Development Level

Tbio 3,348 | 10,625
Tdark 1,812 | 7,003
Tchem 850 | 1,890
Tclin 459 | 602

Collection

Eligible non-olfactory GPCR Proteins 134 | 143
Eligible Ion Channel Proteins 107 | 117
Eligible Kinase Proteins 14 | 134

IMPC Term

preweaning lethality, complete... 187 | 633
abnormal behavior 83 | 226
preweaning lethality, incomple... 82 | 260
decreased total body fat amoun... 76 | 186
decreased lean body mass 71 | 195
embryonic lethality prior to t... 65 | 187
decreased bone mineral content 64 | 157
decreased body weight 63 | 174
decreased bone mineral density 50 | 126
abnormal bone structure 49 | 131
embryonic lethality prior to o... 46 | 148
increased circulating alkaline... 46 | 119
decreased grip strength 44 | 123
hyperactivity 43 | 108
increased lean body mass 42 | 107
increased mean corpuscular hem... 40 | 93
increased or absent threshold ... 39 | 128
enlarged heart 38 | 111
decreased circulating choleste... 34 | 85
decreased circulating glucose ... 34 | 121
decreased circulating triglyce... 34 | 83
hypoactivity 33 | 89
increased mean corpuscular vol... 33 | 91
abnormal embryo size 32 | 112
abnormal retina morphology 32 | 100
decreased circulating HDL chol... 31 | 77
decreased circulating insulin ... 30 | 75
increased bone mineral content 30 | 92
increased circulating sodium l... 30 | 71
decreased body length 28 | 108
increased grip strength 27 | 83
increased fasted circulating g... 25 | 68
abnormal lens morphology 24 | 73
abnormal sleep behavior 24 | 63
decreased circulating alanine ... 24 | 53
decreased circulating serum al... 24 | 79
decreased fasted circulating g... 24 | 49
decreased prepulse inhibition 24 | 52
increased total body fat amoun... 24 | 57
abnormal bone mineralization 23 | 55
abnormal gait 23 | 51
improved glucose tolerance 23 | 56
impaired glucose tolerance 21 | 52
increased exploration in new e... 21 | 56
abnormal retinal pigmentation 20 | 61
cardiovascular system phenotyp... 20 | 35
decreased heart weight 20 | 44
decreased hemoglobin content 20 | 53
decreased rib number 20 | 59
increased circulating HDL chol... 20 | 63
short tibia 20 | 82
decreased eosinophil cell numb... 19 | 41
decreased mean corpuscular vol... 19 | 50
increased blood urea nitrogen ... 19 | 44
abnormal seminal vesicle morph... 18 | 47
decreased caudal vertebrae num... 18 | 49
decreased lumbar vertebrae num... 18 | 62
increased bone mineral density 18 | 52
increased circulating calcium ... 18 | 32
increased circulating choleste... 18 | 53
increased circulating potassiu... 18 | 31
increased heart weight 18 | 37
limb grasping 18 | 35
decreased circulating LDL chol... 17 | 37
enlarged epididymis 17 | 27
increased body weight 17 | 42
increased hemoglobin content 17 | 45
increased sacral vertebrae num... 17 | 62
thrombocytopenia 17 | 46
abnormal eye morphology 16 | 38
abnormal neural tube closure 16 | 37
prenatal lethality prior to he... 16 | 64
tremors 16 | 34
abnormal epididymis morphology 15 | 31
abnormal heart morphology 15 | 51
decreased leukocyte cell numbe... 15 | 54
decreased startle reflex 15 | 48
increased rib number 15 | 41
male infertility 15 | 62
abnormal QRS complex 14 | 25
abnormal behavioral response t... 14 | 52
decreased NK T cell number 14 | 28
decreased circulating calcium ... 14 | 33
decreased circulating creatini... 14 | 31
decreased circulating free fat... 14 | 39
decreased erythrocyte cell num... 14 | 43
increased circulating chloride... 14 | 43
decreased circulating alkaline... 13 | 41
increased hematocrit 13 | 36
increased leukocyte cell numbe... 13 | 37
straub tail 13 | 26
abnormal kidney morphology 12 | 30
decreased T cell number 12 | 31
decreased circulating aspartat... 12 | 27
decreased circulating total pr... 12 | 41
decreased mean corpuscular hem... 12 | 34
decreased monocyte cell number 12 | 28
increased startle reflex 12 | 38
abnormal coat/hair pigmentatio... 11 | 54
decreased circulating fructosa... 11 | 31

