Development Level

Tbio 9,441 | 11,445
Tdark 2,775 | 6,588
Tchem 1,313 | 1,598
Tclin 443 | 613

Collection

RFA-RM-18-021 161 | 328
Kinase: IDG Consortium (Target... 109 | 125
Kinase: IDG Consortium (Comple... 36 | 37
Ion Channel: IDG Consortium (T... 33 | 99
GPCR: IDG Consortium (Targets) 20 | 126
GPCR: IDG Consortium (Complete... 8 | 25

IMPC Phenotype

preweaning lethality, complete... 915 | 979
preweaning lethality, incomple... 422 | 499
embryonic lethality prior to t... 266 | 278
abnormal behavior 237 | 298
embryonic lethality prior to o... 231 | 239
abnormal embryo size 202 | 220
decreased total body fat amoun... 173 | 207
abnormal bone structure 161 | 187
enlarged heart 147 | 210
decreased vertical activity 146 | 208
increased lean body mass 142 | 172
decreased body weight 141 | 161
decreased bone mineral content 128 | 151
decreased lean body mass 119 | 135
hypoactivity 119 | 132
increased total body fat amoun... 118 | 134
abnormal heart morphology 115 | 162
hyperactivity 115 | 148
decreased bone mineral density 103 | 126
increased circulating alkaline... 103 | 122
decreased circulating glucose ... 102 | 126
embryonic growth retardation 102 | 106
male infertility 102 | 123
decreased grip strength 101 | 116
increased startle reflex 101 | 112
abnormal seminal vesicle morph... 88 | 114
increased bone mineral content 87 | 108
decreased circulating choleste... 85 | 93
decreased body length 82 | 101
increased or absent threshold ... 80 | 101
prenatal lethality prior to he... 80 | 87
cataract 78 | 92
increased mean corpuscular hem... 78 | 96
increased mean corpuscular vol... 77 | 92
short tibia 76 | 97
decreased mean corpuscular vol... 73 | 79
decreased circulating serum al... 72 | 82
decreased prepulse inhibition 72 | 82
abnormal lens morphology 71 | 81
decreased lymphocyte cell numb... 68 | 83
decreased circulating triglyce... 67 | 79
increased circulating HDL chol... 67 | 80
improved glucose tolerance 66 | 79
increased bone mineral density 66 | 72
impaired glucose tolerance 64 | 75
increased fasted circulating g... 64 | 76
decreased circulating HDL chol... 63 | 68
decreased hemoglobin content 63 | 68
decreased circulating insulin ... 62 | 76
decreased startle reflex 62 | 75
abnormal retina morphology 60 | 71
decreased leukocyte cell numbe... 60 | 73
increased circulating choleste... 59 | 66
small superior vagus ganglion 59 | 74
edema 57 | 59
increased heart weight 57 | 62
decreased fasted circulating g... 56 | 65
increased circulating sodium l... 56 | 71
abnormal gait 55 | 69
abnormal kidney morphology 54 | 65
abnormal sleep behavior 54 | 70
abnormal behavioral response t... 53 | 66
abnormal coat-hair pigmentatio... 53 | 64
abnormal eye morphology 53 | 68
increased monocyte cell number 51 | 63
decreased erythrocyte cell num... 50 | 62
female infertility 49 | 60
thrombocytopenia 48 | 56
decreased mean corpuscular hem... 47 | 50
small testis 47 | 58
abnormal spleen morphology 45 | 55
decreased caudal vertebrae num... 44 | 53
abnormal neural tube closure 43 | 46
decreased circulating total pr... 43 | 49
decreased blood urea nitrogen ... 42 | 51
decreased circulating alanine ... 42 | 47
decreased circulating alkaline... 41 | 46
decreased hematocrit 40 | 46
increased leukocyte cell numbe... 40 | 47
hydrometra 39 | 53
increased blood urea nitrogen ... 39 | 48
abnormal skin morphology 38 | 50
increased neutrophil cell numb... 38 | 46
increased circulating chloride... 37 | 41
increased hematocrit 37 | 46
increased hemoglobin content 37 | 45
decreased circulating LDL chol... 36 | 38
increased mean platelet volume 36 | 45
abnormal bone mineralization 34 | 38
abnormal testis morphology 34 | 43
enlarged spleen 34 | 41
increased circulating triglyce... 34 | 42
increased grip strength 34 | 41
abnormal cranium morphology 33 | 36
increased circulating creatini... 33 | 38
pallor 33 | 34
prolonged QT interval 33 | 38
tremors 33 | 39
decreased circulating creatini... 32 | 39
prolonged ST segment 32 | 36

