Development Level

Tbio 3,363 | 10,625
Tchem 801 | 1,890
Tdark 633 | 7,003
Tclin 375 | 602

Collection

Eligible Ion Channel Proteins 63 | 117
Eligible Kinase Proteins 20 | 134
Eligible non-olfactory GPCR Proteins 9 | 143

IMPC Term

preweaning lethality, complete... 345 | 633
embryonic lethality prior to t... 113 | 187
embryonic lethality prior to o... 96 | 148
preweaning lethality, incomple... 96 | 260
abnormal behavior 72 | 226
decreased lean body mass 69 | 195
abnormal embryo size 60 | 112
decreased total body fat amoun... 60 | 186
decreased body weight 56 | 174
decreased bone mineral content 53 | 157
abnormal bone structure 50 | 131
decreased circulating glucose ... 44 | 121
increased mean corpuscular vol... 42 | 91
abnormal retina morphology 41 | 100
decreased bone mineral density 41 | 126
decreased body length 40 | 108
decreased grip strength 40 | 123
increased circulating alkaline... 40 | 119
increased grip strength 37 | 83
increased mean corpuscular hem... 36 | 93
increased or absent threshold ... 35 | 128
enlarged heart 33 | 111
hyperactivity 33 | 108
increased lean body mass 31 | 107
abnormal lens morphology 30 | 73
increased bone mineral content 28 | 92
increased circulating sodium l... 28 | 71
increased fasted circulating g... 28 | 68
prenatal lethality prior to he... 28 | 64
decreased circulating choleste... 27 | 85
decreased circulating triglyce... 27 | 83
decreased circulating insulin ... 26 | 75
increased circulating HDL chol... 25 | 63
decreased circulating HDL chol... 24 | 77
decreased lumbar vertebrae num... 24 | 62
abnormal gait 23 | 51
decreased circulating serum al... 23 | 79
increased circulating choleste... 23 | 53
short tibia 23 | 82
decreased circulating alanine ... 22 | 53
decreased leukocyte cell numbe... 22 | 54
increased sacral vertebrae num... 22 | 62
abnormal bone mineralization 21 | 55
hypoactivity 21 | 89
increased exploration in new e... 21 | 56
thrombocytopenia 21 | 46
abnormal retinal pigmentation 20 | 61
decreased mean corpuscular vol... 20 | 50
male infertility 20 | 62
decreased prepulse inhibition 19 | 52
abnormal sleep behavior 18 | 63
embryonic growth retardation 18 | 28
impaired glucose tolerance 18 | 52
increased bone mineral density 18 | 52
increased leukocyte cell numbe... 18 | 37
increased total body fat amoun... 18 | 57
abnormal coat/hair pigmentatio... 17 | 54
abnormal neural tube closure 17 | 37
cardiovascular system phenotyp... 17 | 35
decreased erythrocyte cell num... 17 | 43
decreased fasted circulating g... 17 | 49
decreased heart weight 17 | 44
decreased hemoglobin content 17 | 53
increased circulating chloride... 17 | 43
decreased rib number 16 | 59
abnormal behavioral response t... 15 | 52
abnormal heart morphology 15 | 51
decreased circulating alkaline... 15 | 41
decreased circulating free fat... 15 | 39
decreased startle reflex 15 | 48
increased hematocrit 15 | 36
increased hemoglobin content 15 | 45
abnormal hindbrain development 14 | 24
decreased caudal vertebrae num... 14 | 49
increased blood urea nitrogen ... 14 | 44
increased heart weight 14 | 37
tremors 14 | 34
abnormal midbrain development 13 | 22
abnormal tooth morphology 13 | 24
cataract 13 | 26
decreased circulating LDL chol... 13 | 37
decreased circulating fructosa... 13 | 31
increased body weight 13 | 42
increased circulating triglyce... 13 | 24
vertebral fusion 13 | 23
decreased T cell number 12 | 31
decreased blood urea nitrogen ... 12 | 31
decreased circulating aspartat... 12 | 27
decreased circulating chloride... 12 | 32
decreased eosinophil cell numb... 12 | 41
improved glucose tolerance 12 | 56
persistence of hyaloid vascula... 12 | 22
small testis 12 | 37
abnormal seminal vesicle morph... 11 | 47
decreased circulating calcium ... 11 | 33
decreased circulating total pr... 11 | 41
decreased effector memory CD8-... 11 | 24
decreased mean corpuscular hem... 11 | 34
hydrops fetalis 11 | 22
increased mean corpuscular hem... 11 | 25

