Development Level

Tbio 13 | 11,445
Tdark 2 | 6,588

IMPC Phenotype

preweaning lethality, complete... 3 | 979
abnormal bone structure 1 | 187
abnormal coat appearance 1 | 31
abnormal forebrain morphology 1 | 10
abnormal hair growth 1 | 10
abnormal midbrain morphology 1 | 10
absent pinna reflex 1 | 23
decreased circulating alanine ... 1 | 47
decreased circulating aspartat... 1 | 34
decreased lactate dehydrogenas... 1 | 16
embryonic lethality prior to o... 1 | 239
hemorrhage 1 | 23
prenatal lethality prior to he... 1 | 87

Disease

Carcinoma 10 | 11,493
osteosarcoma 10 | 7,950
Kidney cancer 7 | 2,613
Breast cancer 6 | 3,578
medulloblastoma, large-cell 6 | 6,241
atypical teratoid / rhabdoid tumor 5 | 5,112
ependymoma 5 | 4,679
glioblastoma 5 | 5,792
group 3 medulloblastoma 5 | 4,104
ovarian cancer 5 | 8,520
adult high grade glioma 4 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
lung adenocarcinoma 4 | 2,716
oligodendroglioma 4 | 2,850
psoriasis 4 | 6,694
Astrocytoma, Pilocytic 3 | 3,081
Cancer 3 | 2,499
Endometrial cancer 3 | 311
LEOPARD syndrome 3 | 20
Melanoma 3 | 711
Noonan syndrome 3 | 34
Pick disease 3 | 1,894
astrocytic glioma 3 | 2,597
pancreatic cancer 3 | 2,398
primitive neuroectodermal tumor 3 | 3,035
Acquired scoliosis 2 | 281
Anemia 2 | 365
Anemia, Hemolytic 2 | 55
Anemia, hereditary spherocytic hemolytic 2 | 5
Arteriovenous malformation 2 | 6
Autistic Disorder 2 | 364
Autosomal recessive predisposition 2 | 1,442
Bleeding tendency 2 | 37
Blepharoptosis 2 | 231
Cognitive delay 2 | 608
Congenital hemolytic anemia 2 | 32
Costello Syndrome 2 | 17
Cryptorchidism 2 | 296
Curvature of spine 2 | 282
DOID:2627 2 | 94
Decreased projection of midface 2 | 105
Downward slant of palpebral fissure 2 | 158
Dull intelligence 2 | 645
Elliptocytosis, Hereditary 2 | 9
Exophthalmos 2 | 112
Gaucher disease type 1 2 | 180
Gingival fibromatosis 2 | 14
Global developmental delay 2 | 608
Hereditary elliptocytosis 2 | 22
Hereditary spherocytosis 2 | 16
Hypotrophic midface 2 | 105
Intellectual disability 2 | 1,016
Klippel-Trenaunay syndrome 2 | 13
Liver cancer 2 | 604
Low intelligence 2 | 645
Low posterior hairline 2 | 52
Low-set, posteriorly rotated ears 2 | 110
Mental Retardation 2 | 645
Mental and motor retardation 2 | 608
Mental deficiency 2 | 645
Midface retrusion 2 | 105
Multiple cutaneous and mucosal venous malformations 2 | 10
Muscle Weakness 2 | 170
Muscle hypotonia 2 | 571
Neck webbing 2 | 35
Neurofibromatosis 2 | 40
Orbital separation excessive 2 | 244
Poor school performance 2 | 645
Short stature 2 | 531
Skin cancer 2 | 469
Small head 2 | 374
Small midface 2 | 105
Spherocytosis 2 | 5
astrocytoma 2 | 1,146
diabetes mellitus 2 | 1,728
esophageal adenocarcinoma 2 | 737
interstitial cystitis 2 | 2,312
invasive ductal carcinoma 2 | 2,951
juvenile dermatomyositis 2 | 1,187
lung cancer 2 | 4,740
malignant mesothelioma 2 | 3,232
spina bifida 2 | 1,074
subependymal giant cell astrocytoma 2 | 2,287
Abnormal dermatoglyphic pattern 1 | 24
Abnormal helices 1 | 11
Abnormal platelet function 1 | 12
Acquired cubitus valgus 1 | 18
Albuminuria 1 | 21
Cafe au lait spots, multiple 1 | 17
Cardiofaciocutaneous syndrome 1 | 15
Chondrocalcinosis 1 | 9
Connective tissue cancer 1 | 10
Enlarged thorax 1 | 18
Excess nuchal skin 1 | 30
Hypophosphatasia 1 | 10
Neurofibroma 1 | 8
Neurofibrosarcoma 1 | 7
Reticulocytosis 1 | 20
Taylor's syndrome 1 | 5
Thickened helices 1 | 15

