 28
small superior vagus ganglion 4 | 74
abnormal lung morphology 3 | 26
abnormal placenta size 3 | 20
cardiovascular system phenotyp... 3 | 36
decreased circulating HDL chol... 3 | 68
decreased circulating free fat... 3 | 31
decreased circulating insulin ... 3 | 76
decreased circulating total pr... 3 | 49
decreased spleen weight 3 | 10
increased circulating choleste... 3 | 66
increased circulating iron lev... 3 | 30
increased hemoglobin content 3 | 45
pallor 3 | 34
thrombocytosis 3 | 27
tremors 3 | 39

Disease

Carcinoma 811 | 11,493
ovarian cancer 641 | 8,520
osteosarcoma 542 | 7,950
medulloblastoma, large-cell 483 | 6,241
glioblastoma 448 | 5,792
psoriasis 424 | 6,694
atypical teratoid / rhabdoid tumor 414 | 5,112
ependymoma 403 | 4,679
lung cancer 374 | 4,740
group 3 medulloblastoma 373 | 4,104
Breast cancer 315 | 3,578
adult high grade glioma 295 | 3,801
malignant mesothelioma 268 | 3,232
primitive neuroectodermal tumor 268 | 3,035
Kidney cancer 248 | 2,613
intraductal papillary-mucinous neoplasm (IPMN) 244 | 3,291
intraductal papillary-mucinous carcinoma (IPMC) 237 | 2,989
oligodendroglioma 237 | 2,850
Cancer 234 | 2,499
non-small cell lung cancer 232 | 2,890
invasive ductal carcinoma 216 | 2,951
astrocytic glioma 197 | 2,597
lung adenocarcinoma 197 | 2,716
Astrocytoma, Pilocytic 192 | 3,081
Pick disease 180 | 1,894
intraductal papillary-mucinous adenoma (IPMA) 177 | 2,955
pancreatic cancer 169 | 2,398
subependymal giant cell astrocytoma 159 | 2,287
lung carcinoma 154 | 2,843
adrenocortical carcinoma 148 | 1,428
breast carcinoma 147 | 1,638
colon cancer 145 | 1,478
ductal carcinoma in situ 142 | 1,745
Intellectual disability 139 | 1,016
nasopharyngeal carcinoma 128 | 1,058
Autosomal recessive predisposition 127 | 1,442
group 4 medulloblastoma 121 | 1,855
interstitial cystitis 120 | 2,312
pituitary cancer 117 | 1,972
ulcerative colitis 112 | 1,819
tuberculosis 109 | 2,010
Multiple myeloma 107 | 1,332
diabetes mellitus 106 | 1,728
pancreatic ductal adenocarcinoma liver metastasis 102 | 1,962
Schizophrenia 92 | 1,160
Dull intelligence 91 | 645
Low intelligence 91 | 645
Mental Retardation 91 | 645
Mental deficiency 91 | 645
Poor school performance 91 | 645
acute quadriplegic myopathy 85 | 1,158
Endometriosis 84 | 540
astrocytoma 84 | 1,146
Atopic dermatitis 83 | 952
Cognitive delay 83 | 608
Global developmental delay 83 | 608
Mental and motor retardation 83 | 608
dermatomyositis 83 | 966
Rheumatoid arthritis 81 | 1,191
chronic rhinosinusitis 77 | 512
juvenile dermatomyositis 77 | 1,187
pediatric high grade glioma 77 | 1,064
primary pancreatic ductal adenocarcinoma 74 | 1,109
Waldenstrons macroglobulinemia 71 | 765
cystic fibrosis 70 | 1,696
Short stature 69 | 531
spina bifida 69 | 1,074
Epilepsy 67 | 792
Alzheimer's disease 66 | 658
progressive supranuclear palsy 66 | 676
Neurodegenerative disease 64 | 414
Small head 61 | 374
non primary Sjogren syndrome sicca 60 | 891
Liver cancer 59 | 604
Obesity 59 | 678
active Crohn's disease 59 | 922
Seizures 57 | 596
acute myeloid leukemia 54 | 783
cutaneous lupus erythematosus 54 | 1,057
Amyotrophic lateral sclerosis 52 | 451
Melanoma 51 | 711
medulloblastoma 50 | 720
Microcephaly 49 | 166
Muscle hypotonia 48 | 571
Bipolar Disorder 46 | 666
primary Sjogren syndrome 46 | 735
gastric carcinoma 45 | 807
Breast Neoplasms 44 | 445
Ciliopathy 43 | 71
Down syndrome 42 | 499
Mammary Neoplasms 42 | 425
Duchenne muscular dystrophy 41 | 601
Liver Cirrhosis, Experimental 41 | 769
Nystagmus 41 | 317
Vascular disease 41 | 319
esophageal adenocarcinoma 41 | 737
gastric cancer 41 | 459
hepatocellular carcinoma 41 | 547
posterior fossa group B ependymoma 41 | 416
Stomach Neoplasms 40 | 300

