Development Level

Tbio 5,028 | 10,625
Tdark 2,184 | 7,003
Tchem 1,152 | 1,890
Tclin 508 | 602

Collection

Eligible non-olfactory GPCR Proteins 134 | 143
Eligible Ion Channel Proteins 112 | 117
Eligible Kinase Proteins 39 | 134

IMPC Term

preweaning lethality, complete... 308 | 633
preweaning lethality, incomple... 132 | 260
abnormal behavior 114 | 226
decreased lean body mass 108 | 195
decreased total body fat amoun... 102 | 186
embryonic lethality prior to t... 102 | 187
decreased bone mineral content 94 | 157
decreased body weight 91 | 174
decreased bone mineral density 73 | 126
embryonic lethality prior to o... 73 | 148
abnormal bone structure 71 | 131
increased or absent threshold ... 66 | 128
decreased grip strength 63 | 123
increased circulating alkaline... 63 | 119
hyperactivity 60 | 108
enlarged heart 56 | 111
increased mean corpuscular hem... 55 | 93
abnormal embryo size 54 | 112
increased lean body mass 54 | 107
abnormal retina morphology 53 | 100
decreased circulating glucose ... 53 | 121
hypoactivity 49 | 89
decreased body length 47 | 108
decreased circulating choleste... 47 | 85
increased mean corpuscular vol... 47 | 91
decreased circulating triglyce... 44 | 83
increased grip strength 43 | 83
decreased circulating insulin ... 41 | 75
decreased circulating HDL chol... 40 | 77
increased bone mineral content 40 | 92
increased circulating sodium l... 37 | 71
increased total body fat amoun... 36 | 57
abnormal lens morphology 35 | 73
decreased rib number 34 | 59
short tibia 34 | 82
decreased circulating serum al... 33 | 79
decreased fasted circulating g... 33 | 49
increased fasted circulating g... 33 | 68
improved glucose tolerance 32 | 56
abnormal sleep behavior 31 | 63
decreased prepulse inhibition 31 | 52
abnormal retinal pigmentation 30 | 61
decreased circulating alanine ... 30 | 53
prenatal lethality prior to he... 30 | 64
abnormal bone mineralization 29 | 55
decreased lumbar vertebrae num... 29 | 62
impaired glucose tolerance 29 | 52
abnormal gait 28 | 51
decreased startle reflex 28 | 48
increased circulating HDL chol... 28 | 63
decreased leukocyte cell numbe... 27 | 54
decreased mean corpuscular vol... 27 | 50
male infertility 27 | 62
increased bone mineral density 26 | 52
decreased heart weight 25 | 44
increased heart weight 25 | 37
increased hemoglobin content 25 | 45
decreased hemoglobin content 24 | 53
increased blood urea nitrogen ... 24 | 44
increased circulating choleste... 24 | 53
increased exploration in new e... 24 | 56
increased sacral vertebrae num... 24 | 62
abnormal heart morphology 23 | 51
abnormal neural tube closure 23 | 37
abnormal seminal vesicle morph... 23 | 47
cardiovascular system phenotyp... 23 | 35
increased body weight 23 | 42
increased circulating chloride... 23 | 43
limb grasping 23 | 35
thrombocytopenia 23 | 46
decreased mean corpuscular hem... 22 | 34
increased hematocrit 22 | 36
abnormal behavioral response t... 21 | 52
decreased caudal vertebrae num... 21 | 49
decreased circulating calcium ... 21 | 33
decreased eosinophil cell numb... 21 | 41
increased circulating calcium ... 21 | 32
increased circulating potassiu... 21 | 31
increased leukocyte cell numbe... 21 | 37
decreased circulating LDL chol... 20 | 37
enlarged epididymis 20 | 27
tremors 20 | 34
abnormal epididymis morphology 19 | 31
decreased circulating alkaline... 19 | 41
decreased circulating creatini... 19 | 31
decreased circulating free fat... 19 | 39
abnormal coat/hair pigmentatio... 18 | 54
abnormal eye morphology 18 | 38
decreased NK T cell number 18 | 28
decreased erythrocyte cell num... 18 | 43
decreased circulating total pr... 17 | 41
decreased monocyte cell number 17 | 28
increased circulating phosphat... 17 | 24
increased rib number 17 | 41
increased startle reflex 17 | 38
abnormal spleen morphology 16 | 36
decreased T cell number 16 | 31
decreased circulating aspartat... 16 | 27
small testis 16 | 37
straub tail 16 | 26

