Development Level

Tbio 99 | 10,625
Tdark 26 | 7,003
Tchem 17 | 1,890
Tclin 1 | 602

IMPC Phenotype

preweaning lethality, complete... 7 | 633
decreased body weight 4 | 174
decreased circulating alanine ... 4 | 53
embryonic lethality prior to t... 4 | 187
abnormal eye morphology 3 | 38
abnormal eye size 2 | 11
abnormal retina morphology 2 | 100
decreased bone mineral content 2 | 157
decreased lean body mass 2 | 195
decreased total body fat amoun... 2 | 186
embryonic lethality prior to o... 2 | 148
increased mean corpuscular hem... 2 | 93
increased sacral vertebrae num... 2 | 62
abnormal bone structure 1 | 131
abnormal clavicle morphology 1 | 5
abnormal coat appearance 1 | 25
abnormal cornea morphology 1 | 24
abnormal epididymis morphology 1 | 31
abnormal lens morphology 1 | 73
abnormal retinal blood vessel ... 1 | 18
abnormal retinal vasculature m... 1 | 15
abnormal skin morphology 1 | 23
abnormal tail morphology 1 | 17
absent vibrissae 1 | 14
cataract 1 | 26
decreased CD8-positive, alpha-... 1 | 26
decreased NK T cell number 1 | 28
decreased NK cell number 1 | 16
decreased T cell number 1 | 31
decreased blood urea nitrogen ... 1 | 31
decreased cardiac stroke volum... 1 | 3
decreased caudal vertebrae num... 1 | 49
decreased circulating HDL chol... 1 | 77
decreased circulating LDL chol... 1 | 37
decreased circulating alkaline... 1 | 41
decreased circulating amylase ... 1 | 24
decreased circulating aspartat... 1 | 27
decreased circulating choleste... 1 | 85
decreased circulating fructosa... 1 | 31
decreased circulating glucose ... 1 | 121
decreased circulating glycerol... 1 | 19
decreased circulating insulin ... 1 | 75
decreased circulating iron lev... 1 | 25
decreased circulating magnesiu... 1 | 11
decreased circulating serum al... 1 | 79
decreased circulating total pr... 1 | 41
decreased eosinophil cell numb... 1 | 41
decreased grip strength 1 | 123
decreased heart weight 1 | 44
decreased lumbar vertebrae num... 1 | 62
decreased mean corpuscular hem... 1 | 34
decreased memory-marker CD4-po... 1 | 4
decreased prepulse inhibition 1 | 52
decreased rib number 1 | 59
enlarged epididymis 1 | 27
impaired righting response 1 | 19
increased CD5-positive Ly6C-po... 1 | 4
increased bone mineral content 1 | 92
increased bone mineral density 1 | 52
increased circulating alkaline... 1 | 119
increased circulating choleste... 1 | 53
increased circulating fructosa... 1 | 11
increased circulating magnesiu... 1 | 10
increased effector memory CD8-... 1 | 14
increased fasted circulating g... 1 | 68
increased grip strength 1 | 83
increased heart weight 1 | 37
increased lean body mass 1 | 107
increased mean platelet volume 1 | 19
increased startle reflex 1 | 38
increased total body fat amoun... 1 | 57
male infertility 1 | 62
microphthalmia 1 | 15
prenatal lethality 1 | 16
prenatal lethality prior to he... 1 | 64
thrombocytopenia 1 | 46
tremors 1 | 34

