Development Level

Tbio 306 | 11,445
Tdark 63 | 6,588
Tchem 51 | 1,598
Tclin 19 | 613

Collection

Kinase: IDG Consortium (Target... 4 | 125
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 39 | 979
preweaning lethality, incomple... 17 | 499
abnormal behavior 11 | 298
embryonic lethality prior to t... 11 | 278
abnormal embryo size 10 | 220
decreased total body fat amoun... 9 | 207
embryonic lethality prior to o... 9 | 239
abnormal bone structure 8 | 187
decreased body weight 7 | 161
decreased bone mineral density 6 | 126
decreased circulating glucose ... 6 | 126
decreased circulating serum al... 6 | 82
embryonic growth retardation 6 | 106
hyperactivity 6 | 148
hypoactivity 6 | 132
decreased body length 5 | 101
decreased bone mineral content 5 | 151
decreased circulating LDL chol... 5 | 38
increased mean corpuscular hem... 5 | 96
increased total body fat amoun... 5 | 134
abnormal embryo turning 4 | 31
abnormal head morphology 4 | 10
decreased fasted circulating g... 4 | 65
decreased lean body mass 4 | 135
increased body length 4 | 32
increased bone mineral content 4 | 108
increased circulating alkaline... 4 | 122
increased fasted circulating g... 4 | 76
increased mean corpuscular vol... 4 | 92
increased or absent threshold ... 4 | 101
increased startle reflex 4 | 112
male infertility 4 | 123
prenatal lethality prior to he... 4 | 87
short tibia 4 | 97
abnormal bone mineralization 3 | 38
abnormal cranium morphology 3 | 36
abnormal gait 3 | 69
abnormal lung morphology 3 | 26
abnormal seminal vesicle morph... 3 | 114
abnormal sleep behavior 3 | 70
cardiovascular system phenotyp... 3 | 36
cataract 3 | 92
decreased caudal vertebrae num... 3 | 53
decreased circulating choleste... 3 | 93
decreased circulating total pr... 3 | 49
decreased grip strength 3 | 116
decreased red blood cell distr... 3 | 41
increased circulating creatini... 3 | 38
increased grip strength 3 | 41
increased lean body mass 3 | 172
prolonged QT interval 3 | 38
prolonged ST segment 3 | 36
thrombocytopenia 3 | 56
abnormal behavioral response t... 2 | 66
abnormal coat-hair pigmentatio... 2 | 64
abnormal femur morphology 2 | 14
abnormal lens morphology 2 | 81
abnormal retina morphology 2 | 71
abnormal tail morphology 2 | 25
abnormal tail movements 2 | 12
absent pinna reflex 2 | 23
convulsive seizures 2 | 13
cyanosis 2 | 7
decreased circulating HDL chol... 2 | 68
decreased circulating calcium ... 2 | 36
decreased circulating free fat... 2 | 31
decreased circulating sodium l... 2 | 22
decreased mean corpuscular vol... 2 | 79
decreased startle reflex 2 | 75
edema 2 | 59
enlarged lymph nodes 2 | 37
hemorrhage 2 | 23
improved glucose tolerance 2 | 79
increased blood urea nitrogen ... 2 | 48
increased bone mineral density 2 | 72
increased circulating HDL chol... 2 | 80
increased circulating chloride... 2 | 41
increased circulating glucose ... 2 | 24
increased circulating sodium l... 2 | 71
increased heart weight 2 | 62
increased hematocrit 2 | 46
increased neutrophil cell numb... 2 | 46
limb grasping 2 | 41
long tibia 2 | 25
mammalian phenotype 2 | 17
persistence of hyaloid vascula... 2 | 33
polycystic kidney 2 | 15
abnormal heart looping 1 | 5
abnormal neural tube closure 1 | 46
abnormal neural tube morpholog... 1 | 12
abnormal retinal inner nuclear... 1 | 8
abnormal vocalization 1 | 21
decreased circulating triglyce... 1 | 79
decreased fluid intake 1 | 3
increased circulating magnesiu... 1 | 10
increased circulating triglyce... 1 | 42
increased red blood cell distr... 1 | 34
prenatal lethality 1 | 28
scaly skin 1 | 4
vertebral fusion 1 | 23