Disease

ovarian cancer 4,076 | 8,484
osteosarcoma 3,750 | 7,933
psoriasis 3,302 | 6,685
medulloblastoma, large-cell 3,122 | 6,234
glioblastoma 2,902 | 5,572
lung cancer 2,242 | 4,466
atypical teratoid / rhabdoid tumor 2,231 | 4,369
pilocytic astrocytoma 1,760 | 3,086
intraductal papillary-mucinous neoplasm (IPMN) 1,667 | 3,289
lung carcinoma 1,640 | 2,844
invasive ductal carcinoma 1,559 | 2,950
intraductal papillary-mucinous adenoma (IPMA) 1,530 | 2,956
malignant mesothelioma 1,523 | 3,162
intraductal papillary-mucinous carcinoma (IPMC) 1,510 | 2,988
non-small cell lung cancer 1,499 | 2,798
oligodendroglioma 1,497 | 2,849
Breast cancer 1,496 | 3,094
pediatric high grade glioma 1,468 | 2,712
primitive neuroectodermal tumor 1,468 | 3,031
lung adenocarcinoma 1,467 | 2,713
Cancer 1,421 | 2,346
interstitial cystitis 1,318 | 2,299
ependymoma 1,300 | 2,514
pancreatic cancer 1,256 | 2,300
subependymal giant cell astrocytoma 1,223 | 2,287
Carcinoma 1,191 | 2,147
ulcerative colitis 1,173 | 2,087
astrocytic glioma 1,116 | 2,241
adult high grade glioma 1,092 | 2,148
pituitary cancer 1,013 | 1,972
Pick disease 985 | 1,893
diabetes mellitus 973 | 1,663
pancreatic ductal adenocarcinoma liver metastasis 957 | 1,795
ductal carcinoma in situ 938 | 1,745
group 3 medulloblastoma 936 | 2,254
group 4 medulloblastoma 930 | 1,875
cystic fibrosis 882 | 1,665
astrocytoma 846 | 1,493
posterior fossa group A ependymoma 842 | 1,511
tuberculosis 842 | 1,557
breast carcinoma 815 | 1,614
medulloblastoma 785 | 1,524
colon cancer 745 | 1,475
Multiple myeloma 714 | 1,327
primary pancreatic ductal adenocarcinoma 685 | 1,271
sonic hedgehog group medulloblastoma 684 | 1,482
adrenocortical carcinoma 677 | 1,427
Rheumatoid Arthritis 653 | 1,160
posterior fossa group B ependymoma 634 | 1,530
cutaneous lupus erythematosus 624 | 1,056
acute quadriplegic myopathy 583 | 1,157
juvenile dermatomyositis 569 | 1,189
atypical teratoid/rhabdoid tumor 567 | 1,095
active Crohn's disease 535 | 918
spina bifida 519 | 1,064
dermatomyositis 471 | 933
nasopharyngeal carcinoma 468 | 1,056
Atopic dermatitis 452 | 944
primary Sjogren syndrome 446 | 789
gastric carcinoma 433 | 832
non primary Sjogren syndrome sicca 426 | 840
esophageal adenocarcinoma 423 | 737
Alzheimer's disease 416 | 644
Obesity 391 | 616
Waldenstrons macroglobulinemia 376 | 765
acute myeloid leukemia 357 | 780
aldosterone-producing adenoma 347 | 664
Duchenne muscular dystrophy 336 | 602
Schizophrenia 336 | 501
Down syndrome 335 | 548
Multiple Sclerosis 335 | 498
progressive supranuclear palsy 314 | 674
mucosa-associated lymphoid tissue lymphoma 307 | 480
Kidney disease 306 | 396
pancreatic carcinoma 303 | 567
fibroadenoma 300 | 557
tuberculosis and treatment for 6 months 295 | 686
Intellectual disability 291 | 573
Prostatic Neoplasms 282 | 471
IGA Glomerulonephritis 280 | 454
active ulcerative colitis 275 | 477
Neurodegenerative disease 271 | 383
Endometriosis 270 | 535
autosomal dominant Emery-Dreifuss muscular dystrophy 265 | 499
Epilepsy 263 | 346
Parkinson's disease 244 | 364
Asthma 243 | 349
Hypertension 239 | 287
Mammary Neoplasms 237 | 410
non-small cell lung carcinoma 232 | 413
Amyotrophic Lateral Sclerosis 231 | 431
hepatocellular carcinoma 224 | 532
Autistic Disorder 218 | 320
Arthritis 215 | 248
Vascular disease 212 | 281
Hypersensitivity reaction type II disease 209 | 235
Atherosclerosis 206 | 275
Heart disease 200 | 279
sarcoidosis 199 | 358
gastric cancer 186 | 430

