Development Level

Tbio 5,027 | 10,625
Tdark 2,184 | 7,003
Tchem 1,152 | 1,890
Tclin 508 | 602

Collection

Eligible non-olfactory GPCR Proteins 136 | 145
Eligible Ion Channel Proteins 112 | 117
Eligible Kinase Proteins 39 | 134

IMPC Term

preweaning lethality, complete... 308 | 633
preweaning lethality, incomple... 132 | 260
abnormal behavior 114 | 226
decreased lean body mass 108 | 195
decreased total body fat amoun... 102 | 186
embryonic lethality prior to t... 102 | 187
decreased bone mineral content 94 | 157
decreased body weight 91 | 174
decreased bone mineral density 73 | 126
embryonic lethality prior to o... 73 | 148
abnormal bone structure 71 | 131
increased or absent threshold ... 66 | 128
decreased grip strength 63 | 123
increased circulating alkaline... 63 | 119
hyperactivity 60 | 108
enlarged heart 56 | 111
increased mean corpuscular hem... 55 | 93
abnormal embryo size 54 | 112
increased lean body mass 54 | 107
abnormal retina morphology 53 | 100
decreased circulating glucose ... 53 | 121
hypoactivity 49 | 89
decreased body length 47 | 108
decreased circulating choleste... 47 | 85
increased mean corpuscular vol... 47 | 91
decreased circulating triglyce... 44 | 83
increased grip strength 43 | 83
decreased circulating insulin ... 41 | 75
decreased circulating HDL chol... 40 | 77
increased bone mineral content 40 | 92
increased circulating sodium l... 37 | 71
increased total body fat amoun... 36 | 57
abnormal lens morphology 35 | 73
decreased rib number 34 | 59
short tibia 34 | 82
decreased circulating serum al... 33 | 79
decreased fasted circulating g... 33 | 49
increased fasted circulating g... 33 | 68
improved glucose tolerance 32 | 56
abnormal sleep behavior 31 | 63
decreased prepulse inhibition 31 | 52
abnormal retinal pigmentation 30 | 61
decreased circulating alanine ... 30 | 53
prenatal lethality prior to he... 30 | 64
abnormal bone mineralization 29 | 55
decreased lumbar vertebrae num... 29 | 62
impaired glucose tolerance 29 | 52
abnormal gait 28 | 51
decreased startle reflex 28 | 48
increased circulating HDL chol... 28 | 63
decreased leukocyte cell numbe... 27 | 54
decreased mean corpuscular vol... 27 | 50
male infertility 27 | 62
increased bone mineral density 26 | 52
decreased heart weight 25 | 44
increased heart weight 25 | 37
increased hemoglobin content 25 | 45
decreased hemoglobin content 24 | 53
increased blood urea nitrogen ... 24 | 44
increased circulating choleste... 24 | 53
increased exploration in new e... 24 | 56
increased sacral vertebrae num... 24 | 62
abnormal heart morphology 23 | 51
abnormal neural tube closure 23 | 37
abnormal seminal vesicle morph... 23 | 47
cardiovascular system phenotyp... 23 | 35
increased body weight 23 | 42
limb grasping 23 | 35
thrombocytopenia 23 | 46
decreased mean corpuscular hem... 22 | 34
increased circulating chloride... 22 | 43
increased hematocrit 22 | 36
abnormal behavioral response t... 21 | 52
decreased caudal vertebrae num... 21 | 49
decreased circulating calcium ... 21 | 33
decreased eosinophil cell numb... 21 | 41
increased circulating calcium ... 21 | 32
increased circulating potassiu... 21 | 31
increased leukocyte cell numbe... 21 | 37
decreased circulating LDL chol... 20 | 37
enlarged epididymis 20 | 27
tremors 20 | 34
abnormal epididymis morphology 19 | 31
decreased circulating alkaline... 19 | 41
decreased circulating creatini... 19 | 31
decreased circulating free fat... 19 | 39
abnormal coat/hair pigmentatio... 18 | 54
abnormal eye morphology 18 | 38
decreased NK T cell number 18 | 28
decreased erythrocyte cell num... 18 | 43
decreased circulating total pr... 17 | 41
decreased monocyte cell number 17 | 28
increased circulating phosphat... 17 | 24
increased rib number 17 | 41
increased startle reflex 17 | 38
abnormal spleen morphology 16 | 36
decreased T cell number 16 | 31
decreased circulating aspartat... 16 | 27
small testis 16 | 37
straub tail 16 | 26

