Development Level

Tbio 8,585 | 10,625
Tdark 2,941 | 7,003
Tchem 1,530 | 1,890
Tclin 419 | 602

Collection

Eligible Kinase Proteins 117 | 134
Eligible Ion Channel Proteins 30 | 117
Eligible non-olfactory GPCR Proteins 14 | 145

IMPC Term

preweaning lethality, complete... 582 | 633
preweaning lethality, incomple... 217 | 260
abnormal behavior 185 | 226
embryonic lethality prior to t... 174 | 187
decreased lean body mass 162 | 195
decreased body weight 154 | 174
decreased total body fat amoun... 150 | 186
embryonic lethality prior to o... 143 | 148
decreased bone mineral content 133 | 157
abnormal bone structure 109 | 131
decreased bone mineral density 103 | 126
decreased grip strength 102 | 123
decreased circulating glucose ... 101 | 121
increased or absent threshold ... 101 | 128
abnormal embryo size 100 | 112
increased circulating alkaline... 98 | 119
decreased body length 92 | 108
abnormal retina morphology 89 | 100
increased lean body mass 87 | 107
hyperactivity 82 | 108
increased bone mineral content 78 | 92
decreased circulating choleste... 75 | 85
hypoactivity 74 | 89
enlarged heart 73 | 111
increased mean corpuscular vol... 73 | 91
increased mean corpuscular hem... 72 | 93
decreased circulating triglyce... 70 | 83
decreased circulating HDL chol... 69 | 77
increased grip strength 68 | 83
short tibia 64 | 82
abnormal lens morphology 63 | 73
decreased circulating serum al... 63 | 79
decreased circulating insulin ... 61 | 75
prenatal lethality prior to he... 59 | 64
increased circulating HDL chol... 55 | 63
increased circulating sodium l... 53 | 71
increased fasted circulating g... 51 | 68
decreased lumbar vertebrae num... 50 | 62
increased circulating choleste... 50 | 53
increased sacral vertebrae num... 50 | 62
abnormal retinal pigmentation 49 | 61
increased total body fat amoun... 49 | 57
abnormal sleep behavior 48 | 63
decreased mean corpuscular vol... 48 | 50
male infertility 47 | 62
abnormal bone mineralization 46 | 55
abnormal coat/hair pigmentatio... 46 | 54
decreased hemoglobin content 45 | 53
decreased rib number 45 | 59
improved glucose tolerance 45 | 56
decreased leukocyte cell numbe... 44 | 54
decreased circulating alanine ... 43 | 53
decreased prepulse inhibition 43 | 52
abnormal behavioral response t... 42 | 52
decreased fasted circulating g... 42 | 49
increased bone mineral density 42 | 52
decreased startle reflex 41 | 48
impaired glucose tolerance 41 | 52
increased exploration in new e... 41 | 56
abnormal gait 39 | 51
thrombocytopenia 39 | 46
decreased heart weight 37 | 44
increased body weight 37 | 42
abnormal seminal vesicle morph... 36 | 47
decreased caudal vertebrae num... 36 | 49
increased blood urea nitrogen ... 36 | 44
increased circulating chloride... 36 | 43
increased hemoglobin content 34 | 45
abnormal neural tube closure 33 | 37
decreased circulating LDL chol... 33 | 37
decreased circulating alkaline... 33 | 41
decreased erythrocyte cell num... 33 | 43
increased heart weight 33 | 37
abnormal eye morphology 32 | 38
abnormal heart morphology 32 | 51
decreased eosinophil cell numb... 32 | 41
increased rib number 31 | 41
increased startle reflex 31 | 38
decreased circulating free fat... 30 | 39
decreased circulating total pr... 30 | 41
increased leukocyte cell numbe... 30 | 37
cardiovascular system phenotyp... 29 | 35
decreased T cell number 29 | 31
decreased circulating calcium ... 29 | 33
abnormal kidney morphology 28 | 30
decreased mean corpuscular hem... 28 | 34
small testis 28 | 37
tremors 28 | 34
abnormal cranium morphology 27 | 32
abnormal spleen morphology 27 | 36
decreased circulating fructosa... 27 | 31
embryonic growth retardation 27 | 28
limb grasping 27 | 35
decreased blood urea nitrogen ... 26 | 31
decreased neutrophil cell numb... 26 | 37
increased hematocrit 26 | 36
abnormal rib morphology 25 | 28
decreased circulating aspartat... 25 | 27
female infertility 25 | 34
increased circulating creatini... 25 | 29

