Development Level

Tbio 729 | 10,625
Tdark 189 | 7,003
Tchem 136 | 1,890
Tclin 33 | 602

Collection

Eligible Kinase Proteins 11 | 134
Eligible Ion Channel Proteins 1 | 117

IMPC Term

preweaning lethality, complete... 61 | 633
preweaning lethality, incomple... 19 | 260
decreased body weight 16 | 174
decreased bone mineral content 16 | 157
decreased lean body mass 16 | 195
abnormal behavior 15 | 226
decreased total body fat amoun... 15 | 186
embryonic lethality prior to t... 14 | 187
decreased bone mineral density 12 | 126
increased or absent threshold ... 12 | 128
embryonic lethality prior to o... 11 | 148
increased circulating alkaline... 11 | 119
increased mean corpuscular hem... 10 | 93
increased mean corpuscular vol... 10 | 91
abnormal bone structure 9 | 131
abnormal retina morphology 9 | 100
decreased body length 9 | 108
decreased grip strength 9 | 123
hyperactivity 9 | 108
abnormal embryo size 8 | 112
decreased circulating serum al... 8 | 79
increased fasted circulating g... 8 | 68
abnormal sleep behavior 7 | 63
decreased circulating glucose ... 7 | 121
hypoactivity 7 | 89
increased circulating HDL chol... 7 | 63
increased grip strength 7 | 83
increased lean body mass 7 | 107
increased leukocyte cell numbe... 7 | 37
abnormal cranium morphology 6 | 32
decreased circulating choleste... 6 | 85
decreased lumbar vertebrae num... 6 | 62
increased bone mineral content 6 | 92
increased circulating choleste... 6 | 53
increased exploration in new e... 6 | 56
increased hematocrit 6 | 36
abnormal coat/hair pigmentatio... 5 | 54
abnormal lens morphology 5 | 73
decreased circulating HDL chol... 5 | 77
decreased circulating LDL chol... 5 | 37
decreased mean corpuscular vol... 5 | 50
increased circulating sodium l... 5 | 71
increased sacral vertebrae num... 5 | 62
increased total body fat amoun... 5 | 57
male infertility 5 | 62
prenatal lethality prior to he... 5 | 64
abnormal bone mineralization 4 | 55
abnormal head morphology 4 | 10
abnormal limb bud morphology 4 | 15
decreased caudal vertebrae num... 4 | 49
decreased circulating free fat... 4 | 39
decreased circulating triglyce... 4 | 83
improved glucose tolerance 4 | 56
increased circulating LDL chol... 4 | 15
increased circulating chloride... 4 | 43
increased circulating glucose ... 4 | 16
increased circulating iron lev... 4 | 25
short tibia 4 | 82
thrombocytopenia 4 | 46
abnormal behavioral response t... 3 | 52
abnormal coat/ hair morphology 3 | 18
abnormal embryo turning 3 | 15
abnormal humerus morphology 3 | 11
abnormal joint morphology 3 | 14
abnormal kidney morphology 3 | 30
abnormal neural tube closure 3 | 37
abnormal optic disc morphology 3 | 10
abnormal seminal vesicle morph... 3 | 47
abnormal spleen morphology 3 | 36
abnormal tail morphology 3 | 17
abnormal tail movements 3 | 12
absent pinna reflex 3 | 21
decreased basophil cell number 3 | 11
decreased blood urea nitrogen ... 3 | 31
decreased circulating total pr... 3 | 41
decreased eosinophil cell numb... 3 | 41
decreased erythrocyte cell num... 3 | 43
decreased hematocrit 3 | 25
decreased leukocyte cell numbe... 3 | 54
decreased startle reflex 3 | 48
embryonic growth retardation 3 | 28
hemorrhage 3 | 12
hydrops fetalis 3 | 22
immune system phenotype 3 | 17
impaired glucose tolerance 3 | 52
increased blood urea nitrogen ... 3 | 44
increased body length 3 | 20
increased body weight 3 | 42
increased bone mineral density 3 | 52
increased circulating serum al... 3 | 25
increased erythrocyte cell num... 3 | 26
increased hemoglobin content 3 | 45
increased mean corpuscular hem... 3 | 25
limb grasping 3 | 35
vertebral fusion 3 | 23
decreased circulating calcium ... 2 | 33
decreased hemoglobin content 2 | 53
increased circulating aspartat... 2 | 17
increased circulating bilirubi... 2 | 16
thrombocytosis 2 | 23

