Development Level

Tbio 29 | 11,651
Tdark 6 | 6,593
Tchem 2 | 1,388

IMPC Phenotype

preweaning lethality, complete... 4 | 979
abnormal retinal vasculature m... 2 | 27
embryonic lethality prior to t... 2 | 278
increased total body fat amoun... 2 | 134
abnormal bone structure 1 | 187
abnormal heart left ventricle ... 1 | 16
abnormal retina morphology 1 | 71
abnormal retinal blood vessel ... 1 | 26
absent vibrissae 1 | 12
decreased blood urea nitrogen ... 1 | 51
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased cardiac stroke volum... 1 | 6
decreased circulating amylase ... 1 | 28
decreased circulating creatine... 1 | 4
decreased food intake 1 | 13
decreased grip strength 1 | 116
decreased heart weight 1 | 27
decreased prepulse inhibition 1 | 82
embryonic lethality prior to o... 1 | 239
impaired righting response 1 | 26
increased cardiac muscle contr... 1 | 8
increased fasted circulating g... 1 | 76
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87

Disease

ovarian cancer 21 | 8,520
osteosarcoma 18 | 7,950
Carcinoma 14 | 11,493
lung cancer 13 | 4,740
astrocytic glioma 11 | 2,597
ependymoma 10 | 4,679
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,291
medulloblastoma, large-cell 10 | 6,241
psoriasis 10 | 6,694
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,962
adult high grade glioma 8 | 3,801
group 4 medulloblastoma 8 | 1,855
malignant mesothelioma 8 | 3,232
oligodendroglioma 8 | 2,850
pancreatic cancer 8 | 2,398
glioblastoma 7 | 5,792
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,989
Pick disease 6 | 1,894
atypical teratoid / rhabdoid tumor 6 | 5,112
Autosomal recessive predisposition 5 | 1,442
non-small cell lung cancer 5 | 2,890
ulcerative colitis 5 | 1,819
Breast cancer 4 | 3,578
Cerebellar Ataxia 4 | 304
Multiple myeloma 4 | 1,332
invasive ductal carcinoma 4 | 2,951
primitive neuroectodermal tumor 4 | 3,035
subependymal giant cell astrocytoma 4 | 2,287
Astrocytoma, Pilocytic 3 | 3,081
Atrophy of cerebellum 3 | 103
Cerebellar degeneration 3 | 103
Dysarthria 3 | 192
Dystonia 3 | 164
Infratentorial atrophy 3 | 103
Leigh disease 3 | 100
Neurodegenerative disease 3 | 414
Neuropathy 3 | 261
Optic Atrophy 3 | 242
Waldenstrons macroglobulinemia 3 | 765
acute myeloid leukemia 3 | 783
aldosterone-producing adenoma 3 | 665
group 3 medulloblastoma 3 | 4,104
hereditary spastic paraplegia 3 | 318
interstitial cystitis 3 | 2,312
non primary Sjogren syndrome sicca 3 | 891
pancreatic carcinoma 3 | 562
pituitary cancer 3 | 1,972
3-methylglutaconic aciduria 2 | 29
Acidosis, Lactic 2 | 97
Atopic dermatitis 2 | 952
Babinski Reflex 2 | 100
Chronic progressive external ophthalmoplegia 2 | 26
Cytochrome-c Oxidase Deficiency 2 | 17
Deafness dystonia syndrome 2 | 21
Deglutition Disorders 2 | 132
Epilepsy 2 | 792
Gait Ataxia 2 | 51
Hepatomegaly 2 | 285
Highly variable severity 2 | 157
Hypertrophic Cardiomyopathy 2 | 117
Hypoglycemia 2 | 152
Intellectual disability 2 | 1,016
Lactic acidemia 2 | 95
Multiple acyl-CoA dehydrogenase deficiency 2 | 25
Muscle Weakness 2 | 170
Muscle hypotonia 2 | 571
Nephrotic Syndrome 2 | 78
Nystagmus 2 | 317
Obesity 2 | 678
Paraplegia 2 | 74
Substance-Related Disorders 2 | 115
Variable expressivity 2 | 157
Vascular disease 2 | 319
Vomiting 2 | 116
Wolf-Hirschhorn syndrome 2 | 32
adrenocortical carcinoma 2 | 1,428
breast carcinoma 2 | 1,638
colon cancer 2 | 1,478
cytochrome-c oxidase deficiency disease 2 | 19
ductal carcinoma in situ 2 | 1,745
inflammatory breast cancer 2 | 286
lung carcinoma 2 | 2,843
primary pancreatic ductal adenocarcinoma 2 | 1,109
progressive supranuclear palsy 2 | 676
tuberculosis 2 | 2,010
Ataxia, Appendicular 1 | 25
Dysdiadochokinesis 1 | 25
Dysmetric saccades 1 | 9
Elevated heart rate 1 | 25
Lower limb hyperreflexia 1 | 10
Nystagmus, End-Position 1 | 12
Ophthalmoparesis 1 | 11
Paraparesis, Spastic 1 | 16
SPASTIC ATAXIA 5, AUTOSOMAL RECESSIVE 1 | 1
SPINOCEREBELLAR ATAXIA 28 1 | 1
Slowed saccades 1 | 12
Spastic Ataxia 1 | 18
Tonic - clonic seizures 1 | 44
spinocerebellar ataxia type 28 1 | 3

