Development Level

Tbio 3,362 | 10,625
Tchem 801 | 1,890
Tdark 633 | 7,003
Tclin 375 | 602

Collection

Eligible Ion Channel Proteins 63 | 117
Eligible Kinase Proteins 20 | 134
Eligible non-olfactory GPCR Proteins 9 | 145

IMPC Term

preweaning lethality, complete... 345 | 633
embryonic lethality prior to t... 113 | 187
embryonic lethality prior to o... 96 | 148
preweaning lethality, incomple... 96 | 260
abnormal behavior 72 | 226
decreased lean body mass 69 | 195
abnormal embryo size 60 | 112
decreased total body fat amoun... 60 | 186
decreased body weight 56 | 174
decreased bone mineral content 53 | 157
abnormal bone structure 50 | 131
decreased circulating glucose ... 44 | 121
increased mean corpuscular vol... 42 | 91
abnormal retina morphology 41 | 100
decreased bone mineral density 41 | 126
decreased body length 40 | 108
decreased grip strength 40 | 123
increased circulating alkaline... 40 | 119
increased grip strength 37 | 83
increased mean corpuscular hem... 36 | 93
increased or absent threshold ... 35 | 128
enlarged heart 33 | 111
hyperactivity 33 | 108
increased lean body mass 31 | 107
abnormal lens morphology 30 | 73
increased bone mineral content 28 | 92
increased circulating sodium l... 28 | 71
increased fasted circulating g... 28 | 68
prenatal lethality prior to he... 28 | 64
decreased circulating choleste... 27 | 85
decreased circulating triglyce... 27 | 83
decreased circulating insulin ... 26 | 75
increased circulating HDL chol... 25 | 63
decreased circulating HDL chol... 24 | 77
decreased lumbar vertebrae num... 24 | 62
abnormal gait 23 | 51
decreased circulating serum al... 23 | 79
increased circulating choleste... 23 | 53
short tibia 23 | 82
decreased circulating alanine ... 22 | 53
decreased leukocyte cell numbe... 22 | 54
increased sacral vertebrae num... 22 | 62
abnormal bone mineralization 21 | 55
hypoactivity 21 | 89
increased exploration in new e... 21 | 56
thrombocytopenia 21 | 46
abnormal retinal pigmentation 20 | 61
decreased mean corpuscular vol... 20 | 50
male infertility 20 | 62
decreased prepulse inhibition 19 | 52
abnormal sleep behavior 18 | 63
embryonic growth retardation 18 | 28
impaired glucose tolerance 18 | 52
increased bone mineral density 18 | 52
increased leukocyte cell numbe... 18 | 37
increased total body fat amoun... 18 | 57
abnormal coat/hair pigmentatio... 17 | 54
abnormal neural tube closure 17 | 37
cardiovascular system phenotyp... 17 | 35
decreased erythrocyte cell num... 17 | 43
decreased fasted circulating g... 17 | 49
decreased heart weight 17 | 44
decreased hemoglobin content 17 | 53
decreased rib number 16 | 59
increased circulating chloride... 16 | 43
abnormal behavioral response t... 15 | 52
abnormal heart morphology 15 | 51
decreased circulating alkaline... 15 | 41
decreased circulating free fat... 15 | 39
decreased startle reflex 15 | 48
increased hematocrit 15 | 36
increased hemoglobin content 15 | 45
abnormal hindbrain development 14 | 24
decreased caudal vertebrae num... 14 | 49
increased blood urea nitrogen ... 14 | 44
increased heart weight 14 | 37
tremors 14 | 34
abnormal midbrain development 13 | 22
abnormal tooth morphology 13 | 24
cataract 13 | 26
decreased circulating LDL chol... 13 | 37
decreased circulating fructosa... 13 | 31
increased body weight 13 | 42
increased circulating triglyce... 13 | 24
vertebral fusion 13 | 23
decreased T cell number 12 | 31
decreased blood urea nitrogen ... 12 | 31
decreased circulating aspartat... 12 | 27
decreased circulating chloride... 12 | 32
decreased eosinophil cell numb... 12 | 41
improved glucose tolerance 12 | 56
persistence of hyaloid vascula... 12 | 22
small testis 12 | 37
abnormal seminal vesicle morph... 11 | 47
decreased circulating calcium ... 11 | 33
decreased circulating total pr... 11 | 41
decreased effector memory CD8-... 11 | 24
decreased mean corpuscular hem... 11 | 34
hydrops fetalis 11 | 22
increased mean corpuscular hem... 11 | 25

