Development Level

Tbio 617 | 11,445
Tdark 163 | 6,588
Tchem 53 | 1,598
Tclin 17 | 613

Collection

RFA-RM-18-021 8 | 328
Kinase: IDG Consortium (Target... 7 | 125
GPCR: IDG Consortium (Targets) 1 | 126
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 86 | 979
embryonic lethality prior to o... 33 | 239
embryonic lethality prior to t... 24 | 278
preweaning lethality, incomple... 16 | 499
abnormal embryo size 15 | 220
abnormal behavior 13 | 298
abnormal bone structure 13 | 187
embryonic growth retardation 10 | 106
prenatal lethality prior to he... 9 | 87
abnormal retina morphology 7 | 71
decreased bone mineral density 7 | 126
enlarged heart 7 | 210
increased fasted circulating g... 7 | 76
decreased circulating glucose ... 6 | 126
decreased grip strength 6 | 116
decreased leukocyte cell numbe... 6 | 73
increased lean body mass 6 | 172
increased total body fat amoun... 6 | 134
abnormal coat-hair pigmentatio... 5 | 64
abnormal heart morphology 5 | 162
decreased bone mineral content 5 | 151
decreased neutrophil cell numb... 5 | 42
decreased vertical activity 5 | 208
hypoactivity 5 | 132
increased circulating alkaline... 5 | 122
increased mean corpuscular hem... 5 | 96
increased mean corpuscular vol... 5 | 92
increased mean platelet volume 5 | 45
abnormal lens morphology 4 | 81
decreased circulating choleste... 4 | 93
decreased total body fat amoun... 4 | 207
increased bone mineral content 4 | 108
increased grip strength 4 | 41
male infertility 4 | 123
short tibia 4 | 97
abnormal behavioral response t... 3 | 66
abnormal seminal vesicle morph... 3 | 114
abnormal sleep behavior 3 | 70
abnormal spleen morphology 3 | 55
cataract 3 | 92
decreased erythrocyte cell num... 3 | 62
decreased lean body mass 3 | 135
decreased lymphocyte cell numb... 3 | 83
hyperactivity 3 | 148
improved glucose tolerance 3 | 79
increased circulating HDL chol... 3 | 80
increased circulating chloride... 3 | 41
increased circulating choleste... 3 | 66
increased circulating total pr... 3 | 28
increased heart weight 3 | 62
increased lymphocyte cell numb... 3 | 32
increased or absent threshold ... 3 | 101
increased startle reflex 3 | 112
abnormal bone mineralization 2 | 38
abnormal cornea morphology 2 | 31
abnormal cranium morphology 2 | 36
abnormal embryo turning 2 | 31
abnormal lung morphology 2 | 26
abnormal neural tube closure 2 | 46
abnormal pericardium morpholog... 2 | 26
abnormal placenta size 2 | 20
abnormal skin morphology 2 | 50
abnormal spine curvature 2 | 9
absent startle reflex 2 | 24
cardiovascular system phenotyp... 2 | 36
decreased basophil cell number 2 | 16
decreased blood urea nitrogen ... 2 | 51
decreased body length 2 | 101
decreased caudal vertebrae num... 2 | 53
decreased circulating HDL chol... 2 | 68
decreased circulating calcium ... 2 | 36
decreased circulating phosphat... 2 | 27
decreased circulating potassiu... 2 | 20
decreased circulating total pr... 2 | 49
decreased circulating triglyce... 2 | 79
decreased fasted circulating g... 2 | 65
decreased hemoglobin content 2 | 68
decreased mean corpuscular hem... 2 | 50
decreased mean corpuscular hem... 2 | 31
decreased mean corpuscular vol... 2 | 79
decreased prepulse inhibition 2 | 82
decreased spleen weight 2 | 10
decreased startle reflex 2 | 75
edema 2 | 59
hemorrhage 2 | 23
impaired glucose tolerance 2 | 75
impaired righting response 2 | 26
increased body length 2 | 32
increased bone mineral density 2 | 72
increased circulating calcium ... 2 | 34
increased circulating free fat... 2 | 20
increased erythrocyte cell num... 2 | 39
increased neutrophil cell numb... 2 | 46
increased spleen weight 2 | 10
pallor 2 | 34
small superior vagus ganglion 2 | 74
thrombocytopenia 2 | 56
thrombocytosis 2 | 27
abnormal retinal vasculature m... 1 | 27
increased circulating serum al... 1 | 22

