Development Level

Tbio 1,620 | 11,651
Tchem 255 | 1,388
Tdark 217 | 6,593
Tclin 124 | 612

Collection

RFA-RM-18-021 25 | 328
Ion Channel: IDG Consortium (T... 10 | 99
GPCR: IDG Consortium (Targets) 8 | 126
Kinase: IDG Consortium (Target... 7 | 125
GPCR: IDG Consortium (Complete... 5 | 25
Kinase: IDG Consortium (Comple... 5 | 37

IMPC Phenotype

preweaning lethality, complete... 128 | 979
preweaning lethality, incomple... 67 | 499
abnormal behavior 43 | 298
embryonic lethality prior to t... 42 | 278
embryonic lethality prior to o... 32 | 239
abnormal embryo size 30 | 220
decreased total body fat amoun... 30 | 207
decreased vertical activity 28 | 208
hypoactivity 26 | 132
short tibia 24 | 97
abnormal bone structure 23 | 187
decreased bone mineral content 23 | 151
decreased grip strength 23 | 116
increased circulating alkaline... 22 | 122
increased lean body mass 22 | 172
abnormal seminal vesicle morph... 20 | 114
enlarged heart 20 | 210
increased total body fat amoun... 20 | 134
decreased circulating choleste... 18 | 93
hyperactivity 18 | 148
increased startle reflex 18 | 112
decreased body weight 17 | 161
decreased bone mineral density 16 | 126
decreased circulating HDL chol... 16 | 68
edema 16 | 59
increased bone mineral content 16 | 108
abnormal retina morphology 15 | 71
decreased circulating serum al... 15 | 82
embryonic growth retardation 15 | 106
cataract 14 | 92
decreased circulating glucose ... 14 | 126
decreased circulating insulin ... 14 | 76
decreased mean corpuscular hem... 14 | 50
increased circulating sodium l... 14 | 71
increased mean corpuscular vol... 14 | 92
increased or absent threshold ... 14 | 101
abnormal sleep behavior 13 | 70
decreased lean body mass 13 | 135
impaired glucose tolerance 13 | 75
increased heart weight 13 | 62
abnormal heart morphology 12 | 162
abnormal kidney morphology 12 | 65
abnormal lens morphology 12 | 81
decreased prepulse inhibition 12 | 82
improved glucose tolerance 12 | 79
increased bone mineral density 12 | 72
decreased fasted circulating g... 11 | 65
decreased lymphocyte cell numb... 11 | 83
increased circulating chloride... 11 | 41
increased mean corpuscular hem... 11 | 96
prolonged QT interval 11 | 38
tremors 11 | 39
abnormal behavioral response t... 10 | 66
abnormal coat-hair pigmentatio... 10 | 64
decreased mean corpuscular vol... 10 | 79
decreased startle reflex 10 | 75
enlarged lymph nodes 10 | 37
increased fasted circulating g... 10 | 76
increased leukocyte cell numbe... 10 | 47
abnormal gait 9 | 69
decreased circulating LDL chol... 9 | 38
decreased circulating alkaline... 9 | 46
decreased leukocyte cell numbe... 9 | 73
increased hematocrit 9 | 46
prolonged ST segment 9 | 36
cardiovascular system phenotyp... 8 | 36
decreased circulating total pr... 8 | 49
decreased circulating triglyce... 8 | 79
increased circulating choleste... 8 | 66
increased circulating triglyce... 8 | 42
limb grasping 8 | 41
small superior vagus ganglion 8 | 74
abnormal eye morphology 7 | 68
decreased body length 7 | 101
decreased caudal vertebrae num... 7 | 53
decreased hemoglobin content 7 | 68
increased body weight 7 | 25
increased circulating HDL chol... 7 | 80
increased neutrophil cell numb... 7 | 46
prenatal lethality 7 | 28
prenatal lethality prior to he... 7 | 87
thrombocytosis 7 | 27
abnormal craniofacial morpholo... 6 | 33
abnormal limb morphology 6 | 13
abnormal neural tube closure 6 | 46
decreased circulating bilirubi... 6 | 19
decreased mean corpuscular hem... 6 | 31
decreased threshold for audito... 6 | 26
enlarged spleen 6 | 41
increased circulating free fat... 6 | 20
increased circulating iron lev... 6 | 30
increased hemoglobin content 6 | 45
increased red blood cell distr... 6 | 34
male infertility 6 | 123
small testis 6 | 58
abnormal limb bud morphology 5 | 17
abnormal locomotor behavior 5 | 24
anophthalmia 5 | 33
increased prepulse inhibition 5 | 32
pallor 5 | 34

