Development Level

Tbio 53 | 11,445
Tdark 9 | 6,588
Tchem 4 | 1,598

IMPC Phenotype

preweaning lethality, complete... 9 | 979
increased total body fat amoun... 3 | 134
abnormal bone structure 2 | 187
abnormal retinal vasculature m... 2 | 27
decreased body weight 2 | 161
decreased bone mineral content 2 | 151
decreased circulating iron lev... 2 | 32
decreased heart weight 2 | 27
decreased mean platelet volume 2 | 25
embryonic lethality prior to t... 2 | 278
impaired righting response 2 | 26
increased heart weight 2 | 62
abnormal adrenal gland morphol... 1 | 1
abnormal behavior 1 | 298
abnormal coat appearance 1 | 31
abnormal epididymis morphology 1 | 42
abnormal gait 1 | 69
abnormal heart left ventricle ... 1 | 16
abnormal retina morphology 1 | 71
abnormal retinal blood vessel ... 1 | 26
abnormal seminal vesicle morph... 1 | 114
abnormal skin morphology 1 | 50
abnormal sleep behavior 1 | 70
abnormal thymus morphology 1 | 7
abnormal vibrissa morphology 1 | 25
absent startle reflex 1 | 24
absent vibrissae 1 | 12
aorta dilation 1 | 3
cataract 1 | 92
decreased blood urea nitrogen ... 1 | 51
decreased bone mineral density 1 | 126
decreased cardiac stroke volum... 1 | 6
decreased circulating alkaline... 1 | 46
decreased circulating amylase ... 1 | 28
decreased circulating chloride... 1 | 30
decreased circulating creatine... 1 | 4
decreased circulating glucose ... 1 | 126
decreased circulating magnesiu... 1 | 13
decreased food intake 1 | 13
decreased grip strength 1 | 116
decreased lean body mass 1 | 135
decreased neutrophil cell numb... 1 | 42
decreased prepulse inhibition 1 | 82
decreased vertical activity 1 | 208
embryonic lethality prior to o... 1 | 239
enlarged epididymis 1 | 31
enlarged heart 1 | 210
enlarged spleen 1 | 41
enlarged testis 1 | 6
hyperactivity 1 | 148
hypoactivity 1 | 132
improved glucose tolerance 1 | 79
increased blood urea nitrogen ... 1 | 48
increased cardiac muscle contr... 1 | 8
increased circulating alkaline... 1 | 122
increased circulating bilirubi... 1 | 16
increased circulating calcium ... 1 | 34
increased circulating glycerol... 1 | 9
increased fasted circulating g... 1 | 76
increased lean body mass 1 | 172
long tibia 1 | 25
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
preweaning lethality, incomple... 1 | 499
prolonged QT interval 1 | 38
shortened QT interval 1 | 4
small adrenal glands 1 | 16
small seminal vesicle 1 | 10
small superior vagus ganglion 1 | 74
small thymus 1 | 16

Disease

ovarian cancer 37 | 8,520
osteosarcoma 30 | 7,950
Carcinoma 22 | 11,493
lung cancer 22 | 4,740
medulloblastoma, large-cell 20 | 6,241
psoriasis 17 | 6,694
glioblastoma 16 | 5,792
astrocytic glioma 15 | 2,597
ependymoma 15 | 4,679
adult high grade glioma 14 | 3,801
atypical teratoid / rhabdoid tumor 14 | 5,112
intraductal papillary-mucinous neoplasm (IPMN) 14 | 3,291
group 4 medulloblastoma 12 | 1,855
pancreatic ductal adenocarcinoma liver metastasis 12 | 1,962
Autosomal recessive predisposition 11 | 1,442
intraductal papillary-mucinous adenoma (IPMA) 11 | 2,955
malignant mesothelioma 11 | 3,232
Breast cancer 10 | 3,578
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,989
oligodendroglioma 10 | 2,850
Multiple myeloma 9 | 1,332
Pick disease 9 | 1,894
pancreatic cancer 9 | 2,398
Astrocytoma, Pilocytic 7 | 3,081
Neurodegenerative disease 7 | 414
Neuropathy 7 | 261
Optic Atrophy 7 | 242
group 3 medulloblastoma 7 | 4,104
non-small cell lung cancer 7 | 2,890
primitive neuroectodermal tumor 7 | 3,035
ulcerative colitis 7 | 1,819
aldosterone-producing adenoma 6 | 665
invasive ductal carcinoma 6 | 2,951
subependymal giant cell astrocytoma 6 | 2,287
Cerebellar Ataxia 5 | 304
Hepatomegaly 5 | 285
Muscle hypotonia 5 | 571
colon cancer 5 | 1,478
dermatomyositis 5 | 966
lung carcinoma 5 | 2,843
non primary Sjogren syndrome sicca 5 | 891
pituitary cancer 5 | 1,972
Acidosis, Lactic 4 | 97
Hypertrophic Cardiomyopathy 4 | 117
Lactic acidemia 4 | 95
Obesity 4 | 678
Rheumatoid arthritis 4 | 1,191
Waldenstrons macroglobulinemia 4 | 765
acute myeloid leukemia 4 | 783
acute quadriplegic myopathy 4 | 1,158
diabetes mellitus 4 | 1,728
hereditary spastic paraplegia 4 | 318
medulloblastoma 4 | 720
primary pancreatic ductal adenocarcinoma 4 | 1,109
tuberculosis 4 | 2,010
3-methylglutaconic aciduria 3 | 29
Acquired scoliosis 3 | 281
Alzheimer's disease 3 | 658
Atrophy of cerebellum 3 | 103
Babinski Reflex 3 | 100
Cancer 3 | 2,499
Cardiomegaly 3 | 116
Cardiomyopathy 3 | 116
Cataract 3 | 297
Cerebellar degeneration 3 | 103
Cerebral atrophy 3 | 178
Chronic progressive external ophthalmoplegia 3 | 26
Colorectal Neoplasms 3 | 243
Congenital pes cavus 3 | 88
Curvature of spine 3 | 282
Deglutition Disorders 3 | 132
Dysarthria 3 | 192
Dystonia 3 | 164
Epilepsy 3 | 792
Highly variable severity 3 | 157
Hypoglycemia 3 | 152
Infantile onset 3 | 238
Infratentorial atrophy 3 | 103
Lactic acidosis 3 | 51
Leigh disease 3 | 100
Muscle Weakness 3 | 170
Myopathy 3 | 185
Neurogenic Muscular Atrophy 3 | 139
Neurogenic muscle atrophy, especially in the lower limbs 3 | 139
Nystagmus 3 | 317
Parkinson's disease 3 | 392
Sengers syndrome 3 | 18
Skeletal muscle atrophy 3 | 139
Slow progression 3 | 89
Variable expressivity 3 | 157
Vascular disease 3 | 319
adrenocortical carcinoma 3 | 1,428
esophageal adenocarcinoma 3 | 737
inflammatory breast cancer 3 | 286
interstitial cystitis 3 | 2,312
muscle degeneration 3 | 139
pancreatic carcinoma 3 | 562
progressive supranuclear palsy 3 | 676
Barth syndrome 2 | 23
Gait Ataxia 2 | 51