Disease

ovarian cancer 2,798 | 8,484
osteosarcoma 2,367 | 7,933
psoriasis 2,055 | 6,685
medulloblastoma, large-cell 1,825 | 6,234
glioblastoma 1,738 | 5,572
lung cancer 1,690 | 4,466
Cancer 1,520 | 2,346
atypical teratoid / rhabdoid tumor 1,252 | 4,369
malignant mesothelioma 1,069 | 3,162
Breast cancer 1,061 | 3,094
intraductal papillary-mucinous neoplasm (IPMN) 1,023 | 3,289
invasive ductal carcinoma 941 | 2,950
intraductal papillary-mucinous carcinoma (IPMC) 937 | 2,988
primitive neuroectodermal tumor 916 | 3,031
non-small cell lung cancer 915 | 2,798
pediatric high grade glioma 902 | 2,712
oligodendroglioma 894 | 2,849
lung adenocarcinoma 877 | 2,713
intraductal papillary-mucinous adenoma (IPMA) 866 | 2,956
pilocytic astrocytoma 860 | 3,086
lung carcinoma 827 | 2,844
diabetes mellitus 784 | 1,663
Carcinoma 780 | 2,147
ependymoma 745 | 2,514
group 3 medulloblastoma 733 | 2,254
pancreatic cancer 729 | 2,300
subependymal giant cell astrocytoma 707 | 2,287
Multiple myeloma 677 | 1,327
ulcerative colitis 676 | 2,087
interstitial cystitis 643 | 2,299
astrocytic glioma 609 | 2,241
pancreatic ductal adenocarcinoma liver metastasis 588 | 1,795
Pick disease 583 | 1,893
astrocytoma 571 | 1,493
pituitary cancer 551 | 1,972
tuberculosis 541 | 1,557
colon cancer 535 | 1,475
group 4 medulloblastoma 533 | 1,875
ductal carcinoma in situ 532 | 1,745
breast carcinoma 529 | 1,614
adult high grade glioma 525 | 2,148
Rheumatoid Arthritis 487 | 1,160
cystic fibrosis 483 | 1,665
posterior fossa group A ependymoma 480 | 1,511
adrenocortical carcinoma 479 | 1,427
acute quadriplegic myopathy 473 | 1,157
sonic hedgehog group medulloblastoma 449 | 1,482
juvenile dermatomyositis 439 | 1,189
primary pancreatic ductal adenocarcinoma 423 | 1,271
medulloblastoma 422 | 1,524
dermatomyositis 406 | 933
Waldenstrons macroglobulinemia 392 | 765
cutaneous lupus erythematosus 358 | 1,056
nasopharyngeal carcinoma 338 | 1,056
posterior fossa group B ependymoma 337 | 1,530
atypical teratoid/rhabdoid tumor 327 | 1,095
Obesity 308 | 616
Alzheimer's disease 298 | 644
Kidney disease 289 | 396
gastric carcinoma 288 | 832
acute myeloid leukemia 286 | 780
Atopic dermatitis 284 | 944
primary Sjogren syndrome 275 | 789
spina bifida 259 | 1,064
Mammary Neoplasms 258 | 410
non primary Sjogren syndrome sicca 257 | 840
Multiple Sclerosis 244 | 498
Duchenne muscular dystrophy 243 | 602
active Crohn's disease 242 | 918
Prostatic Neoplasms 235 | 471
Intellectual disability 234 | 573
Endometriosis 232 | 535
Arthritis 229 | 248
esophageal adenocarcinoma 225 | 737
Vascular disease 215 | 281
Down syndrome 214 | 548
progressive supranuclear palsy 214 | 674
aldosterone-producing adenoma 211 | 664
Hypertension 210 | 287
Atherosclerosis 207 | 275
Hypersensitivity reaction type II disease 204 | 235
tuberculosis and treatment for 6 months 204 | 686
Anemia 201 | 252
Schizophrenia 200 | 501
Heart disease 198 | 279
IGA Glomerulonephritis 198 | 454
pancreatic carcinoma 197 | 567
Asthma 195 | 349
autosomal dominant Emery-Dreifuss muscular dystrophy 194 | 499
hepatocellular carcinoma 192 | 532
Cerebrovascular disease 184 | 231
Coronary artery disease 179 | 240
Epilepsy 179 | 346
Parkinson's disease 179 | 364
Neurodegenerative disease 177 | 383
mucosa-associated lymphoid tissue lymphoma 173 | 480
Amyotrophic Lateral Sclerosis 170 | 431
Stomach Neoplasms 168 | 282
Liver disease 162 | 219
non-small cell lung carcinoma 159 | 413

