Development Level

Tbio 3,881 | 11,651
Tdark 604 | 6,593
Tchem 597 | 1,388
Tclin 394 | 612

Collection

RFA-RM-18-021 83 | 328
Ion Channel: IDG Consortium (T... 51 | 99
Kinase: IDG Consortium (Target... 24 | 125
GPCR: IDG Consortium (Targets) 10 | 126
Kinase: IDG Consortium (Comple... 4 | 37
GPCR: IDG Consortium (Complete... 3 | 25

IMPC Phenotype

preweaning lethality, complete... 539 | 979
embryonic lethality prior to t... 167 | 278
preweaning lethality, incomple... 160 | 499
embryonic lethality prior to o... 151 | 239
abnormal embryo size 117 | 220
abnormal behavior 98 | 298
decreased total body fat amoun... 73 | 207
abnormal bone structure 69 | 187
enlarged heart 67 | 210
decreased vertical activity 63 | 208
embryonic growth retardation 60 | 106
decreased bone mineral content 59 | 151
increased total body fat amoun... 54 | 134
decreased body weight 53 | 161
abnormal heart morphology 51 | 162
increased lean body mass 51 | 172
hyperactivity 49 | 148
decreased circulating glucose ... 48 | 126
decreased lean body mass 45 | 135
increased circulating alkaline... 45 | 122
increased mean corpuscular vol... 44 | 92
decreased bone mineral density 40 | 126
impaired glucose tolerance 40 | 75
increased startle reflex 40 | 112
prenatal lethality prior to he... 40 | 87
increased mean corpuscular hem... 39 | 96
hypoactivity 38 | 132
increased bone mineral content 38 | 108
abnormal seminal vesicle morph... 37 | 114
abnormal retina morphology 36 | 71
cataract 36 | 92
male infertility 36 | 123
decreased circulating choleste... 35 | 93
decreased grip strength 34 | 116
abnormal lens morphology 33 | 81
decreased body length 33 | 101
increased fasted circulating g... 33 | 76
increased circulating HDL chol... 31 | 80
short tibia 31 | 97
decreased mean corpuscular vol... 30 | 79
decreased lymphocyte cell numb... 29 | 83
decreased leukocyte cell numbe... 28 | 73
abnormal gait 27 | 69
decreased erythrocyte cell num... 27 | 62
edema 27 | 59
increased circulating choleste... 27 | 66
increased circulating sodium l... 27 | 71
increased heart weight 26 | 62
decreased circulating HDL chol... 25 | 68
decreased circulating insulin ... 25 | 76
increased bone mineral density 25 | 72
increased leukocyte cell numbe... 25 | 47
increased or absent threshold ... 25 | 101
small superior vagus ganglion 25 | 74
thrombocytopenia 25 | 56
decreased circulating triglyce... 24 | 79
decreased prepulse inhibition 24 | 82
increased grip strength 23 | 41
abnormal sleep behavior 22 | 70
decreased circulating serum al... 22 | 82
decreased hemoglobin content 22 | 68
abnormal behavioral response t... 21 | 66
decreased fasted circulating g... 21 | 65
decreased startle reflex 21 | 75
increased neutrophil cell numb... 21 | 46
prolonged QT interval 21 | 38
abnormal eye morphology 20 | 68
decreased circulating alanine ... 20 | 47
decreased neutrophil cell numb... 20 | 42
improved glucose tolerance 20 | 79
increased circulating chloride... 20 | 41
abnormal embryo turning 19 | 31
abnormal kidney morphology 19 | 65
abnormal neural tube closure 19 | 46
decreased circulating alkaline... 19 | 46
increased hemoglobin content 19 | 45
increased lymphocyte cell numb... 19 | 32
prolonged ST segment 19 | 36
decreased mean corpuscular hem... 18 | 50
increased circulating triglyce... 18 | 42
increased monocyte cell number 18 | 63
tremors 18 | 39
abnormal pericardium morpholog... 17 | 26
cardiovascular system phenotyp... 17 | 36
enlarged spleen 17 | 41
small testis 17 | 58
abnormal coat-hair pigmentatio... 16 | 64
decreased blood urea nitrogen ... 16 | 51
decreased caudal vertebrae num... 16 | 53
decreased circulating creatini... 16 | 39
decreased red blood cell distr... 16 | 41
increased mean platelet volume 16 | 45
decreased circulating total pr... 15 | 49
decreased hematocrit 15 | 46
hydrometra 15 | 53
increased hematocrit 15 | 46
limb grasping 15 | 41
pallor 15 | 34
persistence of hyaloid vascula... 15 | 33
prenatal lethality 15 | 28