Tissue

Blood and immune system 37 | 16,909
Cardiovascular System 37 | 15,192
Digestive Tract 37 | 17,369
Endocrine System 37 | 18,159
Female tissues 37 | 17,400
Liver and Pancreas 37 | 16,750
Male tissues 37 | 17,142
Nervous System 37 | 16,725
Respiratory system 37 | 16,393
Skin and soft tissues 37 | 17,230
Urinary Tract 37 | 16,678

Target Family

Non-IDG 18 | 12,091
Enzyme 17 | 4,145
Ion Channel 1 | 344
Transporter 1 | 473

Compartment GO Term

Intrinsic component of mitocho... 37 | 37
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,783 | 8,783
Membrane 8,530 | 8,530
Nucleus 7,563 | 7,563
Cytosol 6,686 | 6,686
Membrane part 6,553 | 6,553
Plasma membrane 5,829 | 5,829
Macromolecular complex 5,476 | 5,476
Intrinsic component of membran... 5,457 | 5,457
Cell periphery 5,381 | 5,381
Integral component of membrane 5,330 | 5,330
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,974 | 3,974
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,673 | 3,673
Organelle membrane 2,846 | 2,846
Extracellular region 2,731 | 2,731
Plasma membrane part 2,593 | 2,593
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,216 | 2,216
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,638 | 1,638
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 968 | 968
Supramolecular complex 967 | 967
Cell junction 960 | 960
Supramolecular fiber 960 | 960
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 931 | 931
Nucleolus 927 | 927
Chromosomal part 889 | 889
GO:0098796 883 | 883
Ribonucleoprotein complex 864 | 864
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 849 | 849
Transferase complex 849 | 849
Cell surface 841 | 841
Plasma membrane region 841 | 841
Vesicle membrane 800 | 800
Cytoplasmic vesicle membrane 794 | 794
Polymeric cytoskeletal fiber 765 | 765
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 713 | 713
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Transmembrane protein 11, mitochondrial TMEM11 Tdark Non-IDG -2.44072 252.5 35
Mitochondrial pyruvate carrier 1 MPC1 Tbio Non-IDG -1.77095 56.4 96
Cytochrome c oxidase assembly factor 3 homolog, mitochondrial COA3 Tbio Enzyme -0.93118 9.16 38
DnaJ homolog subfamily C member 11 DNAJC11 Tbio Non-IDG -0.36650 2.83 91
MICOS complex subunit MIC13 C19orf70 Tbio Non-IDG -1.22343 17.5 18
MICOS complex subunit MIC19 CHCHD3 Tbio Non-IDG -1.16714 14.1 178
Acylglycerol kinase, mitochondrial AGK Tbio Enzyme -1.87891 75.3 137
Paraplegin SPG7 Tbio Enzyme -2.81408 647.5 238
Essential MCU regulator, mitochondrial SMDT1 Tbio Non-IDG -1.60735 39.4 11
Mitochondrial import inner membrane translocase subunit Tim23 TIMM23 Tbio Enzyme -0.77409 8.83 49