Development Level

Tbio 533 | 10,625
Tdark 183 | 7,003
Tchem 58 | 1,890
Tclin 15 | 602

Collection

Kinase: IDG Consortium (Targets) 4 | 125
GPCR: IDG Consortium (Targets) 1 | 127
Kinase: IDG Consortium (Complete/Control) 1 | 37

IMPC Phenotype

preweaning lethality, complete... 47 | 633
embryonic lethality prior to o... 19 | 148
embryonic lethality prior to t... 16 | 187
preweaning lethality, incomple... 11 | 260
abnormal behavior 7 | 226
abnormal bone structure 7 | 131
abnormal embryo size 7 | 112
abnormal retina morphology 7 | 100
abnormal retinal pigmentation 6 | 61
decreased grip strength 6 | 123
increased grip strength 6 | 83
decreased body length 5 | 108
decreased circulating glucose ... 5 | 121
decreased leukocyte cell numbe... 5 | 54
increased fasted circulating g... 5 | 68
decreased lean body mass 4 | 195
increased NK cell number 4 | 19
increased mean corpuscular vol... 4 | 91
increased or absent threshold ... 4 | 128
prenatal lethality prior to he... 4 | 64
abnormal coat-hair pigmentatio... 3 | 54
abnormal sleep behavior 3 | 63
decreased bone mineral content 3 | 157
decreased bone mineral density 3 | 126
decreased neutrophil cell numb... 3 | 37
embryonic growth retardation 3 | 28
hyperactivity 3 | 108
increased circulating HDL chol... 3 | 63
increased circulating alkaline... 3 | 119
increased circulating choleste... 3 | 53
increased exploration in new e... 3 | 56
increased mean corpuscular hem... 3 | 93
increased mean platelet volume 3 | 19
increased rib number 3 | 41
abnormal behavioral response t... 2 | 52
abnormal cornea morphology 2 | 24
abnormal cranium morphology 2 | 32
abnormal lens morphology 2 | 73
abnormal lung morphology 2 | 15
abnormal neural tube closure 2 | 37
abnormal seminal vesicle morph... 2 | 47
abnormal spine curvature 2 | 7
abnormal spleen morphology 2 | 36
absent startle reflex 2 | 15
decreased CD4-positive, CD25-p... 2 | 24
decreased Ly6C high monocyte n... 2 | 18
decreased body weight 2 | 174
decreased effector memory CD8-... 2 | 24
decreased eosinophil cell numb... 2 | 41
decreased fasted circulating g... 2 | 49
decreased lymphocyte cell numb... 2 | 9
decreased monocyte cell number 2 | 28
decreased total body fat amoun... 2 | 186
enlarged heart 2 | 111
improved glucose tolerance 2 | 56
increased CD4-positive, CD25-p... 2 | 18
increased CD4-positive, alpha ... 2 | 15
increased bone mineral content 2 | 92
increased circulating calcium ... 2 | 32
increased circulating chloride... 2 | 43
increased circulating total pr... 2 | 20
increased granulocyte number 2 | 8
increased lean body mass 2 | 107
male infertility 2 | 62
thrombocytosis 2 | 23
abnormal coat appearance 1 | 25
abnormal embryo turning 1 | 15
abnormal kidney morphology 1 | 30
abnormal neural tube morpholog... 1 | 8
abnormal rib morphology 1 | 28
abnormal snout morphology 1 | 18
abnormal vocalization 1 | 21
absent pinna reflex 1 | 21
convulsive seizures 1 | 11
corneal opacity 1 | 25
decreased KLRG1+ CD4 alpha bet... 1 | 2
decreased NK cell number 1 | 16
decreased blood urea nitrogen ... 1 | 31
decreased cervical vertebrae n... 1 | 12
decreased circulating chloride... 1 | 32
decreased circulating sodium l... 1 | 18
decreased circulating triglyce... 1 | 83
decreased exploration in new e... 1 | 9
decreased heart weight 1 | 44
decreased mean corpuscular hem... 1 | 34
decreased total retina thickne... 1 | 20
decreased vertical activity 1 | 22
female infertility 1 | 34
impaired righting response 1 | 19
increased KLRG1+ CD4 alpha bet... 1 | 5
increased body length 1 | 20
increased bone mineral density 1 | 52
increased circulating creatini... 1 | 29
increased circulating glucose ... 1 | 16
increased circulating iron lev... 1 | 25
increased circulating triglyce... 1 | 24
increased effector memory CD4-... 1 | 15
increased sacral vertebrae num... 1 | 62
persistence of hyaloid vascula... 1 | 22
vertebral fusion 1 | 23