Disease

ovarian cancer 4,081 | 8,492
osteosarcoma 3,749 | 7,933
psoriasis 3,302 | 6,685
medulloblastoma, large-cell 3,122 | 6,234
glioblastoma 2,901 | 5,572
lung cancer 2,246 | 4,473
atypical teratoid / rhabdoid tumor 2,230 | 4,369
pilocytic astrocytoma 1,759 | 3,086
intraductal papillary-mucinous neoplasm (IPMN) 1,666 | 3,289
lung carcinoma 1,639 | 2,844
invasive ductal carcinoma 1,558 | 2,950
intraductal papillary-mucinous adenoma (IPMA) 1,529 | 2,956
malignant mesothelioma 1,524 | 3,163
intraductal papillary-mucinous carcinoma (IPMC) 1,509 | 2,988
Breast cancer 1,500 | 3,099
non-small cell lung cancer 1,499 | 2,798
oligodendroglioma 1,497 | 2,849
lung adenocarcinoma 1,467 | 2,714
pediatric high grade glioma 1,467 | 2,712
primitive neuroectodermal tumor 1,467 | 3,031
Cancer 1,420 | 2,346
interstitial cystitis 1,318 | 2,299
ependymoma 1,300 | 2,514
pancreatic cancer 1,255 | 2,300
subependymal giant cell astrocytoma 1,222 | 2,287
Carcinoma 1,191 | 2,147
ulcerative colitis 1,172 | 2,087
astrocytic glioma 1,116 | 2,241
adult high grade glioma 1,092 | 2,148
pituitary cancer 1,012 | 1,972
Pick disease 985 | 1,893
diabetes mellitus 973 | 1,663
pancreatic ductal adenocarcinoma liver metastasis 957 | 1,795
ductal carcinoma in situ 938 | 1,745
group 3 medulloblastoma 936 | 2,254
group 4 medulloblastoma 930 | 1,875
cystic fibrosis 885 | 1,670
astrocytoma 845 | 1,493
tuberculosis 845 | 1,563
posterior fossa group A ependymoma 841 | 1,511
breast carcinoma 815 | 1,614
medulloblastoma 785 | 1,524
colon cancer 745 | 1,475
Multiple myeloma 714 | 1,328
primary pancreatic ductal adenocarcinoma 684 | 1,271
sonic hedgehog group medulloblastoma 683 | 1,482
adrenocortical carcinoma 677 | 1,427
Rheumatoid Arthritis 654 | 1,171
posterior fossa group B ependymoma 634 | 1,530
cutaneous lupus erythematosus 624 | 1,056
acute quadriplegic myopathy 582 | 1,157
juvenile dermatomyositis 568 | 1,189
atypical teratoid/rhabdoid tumor 567 | 1,095
active Crohn's disease 535 | 918
spina bifida 519 | 1,064
dermatomyositis 505 | 967
nasopharyngeal carcinoma 468 | 1,056
Atopic dermatitis 452 | 944
primary Sjogren syndrome 446 | 789
gastric carcinoma 432 | 832
non primary Sjogren syndrome sicca 425 | 840
esophageal adenocarcinoma 423 | 737
Alzheimer's disease 416 | 644
Obesity 391 | 616
Waldenstrons macroglobulinemia 376 | 765
acute myeloid leukemia 359 | 785
aldosterone-producing adenoma 347 | 664
Schizophrenia 336 | 503
Duchenne muscular dystrophy 335 | 602
Multiple Sclerosis 335 | 498
Down syndrome 334 | 548
progressive supranuclear palsy 314 | 674
Kidney disease 307 | 397
mucosa-associated lymphoid tissue lymphoma 307 | 480
pancreatic carcinoma 303 | 567
fibroadenoma 299 | 557
tuberculosis and treatment for 6 months 295 | 686
Intellectual disability 291 | 573
Prostatic Neoplasms 281 | 471
IGA Glomerulonephritis 280 | 454
active ulcerative colitis 275 | 477
Neurodegenerative disease 271 | 383
Endometriosis 270 | 535
autosomal dominant Emery-Dreifuss muscular dystrophy 264 | 499
Epilepsy 263 | 346
Hypertension 245 | 293
Asthma 243 | 349
Parkinson's disease 243 | 364
hepatocellular carcinoma 238 | 550
Mammary Neoplasms 236 | 410
non-small cell lung carcinoma 232 | 413
Amyotrophic Lateral Sclerosis 231 | 432
Autistic Disorder 218 | 320
Arthritis 215 | 248
Vascular disease 212 | 281
Hypersensitivity reaction type II disease 209 | 235
Atherosclerosis 206 | 275
Heart disease 200 | 279
sarcoidosis 199 | 368
gastric cancer 189 | 436

