Development Level

Tbio 113 | 11,445
Tdark 26 | 6,588
Tchem 17 | 1,598
Tclin 2 | 613

IMPC Phenotype

preweaning lethality, complete... 15 | 979
embryonic lethality prior to t... 6 | 278
decreased total body fat amoun... 4 | 207
decreased vertical activity 4 | 208
embryonic lethality prior to o... 4 | 239
increased lean body mass 4 | 172
increased total body fat amoun... 4 | 134
abnormal embryo size 3 | 220
cataract 3 | 92
decreased body weight 3 | 161
decreased circulating alanine ... 3 | 47
decreased circulating choleste... 3 | 93
decreased heart weight 3 | 27
preweaning lethality, incomple... 3 | 499
abnormal behavior 2 | 298
abnormal bone structure 2 | 187
abnormal coat appearance 2 | 31
abnormal eye morphology 2 | 68
abnormal gait 2 | 69
abnormal lens morphology 2 | 81
abnormal retina morphology 2 | 71
abnormal retinal vasculature m... 2 | 27
abnormal sleep behavior 2 | 70
decreased bone mineral content 2 | 151
decreased circulating HDL chol... 2 | 68
decreased circulating iron lev... 2 | 32
decreased grip strength 2 | 116
decreased lean body mass 2 | 135
decreased mean platelet volume 2 | 25
embryonic growth retardation 2 | 106
enlarged heart 2 | 210
impaired righting response 2 | 26
increased circulating alkaline... 2 | 122
increased heart weight 2 | 62
male infertility 2 | 123
prolonged QT interval 2 | 38
small superior vagus ganglion 2 | 74
abnormal behavioral response t... 1 | 66
abnormal coat-hair pigmentatio... 1 | 64
abnormal cornea morphology 1 | 31
abnormal epididymis morphology 1 | 42
abnormal forebrain development 1 | 20
abnormal heart left ventricle ... 1 | 16
abnormal hindbrain development 1 | 16
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal placenta size 1 | 20
abnormal retinal blood vessel ... 1 | 26
abnormal seminal vesicle morph... 1 | 114
abnormal vibrissa morphology 1 | 25
absent startle reflex 1 | 24
absent vibrissae 1 | 12
cardiovascular system phenotyp... 1 | 36
decreased blood urea nitrogen ... 1 | 51
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating LDL chol... 1 | 38
decreased circulating amylase ... 1 | 28
decreased circulating chloride... 1 | 30
decreased circulating creatine... 1 | 4
decreased circulating insulin ... 1 | 76
decreased circulating magnesiu... 1 | 13
decreased circulating serum al... 1 | 82
decreased food intake 1 | 13
decreased heart rate variabili... 1 | 13
decreased neutrophil cell numb... 1 | 42
decreased prepulse inhibition 1 | 82
edema 1 | 59
enlarged epididymis 1 | 31
enlarged spleen 1 | 41
hydrometra 1 | 53
hyperactivity 1 | 148
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
impaired pupillary reflex 1 | 26
increased blood urea nitrogen ... 1 | 48
increased body length 1 | 32
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased cardiac muscle contr... 1 | 8
increased circulating amylase ... 1 | 25
increased circulating bilirubi... 1 | 16
increased circulating calcium ... 1 | 34
increased circulating choleste... 1 | 66
increased circulating fructosa... 1 | 13
increased circulating glycerol... 1 | 9
increased circulating magnesiu... 1 | 10
increased fasted circulating g... 1 | 76
increased heart rate 1 | 23
increased mean corpuscular hem... 1 | 96
increased mean platelet volume 1 | 45
increased startle reflex 1 | 112
long tibia 1 | 25
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
shortened RR interval 1 | 17
small adrenal glands 1 | 16
small seminal vesicle 1 | 10
small thymus 1 | 16
tremors 1 | 39

