Development Level

Tbio 192 | 11,651
Tdark 22 | 6,593
Tchem 16 | 1,388
Tclin 14 | 612

IMPC Phenotype

preweaning lethality, complete... 19 | 979
preweaning lethality, incomple... 10 | 499
abnormal behavior 9 | 298
embryonic lethality prior to o... 8 | 239
abnormal embryo size 6 | 220
decreased body weight 6 | 161
hypoactivity 5 | 132
embryonic lethality prior to t... 4 | 278
prolonged QT interval 4 | 38
abnormal sleep behavior 3 | 70
decreased circulating choleste... 3 | 93
decreased mean corpuscular hem... 3 | 50
decreased total body fat amoun... 3 | 207
hyperactivity 3 | 148
increased circulating potassiu... 3 | 29
increased lean body mass 3 | 172
increased startle reflex 3 | 112
prolonged ST segment 3 | 36
short tibia 3 | 97
thrombocytosis 3 | 27
abnormal body wall morphology 2 | 9
abnormal craniofacial morpholo... 2 | 33
abnormal epididymis morphology 2 | 42
abnormal gait 2 | 69
abnormal kidney morphology 2 | 65
abnormal lens morphology 2 | 81
abnormal response to new envir... 2 | 10
abnormal retina morphology 2 | 71
cataract 2 | 92
decreased blood urea nitrogen ... 2 | 51
decreased circulating HDL chol... 2 | 68
decreased circulating creatini... 2 | 39
decreased circulating insulin ... 2 | 76
decreased circulating triglyce... 2 | 79
decreased grip strength 2 | 116
decreased lean body mass 2 | 135
decreased leukocyte cell numbe... 2 | 73
decreased prepulse inhibition 2 | 82
decreased total retina thickne... 2 | 17
edema 2 | 59
embryonic growth retardation 2 | 106
enlarged epididymis 2 | 31
impaired glucose tolerance 2 | 75
increased body weight 2 | 25
increased circulating alkaline... 2 | 122
increased circulating serum al... 2 | 22
increased circulating sodium l... 2 | 71
increased fasted circulating g... 2 | 76
increased leukocyte cell numbe... 2 | 47
increased mean corpuscular vol... 2 | 92
increased total body fat amoun... 2 | 134
abnormal behavioral response t... 1 | 66
abnormal embryo turning 1 | 31
abnormal femur morphology 1 | 14
abnormal hindbrain morphology 1 | 10
abnormal iris morphology 1 | 13
abnormal motor capabilities-co... 1 | 5
abnormal neural tube closure 1 | 46
abnormal pelvic girdle bone mo... 1 | 12
abnormal pericardium morpholog... 1 | 26
abnormal retinal inner nuclear... 1 | 8
abnormal skin coloration 1 | 25
abnormal tail movements 1 | 12
abnormal testis morphology 1 | 43
abnormal thymus morphology 1 | 7
abnormal vibrissa morphology 1 | 25
absent startle reflex 1 | 24
decreased IgE level 1 | 6
decreased bone mineral density 1 | 126
decreased circulating bilirubi... 1 | 19
decreased circulating chloride... 1 | 30
decreased fasted circulating g... 1 | 65
decreased red blood cell distr... 1 | 41
enlarged lymph nodes 1 | 37
enlarged spleen 1 | 41
increased blood urea nitrogen ... 1 | 48
increased body length 1 | 32
increased bone mineral content 1 | 108
increased circulating HDL chol... 1 | 80
increased circulating calcium ... 1 | 34
increased circulating choleste... 1 | 66
increased circulating glucose ... 1 | 24
increased circulating iron lev... 1 | 30
increased circulating triglyce... 1 | 42
increased heart rate 1 | 23
increased heart weight 1 | 62
increased hemoglobin content 1 | 45
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 96
limb grasping 1 | 41
mammalian phenotype 1 | 17
persistence of hyaloid vascula... 1 | 33
premature death 1 | 5
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
small adrenal glands 1 | 16
small thymus 1 | 16
tremors 1 | 39
trunk curl 1 | 16
vertebral fusion 1 | 23