Disease

Carcinoma 8,723 | 11,493
ovarian cancer 6,983 | 8,520
osteosarcoma 6,318 | 7,950
psoriasis 5,107 | 6,694
medulloblastoma, large-cell 4,896 | 6,241
glioblastoma 4,628 | 5,792
atypical teratoid / rhabdoid tumor 4,020 | 5,112
lung cancer 3,939 | 4,740
ependymoma 3,587 | 4,679
group 3 medulloblastoma 3,294 | 4,104
adult high grade glioma 2,890 | 3,801
Breast cancer 2,880 | 3,578
malignant mesothelioma 2,685 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 2,668 | 3,291
primitive neuroectodermal tumor 2,424 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,389 | 2,989
invasive ductal carcinoma 2,346 | 2,951
Astrocytoma, Pilocytic 2,337 | 3,081
intraductal papillary-mucinous adenoma (IPMA) 2,319 | 2,955
non-small cell lung cancer 2,277 | 2,890
Cancer 2,250 | 2,499
oligodendroglioma 2,238 | 2,850
lung adenocarcinoma 2,091 | 2,716
lung carcinoma 2,075 | 2,843
Kidney cancer 2,036 | 2,613
astrocytic glioma 2,028 | 2,597
pancreatic cancer 1,903 | 2,398
subependymal giant cell astrocytoma 1,801 | 2,287
interstitial cystitis 1,662 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 1,637 | 1,962
tuberculosis 1,612 | 2,010
Pick disease 1,573 | 1,894
group 4 medulloblastoma 1,493 | 1,855
pituitary cancer 1,479 | 1,972
ulcerative colitis 1,407 | 1,819
diabetes mellitus 1,385 | 1,728
ductal carcinoma in situ 1,368 | 1,745
breast carcinoma 1,326 | 1,638
cystic fibrosis 1,289 | 1,696
Autosomal recessive predisposition 1,251 | 1,442
Multiple myeloma 1,244 | 1,332
colon cancer 1,183 | 1,478
adrenocortical carcinoma 1,150 | 1,428
Rheumatoid arthritis 1,013 | 1,191
juvenile dermatomyositis 1,012 | 1,187
acute quadriplegic myopathy 1,002 | 1,158
astrocytoma 981 | 1,146
Intellectual disability 929 | 1,016
Schizophrenia 911 | 1,160
dermatomyositis 892 | 966
primary pancreatic ductal adenocarcinoma 884 | 1,109
pediatric high grade glioma 873 | 1,064
spina bifida 872 | 1,074
nasopharyngeal carcinoma 823 | 1,058
cutaneous lupus erythematosus 817 | 1,057
Atopic dermatitis 737 | 952
non primary Sjogren syndrome sicca 733 | 891
Waldenstrons macroglobulinemia 720 | 765
active Crohn's disease 702 | 922
Epilepsy 688 | 792
acute myeloid leukemia 680 | 783
gastric carcinoma 634 | 807
Liver Cirrhosis, Experimental 628 | 769
esophageal adenocarcinoma 626 | 737
Dull intelligence 595 | 645
Low intelligence 595 | 645
Mental Retardation 595 | 645
Mental deficiency 595 | 645
Poor school performance 595 | 645
primary Sjogren syndrome 587 | 735
Cognitive delay 579 | 608
Global developmental delay 579 | 608
Mental and motor retardation 579 | 608
active ulcerative colitis 579 | 764
Obesity 574 | 678
Alzheimer's disease 560 | 658
aldosterone-producing adenoma 558 | 665
progressive supranuclear palsy 558 | 676
medulloblastoma 554 | 720
Bipolar Disorder 543 | 666
Seizures 543 | 596
Melanoma 525 | 711
Muscle hypotonia 522 | 571
Duchenne muscular dystrophy 490 | 601
Short stature 488 | 531
hepatocellular carcinoma 466 | 547
pancreatic carcinoma 466 | 562
Liver cancer 448 | 604
Prostatic Neoplasms 442 | 495
Endometriosis 432 | 540
autosomal dominant Emery-Dreifuss muscular dystrophy 421 | 510
Multiple Sclerosis 420 | 540
Down syndrome 414 | 499
fibroadenoma 414 | 559
Breast Neoplasms 404 | 445
Amyotrophic lateral sclerosis 399 | 451
Neurodegenerative disease 391 | 414
Mammary Neoplasms 385 | 425
Kidney disease 382 | 430
gastric cancer 382 | 459