Tissue

Blood and immune system 15 | 16,909
Endocrine System 15 | 18,159
Digestive Tract 14 | 17,369
Female tissues 14 | 17,400
Liver and Pancreas 14 | 16,750
Nervous System 14 | 16,725
Skin and soft tissues 14 | 17,230
Urinary Tract 14 | 16,678
Male tissues 13 | 17,142
Respiratory system 13 | 16,393
Cardiovascular System 12 | 15,192

Target Family

Non-IDG 8 | 12,091
Enzyme 7 | 4,145

Compartment GO Term

Intrinsic component of the cyt... 15 | 15
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,109 | 14,109
Intracellular part 13,972 | 13,972
Organelle 12,237 | 12,237
Intracellular organelle 12,023 | 12,023
membrane-bounded organelle 11,130 | 11,130
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,340 | 10,340
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,784 | 8,784
Membrane 8,531 | 8,531
Nucleus 7,561 | 7,561
Cytosol 6,686 | 6,686
Membrane part 6,554 | 6,554
Plasma membrane 5,830 | 5,830
Macromolecular complex 5,476 | 5,476
Intrinsic component of membran... 5,458 | 5,458
Cell periphery 5,382 | 5,382
Integral component of membrane 5,331 | 5,331
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,972 | 3,972
non-membrane-bounded organelle 3,972 | 3,972
Nuclear lumen 3,968 | 3,968
Protein complex 3,674 | 3,674
Organelle membrane 2,846 | 2,846
Extracellular region 2,732 | 2,732
Plasma membrane part 2,594 | 2,594
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,217 | 2,217
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,955 | 1,955
Golgi apparatus 1,932 | 1,932
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,641 | 1,641
Cytoskeletal part 1,637 | 1,637
Extracellular region part 1,628 | 1,628
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,547 | 1,547
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,123 | 1,123
Nuclear outer membrane-endopla... 1,121 | 1,121
Nucleoplasm part 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,040 | 1,040
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 967 | 967
Supramolecular complex 966 | 966
Cell junction 960 | 960
Supramolecular fiber 959 | 959
Golgi apparatus part 949 | 949
Nucleoli 942 | 942
Endosome 931 | 931
Nucleolus 926 | 926
Chromosomal part 889 | 889
GO:0098796 884 | 884
Ribonucleoprotein complex 864 | 864
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 849 | 849
Transferase complex 848 | 848
Cell surface 842 | 842
Plasma membrane region 841 | 841
Vesicle membrane 801 | 801
Cytoplasmic vesicle membrane 795 | 795
Polymeric cytoskeletal fiber 764 | 764
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 714 | 714
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ras GTPase-activating protein 4B RASA4B Tdark Enzyme 0.00000 0
Ras/Rap GTPase-activating protein SynGAP SYNGAP1 Tbio Enzyme -1.91757 81.2 178
Ras GTPase-activating protein nGAP RASAL2 Tbio Enzyme -1.51440 33.0 99
Spectrin beta chain, erythrocytic SPTB Tbio Non-IDG -2.45982 275.1 59
RAS protein activator like-3 RASAL3 Tbio Non-IDG -0.25123 2.81 57
Ras GTPase-activating protein 4 RASA4 Tbio Enzyme -2.47836 299.2 58
Spectrin alpha chain, erythrocytic 1 SPTA1 Tbio Non-IDG -2.93650 850.7 86
Ras GTPase-activating protein 2 RASA2 Tdark Enzyme -0.99879 9.85 24
RasGAP-activating-like protein 1 RASAL1 Tbio Non-IDG -1.75700 55.9 163
Neurofibromin NF1 Tbio Non-IDG -3.60161 4054.2 355