Disease

ovarian cancer 454 | 8,491
osteosarcoma 328 | 7,933
lung cancer 249 | 4,473
medulloblastoma, large-cell 236 | 6,234
psoriasis 223 | 6,685
glioblastoma 179 | 5,572
Multiple myeloma 168 | 1,327
atypical teratoid / rhabdoid tumor 148 | 4,369
group 3 medulloblastoma 137 | 2,254
intraductal papillary-mucinous neoplasm (IPMN) 122 | 3,289
oligodendroglioma 111 | 2,849
Breast cancer 110 | 3,098
intraductal papillary-mucinous adenoma (IPMA) 109 | 2,956
ependymoma 107 | 2,514
acute quadriplegic myopathy 106 | 1,157
intraductal papillary-mucinous carcinoma (IPMC) 106 | 2,988
malignant mesothelioma 106 | 3,163
Cancer 104 | 2,346
primitive neuroectodermal tumor 101 | 3,031
diabetes mellitus 97 | 1,663
Waldenstrons macroglobulinemia 94 | 764
astrocytoma 87 | 1,493
pediatric high grade glioma 87 | 2,712
pancreatic ductal adenocarcinoma liver metastasis 85 | 1,795
non-small cell lung cancer 84 | 2,798
lung adenocarcinoma 76 | 2,714
astrocytic glioma 74 | 2,241
dermatomyositis 74 | 966
Carcinoma 73 | 2,147
Pick disease 73 | 1,893
subependymal giant cell astrocytoma 72 | 2,287
invasive ductal carcinoma 69 | 2,950
sonic hedgehog group medulloblastoma 69 | 1,482
colon cancer 68 | 1,475
juvenile dermatomyositis 62 | 1,189
pilocytic astrocytoma 57 | 3,086
adult high grade glioma 54 | 2,148
pancreatic cancer 53 | 2,300
acute myeloid leukemia 51 | 785
group 4 medulloblastoma 51 | 1,875
non primary Sjogren syndrome sicca 50 | 840
progressive supranuclear palsy 44 | 674
atypical teratoid/rhabdoid tumor 43 | 1,095
cystic fibrosis 41 | 1,670
tuberculosis and treatment for 6 months 41 | 686
Amyotrophic Lateral Sclerosis 40 | 432
medulloblastoma 38 | 1,524
Rheumatoid Arthritis 37 | 1,170
breast carcinoma 37 | 1,614
primary pancreatic ductal adenocarcinoma 36 | 1,271
lung carcinoma 34 | 2,844
pituitary cancer 31 | 1,972
Mammary Neoplasms 30 | 410
adrenocortical carcinoma 30 | 1,427
posterior fossa group A ependymoma 30 | 1,511
Neurodegenerative disease 29 | 383
Stomach Neoplasms 29 | 282
Intellectual disability 27 | 573
hepatocellular carcinoma 26 | 550
spina bifida 26 | 1,064
ulcerative colitis 26 | 2,087
Diamond-Blackfan anemia 25 | 30
Disease Progression 25 | 125
nasopharyngeal carcinoma 25 | 1,056
Alzheimer's disease 23 | 644
cutaneous lupus erythematosus 22 | 1,056
Anemia 21 | 252
ductal carcinoma in situ 21 | 1,745
tuberculosis 21 | 1,563
Prostatic Neoplasms 20 | 471
hereditary spastic paraplegia 20 | 313
HIV Infections 19 | 99
posterior fossa group B ependymoma 19 | 1,530
Down syndrome 18 | 548
Duchenne muscular dystrophy 18 | 602
autosomal dominant Emery-Dreifuss muscular dystrophy 18 | 499
Gaucher disease type 1 17 | 171
IGA Glomerulonephritis 17 | 454
active Crohn's disease 17 | 918
glioblastoma multiforme 17 | 347
inflammatory breast cancer 17 | 404
mucosa-associated lymphoid tissue lymphoma 17 | 480
Melanoma 16 | 261
Muscular atrophy 16 | 67
Obesity 16 | 616
Osteoporosis 16 | 259
Schizophrenia 16 | 503
aldosterone-producing adenoma 16 | 664
Kidney disease 15 | 397
Polycystic Ovary Syndrome 15 | 334
Vascular disease 15 | 281
gastric cancer 15 | 436
gastric carcinoma 15 | 832
pancreatic carcinoma 15 | 567
Heart disease 14 | 279
Mammary Neoplasms, Experimental 14 | 149
interstitial lung disease 14 | 292
Male infertility 13 | 170
interstitial cystitis 13 | 2,299
primary Sjogren syndrome 13 | 788