Tissue

Endocrine System 1,114 | 18,159
Female tissues 1,102 | 17,400
Skin and soft tissues 1,101 | 17,230
Male tissues 1,096 | 17,142
Digestive Tract 1,095 | 17,369
Blood and immune system 1,090 | 16,909
Urinary Tract 1,089 | 16,678
Respiratory system 1,087 | 16,393
Nervous System 1,085 | 16,725
Liver and Pancreas 1,084 | 16,750
Cardiovascular System 1,036 | 15,192

Target Family

Non-IDG 826 | 12,091
Enzyme 175 | 4,145
Kinase 81 | 634
Transcription Factor 25 | 1,400
Epigenetic 14 | 242
Ion Channel 5 | 344
Transporter 5 | 473
Nuclear Receptor 3 | 48
GPCR 2 | 408
oGPCR 1 | 421

Compartment GO Term

Microtubule cytoskeleton 1,137 | 1,137
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,783 | 8,783
Membrane 8,530 | 8,530
Nucleus 7,563 | 7,563
Cytosol 6,686 | 6,686
Membrane part 6,553 | 6,553
Plasma membrane 5,829 | 5,829
Macromolecular complex 5,476 | 5,476
Intrinsic component of membran... 5,457 | 5,457
Cell periphery 5,381 | 5,381
Integral component of membrane 5,330 | 5,330
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,974 | 3,974
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,673 | 3,673
Organelle membrane 2,846 | 2,846
Extracellular region 2,731 | 2,731
Plasma membrane part 2,593 | 2,593
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,216 | 2,216
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,638 | 1,638
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 968 | 968
Supramolecular complex 967 | 967
Cell junction 960 | 960
Supramolecular fiber 960 | 960
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 931 | 931
Nucleolus 927 | 927
Chromosomal part 889 | 889
GO:0098796 883 | 883
Ribonucleoprotein complex 864 | 864
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 849 | 849
Transferase complex 849 | 849
Cell surface 841 | 841
Plasma membrane region 841 | 841
Vesicle membrane 800 | 800
Cytoplasmic vesicle membrane 794 | 794
Polymeric cytoskeletal fiber 765 | 765
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 713 | 713
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
43 kDa receptor-associated protein of the synapse RAPSN Tbio Non-IDG -2.09902 132.1 134
Echinoderm microtubule-associated protein-like 5 EML5 Tdark Non-IDG -0.47268 3.14 28
T-complex protein 1 subunit zeta CCT6A Tbio Non-IDG -1.39880 26.2 90
RBPJ-interacting and tubulin-associated protein 1 RITA1 Tbio Non-IDG -0.85891 6.79 61
Chromosome alignment-maintaining phosphoprotein 1 CHAMP1 Tbio Non-IDG -0.61730 4.58 106
Serine/threonine-protein kinase DCLK2 DCLK2 Tchem Kinase -0.89222 8.01 148
Centrosomal protein of 295 kDa CEP295 Tdark Non-IDG -0.40512 3.13 13
Chromobox protein homolog 3 CBX3 Tbio Epigenetic -2.00023 90.5 366
Serine/threonine-protein kinase MAK MAK Tchem Kinase -1.20155 15.2 266