Disease

ovarian cancer 492 | 8,520
Carcinoma 486 | 11,493
osteosarcoma 359 | 7,950
lung cancer 273 | 4,740
medulloblastoma, large-cell 268 | 6,241
psoriasis 245 | 6,694
group 3 medulloblastoma 216 | 4,104
glioblastoma 214 | 5,792
atypical teratoid / rhabdoid tumor 191 | 5,112
Multiple myeloma 178 | 1,332
ependymoma 152 | 4,679
Breast cancer 140 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 131 | 3,291
Cancer 126 | 2,499
malignant mesothelioma 124 | 3,232
oligodendroglioma 124 | 2,850
Kidney cancer 120 | 2,613
intraductal papillary-mucinous adenoma (IPMA) 119 | 2,955
primitive neuroectodermal tumor 116 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 115 | 2,989
adult high grade glioma 112 | 3,801
acute quadriplegic myopathy 111 | 1,158
diabetes mellitus 109 | 1,728
Waldenstrons macroglobulinemia 99 | 765
astrocytic glioma 97 | 2,597
non-small cell lung cancer 94 | 2,890
pancreatic ductal adenocarcinoma liver metastasis 93 | 1,962
lung adenocarcinoma 89 | 2,716
invasive ductal carcinoma 83 | 2,951
dermatomyositis 81 | 966
subependymal giant cell astrocytoma 81 | 2,287
astrocytoma 79 | 1,146
Pick disease 76 | 1,894
Astrocytoma, Pilocytic 71 | 3,081
colon cancer 67 | 1,478
juvenile dermatomyositis 65 | 1,187
pancreatic cancer 62 | 2,398
group 4 medulloblastoma 61 | 1,855
Intellectual disability 54 | 1,016
acute myeloid leukemia 54 | 783
non primary Sjogren syndrome sicca 53 | 891
pediatric high grade glioma 49 | 1,064
cystic fibrosis 48 | 1,696
breast carcinoma 47 | 1,638
progressive supranuclear palsy 46 | 676
Amyotrophic lateral sclerosis 43 | 451
lung carcinoma 43 | 2,843
tuberculosis 43 | 2,010
Rheumatoid arthritis 42 | 1,191
adrenocortical carcinoma 38 | 1,428
Autosomal recessive predisposition 37 | 1,442
pituitary cancer 37 | 1,972
primary pancreatic ductal adenocarcinoma 37 | 1,109
Breast Neoplasms 35 | 445
ulcerative colitis 35 | 1,819
Anemia 34 | 365
Mammary Neoplasms 34 | 425
Schizophrenia 34 | 1,160
Short stature 33 | 531
Neurodegenerative disease 32 | 414
spina bifida 32 | 1,074
Dull intelligence 30 | 645
Low intelligence 30 | 645
Mental Retardation 30 | 645
Mental deficiency 30 | 645
Poor school performance 30 | 645
Stomach Neoplasms 30 | 300
nasopharyngeal carcinoma 30 | 1,058
Fatigue 29 | 182
cutaneous lupus erythematosus 29 | 1,057
hepatocellular carcinoma 29 | 547
Epilepsy 28 | 792
ductal carcinoma in situ 28 | 1,745
Cognitive delay 27 | 608
Diamond-Blackfan anemia 27 | 31
Disease Models, Animal 27 | 155
Global developmental delay 27 | 608
Mental and motor retardation 27 | 608
tuberculosis and treatment for 6 months 27 | 409
Adenocarcinoma of lung 26 | 142
Disease Progression 26 | 136
Melanoma 26 | 711
sonic hedgehog group medulloblastoma 26 | 467
Alzheimer's disease 25 | 658
Depressive disorder 25 | 409
Prostatic Neoplasms 25 | 495
Cleft Palate 24 | 271
Obesity 24 | 678
interstitial cystitis 24 | 2,312
medulloblastoma 24 | 720
Bipolar Disorder 23 | 666
Cardiac Arrhythmia 23 | 103
Cardiac conduction abnormalities 23 | 78
Conduction disorder of the heart 23 | 79
EKG abnormalities 23 | 78
Electrocardiogram abnormal 23 | 81
Electrocardiogram change 23 | 78
Osteoporosis 23 | 363
Small head 22 | 374
active Crohn's disease 22 | 922