Tissue

Female tissues 5,039 | 18,647
Nervous System 5,035 | 18,561
Endocrine System 5,026 | 18,512
Digestive Tract 5,023 | 18,473
Urinary Tract 5,020 | 18,444
Liver and Pancreas 5,011 | 18,136
Blood and immune system 5,000 | 17,995
Cardiovascular System 4,995 | 17,958
Male tissues 4,978 | 17,969
Skin and soft tissues 4,961 | 18,115
Respiratory system 4,950 | 17,484

Target Family

Non-IDG 3,202 | 11,971
Enzyme 1,001 | 4,146
Transcription Factor 266 | 1,400
Kinase 208 | 634
Ion Channel 199 | 341
Epigenetic 130 | 242
GPCR 72 | 406
Transporter 56 | 473
Nuclear Receptor 25 | 48
TF/Epigenetic 13 | 38

Compartment GO Term

Macromolecular complex 5,172 | 5,172
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,170 | 8,170
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,830 | 7,830
Nucleus 6,897 | 6,897
Membrane part 6,469 | 6,469
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Cell periphery 5,145 | 5,145
Plasma membrane 5,059 | 5,059
Extracellular region 4,606 | 4,606
Protein complex 4,438 | 4,438
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Cytosol 3,352 | 3,352
Nucleoplasm 2,938 | 2,938
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,563 | 2,563
Cytoskeleton 2,045 | 2,045
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Endoplasmic reticulum 1,663 | 1,663
Cytoskeletal part 1,567 | 1,567
Mitochondrion 1,530 | 1,530
Cell projection 1,426 | 1,426
Golgi apparatus 1,402 | 1,402
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,233 | 1,233
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Chromosome 999 | 999
Mitochondrial part 989 | 989
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 780 | 780
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 738 | 738
Plasma membrane protein comple... 720 | 720
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Microtubule organizing center 617 | 617
Synapse 594 | 594
Lysosome 571 | 571
Lytic vacuole 571 | 571
Vesicle membrane 559 | 559
cell-cell junction 557 | 557
Cytoplasmic vesicle membrane 552 | 552

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
D(2) dopamine receptor DRD2 Tclin GPCR -3.24474 1775.2 248
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Syntaxin-1B STX1B Tbio Non-IDG -1.74488 52.6 27
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
C-reactive protein CRP Tbio Non-IDG -4.51399 33883.5 1160
cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A Tclin Enzyme -3.31593 2169.0 108
Nucleoprotein TPR TPR Tbio Non-IDG -2.07876 130.9 158
ATP synthase F(0) complex subunit C3, mitochondrial ATP5G3 Tdark Enzyme -1.10871 11.9 27