Disease

ovarian cancer 2,733 | 8,484
osteosarcoma 2,585 | 7,933
psoriasis 2,353 | 6,685
medulloblastoma, large-cell 2,175 | 6,234
glioblastoma 2,046 | 5,572
atypical teratoid / rhabdoid tumor 1,586 | 4,369
lung cancer 1,500 | 4,466
pilocytic astrocytoma 1,337 | 3,086
lung carcinoma 1,279 | 2,844
intraductal papillary-mucinous neoplasm (IPMN) 1,177 | 3,289
intraductal papillary-mucinous adenoma (IPMA) 1,120 | 2,956
invasive ductal carcinoma 1,120 | 2,950
intraductal papillary-mucinous carcinoma (IPMC) 1,078 | 2,988
lung adenocarcinoma 1,064 | 2,713
Breast cancer 1,058 | 3,094
non-small cell lung cancer 1,051 | 2,798
oligodendroglioma 1,051 | 2,849
pediatric high grade glioma 1,051 | 2,712
malignant mesothelioma 1,041 | 3,162
interstitial cystitis 1,034 | 2,299
primitive neuroectodermal tumor 1,023 | 3,031
Cancer 993 | 2,346
ependymoma 915 | 2,514
pancreatic cancer 911 | 2,300
subependymal giant cell astrocytoma 884 | 2,287
ulcerative colitis 873 | 2,087
Carcinoma 866 | 2,147
astrocytic glioma 784 | 2,241
pituitary cancer 781 | 1,972
adult high grade glioma 777 | 2,148
diabetes mellitus 692 | 1,663
ductal carcinoma in situ 691 | 1,745
pancreatic ductal adenocarcinoma liver metastasis 688 | 1,795
Pick disease 684 | 1,893
cystic fibrosis 670 | 1,665
group 4 medulloblastoma 669 | 1,875
tuberculosis 638 | 1,557
posterior fossa group A ependymoma 627 | 1,511
group 3 medulloblastoma 607 | 2,254
breast carcinoma 592 | 1,614
astrocytoma 574 | 1,493
medulloblastoma 562 | 1,524
colon cancer 516 | 1,475
primary pancreatic ductal adenocarcinoma 490 | 1,271
adrenocortical carcinoma 478 | 1,427
cutaneous lupus erythematosus 477 | 1,056
sonic hedgehog group medulloblastoma 469 | 1,482
posterior fossa group B ependymoma 463 | 1,530
Rheumatoid Arthritis 462 | 1,160
Multiple myeloma 436 | 1,327
active Crohn's disease 408 | 918
atypical teratoid/rhabdoid tumor 392 | 1,095
juvenile dermatomyositis 388 | 1,189
acute quadriplegic myopathy 377 | 1,157
nasopharyngeal carcinoma 325 | 1,056
Atopic dermatitis 323 | 944
primary Sjogren syndrome 323 | 789
spina bifida 323 | 1,064
gastric carcinoma 319 | 832
Alzheimer's disease 317 | 644
Obesity 310 | 616
dermatomyositis 298 | 933
esophageal adenocarcinoma 295 | 737
non primary Sjogren syndrome sicca 286 | 840
Multiple Sclerosis 284 | 498
Schizophrenia 278 | 501
Down syndrome 259 | 548
Duchenne muscular dystrophy 255 | 602
aldosterone-producing adenoma 251 | 664
Kidney disease 248 | 396
mucosa-associated lymphoid tissue lymphoma 241 | 480
fibroadenoma 224 | 557
acute myeloid leukemia 223 | 780
active ulcerative colitis 221 | 477
progressive supranuclear palsy 216 | 674
Waldenstrons macroglobulinemia 214 | 765
pancreatic carcinoma 211 | 567
Epilepsy 209 | 346
Asthma 203 | 349
Prostatic Neoplasms 200 | 471
Intellectual disability 197 | 573
Hypersensitivity reaction type II disease 191 | 235
tuberculosis and treatment for 6 months 190 | 686
autosomal dominant Emery-Dreifuss muscular dystrophy 188 | 499
Endometriosis 187 | 535
Hypertension 185 | 287
IGA Glomerulonephritis 185 | 454
Arthritis 183 | 248
Parkinson's disease 182 | 364
non-small cell lung carcinoma 182 | 413
Autistic Disorder 180 | 320
Neurodegenerative disease 178 | 383
Atherosclerosis 163 | 275
Vascular disease 161 | 281
Mammary Neoplasms 160 | 410
Heart disease 158 | 279
Liver disease 157 | 219
Anemia 156 | 252
hepatocellular carcinoma 152 | 532
sarcoidosis 150 | 358