Tissue

Endocrine System 13,439 | 18,159
Digestive Tract 13,138 | 17,369
Female tissues 13,116 | 17,400
Skin and soft tissues 13,106 | 17,230
Male tissues 12,975 | 17,142
Blood and immune system 12,874 | 16,909
Liver and Pancreas 12,815 | 16,750
Nervous System 12,781 | 16,725
Urinary Tract 12,772 | 16,678
Respiratory system 12,603 | 16,393
Cardiovascular System 11,960 | 15,192

Target Family

Non-IDG 7,663 | 12,091
Enzyme 3,494 | 4,145
Transcription Factor 1,384 | 1,400
Kinase 585 | 634
Transporter 255 | 473
Epigenetic 227 | 242
Ion Channel 140 | 344
GPCR 135 | 408
Nuclear Receptor 47 | 48
TF/Epigenetic 37 | 38
oGPCR 5 | 421

Compartment GO Term

Intracellular part 13,972 | 13,972
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,109 | 14,109
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,975 | 8,975
Intracellular organelle part 8,783 | 8,783
Membrane 8,531 | 8,531
Nucleus 7,562 | 7,562
Cytosol 6,686 | 6,686
Membrane part 6,554 | 6,554
Plasma membrane 5,830 | 5,830
Macromolecular complex 5,475 | 5,475
Intrinsic component of membran... 5,458 | 5,458
Cell periphery 5,382 | 5,382
Integral component of membrane 5,331 | 5,331
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,975 | 3,975
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,674 | 3,674
Organelle membrane 2,846 | 2,846
Extracellular region 2,732 | 2,732
Plasma membrane part 2,594 | 2,594
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,217 | 2,217
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,637 | 1,637
Extracellular region part 1,628 | 1,628
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 967 | 967
Supramolecular complex 966 | 966
Cell junction 960 | 960
Supramolecular fiber 959 | 959
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 930 | 930
Nucleolus 926 | 926
Chromosomal part 889 | 889
GO:0098796 884 | 884
Ribonucleoprotein complex 865 | 865
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 850 | 850
Transferase complex 849 | 849
Cell surface 842 | 842
Plasma membrane region 841 | 841
Vesicle membrane 801 | 801
Cytoplasmic vesicle membrane 795 | 795
Polymeric cytoskeletal fiber 764 | 764
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 714 | 714
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 663 | 663
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C Tbio Non-IDG -2.61667 619.4 0
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.27709 182.9 314
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.50063 311.1 13
Inactive cytidine monophosphate-N-acetylneuraminic acid hydroxylase CMAHP Tbio Enzyme -1.76743 57.3 0
Zinc finger protein 175 ZNF175 Tbio Transcription Factor -0.86533 8.35 88
RWD domain-containing protein 3 RWDD3 Tbio Non-IDG -1.02793 10.9 98
Glutaredoxin domain-containing cysteine-rich protein 2 GRXCR2 Tbio Non-IDG 0.00000 1.00 14
Serine incorporator 5 SERINC5 Tbio Non-IDG -1.50535 34.0 11
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.55550 343.3 205
WD repeat domain phosphoinositide-interacting protein 4 WDR45 Tbio Non-IDG -1.29355 17.4 93