Disease

Carcinoma 3,409 | 11,493
ovarian cancer 2,977 | 8,520
osteosarcoma 2,516 | 7,950
psoriasis 2,169 | 6,694
medulloblastoma, large-cell 1,929 | 6,241
glioblastoma 1,900 | 5,792
lung cancer 1,842 | 4,740
Cancer 1,634 | 2,499
atypical teratoid / rhabdoid tumor 1,543 | 5,112
ependymoma 1,407 | 4,679
group 3 medulloblastoma 1,329 | 4,104
Breast cancer 1,290 | 3,578
malignant mesothelioma 1,177 | 3,232
adult high grade glioma 1,131 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 1,064 | 3,291
non-small cell lung cancer 995 | 2,890
invasive ductal carcinoma 989 | 2,951
Kidney cancer 960 | 2,613
intraductal papillary-mucinous carcinoma (IPMC) 954 | 2,989
primitive neuroectodermal tumor 949 | 3,035
oligodendroglioma 942 | 2,850
lung adenocarcinoma 912 | 2,716
Astrocytoma, Pilocytic 899 | 3,081
intraductal papillary-mucinous adenoma (IPMA) 896 | 2,955
lung carcinoma 892 | 2,843
diabetes mellitus 850 | 1,728
astrocytic glioma 799 | 2,597
pancreatic cancer 795 | 2,398
subependymal giant cell astrocytoma 732 | 2,287
tuberculosis 703 | 2,010
Multiple myeloma 701 | 1,332
interstitial cystitis 685 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 677 | 1,962
Autosomal recessive predisposition 659 | 1,442
ulcerative colitis 636 | 1,819
Pick disease 618 | 1,894
breast carcinoma 582 | 1,638
pituitary cancer 580 | 1,972
colon cancer 564 | 1,478
ductal carcinoma in situ 564 | 1,745
group 4 medulloblastoma 552 | 1,855
Schizophrenia 532 | 1,160
Rheumatoid arthritis 512 | 1,191
cystic fibrosis 512 | 1,696
adrenocortical carcinoma 487 | 1,428
acute quadriplegic myopathy 480 | 1,158
Intellectual disability 466 | 1,016
dermatomyositis 460 | 966
astrocytoma 457 | 1,146
juvenile dermatomyositis 448 | 1,187
Waldenstrons macroglobulinemia 398 | 765
Epilepsy 393 | 792
cutaneous lupus erythematosus 386 | 1,057
pediatric high grade glioma 371 | 1,064
primary pancreatic ductal adenocarcinoma 369 | 1,109
Obesity 358 | 678
nasopharyngeal carcinoma 351 | 1,058
Alzheimer's disease 325 | 658
Kidney disease 312 | 430
Liver Cirrhosis, Experimental 312 | 769
Atopic dermatitis 306 | 952
Seizures 306 | 596
Bipolar Disorder 305 | 666
Dull intelligence 304 | 645
Low intelligence 304 | 645
Mental Retardation 304 | 645
Mental deficiency 304 | 645
Poor school performance 304 | 645
acute myeloid leukemia 302 | 783
Cognitive delay 299 | 608
Global developmental delay 299 | 608
Hypertension 299 | 396
Mental and motor retardation 299 | 608
Short stature 298 | 531
non primary Sjogren syndrome sicca 297 | 891
Breast Neoplasms 285 | 445
Melanoma 284 | 711
gastric carcinoma 279 | 807
spina bifida 277 | 1,074
Mammary Neoplasms 273 | 425
Muscle hypotonia 272 | 571
Multiple Sclerosis 271 | 540
Anemia 264 | 365
primary Sjogren syndrome 264 | 735
active Crohn's disease 262 | 922
Arthritis 251 | 290
Vascular disease 244 | 319
Prostatic Neoplasms 243 | 495
Duchenne muscular dystrophy 242 | 601
Liver cancer 241 | 604
Depressive disorder 238 | 409
esophageal adenocarcinoma 237 | 737
Endometriosis 235 | 540
progressive supranuclear palsy 225 | 676
Asthma 224 | 385
Hypersensitivity reaction type II disease 224 | 253
aldosterone-producing adenoma 223 | 665
Atherosclerosis 221 | 291
active ulcerative colitis 215 | 764
Small head 213 | 374