Disease

Carcinoma 1,390 | 11,493
ovarian cancer 1,168 | 8,520
osteosarcoma 1,069 | 7,950
psoriasis 913 | 6,694
glioblastoma 860 | 5,792
medulloblastoma, large-cell 811 | 6,241
lung cancer 685 | 4,740
atypical teratoid / rhabdoid tumor 684 | 5,112
ependymoma 632 | 4,679
Cancer 571 | 2,499
adult high grade glioma 537 | 3,801
Astrocytoma, Pilocytic 522 | 3,081
lung carcinoma 485 | 2,843
malignant mesothelioma 482 | 3,232
Breast cancer 466 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 466 | 3,291
invasive ductal carcinoma 442 | 2,951
group 3 medulloblastoma 431 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 428 | 2,955
non-small cell lung cancer 428 | 2,890
intraductal papillary-mucinous carcinoma (IPMC) 418 | 2,989
lung adenocarcinoma 413 | 2,716
oligodendroglioma 407 | 2,850
tuberculosis 405 | 2,010
diabetes mellitus 400 | 1,728
pancreatic cancer 394 | 2,398
astrocytic glioma 372 | 2,597
interstitial cystitis 369 | 2,312
subependymal giant cell astrocytoma 369 | 2,287
primitive neuroectodermal tumor 362 | 3,035
Kidney cancer 357 | 2,613
ulcerative colitis 313 | 1,819
pancreatic ductal adenocarcinoma liver metastasis 304 | 1,962
Pick disease 281 | 1,894
Autosomal recessive predisposition 263 | 1,442
cystic fibrosis 254 | 1,696
Schizophrenia 251 | 1,160
Multiple myeloma 250 | 1,332
group 4 medulloblastoma 250 | 1,855
ductal carcinoma in situ 249 | 1,745
pituitary cancer 249 | 1,972
Rheumatoid arthritis 239 | 1,191
breast carcinoma 236 | 1,638
juvenile dermatomyositis 225 | 1,187
dermatomyositis 221 | 966
cutaneous lupus erythematosus 218 | 1,057
astrocytoma 208 | 1,146
colon cancer 206 | 1,478
primary pancreatic ductal adenocarcinoma 198 | 1,109
acute quadriplegic myopathy 192 | 1,158
Liver Cirrhosis, Experimental 181 | 769
adrenocortical carcinoma 179 | 1,428
Alzheimer's disease 173 | 658
Intellectual disability 168 | 1,016
Waldenstrons macroglobulinemia 160 | 765
pediatric high grade glioma 158 | 1,064
Epilepsy 155 | 792
esophageal adenocarcinoma 154 | 737
gastric carcinoma 153 | 807
Bipolar Disorder 151 | 666
Kidney disease 150 | 430
Arthritis 148 | 290
mucosa-associated lymphoid tissue lymphoma 147 | 484
spina bifida 146 | 1,074
active Crohn's disease 142 | 922
primary Sjogren syndrome 138 | 735
Duchenne muscular dystrophy 136 | 601
Obesity 136 | 678
Multiple Sclerosis 132 | 540
nasopharyngeal carcinoma 132 | 1,058
Neurodegenerative disease 127 | 414
Atopic dermatitis 125 | 952
Hypersensitivity reaction type II disease 123 | 253
non primary Sjogren syndrome sicca 123 | 891
Hypertension 121 | 396
Seizures 120 | 596
active ulcerative colitis 116 | 764
Melanoma 114 | 711
Down syndrome 109 | 499
Dull intelligence 109 | 645
Low intelligence 109 | 645
Mental Retardation 109 | 645
Mental deficiency 109 | 645
Poor school performance 109 | 645
Prostatic Neoplasms 109 | 495
Depressive disorder 107 | 409
pancreatic carcinoma 104 | 562
Atherosclerosis 103 | 291
Anemia 101 | 365
Parkinson's disease 100 | 392
acute myeloid leukemia 97 | 783
Asthma 96 | 385
Liver disease 95 | 237
Liver cancer 94 | 604
autosomal dominant Emery-Dreifuss muscular dystrophy 94 | 510
Vascular disease 92 | 319
hepatocellular carcinoma 91 | 547
Cognitive delay 90 | 608
Global developmental delay 90 | 608
Mental and motor retardation 90 | 608