Disease

ovarian cancer 84 | 8,520
osteosarcoma 71 | 7,950
Carcinoma 70 | 11,493
medulloblastoma, large-cell 58 | 6,241
glioblastoma 51 | 5,792
psoriasis 49 | 6,694
atypical teratoid / rhabdoid tumor 48 | 5,112
ependymoma 38 | 4,679
lung cancer 38 | 4,740
adult high grade glioma 30 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 30 | 3,291
Breast cancer 28 | 3,578
intraductal papillary-mucinous adenoma (IPMA) 28 | 2,955
group 3 medulloblastoma 27 | 4,104
astrocytic glioma 26 | 2,597
pancreatic ductal adenocarcinoma liver metastasis 25 | 1,962
Autosomal recessive predisposition 24 | 1,442
intraductal papillary-mucinous carcinoma (IPMC) 24 | 2,989
oligodendroglioma 23 | 2,850
Astrocytoma, Pilocytic 22 | 3,081
Pick disease 22 | 1,894
primitive neuroectodermal tumor 21 | 3,035
malignant mesothelioma 20 | 3,232
Epilepsy 19 | 792
group 4 medulloblastoma 19 | 1,855
non-small cell lung cancer 18 | 2,890
subependymal giant cell astrocytoma 18 | 2,287
ulcerative colitis 17 | 1,819
interstitial cystitis 16 | 2,312
Muscle hypotonia 15 | 571
Optic Atrophy 15 | 242
lung carcinoma 15 | 2,843
Cognitive delay 14 | 608
Global developmental delay 14 | 608
Mental and motor retardation 14 | 608
invasive ductal carcinoma 14 | 2,951
pancreatic cancer 14 | 2,398
pituitary cancer 14 | 1,972
Cataract 13 | 297
Cerebellar Ataxia 13 | 304
Hepatomegaly 13 | 285
Multiple myeloma 13 | 1,332
lung adenocarcinoma 13 | 2,716
Seizures 12 | 596
tuberculosis 12 | 2,010
Blepharoptosis 11 | 231
Neurodegenerative disease 11 | 414
Rheumatoid arthritis 11 | 1,191
Small head 11 | 374
dermatomyositis 11 | 966
Big calvaria 10 | 147
Byzanthine arch palate 10 | 194
Failure to gain weight 10 | 365
Feeding difficulties in infancy 10 | 175
High forehead 10 | 102
Icterus 10 | 82
Increased head circumference 10 | 147
Increased size of cranium 10 | 147
Increased size of skull 10 | 147
Lens Opacities 10 | 231
Muscle Spasticity 10 | 195
Nystagmus 10 | 317
Pediatric failure to thrive 10 | 365
Strabismus 10 | 270
Tall forehead 10 | 102
Zellweger syndrome 10 | 37
progressive supranuclear palsy 10 | 676
Concave bridge of nose 9 | 195
Decreased to absent deep tendon reflexes 9 | 42
Depressed nasal bridge 9 | 195
Depressed nasal root/bridge 9 | 195
Flat back of the head 9 | 26
Flat occiput 9 | 26
Hyperreflexia 9 | 209
Hypoplastic mandible condyle 9 | 275
Hypotonia, severe 9 | 33
Intellectual disability 9 | 1,016
Liver Failure 9 | 73
Mandibular hypoplasia 9 | 275
Micrognathism 9 | 275
Peroxisomal disease 9 | 22
Respiratory Insufficiency 9 | 132
Respiratory function loss 9 | 121
Short stature 9 | 531
non primary Sjogren syndrome sicca 9 | 891
Abnormal behavior 8 | 52
Anteverted nostril 8 | 191
Broad flat nasal bridge 8 | 236
Clouding of corneal stroma 8 | 50
Corneal Opacity 8 | 53
Electroencephalogram abnormal 8 | 101
Impaired cognition 8 | 96
Low Vision 8 | 174
Movement Disorders 8 | 55
Nasal bridge wide 8 | 236
Neuropathy 8 | 261
Polymicrogyria 8 | 48
Waldenstrons macroglobulinemia 8 | 765
aldosterone-producing adenoma 8 | 665
esophageal adenocarcinoma 8 | 737

Tissue

Endocrine System 157 | 18,159
Digestive Tract 156 | 17,369
Female tissues 156 | 17,400
Liver and Pancreas 155 | 16,750
Male tissues 155 | 17,142
Skin and soft tissues 155 | 17,230
Nervous System 154 | 16,725
Respiratory system 154 | 16,393
Blood and immune system 153 | 16,909
Urinary Tract 153 | 16,678
Cardiovascular System 149 | 15,192

Target Family

Non-IDG 77 | 12,091
Enzyme 52 | 4,145
Transporter 16 | 473
Ion Channel 10 | 344
Kinase 2 | 634
Epigenetic 1 | 242

Compartment GO Term

Intrinsic component of organel... 158 | 158
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,109 | 14,109
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,975 | 8,975
Intracellular organelle part 8,783 | 8,783
Membrane 8,531 | 8,531
Nucleus 7,562 | 7,562
Cytosol 6,686 | 6,686
Membrane part 6,554 | 6,554
Plasma membrane 5,830 | 5,830
Macromolecular complex 5,475 | 5,475
Intrinsic component of membran... 5,458 | 5,458
Cell periphery 5,382 | 5,382
Integral component of membrane 5,331 | 5,331
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,975 | 3,975
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,674 | 3,674
Organelle membrane 2,846 | 2,846
Extracellular region 2,732 | 2,732
Plasma membrane part 2,594 | 2,594
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,217 | 2,217
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,637 | 1,637
Extracellular region part 1,628 | 1,628
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 967 | 967
Supramolecular complex 966 | 966
Cell junction 960 | 960
Supramolecular fiber 959 | 959
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 930 | 930
Nucleolus 926 | 926
Chromosomal part 889 | 889
GO:0098796 884 | 884
Ribonucleoprotein complex 865 | 865
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 850 | 850
Transferase complex 849 | 849
Cell surface 842 | 842
Plasma membrane region 841 | 841
Vesicle membrane 801 | 801
Cytoplasmic vesicle membrane 795 | 795
Polymeric cytoskeletal fiber 764 | 764
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 714 | 714
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 663 | 663
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Peroxisome biogenesis factor 2 PEX2 Tbio Non-IDG -1.76849 57.3 170
Calcium uniporter regulatory subunit MCUb, mitochondrial MCUB Tdark Non-IDG -0.76467 3.88 57
Fatty acyl-CoA reductase 1 FAR1 Tbio Enzyme -1.65427 43.8 27
Peroxisomal membrane protein PEX16 PEX16 Tbio Non-IDG -1.43594 27.8 78
MICOS complex subunit MIC13 C19orf70 Tbio Non-IDG -1.22343 17.5 18
MICOS complex subunit MIC26 APOO Tbio Non-IDG -1.25338 18.9 141
Endothelin-converting enzyme 1 ECE1 Tchem Enzyme -2.56360 355.0 278
UbiA prenyltransferase domain-containing protein 1 UBIAD1 Tbio Enzyme -1.59893 42.5 50
Sorting and assembly machinery component 50 homolog SAMM50 Tbio Non-IDG -2.09079 120.9 124
Phosphatidylcholine:ceramide cholinephosphotransferase 1 SGMS1 Tchem Enzyme -1.61164 41.6 0