Disease

Carcinoma 318 | 11,493
ovarian cancer 233 | 8,520
osteosarcoma 201 | 7,950
medulloblastoma, large-cell 200 | 6,241
glioblastoma 185 | 5,792
psoriasis 175 | 6,694
ependymoma 174 | 4,679
atypical teratoid / rhabdoid tumor 170 | 5,112
lung cancer 162 | 4,740
group 3 medulloblastoma 159 | 4,104
Breast cancer 134 | 3,578
adult high grade glioma 130 | 3,801
primitive neuroectodermal tumor 115 | 3,035
Kidney cancer 108 | 2,613
malignant mesothelioma 107 | 3,232
intraductal papillary-mucinous carcinoma (IPMC) 99 | 2,989
oligodendroglioma 99 | 2,850
non-small cell lung cancer 96 | 2,890
intraductal papillary-mucinous neoplasm (IPMN) 95 | 3,291
Astrocytoma, Pilocytic 94 | 3,081
invasive ductal carcinoma 87 | 2,951
Cancer 86 | 2,499
astrocytic glioma 85 | 2,597
lung adenocarcinoma 77 | 2,716
pancreatic cancer 76 | 2,398
Pick disease 70 | 1,894
adrenocortical carcinoma 67 | 1,428
colon cancer 67 | 1,478
lung carcinoma 67 | 2,843
subependymal giant cell astrocytoma 67 | 2,287
intraductal papillary-mucinous adenoma (IPMA) 66 | 2,955
breast carcinoma 63 | 1,638
ductal carcinoma in situ 60 | 1,745
nasopharyngeal carcinoma 60 | 1,058
group 4 medulloblastoma 50 | 1,855
Intellectual disability 49 | 1,016
pituitary cancer 49 | 1,972
Schizophrenia 47 | 1,160
interstitial cystitis 44 | 2,312
Endometriosis 43 | 540
Atopic dermatitis 42 | 952
ulcerative colitis 40 | 1,819
Multiple myeloma 39 | 1,332
diabetes mellitus 38 | 1,728
Alzheimer's disease 37 | 658
Autosomal recessive predisposition 37 | 1,442
tuberculosis 37 | 2,010
Neurodegenerative disease 36 | 414
Epilepsy 35 | 792
Liver cancer 33 | 604
astrocytoma 33 | 1,146
juvenile dermatomyositis 33 | 1,187
acute quadriplegic myopathy 32 | 1,158
pancreatic ductal adenocarcinoma liver metastasis 32 | 1,962
Cognitive delay 31 | 608
Global developmental delay 31 | 608
Mental and motor retardation 31 | 608
dermatomyositis 30 | 966
Microcephaly 29 | 166
chronic rhinosinusitis 29 | 512
Small head 28 | 374
progressive supranuclear palsy 28 | 676
Dull intelligence 27 | 645
Low intelligence 27 | 645
Mental Retardation 27 | 645
Mental deficiency 27 | 645
Poor school performance 27 | 645
Seizures 27 | 596
primary pancreatic ductal adenocarcinoma 27 | 1,109
Amyotrophic lateral sclerosis 26 | 451
spina bifida 26 | 1,074
Endometrial cancer 25 | 311
Waldenstrons macroglobulinemia 25 | 765
pediatric high grade glioma 25 | 1,064
acute myeloid leukemia 23 | 783
Bipolar Disorder 22 | 666
Melanoma 22 | 711
Rheumatoid arthritis 21 | 1,191
cystic fibrosis 21 | 1,696
gastric carcinoma 21 | 807
Obesity 20 | 678
Parkinson's disease 20 | 392
Toxic encephalopathy 20 | 141
medulloblastoma 20 | 720
Lissencephaly 19 | 69
Muscle hypotonia 19 | 571
Neuropathy 19 | 261
Primary ciliary dyskinesia 19 | 76
primary Sjogren syndrome 19 | 735
Down syndrome 18 | 499
Short stature 18 | 531
Skin cancer 18 | 469
Vascular disease 18 | 319
hepatocellular carcinoma 18 | 547
Depressive disorder 17 | 409
Stomach Neoplasms 17 | 300
cutaneous lupus erythematosus 17 | 1,057
non primary Sjogren syndrome sicca 17 | 891
non-small cell lung carcinoma 17 | 317
gastric cancer 16 | 459