Disease

ovarian cancer 608 | 8,492
osteosarcoma 523 | 7,933
medulloblastoma, large-cell 466 | 6,234
glioblastoma 427 | 5,572
psoriasis 422 | 6,685
lung cancer 347 | 4,473
atypical teratoid / rhabdoid tumor 326 | 4,369
Breast cancer 270 | 3,099
primitive neuroectodermal tumor 258 | 3,031
malignant mesothelioma 254 | 3,163
intraductal papillary-mucinous neoplasm (IPMN) 232 | 3,289
oligodendroglioma 227 | 2,849
intraductal papillary-mucinous carcinoma (IPMC) 225 | 2,988
pediatric high grade glioma 225 | 2,712
non-small cell lung cancer 218 | 2,798
Cancer 215 | 2,346
group 3 medulloblastoma 215 | 2,254
invasive ductal carcinoma 208 | 2,950
Carcinoma 193 | 2,147
lung adenocarcinoma 190 | 2,714
pilocytic astrocytoma 187 | 3,086
ependymoma 181 | 2,514
Pick disease 175 | 1,893
intraductal papillary-mucinous adenoma (IPMA) 171 | 2,956
posterior fossa group B ependymoma 171 | 1,530
astrocytic glioma 166 | 2,241
pancreatic cancer 165 | 2,300
subependymal giant cell astrocytoma 158 | 2,287
colon cancer 142 | 1,475
lung carcinoma 142 | 2,844
adrenocortical carcinoma 141 | 1,427
ductal carcinoma in situ 138 | 1,745
breast carcinoma 133 | 1,614
adult high grade glioma 132 | 2,148
group 4 medulloblastoma 124 | 1,875
nasopharyngeal carcinoma 124 | 1,056
ulcerative colitis 117 | 2,087
pituitary cancer 112 | 1,972
astrocytoma 109 | 1,493
interstitial cystitis 108 | 2,299
medulloblastoma 107 | 1,524
sonic hedgehog group medulloblastoma 107 | 1,482
atypical teratoid/rhabdoid tumor 105 | 1,095
Multiple myeloma 102 | 1,328
posterior fossa group A ependymoma 102 | 1,511
diabetes mellitus 98 | 1,663
pancreatic ductal adenocarcinoma liver metastasis 92 | 1,795
tuberculosis 92 | 1,563
Endometriosis 82 | 535
primary pancreatic ductal adenocarcinoma 81 | 1,271
acute quadriplegic myopathy 80 | 1,157
Atopic dermatitis 79 | 944
Intellectual disability 78 | 573
Rheumatoid Arthritis 78 | 1,171
dermatomyositis 76 | 967
Waldenstrons macroglobulinemia 74 | 765
juvenile dermatomyositis 70 | 1,189
chronic rhinosinusitis 67 | 512
progressive supranuclear palsy 66 | 674
cystic fibrosis 65 | 1,670
spina bifida 64 | 1,064
Alzheimer's disease 61 | 644
Neurodegenerative disease 61 | 383
non primary Sjogren syndrome sicca 57 | 840
IGA Glomerulonephritis 56 | 454
acute myeloid leukemia 56 | 785
active Crohn's disease 52 | 918
Obesity 50 | 616
tuberculosis and treatment for 6 months 50 | 686
cutaneous lupus erythematosus 48 | 1,056
Microcephaly 47 | 149
hepatocellular carcinoma 46 | 550
Amyotrophic Lateral Sclerosis 45 | 432
gastric carcinoma 44 | 832
gastric cancer 43 | 436
primary Sjogren syndrome 43 | 789
pancreatic carcinoma 42 | 567
Down syndrome 41 | 548
Schizophrenia 40 | 503
Mammary Neoplasms 39 | 410
Prostatic Neoplasms 39 | 471
Vascular disease 39 | 281
esophageal adenocarcinoma 38 | 737
Kidney disease 37 | 397
hereditary spastic paraplegia 37 | 313
non-small cell lung carcinoma 37 | 413
Duchenne muscular dystrophy 36 | 602
Parkinson's disease 36 | 364
aldosterone-producing adenoma 36 | 664
Ciliopathy 35 | 57
fibroadenoma 35 | 557
Polydactyly 32 | 93
Retinitis pigmentosa 32 | 156
Stomach Neoplasms 31 | 282
Neuropathy 29 | 210
Primary ciliary dyskinesia 29 | 75
inflammatory breast cancer 29 | 404
Joubert syndrome 28 | 62
Peripheral Neuropathy 28 | 303
autosomal dominant Emery-Dreifuss muscular dystrophy 28 | 499