Tissue

Endocrine System 830 | 18,159
Female tissues 822 | 17,400
Digestive Tract 821 | 17,369
Blood and immune system 819 | 16,909
Male tissues 818 | 17,142
Skin and soft tissues 818 | 17,230
Nervous System 816 | 16,725
Liver and Pancreas 815 | 16,750
Urinary Tract 814 | 16,678
Respiratory system 813 | 16,393
Cardiovascular System 800 | 15,192

Target Family

Non-IDG 638 | 12,091
Enzyme 157 | 4,145
Kinase 23 | 634
Transcription Factor 14 | 1,400
Epigenetic 13 | 242
Transporter 2 | 473
GPCR 1 | 408
Nuclear Receptor 1 | 48
TF/Epigenetic 1 | 38

Compartment GO Term

Intracellular ribonucleoprotei... 850 | 850
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,109 | 14,109
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,975 | 8,975
Intracellular organelle part 8,783 | 8,783
Membrane 8,531 | 8,531
Nucleus 7,562 | 7,562
Cytosol 6,686 | 6,686
Membrane part 6,554 | 6,554
Plasma membrane 5,830 | 5,830
Macromolecular complex 5,475 | 5,475
Intrinsic component of membran... 5,458 | 5,458
Cell periphery 5,382 | 5,382
Integral component of membrane 5,331 | 5,331
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,975 | 3,975
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,674 | 3,674
Organelle membrane 2,846 | 2,846
Extracellular region 2,732 | 2,732
Plasma membrane part 2,594 | 2,594
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,217 | 2,217
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,637 | 1,637
Extracellular region part 1,628 | 1,628
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 967 | 967
Supramolecular complex 966 | 966
Cell junction 960 | 960
Supramolecular fiber 959 | 959
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 930 | 930
Nucleolus 926 | 926
Chromosomal part 889 | 889
GO:0098796 884 | 884
Ribonucleoprotein complex 865 | 865
Secretory granule 852 | 852
Cell projection part 850 | 850
Transferase complex 849 | 849
Cell surface 842 | 842
Plasma membrane region 841 | 841
Vesicle membrane 801 | 801
Cytoplasmic vesicle membrane 795 | 795
Polymeric cytoskeletal fiber 764 | 764
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 714 | 714
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 663 | 663
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
60S ribosomal protein L3 RPL3 Tbio Non-IDG -2.02901 103.9 190
40S ribosomal protein S19 RPS19 Tbio Non-IDG -3.14746 1380.8 267
Pre-mRNA-splicing factor CWC22 homolog CWC22 Tbio Non-IDG -3.08456 1172.8 103
Heterogeneous nuclear ribonucleoprotein H3 HNRNPH3 Tbio Non-IDG -1.80776 63.4 80
60S ribosomal protein L36 RPL36 Tbio Non-IDG -1.62928 39.9 123
Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 ASZ1 Tbio Non-IDG -2.81661 644.9 107
Heterogeneous nuclear ribonucleoprotein M HNRNPM Tbio Non-IDG -1.64443 45.9 331
Putative postmeiotic segregation increased 2-like protein 11 PMS2P11 Tdark Enzyme -2.19299 339.5 0
Ataxin-2-like protein ATXN2L Tbio Non-IDG -1.58925 37.9 93
Box C/D snoRNA protein 1 ZNHIT6 Tbio Non-IDG 0.48 0.74 87