Disease

ovarian cancer 76 | 8,491
osteosarcoma 63 | 7,933
medulloblastoma, large-cell 48 | 6,234
glioblastoma 46 | 5,572
psoriasis 43 | 6,685
atypical teratoid / rhabdoid tumor 36 | 4,369
lung cancer 33 | 4,473
intraductal papillary-mucinous neoplasm (IPMN) 27 | 3,289
intraductal papillary-mucinous adenoma (IPMA) 24 | 2,956
Breast cancer 23 | 3,098
pancreatic ductal adenocarcinoma liver metastasis 23 | 1,795
astrocytic glioma 22 | 2,241
intraductal papillary-mucinous carcinoma (IPMC) 22 | 2,988
oligodendroglioma 22 | 2,849
pilocytic astrocytoma 21 | 3,086
primitive neuroectodermal tumor 20 | 3,031
Pick disease 19 | 1,893
ependymoma 19 | 2,514
malignant mesothelioma 19 | 3,163
ulcerative colitis 19 | 2,087
adult high grade glioma 17 | 2,148
subependymal giant cell astrocytoma 17 | 2,287
group 3 medulloblastoma 15 | 2,254
interstitial cystitis 15 | 2,299
non-small cell lung cancer 15 | 2,798
group 4 medulloblastoma 14 | 1,875
invasive ductal carcinoma 14 | 2,950
lung carcinoma 14 | 2,844
pediatric high grade glioma 14 | 2,712
Multiple myeloma 13 | 1,327
pituitary cancer 13 | 1,972
pancreatic cancer 12 | 2,300
posterior fossa group A ependymoma 12 | 1,511
Neurodegenerative disease 11 | 383
dermatomyositis 11 | 966
lung adenocarcinoma 11 | 2,714
medulloblastoma 11 | 1,524
Rheumatoid Arthritis 10 | 1,170
Zellweger Syndrome 10 | 38
tuberculosis 10 | 1,563
Peroxisomal disease 9 | 20
Epilepsy 8 | 346
Infantile refsum disease 8 | 23
Waldenstrons macroglobulinemia 8 | 764
astrocytoma 8 | 1,493
chronic lymphocytic leukemia 8 | 244
non primary Sjogren syndrome sicca 8 | 840
posterior fossa group B ependymoma 8 | 1,530
progressive supranuclear palsy 8 | 674
Adrenoleukodystrophy, Neonatal 7 | 13
Cancer 7 | 2,346
Infantile Refsum Disease (disorder) 7 | 13
Neonatal adrenoleukodystrophy 7 | 14
aldosterone-producing adenoma 7 | 664
atypical teratoid/rhabdoid tumor 7 | 1,095
Adrenoleukodystrophy 6 | 31
Alzheimer's disease 6 | 644
Parkinson's disease 6 | 364
Peroxisome Biogenesis Disorder 3B 6 | 11
Peroxisome biogenesis disorders 6 | 11
active Crohn's disease 6 | 918
acute myeloid leukemia 6 | 785
cutaneous lupus erythematosus 6 | 1,056
cystic fibrosis 6 | 1,670
diabetes mellitus 6 | 1,663
gastric carcinoma 6 | 832
hereditary spastic paraplegia 6 | 313
juvenile dermatomyositis 6 | 1,189
primary pancreatic ductal adenocarcinoma 6 | 1,271
sonic hedgehog group medulloblastoma 6 | 1,482
Chondrodysplasia punctata 5 | 41
Peroxisome Biogenesis Disorder 1A (Zellweger) 5 | 12
acute quadriplegic myopathy 5 | 1,157
adrenocortical carcinoma 5 | 1,427
esophageal adenocarcinoma 5 | 737
nasopharyngeal carcinoma 5 | 1,056
pancreatic carcinoma 5 | 567
primary Sjogren syndrome 5 | 788
spina bifida 5 | 1,064
Atopic dermatitis 4 | 944
Cerebellar Ataxia 4 | 72
Neuropathy 4 | 210
Obesity 4 | 616
Peripheral Neuropathy 4 | 303
active ulcerative colitis 4 | 477
breast carcinoma 4 | 1,614
colon cancer 4 | 1,475
hepatocellular carcinoma 4 | 550
Amyotrophic Lateral Sclerosis 3 | 432
Dementia 3 | 129
IGA Glomerulonephritis 3 | 454
Kidney disease 3 | 397
Metabolic syndrome X 3 | 155
Substance-Related Disorders 3 | 114
Vascular disease 3 | 281
ductal carcinoma in situ 3 | 1,745
fibroadenoma 3 | 557
gastric cancer 3 | 436
inflammatory breast cancer 3 | 404
urothelial carcinoma 3 | 318