Tissue

Endocrine System 431 | 18,159
Female tissues 425 | 17,400
Skin and soft tissues 423 | 17,230
Digestive Tract 419 | 17,369
Male tissues 419 | 17,142
Respiratory system 418 | 16,393
Urinary Tract 416 | 16,678
Blood and immune system 415 | 16,909
Liver and Pancreas 414 | 16,750
Nervous System 414 | 16,725
Cardiovascular System 390 | 15,192

Target Family

Non-IDG 357 | 12,091
Enzyme 50 | 4,145
Kinase 23 | 634
Epigenetic 4 | 242
Transcription Factor 4 | 1,400
GPCR 1 | 408

Compartment GO Term

Microtubule 439 | 439
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,784 | 8,784
Membrane 8,531 | 8,531
Nucleus 7,562 | 7,562
Cytosol 6,686 | 6,686
Membrane part 6,554 | 6,554
Plasma membrane 5,830 | 5,830
Macromolecular complex 5,475 | 5,475
Intrinsic component of membran... 5,458 | 5,458
Cell periphery 5,382 | 5,382
Integral component of membrane 5,331 | 5,331
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,975 | 3,975
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,674 | 3,674
Organelle membrane 2,846 | 2,846
Extracellular region 2,732 | 2,732
Plasma membrane part 2,594 | 2,594
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,217 | 2,217
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,932 | 1,932
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,641 | 1,641
Cytoskeletal part 1,637 | 1,637
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 970 | 970
Neuron part 969 | 969
Supramolecular polymer 967 | 967
Supramolecular complex 966 | 966
Cell junction 960 | 960
Supramolecular fiber 959 | 959
Golgi apparatus part 950 | 950
Nucleoli 942 | 942
Endosome 930 | 930
Nucleolus 926 | 926
Chromosomal part 889 | 889
GO:0098796 884 | 884
Ribonucleoprotein complex 865 | 865
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 850 | 850
Transferase complex 849 | 849
Cell surface 842 | 842
Plasma membrane region 841 | 841
Vesicle membrane 801 | 801
Cytoplasmic vesicle membrane 795 | 795
Polymeric cytoskeletal fiber 764 | 764
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 714 | 714
Neuron projection 711 | 711
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
T-complex protein 1 subunit zeta CCT6A Tbio Non-IDG -1.39880 26.2 90
Tubulin-specific chaperone D TBCD Tbio Non-IDG -1.71996 50.5 50
Poly [ADP-ribose] polymerase 4 PARP4 Tchem Enzyme -1.45503 26.0 123
Ras association domain-containing protein 5 RASSF5 Tbio Non-IDG -1.81149 71.3 155
GAS2-like protein 3 GAS2L3 Tbio Non-IDG -0.65733 5.79 78
Adenomatous polyposis coli protein 2 APC2 Tbio Non-IDG -1.50271 33.3 93
Growth arrest-specific protein 8 GAS8 Tbio Non-IDG -1.20822 17.3 102
Protein Shroom2 SHROOM2 Tbio Non-IDG -1.07032 11.9 112
Tubulin alpha-8 chain TUBA8 Tbio Non-IDG -0.87821 7.61 118
Centrosomal protein of 57 kDa CEP57 Tbio Non-IDG -0.98216 11.8 177