Tissue

Blood and immune system 66 | 16,909
Cardiovascular System 66 | 15,192
Digestive Tract 66 | 17,369
Endocrine System 66 | 18,159
Female tissues 66 | 17,400
Liver and Pancreas 66 | 16,750
Male tissues 66 | 17,142
Nervous System 66 | 16,725
Respiratory system 66 | 16,393
Skin and soft tissues 66 | 17,230
Urinary Tract 66 | 16,678

Target Family

Non-IDG 36 | 12,091
Enzyme 21 | 4,145
Transporter 6 | 473
Kinase 2 | 634
Ion Channel 1 | 344

Compartment GO Term

Intrinsic component of mitocho... 66 | 66
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,784 | 8,784
Membrane 8,531 | 8,531
Nucleus 7,562 | 7,562
Cytosol 6,686 | 6,686
Membrane part 6,554 | 6,554
Plasma membrane 5,830 | 5,830
Macromolecular complex 5,475 | 5,475
Intrinsic component of membran... 5,458 | 5,458
Cell periphery 5,382 | 5,382
Integral component of membrane 5,331 | 5,331
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,975 | 3,975
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,674 | 3,674
Organelle membrane 2,846 | 2,846
Extracellular region 2,732 | 2,732
Plasma membrane part 2,594 | 2,594
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,217 | 2,217
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,932 | 1,932
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,641 | 1,641
Cytoskeletal part 1,637 | 1,637
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 970 | 970
Neuron part 969 | 969
Supramolecular polymer 967 | 967
Supramolecular complex 966 | 966
Cell junction 960 | 960
Supramolecular fiber 959 | 959
Golgi apparatus part 950 | 950
Nucleoli 942 | 942
Endosome 930 | 930
Nucleolus 926 | 926
Chromosomal part 889 | 889
GO:0098796 884 | 884
Ribonucleoprotein complex 865 | 865
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 850 | 850
Transferase complex 849 | 849
Cell surface 842 | 842
Plasma membrane region 841 | 841
Vesicle membrane 801 | 801
Cytoplasmic vesicle membrane 795 | 795
Polymeric cytoskeletal fiber 764 | 764
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 714 | 714
Neuron projection 711 | 711
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
MICOS complex subunit MIC13 C19orf70 Tbio Non-IDG -1.22343 17.5 18
MICOS complex subunit MIC26 APOO Tbio Non-IDG -1.25338 18.9 141
MICOS complex subunit MIC19 CHCHD3 Tbio Non-IDG -1.16714 14.1 178
MICOS complex subunit MIC25 CHCHD6 Tbio Non-IDG -1.55591 35.0 155
FUN14 domain-containing protein 1 FUNDC1 Tbio Non-IDG -1.21206 16.0 151
ADP/ATP translocase 1 SLC25A4 Tbio Transporter -2.07841 114.8 103
Mitochondrial thiamine pyrophosphate carrier SLC25A19 Tbio Transporter -2.34612 194.5 69
MICOS complex subunit MIC10 MINOS1 Tdark Non-IDG -0.09691 1.46 56
Calcium uniporter protein, mitochondrial MCU Tbio Ion Channel -2.67075 458.1 25
Calcium uniporter regulatory subunit MCUb, mitochondrial MCUB Tdark Non-IDG -0.76467 3.88 57