Development Level

Tbio 197 | 10,625
Tdark 44 | 7,003
Tchem 37 | 1,890
Tclin 6 | 602

Collection

Ion Channel: IDG Consortium (Targets) 2 | 102
GPCR: IDG Consortium (Targets) 1 | 127

IMPC Phenotype

preweaning lethality, complete... 16 | 633
embryonic lethality prior to t... 10 | 187
abnormal behavior 9 | 226
decreased mean corpuscular vol... 7 | 50
decreased total body fat amoun... 7 | 186
embryonic lethality prior to o... 7 | 148
decreased body weight 6 | 174
increased mean corpuscular hem... 6 | 93
preweaning lethality, incomple... 6 | 260
increased bone mineral content 5 | 92
increased circulating alkaline... 5 | 119
abnormal bone mineralization 4 | 55
abnormal bone structure 4 | 131
abnormal sleep behavior 4 | 63
decreased lean body mass 4 | 195
decreased mean corpuscular hem... 4 | 34
decreased prepulse inhibition 4 | 52
hypoactivity 4 | 89
increased bone mineral density 4 | 52
increased circulating sodium l... 4 | 71
increased lean body mass 4 | 107
short tibia 4 | 82
thrombocytosis 4 | 23
abnormal retina morphology 3 | 100
abnormal retinal pigmentation 3 | 61
absent pinna reflex 3 | 21
cardiovascular system phenotyp... 3 | 35
decreased body length 3 | 108
decreased bone mineral density 3 | 126
decreased circulating HDL chol... 3 | 77
decreased erythrocyte cell num... 3 | 43
decreased hemoglobin content 3 | 53
decreased rib number 3 | 59
improved glucose tolerance 3 | 56
increased circulating choleste... 3 | 53
increased circulating potassiu... 3 | 31
increased mean corpuscular vol... 3 | 91
abnormal epididymis morphology 2 | 31
abnormal eye size 2 | 11
abnormal iris morphology 2 | 12
abnormal limb bud morphology 2 | 15
abnormal lung morphology 2 | 15
abnormal pericardium morpholog... 2 | 11
abnormal seminal vesicle morph... 2 | 47
decreased B cell number 2 | 30
decreased CD4-positive, alpha ... 2 | 19
decreased CD8-positive, alpha-... 2 | 26
decreased T cell number 2 | 31
decreased bone mineral content 2 | 157
decreased circulating amylase ... 2 | 24
decreased circulating choleste... 2 | 85
decreased circulating phosphat... 2 | 15
decreased circulating serum al... 2 | 79
decreased circulating triglyce... 2 | 83
decreased eosinophil cell numb... 2 | 41
decreased grip strength 2 | 123
decreased heart rate 2 | 10
decreased hematocrit 2 | 25
decreased lumbar vertebrae num... 2 | 62
decreased mean corpuscular hem... 2 | 19
enlarged heart 2 | 111
enlarged lymph nodes 2 | 27
hemorrhage 2 | 12
impaired glucose tolerance 2 | 52
increased B cell number 2 | 23
increased NK T cell number 2 | 11
increased blood urea nitrogen ... 2 | 44
increased circulating LDL chol... 2 | 15
increased circulating chloride... 2 | 43
increased fasted circulating g... 2 | 68
increased leukocyte cell numbe... 2 | 37
increased or absent threshold ... 2 | 128
increased sacral vertebrae num... 2 | 62
small adrenal glands 2 | 15
trunk curl 2 | 15
abnormal behavioral response t... 1 | 52
abnormal coat appearance 1 | 25
abnormal embryo size 1 | 112
abnormal heart morphology 1 | 51
abnormal kidney morphology 1 | 30
abnormal locomotor activation 1 | 26
abnormal rib morphology 1 | 28
abnormal tail movements 1 | 12
abnormal testis morphology 1 | 30
abnormal vocalization 1 | 21
corneal opacity 1 | 25
decreased cervical vertebrae n... 1 | 12
decreased circulating sodium l... 1 | 18
decreased heart weight 1 | 44
decreased red blood cell distr... 1 | 11
enlarged spleen 1 | 26
impaired righting response 1 | 19
increased NK cell number 1 | 19
increased circulating HDL chol... 1 | 63
increased eosinophil cell numb... 1 | 9
persistence of hyaloid vascula... 1 | 22
prenatal lethality prior to he... 1 | 64
straub tail 1 | 26
thrombocytopenia 1 | 46
vertebral fusion 1 | 23