Tissue

Endocrine System 5,275 | 18,159
Digestive Tract 5,207 | 17,369
Female tissues 5,188 | 17,400
Skin and soft tissues 5,177 | 17,230
Male tissues 5,143 | 17,142
Blood and immune system 5,117 | 16,909
Liver and Pancreas 5,100 | 16,750
Nervous System 5,087 | 16,725
Urinary Tract 5,083 | 16,678
Respiratory system 5,038 | 16,393
Cardiovascular System 4,817 | 15,192

Target Family

Non-IDG 3,403 | 12,091
Enzyme 1,101 | 4,145
Transcription Factor 260 | 1,400
Kinase 215 | 634
Ion Channel 204 | 344
Epigenetic 118 | 242
GPCR 83 | 408
Transporter 59 | 473
Nuclear Receptor 22 | 48
TF/Epigenetic 11 | 38

Compartment GO Term

Macromolecular complex 5,476 | 5,476
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,783 | 8,783
Membrane 8,530 | 8,530
Nucleus 7,563 | 7,563
Cytosol 6,686 | 6,686
Membrane part 6,553 | 6,553
Plasma membrane 5,829 | 5,829
Intrinsic component of membran... 5,457 | 5,457
Cell periphery 5,381 | 5,381
Integral component of membrane 5,330 | 5,330
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,974 | 3,974
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,673 | 3,673
Organelle membrane 2,846 | 2,846
Extracellular region 2,731 | 2,731
Plasma membrane part 2,593 | 2,593
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,216 | 2,216
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,638 | 1,638
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 968 | 968
Supramolecular complex 967 | 967
Cell junction 960 | 960
Supramolecular fiber 960 | 960
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 931 | 931
Nucleolus 927 | 927
Chromosomal part 889 | 889
GO:0098796 883 | 883
Ribonucleoprotein complex 864 | 864
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 849 | 849
Transferase complex 849 | 849
Cell surface 841 | 841
Plasma membrane region 841 | 841
Vesicle membrane 800 | 800
Cytoplasmic vesicle membrane 794 | 794
Polymeric cytoskeletal fiber 765 | 765
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 713 | 713
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
COP9 signalosome complex subunit 9 COPS9 Tbio Non-IDG 0.21 0.92 14
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
Interleukin-9 IL9 Tbio Non-IDG -2.50811 334.4 459
Pyrin domain-containing protein 1 PYDC1 Tbio Non-IDG -2.88567 750.0 115
DBIRD complex subunit ZNF326 ZNF326 Tbio Non-IDG -0.42207 3.94 120
Integrin alpha-11 ITGA11 Tbio Non-IDG -1.13736 14.3 76
Myosin-13 MYH13 Tbio Non-IDG -1.26079 16.6 12
Myosin-2 MYH2 Tbio Non-IDG -2.14128 114.9 63
Eukaryotic translation initiation factor 1 EIF1 Tbio Non-IDG -2.06392 118.5 92