Tissue

Endocrine System 2,084 | 18,159
Digestive Tract 2,059 | 17,369
Female tissues 2,055 | 17,400
Skin and soft tissues 2,043 | 17,230
Liver and Pancreas 2,026 | 16,750
Male tissues 2,024 | 17,142
Blood and immune system 2,019 | 16,909
Urinary Tract 2,010 | 16,678
Nervous System 1,997 | 16,725
Respiratory system 1,988 | 16,393
Cardiovascular System 1,864 | 15,192

Target Family

Non-IDG 1,437 | 12,091
Enzyme 487 | 4,145
Kinase 92 | 634
Transporter 71 | 473
GPCR 58 | 408
Ion Channel 51 | 344
Transcription Factor 11 | 1,400
oGPCR 5 | 421
Epigenetic 3 | 242
TF/Epigenetic 1 | 38

Compartment GO Term

Intracellular vesicle 2,216 | 2,216
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,783 | 8,783
Membrane 8,530 | 8,530
Nucleus 7,563 | 7,563
Cytosol 6,686 | 6,686
Membrane part 6,553 | 6,553
Plasma membrane 5,829 | 5,829
Macromolecular complex 5,476 | 5,476
Intrinsic component of membran... 5,457 | 5,457
Cell periphery 5,381 | 5,381
Integral component of membrane 5,330 | 5,330
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,974 | 3,974
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,673 | 3,673
Organelle membrane 2,846 | 2,846
Extracellular region 2,731 | 2,731
Plasma membrane part 2,593 | 2,593
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,638 | 1,638
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 968 | 968
Supramolecular complex 967 | 967
Cell junction 960 | 960
Supramolecular fiber 960 | 960
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 931 | 931
Nucleolus 927 | 927
Chromosomal part 889 | 889
GO:0098796 883 | 883
Ribonucleoprotein complex 864 | 864
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 849 | 849
Transferase complex 849 | 849
Cell surface 841 | 841
Plasma membrane region 841 | 841
Vesicle membrane 800 | 800
Cytoplasmic vesicle membrane 794 | 794
Polymeric cytoskeletal fiber 765 | 765
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 713 | 713
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ras-related protein Rab-21 RAB21 Tbio Enzyme -1.33715 23.1 275
Beta-secretase 2 BACE2 Tchem Enzyme -2.09709 114.0 418
Ras-related protein Rab-22A RAB22A Tbio Enzyme -1.40824 19.7 123
Annexin A13 ANXA13 Tbio Non-IDG -1.19458 15.6 162
GTP-binding protein SAR1b SAR1B Tbio Enzyme -1.91051 79.7 184
Endothelin-converting enzyme 1 ECE1 Tchem Enzyme -2.56360 355.0 278
Probable ergosterol biosynthetic protein 28 ERG28 Tdark Non-IDG -1.25331 16.7 40
Myeloperoxidase MPO Tchem Enzyme -3.51470 3209.3 1255
ATP-binding cassette sub-family A member 1 ABCA1 Tclin Transporter -3.15111 1451.8 388
Cytoplasmic FMR1-interacting protein 1 CYFIP1 Tbio Non-IDG -1.46134 28.5 64