Disease

ovarian cancer 175 | 8,491
osteosarcoma 135 | 7,933
medulloblastoma, large-cell 108 | 6,234
glioblastoma 107 | 5,572
psoriasis 80 | 6,685
atypical teratoid / rhabdoid tumor 76 | 4,369
lung cancer 64 | 4,473
lung carcinoma 62 | 2,844
invasive ductal carcinoma 54 | 2,950
pilocytic astrocytoma 53 | 3,086
ependymoma 52 | 2,514
intraductal papillary-mucinous adenoma (IPMA) 52 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 50 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 50 | 3,289
pediatric high grade glioma 50 | 2,712
Breast cancer 47 | 3,098
malignant mesothelioma 47 | 3,163
pancreatic cancer 47 | 2,300
subependymal giant cell astrocytoma 45 | 2,287
oligodendroglioma 43 | 2,849
astrocytoma 42 | 1,493
tuberculosis 41 | 1,563
Cancer 40 | 2,346
Pick disease 39 | 1,893
Rheumatoid Arthritis 38 | 1,170
primitive neuroectodermal tumor 38 | 3,031
adult high grade glioma 37 | 2,148
astrocytic glioma 37 | 2,241
diabetes mellitus 37 | 1,663
non-small cell lung cancer 36 | 2,798
pancreatic ductal adenocarcinoma liver metastasis 36 | 1,795
ulcerative colitis 36 | 2,087
Carcinoma 35 | 2,147
Multiple myeloma 35 | 1,327
interstitial cystitis 35 | 2,299
juvenile dermatomyositis 35 | 1,189
lung adenocarcinoma 34 | 2,714
primary pancreatic ductal adenocarcinoma 34 | 1,271
breast carcinoma 31 | 1,614
acute quadriplegic myopathy 30 | 1,157
group 4 medulloblastoma 30 | 1,875
dermatomyositis 28 | 966
adrenocortical carcinoma 27 | 1,427
pituitary cancer 27 | 1,972
cystic fibrosis 26 | 1,670
ductal carcinoma in situ 26 | 1,745
medulloblastoma 26 | 1,524
posterior fossa group A ependymoma 26 | 1,511
Alzheimer's disease 25 | 644
active Crohn's disease 23 | 918
colon cancer 23 | 1,475
cutaneous lupus erythematosus 21 | 1,056
Neurodegenerative disease 20 | 383
esophageal adenocarcinoma 20 | 737
group 3 medulloblastoma 20 | 2,254
primary Sjogren syndrome 20 | 788
Duchenne muscular dystrophy 18 | 602
Waldenstrons macroglobulinemia 18 | 764
mucosa-associated lymphoid tissue lymphoma 18 | 480
sonic hedgehog group medulloblastoma 18 | 1,482
spina bifida 18 | 1,064
Down syndrome 17 | 548
Parkinson's disease 16 | 364
atypical teratoid/rhabdoid tumor 15 | 1,095
posterior fossa group B ependymoma 15 | 1,530
progressive supranuclear palsy 15 | 674
Multiple Sclerosis 14 | 498
gastric carcinoma 14 | 832
non primary Sjogren syndrome sicca 14 | 840
Hermansky-Pudlak syndrome 13 | 43
sarcoidosis 13 | 368
Kidney disease 12 | 397
Schizophrenia 12 | 503
IGA Glomerulonephritis 11 | 454
Parkinson Disease 11 | 105
pancreatic carcinoma 11 | 567
Atopic dermatitis 10 | 944
Hypersensitivity reaction type II disease 10 | 235
active ulcerative colitis 10 | 477
aldosterone-producing adenoma 10 | 664
head and neck cancer and chronic obstructive pulmonary disease 10 | 237
hepatocellular carcinoma 10 | 550
systemic lupus erythematosus 10 | 172
Amyotrophic Lateral Sclerosis 9 | 432
Asthma 9 | 349
Becker muscular dystrophy 9 | 187
Intellectual disability 9 | 573
Melanoma 9 | 261
Obesity 9 | 616
Renal Cell Carcinoma 9 | 199
Vascular disease 9 | 281
acute myeloid leukemia 9 | 785
tuberculosis and treatment for 3 months 9 | 327
Epilepsy 8 | 346
Influenza 8 | 142
Lysosomal storage disease 8 | 11
Osteopetrosis 8 | 40
Stomach Neoplasms 8 | 282
fibroadenoma 8 | 557
hereditary spastic paraplegia 8 | 313