Tissue

Blood and immune system 1,068 | 17,995
Digestive Tract 1,067 | 18,473
Endocrine System 1,067 | 18,512
Female tissues 1,067 | 18,647
Nervous System 1,067 | 18,561
Liver and Pancreas 1,065 | 18,136
Male tissues 1,065 | 17,969
Urinary Tract 1,064 | 18,444
Cardiovascular System 1,063 | 17,958
Skin and soft tissues 1,059 | 18,115
Respiratory system 1,054 | 17,484

Target Family

Non-IDG 787 | 11,969
Enzyme 172 | 4,146
Kinase 77 | 634
Transcription Factor 26 | 1,400
Epigenetic 13 | 242
Transporter 5 | 473
Ion Channel 3 | 341
Nuclear Receptor 2 | 48
GPCR 1 | 408
oGPCR 1 | 421

Compartment GO Term

Microtubule cytoskeleton 1,087 | 1,087
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,612 | 13,612
Intracellular part 13,475 | 13,475
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,353 | 10,353
Membrane 8,871 | 8,871
Organelle part 8,169 | 8,169
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,831 | 7,831
Nucleus 7,577 | 7,577
Membrane part 6,469 | 6,469
Cytosol 6,034 | 6,034
Plasma membrane 5,673 | 5,673
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,171 | 5,171
Cell periphery 5,146 | 5,146
Nucleoplasm 4,930 | 4,930
Extracellular region 4,607 | 4,607
Protein complex 4,439 | 4,439
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,874 | 3,874
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,592 | 2,592
Plasma membrane part 2,564 | 2,564
Cytoskeleton 2,046 | 2,046
Golgi apparatus 1,946 | 1,946
Endoplasmic reticulum 1,872 | 1,872
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Vesicles 1,625 | 1,625
Cytoskeletal part 1,568 | 1,568
Mitochondrion 1,530 | 1,530
Cell projection 1,425 | 1,425
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,234 | 1,234
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,092 | 1,092
Organelle envelope 1,084 | 1,084
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Mitochondria 1,003 | 1,003
Chromosome 999 | 999
Mitochondrial part 988 | 988
Nucleoli 950 | 950
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 815 | 815
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 781 | 781
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 739 | 739
Plasma membrane protein comple... 721 | 721
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Microtubule organizing center 680 | 680
Centrosome 676 | 676
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 656 | 656
Extracellular matrix 633 | 633
Synapse 594 | 594
Lytic vacuole 571 | 571

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
cAMP-dependent protein kinase catalytic subunit alpha PRKACA Tchem Kinase -1.02404 9.59 274
Lebercilin LCA5 Tbio Non-IDG -1.21162 16.7 65
Rab GTPase-activating protein 1 RABGAP1 Tbio Enzyme -0.67656 3.42 165
Small kinetochore-associated protein KNSTRN Tbio Non-IDG -1.24054 16.5 27
Protein Hook homolog 3 HOOK3 Tbio Non-IDG -1.18684 0.00000 55
Synembryn-B RIC8B Tbio Non-IDG -1.63259 43.4 37
Calcium and integrin-binding protein 1 CIB1 Tbio Non-IDG -2.05927 116.0 218
Tektin-4 TEKT4 Tbio Non-IDG -0.86653 7.05 96
Cell division control protein 6 homolog CDC6 Tchem Non-IDG -2.49821 321.6 473
Ankyrin repeat domain-containing protein 53 ANKRD53 Tbio Non-IDG 0.30 0.62 79