Disease

ovarian cancer 2,804 | 8,492
osteosarcoma 2,366 | 7,933
psoriasis 2,055 | 6,685
medulloblastoma, large-cell 1,825 | 6,234
glioblastoma 1,737 | 5,572
lung cancer 1,693 | 4,473
Cancer 1,519 | 2,346
atypical teratoid / rhabdoid tumor 1,251 | 4,369
malignant mesothelioma 1,070 | 3,163
Breast cancer 1,065 | 3,099
intraductal papillary-mucinous neoplasm (IPMN) 1,022 | 3,289
invasive ductal carcinoma 940 | 2,950
intraductal papillary-mucinous carcinoma (IPMC) 936 | 2,988
non-small cell lung cancer 915 | 2,798
primitive neuroectodermal tumor 915 | 3,031
pediatric high grade glioma 901 | 2,712
oligodendroglioma 894 | 2,849
lung adenocarcinoma 878 | 2,714
intraductal papillary-mucinous adenoma (IPMA) 865 | 2,956
pilocytic astrocytoma 859 | 3,086
lung carcinoma 826 | 2,844
diabetes mellitus 784 | 1,663
Carcinoma 780 | 2,147
ependymoma 745 | 2,514
group 3 medulloblastoma 733 | 2,254
pancreatic cancer 728 | 2,300
subependymal giant cell astrocytoma 706 | 2,287
Multiple myeloma 677 | 1,328
ulcerative colitis 675 | 2,087
interstitial cystitis 643 | 2,299
astrocytic glioma 609 | 2,241
pancreatic ductal adenocarcinoma liver metastasis 588 | 1,795
Pick disease 583 | 1,893
astrocytoma 570 | 1,493
pituitary cancer 550 | 1,972
tuberculosis 542 | 1,563
colon cancer 535 | 1,475
group 4 medulloblastoma 533 | 1,875
ductal carcinoma in situ 532 | 1,745
breast carcinoma 529 | 1,614
adult high grade glioma 525 | 2,148
Rheumatoid Arthritis 487 | 1,171
cystic fibrosis 486 | 1,670
adrenocortical carcinoma 479 | 1,427
posterior fossa group A ependymoma 479 | 1,511
acute quadriplegic myopathy 472 | 1,157
sonic hedgehog group medulloblastoma 448 | 1,482
dermatomyositis 440 | 967
juvenile dermatomyositis 438 | 1,189
medulloblastoma 422 | 1,524
primary pancreatic ductal adenocarcinoma 422 | 1,271
Waldenstrons macroglobulinemia 392 | 765
cutaneous lupus erythematosus 358 | 1,056
nasopharyngeal carcinoma 338 | 1,056
posterior fossa group B ependymoma 337 | 1,530
atypical teratoid/rhabdoid tumor 327 | 1,095
Obesity 308 | 616
Alzheimer's disease 298 | 644
acute myeloid leukemia 290 | 785
Kidney disease 289 | 397
gastric carcinoma 287 | 832
Atopic dermatitis 284 | 944
primary Sjogren syndrome 275 | 789
spina bifida 259 | 1,064
Mammary Neoplasms 257 | 410
non primary Sjogren syndrome sicca 256 | 840
Multiple Sclerosis 244 | 498
Duchenne muscular dystrophy 242 | 602
active Crohn's disease 242 | 918
Intellectual disability 234 | 573
Prostatic Neoplasms 234 | 471
Endometriosis 232 | 535
Arthritis 229 | 248
esophageal adenocarcinoma 225 | 737
Hypertension 215 | 293
Vascular disease 215 | 281
progressive supranuclear palsy 214 | 674
Down syndrome 213 | 548
aldosterone-producing adenoma 211 | 664
Atherosclerosis 207 | 275
Hypersensitivity reaction type II disease 204 | 235
hepatocellular carcinoma 204 | 550
tuberculosis and treatment for 6 months 204 | 686
Schizophrenia 202 | 503
Anemia 201 | 252
Heart disease 198 | 279
IGA Glomerulonephritis 198 | 454
pancreatic carcinoma 197 | 567
Asthma 195 | 349
autosomal dominant Emery-Dreifuss muscular dystrophy 193 | 499
Cerebrovascular disease 184 | 231
Coronary artery disease 179 | 240
Epilepsy 179 | 346
Parkinson's disease 178 | 364
Neurodegenerative disease 177 | 383
mucosa-associated lymphoid tissue lymphoma 173 | 480
Amyotrophic Lateral Sclerosis 170 | 432
Stomach Neoplasms 168 | 282
Liver disease 162 | 219
non-small cell lung carcinoma 159 | 413