Tissue

Digestive Tract 280 | 18,472
Female tissues 280 | 18,646
Liver and Pancreas 280 | 18,135
Nervous System 280 | 18,560
Urinary Tract 280 | 18,443
Blood and immune system 279 | 17,994
Cardiovascular System 279 | 17,957
Endocrine System 279 | 18,511
Male tissues 279 | 17,968
Skin and soft tissues 278 | 18,114
Respiratory system 277 | 17,483

Target Family

Non-IDG 179 | 11,969
Enzyme 65 | 4,146
Transporter 25 | 473
Ion Channel 9 | 341
Kinase 3 | 634
Transcription Factor 2 | 1,400
GPCR 1 | 408

Compartment GO Term

Lytic vacuole membrane 284 | 284
cellular_component 18,237 | 18,237
Cell 15,806 | 15,806
Cell part 15,806 | 15,806
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,648 | 12,648
membrane-bounded organelle 11,793 | 11,793
Intracellular organelle 11,617 | 11,617
Intracellular membrane-bounded... 10,618 | 10,618
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,169 | 8,169
Intracellular organelle part 8,011 | 8,011
Cytoplasmic part 7,830 | 7,830
Nucleus 7,577 | 7,577
Membrane part 6,470 | 6,470
Cytosol 6,035 | 6,035
Plasma membrane 5,673 | 5,673
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,171 | 5,171
Cell periphery 5,146 | 5,146
Nucleoplasm 4,929 | 4,929
Extracellular region 4,606 | 4,606
Protein complex 4,439 | 4,439
Intracellular organelle lumen 4,330 | 4,330
Organelle lumen 4,330 | 4,330
membrane-enclosed lumen 4,330 | 4,330
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,839 | 3,839
non-membrane-bounded organelle 3,838 | 3,838
Nuclear part 3,807 | 3,807
Endomembrane system 3,720 | 3,720
Vesicle 3,666 | 3,666
membrane-bounded vesicle 3,494 | 3,494
Nuclear lumen 3,464 | 3,464
Extracellular organelle 2,849 | 2,849
Extracellular vesicle 2,848 | 2,848
Extracellular exosome 2,828 | 2,828
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,564 | 2,564
Cytoskeleton 2,046 | 2,046
Golgi apparatus 1,946 | 1,946
Endoplasmic reticulum 1,872 | 1,872
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Vesicles 1,625 | 1,625
Cytoskeletal part 1,568 | 1,568
Mitochondrion 1,531 | 1,531
Cell projection 1,426 | 1,426
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,305 | 1,305
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,234 | 1,234
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Mitochondria 1,003 | 1,003
Chromosome 999 | 999
Mitochondrial part 989 | 989
Nucleoli 952 | 952
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 793 | 793
Intracellular ribonucleoprotei... 789 | 789
Nucleoplasm part 781 | 781
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 739 | 739
Plasma membrane protein comple... 721 | 721
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Microtubule organizing center 680 | 680
Centrosome 676 | 676
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Synapse 594 | 594
Lytic vacuole 571 | 571

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
WD repeat-containing protein mio MIOS Tdark Non-IDG -1.44864 27.4 14
Interferon-induced transmembrane protein 3 IFITM3 Tbio Non-IDG -1.87958 126.0 172
Pro-epidermal growth factor EGF Tbio Non-IDG -3.74596 4837.7 851
Two pore calcium channel protein 1 TPCN1 Tbio Ion Channel -1.84159 59.3 38
Pleckstrin homology domain-containing family F member 1 PLEKHF1 Tbio Non-IDG -1.78639 62.5 99
Disabled homolog 2 DAB2 Tbio Non-IDG -2.24622 174.6 226
Dipeptidyl peptidase 4 DPP4 Tclin Enzyme -3.60140 4091.0 900
V-type proton ATPase 16 kDa proteolipid subunit ATP6V0C Tbio Enzyme -1.84880 72.6 59
Oxysterol-binding protein-related protein 1 OSBPL1A Tbio Non-IDG -0.52465 3.58 131
Synaptotagmin-7 SYT7 Tbio Non-IDG -1.72363 48.4 144