Tissue

Female tissues 6,191 | 18,647
Urinary Tract 6,149 | 18,444
Nervous System 6,129 | 18,561
Endocrine System 6,116 | 18,512
Digestive Tract 6,087 | 18,473
Skin and soft tissues 5,979 | 18,115
Liver and Pancreas 5,939 | 18,136
Blood and immune system 5,873 | 17,995
Cardiovascular System 5,867 | 17,958
Male tissues 5,825 | 17,969
Respiratory system 5,738 | 17,484

Target Family

Non-IDG 3,384 | 11,971
Enzyme 1,259 | 4,146
Transporter 459 | 473
GPCR 397 | 406
oGPCR 380 | 421
Ion Channel 327 | 341
Kinase 191 | 634
Transcription Factor 57 | 1,400
Epigenetic 9 | 242
Nuclear Receptor 5 | 48
TF/Epigenetic 1 | 38

Compartment GO Term

Membrane part 6,469 | 6,469
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,170 | 8,170
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,830 | 7,830
Nucleus 6,897 | 6,897
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,172 | 5,172
Cell periphery 5,145 | 5,145
Plasma membrane 5,059 | 5,059
Extracellular region 4,606 | 4,606
Protein complex 4,438 | 4,438
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Cytosol 3,352 | 3,352
Nucleoplasm 2,938 | 2,938
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,563 | 2,563
Cytoskeleton 2,045 | 2,045
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Endoplasmic reticulum 1,663 | 1,663
Cytoskeletal part 1,567 | 1,567
Mitochondrion 1,530 | 1,530
Cell projection 1,426 | 1,426
Golgi apparatus 1,402 | 1,402
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,233 | 1,233
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Chromosome 999 | 999
Mitochondrial part 989 | 989
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 780 | 780
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 738 | 738
Plasma membrane protein comple... 720 | 720
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Microtubule organizing center 617 | 617
Synapse 594 | 594
Lysosome 571 | 571
Lytic vacuole 571 | 571
Vesicle membrane 559 | 559
cell-cell junction 557 | 557
Cytoplasmic vesicle membrane 552 | 552

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitochondrial 2-oxodicarboxylate carrier SLC25A21 Tbio Transporter -0.46900 2.68 102
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
D(2) dopamine receptor DRD2 Tclin GPCR -3.24474 1775.2 248
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Syntaxin-1B STX1B Tbio Non-IDG -1.74488 52.6 27
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
Nucleoprotein TPR TPR Tbio Non-IDG -2.07876 130.9 158
ATP synthase F(0) complex subunit C3, mitochondrial ATP5G3 Tdark Enzyme -1.10871 11.9 27
ADP/ATP translocase 3 SLC25A6 Tbio Transporter -2.06581 118.3 193