Tissue

Cardiovascular System 143 | 17,957
Endocrine System 142 | 18,511
Liver and Pancreas 142 | 18,135
Male tissues 142 | 17,968
Nervous System 142 | 18,560
Blood and immune system 141 | 17,994
Digestive Tract 141 | 18,472
Female tissues 141 | 18,646
Respiratory system 141 | 17,483
Urinary Tract 141 | 18,443
Skin and soft tissues 140 | 18,114

Target Family

Non-IDG 73 | 11,969
Enzyme 45 | 4,146
Transporter 13 | 473
Ion Channel 9 | 341
Kinase 2 | 634
Epigenetic 1 | 242

Compartment GO Term

Intrinsic component of organel... 143 | 143
cellular_component 18,237 | 18,237
Cell 15,806 | 15,806
Cell part 15,806 | 15,806
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,648 | 12,648
membrane-bounded organelle 11,793 | 11,793
Intracellular organelle 11,617 | 11,617
Intracellular membrane-bounded... 10,618 | 10,618
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,169 | 8,169
Intracellular organelle part 8,011 | 8,011
Cytoplasmic part 7,830 | 7,830
Nucleus 7,577 | 7,577
Membrane part 6,470 | 6,470
Cytosol 6,035 | 6,035
Plasma membrane 5,673 | 5,673
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,171 | 5,171
Cell periphery 5,146 | 5,146
Nucleoplasm 4,929 | 4,929
Extracellular region 4,606 | 4,606
Protein complex 4,439 | 4,439
Intracellular organelle lumen 4,330 | 4,330
Organelle lumen 4,330 | 4,330
membrane-enclosed lumen 4,330 | 4,330
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,839 | 3,839
non-membrane-bounded organelle 3,838 | 3,838
Nuclear part 3,807 | 3,807
Endomembrane system 3,720 | 3,720
Vesicle 3,666 | 3,666
membrane-bounded vesicle 3,494 | 3,494
Nuclear lumen 3,464 | 3,464
Extracellular organelle 2,849 | 2,849
Extracellular vesicle 2,848 | 2,848
Extracellular exosome 2,828 | 2,828
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,564 | 2,564
Cytoskeleton 2,046 | 2,046
Golgi apparatus 1,946 | 1,946
Endoplasmic reticulum 1,872 | 1,872
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Vesicles 1,625 | 1,625
Cytoskeletal part 1,568 | 1,568
Mitochondrion 1,531 | 1,531
Cell projection 1,426 | 1,426
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,305 | 1,305
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,234 | 1,234
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Mitochondria 1,003 | 1,003
Chromosome 999 | 999
Mitochondrial part 989 | 989
Nucleoli 952 | 952
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 793 | 793
Intracellular ribonucleoprotei... 789 | 789
Nucleoplasm part 781 | 781
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 739 | 739
Plasma membrane protein comple... 721 | 721
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Microtubule organizing center 680 | 680
Centrosome 676 | 676
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Synapse 594 | 594
Lytic vacuole 571 | 571

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Protein PET100 homolog, mitochondrial PET100 Tdark Non-IDG -1.08039 12.3 0
Serine/threonine-protein kinase PINK1, mitochondrial PINK1 Tchem Kinase -2.75634 590.2 473
Calcium uniporter protein, mitochondrial MCU Tbio Ion Channel -2.62931 408.9 18
ER membrane protein complex subunit 6 EMC6 Tbio Non-IDG 0.30 1.05 23
FUN14 domain-containing protein 2 FUNDC2 Tdark Non-IDG -0.55351 3.51 66
Myotonin-protein kinase DMPK Tchem Kinase -2.69587 476.6 171
Lysosomal amino acid transporter 1 homolog PQLC2 Tdark Non-IDG -0.24304 2.13 51
Protein TEX261 TEX261 Tdark Non-IDG 0.95 0.11 57
Probable cation-transporting ATPase 13A2 ATP13A2 Tbio Transporter -2.00056 92.5 127
Transmembrane protein 11, mitochondrial TMEM11 Tdark Non-IDG -2.42958 286.1 23