Tissue

Female tissues 8,551 | 18,647
Urinary Tract 8,498 | 18,444
Nervous System 8,488 | 18,561
Endocrine System 8,470 | 18,512
Digestive Tract 8,446 | 18,473
Skin and soft tissues 8,316 | 18,115
Liver and Pancreas 8,281 | 18,136
Blood and immune system 8,215 | 17,995
Cardiovascular System 8,205 | 17,958
Male tissues 8,160 | 17,969
Respiratory system 8,050 | 17,484

Target Family

Non-IDG 4,895 | 11,969
Enzyme 1,933 | 4,146
Transporter 464 | 473
GPCR 399 | 408
oGPCR 380 | 421
Ion Channel 336 | 341
Kinase 313 | 634
Transcription Factor 107 | 1,400
Epigenetic 30 | 242
Nuclear Receptor 11 | 48
TF/Epigenetic 3 | 38

Compartment GO Term

Membrane 8,871 | 8,871
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,612 | 13,612
Intracellular part 13,475 | 13,475
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,353 | 10,353
Organelle part 8,169 | 8,169
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,831 | 7,831
Nucleus 7,577 | 7,577
Membrane part 6,469 | 6,469
Cytosol 6,034 | 6,034
Plasma membrane 5,673 | 5,673
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,171 | 5,171
Cell periphery 5,146 | 5,146
Nucleoplasm 4,930 | 4,930
Extracellular region 4,607 | 4,607
Protein complex 4,439 | 4,439
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,874 | 3,874
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,592 | 2,592
Plasma membrane part 2,564 | 2,564
Cytoskeleton 2,046 | 2,046
Golgi apparatus 1,946 | 1,946
Endoplasmic reticulum 1,872 | 1,872
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Vesicles 1,625 | 1,625
Cytoskeletal part 1,568 | 1,568
Mitochondrion 1,530 | 1,530
Cell projection 1,425 | 1,425
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,234 | 1,234
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,092 | 1,092
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,084 | 1,084
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Mitochondria 1,003 | 1,003
Chromosome 999 | 999
Mitochondrial part 988 | 988
Nucleoli 950 | 950
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 815 | 815
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 781 | 781
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 739 | 739
Plasma membrane protein comple... 721 | 721
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Microtubule organizing center 680 | 680
Centrosome 676 | 676
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 656 | 656
Extracellular matrix 633 | 633
Synapse 594 | 594
Lytic vacuole 571 | 571

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA polymerase delta catalytic subunit POLD1 Tclin Enzyme -2.02098 96.6 198
V-type proton ATPase 116 kDa subunit a isoform 2 ATP6V0A2 Tbio Enzyme -2.43448 279.3 62
HLA class I histocompatibility antigen, alpha chain G HLA-G Tbio Non-IDG -3.07995 1275.9 729
cAMP-dependent protein kinase catalytic subunit alpha PRKACA Tchem Kinase -1.02404 9.59 274
GPI mannosyltransferase 4 PIGZ Tdark Enzyme -1.17375 14.4 26
Mitochondrial coenzyme A transporter SLC25A42 SLC25A42 Tbio Transporter -0.38872 3.06 24
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.25741 172.1 240
Equilibrative nucleoside transporter 1 SLC29A1 Tclin Transporter -2.59024 397.3 363
Transmembrane 9 superfamily member 2 TM9SF2 Tdark Non-IDG -0.27748 1.00 57
Solute carrier family 25 member 33 SLC25A33 Tbio Transporter -0.28165 1.49 35