Tissue

Female tissues 5,038 | 18,647
Nervous System 5,034 | 18,561
Endocrine System 5,025 | 18,512
Digestive Tract 5,022 | 18,473
Urinary Tract 5,019 | 18,444
Liver and Pancreas 5,010 | 18,136
Blood and immune system 4,999 | 17,995
Cardiovascular System 4,994 | 17,958
Male tissues 4,977 | 17,969
Skin and soft tissues 4,960 | 18,115
Respiratory system 4,949 | 17,484

Target Family

Non-IDG 3,201 | 11,969
Enzyme 1,001 | 4,146
Transcription Factor 266 | 1,400
Kinase 208 | 634
Ion Channel 199 | 341
Epigenetic 130 | 242
GPCR 72 | 408
Transporter 56 | 473
Nuclear Receptor 25 | 48
TF/Epigenetic 13 | 38

Compartment GO Term

Macromolecular complex 5,171 | 5,171
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,612 | 13,612
Intracellular part 13,475 | 13,475
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,353 | 10,353
Membrane 8,871 | 8,871
Organelle part 8,169 | 8,169
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,831 | 7,831
Nucleus 7,577 | 7,577
Membrane part 6,469 | 6,469
Cytosol 6,034 | 6,034
Plasma membrane 5,673 | 5,673
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Cell periphery 5,146 | 5,146
Nucleoplasm 4,930 | 4,930
Extracellular region 4,607 | 4,607
Protein complex 4,439 | 4,439
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,874 | 3,874
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,592 | 2,592
Plasma membrane part 2,564 | 2,564
Cytoskeleton 2,046 | 2,046
Golgi apparatus 1,946 | 1,946
Endoplasmic reticulum 1,872 | 1,872
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Vesicles 1,625 | 1,625
Cytoskeletal part 1,568 | 1,568
Mitochondrion 1,530 | 1,530
Cell projection 1,425 | 1,425
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,234 | 1,234
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,092 | 1,092
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,084 | 1,084
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Mitochondria 1,003 | 1,003
Chromosome 999 | 999
Mitochondrial part 988 | 988
Nucleoli 950 | 950
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 815 | 815
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 781 | 781
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 739 | 739
Plasma membrane protein comple... 721 | 721
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Microtubule organizing center 680 | 680
Centrosome 676 | 676
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 656 | 656
Extracellular matrix 633 | 633
Synapse 594 | 594
Lytic vacuole 571 | 571

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA polymerase delta catalytic subunit POLD1 Tclin Enzyme -2.02098 96.6 198
V-type proton ATPase 116 kDa subunit a isoform 2 ATP6V0A2 Tbio Enzyme -2.43448 279.3 62
HLA class I histocompatibility antigen, alpha chain G HLA-G Tbio Non-IDG -3.07995 1275.9 729
cAMP-dependent protein kinase catalytic subunit alpha PRKACA Tchem Kinase -1.02404 9.59 274
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.49889 302.1 11
Protein BRICK1 BRK1 Tbio Non-IDG -1.42109 29.2 53
ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 Tbio Transporter -0.85002 7.01 82
Cullin-associated NEDD8-dissociated protein 1 CAND1 Tbio Non-IDG -1.85520 69.1 156
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial MCCC2 Tbio Enzyme -1.23140 15.5 156
Rab GTPase-activating protein 1 RABGAP1 Tbio Enzyme -0.67656 3.42 165