Tissue

Female tissues 780 | 18,646
Digestive Tract 779 | 18,472
Nervous System 779 | 18,560
Endocrine System 778 | 18,511
Blood and immune system 777 | 17,994
Liver and Pancreas 777 | 18,135
Male tissues 777 | 17,968
Cardiovascular System 776 | 17,957
Urinary Tract 776 | 18,443
Respiratory system 771 | 17,483
Skin and soft tissues 767 | 18,114

Target Family

Non-IDG 609 | 11,969
Enzyme 131 | 4,146
Kinase 17 | 634
Transcription Factor 14 | 1,400
Epigenetic 13 | 242
Transporter 2 | 473
GPCR 1 | 408
Nuclear Receptor 1 | 48
TF/Epigenetic 1 | 38

Compartment GO Term

Intracellular ribonucleoprotei... 789 | 789
cellular_component 18,237 | 18,237
Cell 15,806 | 15,806
Cell part 15,806 | 15,806
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,648 | 12,648
membrane-bounded organelle 11,793 | 11,793
Intracellular organelle 11,617 | 11,617
Intracellular membrane-bounded... 10,618 | 10,618
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,169 | 8,169
Intracellular organelle part 8,011 | 8,011
Cytoplasmic part 7,830 | 7,830
Nucleus 7,577 | 7,577
Membrane part 6,470 | 6,470
Cytosol 6,035 | 6,035
Plasma membrane 5,673 | 5,673
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,171 | 5,171
Cell periphery 5,146 | 5,146
Nucleoplasm 4,929 | 4,929
Extracellular region 4,606 | 4,606
Protein complex 4,439 | 4,439
Intracellular organelle lumen 4,330 | 4,330
Organelle lumen 4,330 | 4,330
membrane-enclosed lumen 4,330 | 4,330
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,839 | 3,839
non-membrane-bounded organelle 3,838 | 3,838
Nuclear part 3,807 | 3,807
Endomembrane system 3,720 | 3,720
Vesicle 3,666 | 3,666
membrane-bounded vesicle 3,494 | 3,494
Nuclear lumen 3,464 | 3,464
Extracellular organelle 2,849 | 2,849
Extracellular vesicle 2,848 | 2,848
Extracellular exosome 2,828 | 2,828
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,564 | 2,564
Cytoskeleton 2,046 | 2,046
Golgi apparatus 1,946 | 1,946
Endoplasmic reticulum 1,872 | 1,872
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Vesicles 1,625 | 1,625
Cytoskeletal part 1,568 | 1,568
Mitochondrion 1,531 | 1,531
Cell projection 1,426 | 1,426
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,305 | 1,305
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,234 | 1,234
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Mitochondria 1,003 | 1,003
Chromosome 999 | 999
Mitochondrial part 989 | 989
Nucleoli 952 | 952
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 793 | 793
Nucleoplasm part 781 | 781
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 739 | 739
Plasma membrane protein comple... 721 | 721
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Microtubule organizing center 680 | 680
Centrosome 676 | 676
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Synapse 594 | 594
Lytic vacuole 571 | 571

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Splicing regulatory glutamine/lysine-rich protein 1 SREK1 Tdark Non-IDG -0.37946 3.77 39
DNA-directed RNA polymerase II subunit RPB2 POLR2B Tbio Enzyme -2.47495 286.5 135
Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 DHX15 Tbio Enzyme -1.70052 49.6 108
Galectin-3 LGALS3 Tchem Non-IDG -3.33005 2249.5 911
28S ribosomal protein S18a, mitochondrial MRPS18A Tdark Non-IDG 0.32 0.72 46
U4/U6 small nuclear ribonucleoprotein Prp4 PRPF4 Tchem Non-IDG -0.55879 7.56 79
Heterogeneous nuclear ribonucleoprotein L-like HNRNPLL Tbio Non-IDG -1.32345 15.4 109
Ribosomal biogenesis protein LAS1L LAS1L Tdark Non-IDG -0.45120 2.84 94
Mitochondrial ribosome-associated GTPase 1 MTG1 Tdark Enzyme -0.54103 1.85 75
Notchless protein homolog 1 NLE1 Tbio Non-IDG -2.68863 425.5 142