Disease

ovarian cancer 149 | 8,520
Carcinoma 136 | 11,493
osteosarcoma 113 | 7,950
medulloblastoma, large-cell 91 | 6,241
glioblastoma 84 | 5,792
psoriasis 81 | 6,694
atypical teratoid / rhabdoid tumor 66 | 5,112
lung cancer 66 | 4,740
ependymoma 55 | 4,679
tuberculosis 49 | 2,010
Astrocytoma, Pilocytic 43 | 3,081
malignant mesothelioma 43 | 3,232
Breast cancer 42 | 3,578
Multiple myeloma 42 | 1,332
intraductal papillary-mucinous neoplasm (IPMN) 42 | 3,291
adult high grade glioma 41 | 3,801
Cancer 40 | 2,499
invasive ductal carcinoma 40 | 2,951
pancreatic cancer 40 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 40 | 1,962
intraductal papillary-mucinous carcinoma (IPMC) 39 | 2,989
lung carcinoma 39 | 2,843
Kidney cancer 38 | 2,613
intraductal papillary-mucinous adenoma (IPMA) 38 | 2,955
oligodendroglioma 38 | 2,850
diabetes mellitus 34 | 1,728
Pick disease 33 | 1,894
group 4 medulloblastoma 31 | 1,855
lung adenocarcinoma 31 | 2,716
non-small cell lung cancer 31 | 2,890
subependymal giant cell astrocytoma 31 | 2,287
group 3 medulloblastoma 30 | 4,104
Autosomal recessive predisposition 29 | 1,442
Neurodegenerative disease 28 | 414
primitive neuroectodermal tumor 28 | 3,035
astrocytic glioma 27 | 2,597
interstitial cystitis 26 | 2,312
Rheumatoid arthritis 25 | 1,191
acute quadriplegic myopathy 25 | 1,158
juvenile dermatomyositis 25 | 1,187
dermatomyositis 24 | 966
astrocytoma 23 | 1,146
breast carcinoma 23 | 1,638
primary pancreatic ductal adenocarcinoma 23 | 1,109
ulcerative colitis 23 | 1,819
ductal carcinoma in situ 22 | 1,745
pituitary cancer 22 | 1,972
Multiple Sclerosis 21 | 540
adrenocortical carcinoma 21 | 1,428
Intellectual disability 20 | 1,016
Alzheimer's disease 18 | 658
Schizophrenia 18 | 1,160
Waldenstrons macroglobulinemia 18 | 765
colon cancer 18 | 1,478
cystic fibrosis 18 | 1,696
esophageal adenocarcinoma 18 | 737
pediatric high grade glioma 18 | 1,064
Epilepsy 17 | 792
spina bifida 17 | 1,074
Down syndrome 16 | 499
active ulcerative colitis 15 | 764
Dull intelligence 14 | 645
Low intelligence 14 | 645
Mental Retardation 14 | 645
Mental deficiency 14 | 645
Poor school performance 14 | 645
non primary Sjogren syndrome sicca 14 | 891
pancreatic carcinoma 13 | 562
primary Sjogren syndrome 13 | 735
Failure to gain weight 12 | 365
Pediatric failure to thrive 12 | 365
Seizures 12 | 596
active Crohn's disease 12 | 922
progressive supranuclear palsy 12 | 676
Dementia 11 | 175
Duchenne muscular dystrophy 11 | 601
Muscle Spasticity 11 | 195
Muscle hypotonia 11 | 571
acute myeloid leukemia 11 | 783
hereditary spastic paraplegia 11 | 318
mucosa-associated lymphoid tissue lymphoma 11 | 484
Anemia 10 | 365
Bipolar Disorder 10 | 666
Depressive disorder 10 | 409
Hepatomegaly 10 | 285
Liver Cirrhosis, Experimental 10 | 769
Mental Depression 10 | 333
Parkinson's disease 10 | 392
Vascular disease 10 | 319
cutaneous lupus erythematosus 10 | 1,057
Arthritis 9 | 290
Cognitive delay 9 | 608
Global developmental delay 9 | 608
Mental and motor retardation 9 | 608
Prostatic Neoplasms 9 | 495
Short stature 9 | 531
Splenomegaly 9 | 190
aldosterone-producing adenoma 9 | 665
gastric carcinoma 9 | 807
hepatocellular carcinoma 9 | 547

Tissue

Endocrine System 235 | 18,159
Digestive Tract 233 | 17,369
Female tissues 233 | 17,400
Nervous System 232 | 16,725
Respiratory system 232 | 16,393
Skin and soft tissues 232 | 17,230
Urinary Tract 232 | 16,678
Blood and immune system 231 | 16,909
Male tissues 231 | 17,142
Liver and Pancreas 230 | 16,750
Cardiovascular System 226 | 15,192

Target Family

Non-IDG 165 | 12,091
Enzyme 46 | 4,145
Kinase 11 | 634
Transporter 10 | 473
Ion Channel 6 | 344
GPCR 3 | 408
Transcription Factor 2 | 1,400
Epigenetic 1 | 242

Compartment GO Term

Late endosome 244 | 244
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,783 | 8,783
Membrane 8,530 | 8,530
Nucleus 7,563 | 7,563
Cytosol 6,686 | 6,686
Membrane part 6,553 | 6,553
Plasma membrane 5,829 | 5,829
Macromolecular complex 5,476 | 5,476
Intrinsic component of membran... 5,457 | 5,457
Cell periphery 5,381 | 5,381
Integral component of membrane 5,330 | 5,330
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,974 | 3,974
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,673 | 3,673
Organelle membrane 2,846 | 2,846
Extracellular region 2,731 | 2,731
Plasma membrane part 2,593 | 2,593
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,216 | 2,216
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,638 | 1,638
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 968 | 968
Supramolecular complex 967 | 967
Cell junction 960 | 960
Supramolecular fiber 960 | 960
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 931 | 931
Nucleolus 927 | 927
Chromosomal part 889 | 889
GO:0098796 883 | 883
Ribonucleoprotein complex 864 | 864
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 849 | 849
Transferase complex 849 | 849
Cell surface 841 | 841
Plasma membrane region 841 | 841
Vesicle membrane 800 | 800
Cytoplasmic vesicle membrane 794 | 794
Polymeric cytoskeletal fiber 765 | 765
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 713 | 713
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ras-related protein Rab-22A RAB22A Tbio Enzyme -1.40824 19.7 123
UPF0577 protein KIAA1324 KIAA1324 Tbio Non-IDG -1.30268 19.8 137
CMRF35-like molecule 9 CD300LG Tdark Non-IDG -0.92828 10.3 49
Vesicle-associated membrane protein 8 VAMP8 Tbio Non-IDG -1.79654 64.6 107
Kinase D-interacting substrate of 220 kDa KIDINS220 Tbio Enzyme -2.42897 262.3 191
Vacuolar protein sorting-associated protein 37D VPS37D Tdark Non-IDG 0.51 0.16 8
E3 ubiquitin-protein ligase NEDD4-like NEDD4L Tbio Enzyme -2.52486 353.9 144
Vacuolar protein sorting-associated protein 35 VPS35 Tbio Non-IDG -2.02621 104.1 124
Disintegrin and metalloproteinase domain-containing protein 30 ADAM30 Tdark Enzyme -0.39305 2.44 64
Sequestosome-1 SQSTM1 Tbio Non-IDG -2.78728 635.1 766