Tissue

Female tissues 8,552 | 18,647
Urinary Tract 8,499 | 18,444
Nervous System 8,489 | 18,561
Endocrine System 8,471 | 18,512
Digestive Tract 8,447 | 18,473
Skin and soft tissues 8,317 | 18,115
Liver and Pancreas 8,282 | 18,136
Blood and immune system 8,216 | 17,995
Cardiovascular System 8,206 | 17,958
Male tissues 8,161 | 17,969
Respiratory system 8,051 | 17,484

Target Family

Non-IDG 4,898 | 11,971
Enzyme 1,933 | 4,146
Transporter 464 | 473
GPCR 397 | 406
oGPCR 380 | 421
Ion Channel 336 | 341
Kinase 313 | 634
Transcription Factor 107 | 1,400
Epigenetic 30 | 242
Nuclear Receptor 11 | 48
TF/Epigenetic 3 | 38

Compartment GO Term

Membrane 8,872 | 8,872
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,352 | 10,352
Organelle part 8,170 | 8,170
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,830 | 7,830
Nucleus 6,897 | 6,897
Membrane part 6,469 | 6,469
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,172 | 5,172
Cell periphery 5,145 | 5,145
Plasma membrane 5,059 | 5,059
Extracellular region 4,606 | 4,606
Protein complex 4,438 | 4,438
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Cytosol 3,352 | 3,352
Nucleoplasm 2,938 | 2,938
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,563 | 2,563
Cytoskeleton 2,045 | 2,045
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Endoplasmic reticulum 1,663 | 1,663
Cytoskeletal part 1,567 | 1,567
Mitochondrion 1,530 | 1,530
Cell projection 1,426 | 1,426
Golgi apparatus 1,402 | 1,402
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,233 | 1,233
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Chromosome 999 | 999
Mitochondrial part 989 | 989
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 780 | 780
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 738 | 738
Plasma membrane protein comple... 720 | 720
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Microtubule organizing center 617 | 617
Synapse 594 | 594
Lysosome 571 | 571
Lytic vacuole 571 | 571
Vesicle membrane 559 | 559
cell-cell junction 557 | 557
Cytoplasmic vesicle membrane 552 | 552

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitochondrial 2-oxodicarboxylate carrier SLC25A21 Tbio Transporter -0.46900 2.68 102
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
D(2) dopamine receptor DRD2 Tclin GPCR -3.24474 1775.2 248
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Syntaxin-1B STX1B Tbio Non-IDG -1.74488 52.6 27
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
C-reactive protein CRP Tbio Non-IDG -4.51399 33883.5 1160
Nucleoprotein TPR TPR Tbio Non-IDG -2.07876 130.9 158
ATP synthase F(0) complex subunit C3, mitochondrial ATP5G3 Tdark Enzyme -1.10871 11.9 27