Disease

ovarian cancer 6,771 | 8,492
osteosarcoma 6,099 | 7,933
psoriasis 4,886 | 6,685
medulloblastoma, large-cell 4,760 | 6,234
glioblastoma 4,335 | 5,572
lung cancer 3,654 | 4,473
atypical teratoid / rhabdoid tumor 3,331 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 2,593 | 3,289
malignant mesothelioma 2,541 | 3,163
Breast cancer 2,448 | 3,099
primitive neuroectodermal tumor 2,370 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,309 | 2,988
invasive ductal carcinoma 2,273 | 2,950
pilocytic astrocytoma 2,260 | 3,086
intraductal papillary-mucinous adenoma (IPMA) 2,239 | 2,956
oligodendroglioma 2,192 | 2,849
non-small cell lung cancer 2,137 | 2,798
pediatric high grade glioma 2,100 | 2,712
Cancer 2,094 | 2,346
lung adenocarcinoma 2,008 | 2,714
lung carcinoma 1,988 | 2,844
ependymoma 1,943 | 2,514
group 3 medulloblastoma 1,801 | 2,254
pancreatic cancer 1,770 | 2,300
subependymal giant cell astrocytoma 1,739 | 2,287
astrocytic glioma 1,689 | 2,241
Carcinoma 1,592 | 2,147
interstitial cystitis 1,584 | 2,299
ulcerative colitis 1,550 | 2,087
adult high grade glioma 1,538 | 2,148
Pick disease 1,535 | 1,893
group 4 medulloblastoma 1,470 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,460 | 1,795
pituitary cancer 1,429 | 1,972
ductal carcinoma in situ 1,328 | 1,745
breast carcinoma 1,260 | 1,614
diabetes mellitus 1,258 | 1,663
astrocytoma 1,232 | 1,493
Multiple myeloma 1,230 | 1,328
cystic fibrosis 1,227 | 1,670
tuberculosis 1,193 | 1,563
medulloblastoma 1,171 | 1,524
colon cancer 1,162 | 1,475
sonic hedgehog group medulloblastoma 1,125 | 1,482
adrenocortical carcinoma 1,111 | 1,427
posterior fossa group A ependymoma 1,107 | 1,511
posterior fossa group B ependymoma 1,063 | 1,530
juvenile dermatomyositis 983 | 1,189
primary pancreatic ductal adenocarcinoma 974 | 1,271
Rheumatoid Arthritis 973 | 1,171
acute quadriplegic myopathy 972 | 1,157
dermatomyositis 865 | 967
spina bifida 840 | 1,064
atypical teratoid/rhabdoid tumor 835 | 1,095
nasopharyngeal carcinoma 787 | 1,056
cutaneous lupus erythematosus 780 | 1,056
Waldenstrons macroglobulinemia 707 | 765
Atopic dermatitis 680 | 944
active Crohn's disease 680 | 918
non primary Sjogren syndrome sicca 669 | 840
acute myeloid leukemia 659 | 785
gastric carcinoma 627 | 832
esophageal adenocarcinoma 600 | 737
primary Sjogren syndrome 596 | 789
tuberculosis and treatment for 6 months 565 | 686
progressive supranuclear palsy 554 | 674
aldosterone-producing adenoma 542 | 664
Alzheimer's disease 533 | 644
Intellectual disability 513 | 573
Obesity 501 | 616
Duchenne muscular dystrophy 465 | 602
pancreatic carcinoma 465 | 567
hepatocellular carcinoma 461 | 550
Down syndrome 445 | 548
Endometriosis 422 | 535
Prostatic Neoplasms 411 | 471
fibroadenoma 398 | 557
Schizophrenia 392 | 503
autosomal dominant Emery-Dreifuss muscular dystrophy 391 | 499
Amyotrophic Lateral Sclerosis 378 | 432
Multiple Sclerosis 376 | 498
IGA Glomerulonephritis 372 | 454
Mammary Neoplasms 367 | 410
chronic rhinosinusitis 365 | 512
gastric cancer 359 | 436
Neurodegenerative disease 355 | 383
Kidney disease 346 | 397
active ulcerative colitis 340 | 477
mucosa-associated lymphoid tissue lymphoma 335 | 480
inflammatory breast cancer 315 | 404
Parkinson's disease 305 | 364
Polycystic Ovary Syndrome 290 | 335
hereditary spastic paraplegia 289 | 313
non-small cell lung carcinoma 283 | 413
sarcoidosis 276 | 368
Asthma 262 | 349
Peripheral Neuropathy 259 | 303
Epilepsy 258 | 346
glioblastoma multiforme 257 | 347
tuberculosis and treatment for 3 months 256 | 327

Tissue

Female tissues 13,179 | 18,647
Nervous System 13,152 | 18,561
Endocrine System 13,139 | 18,512
Digestive Tract 13,121 | 18,473
Urinary Tract 13,072 | 18,444
Liver and Pancreas 13,022 | 18,136
Blood and immune system 13,001 | 17,995
Male tissues 12,991 | 17,969
Cardiovascular System 12,964 | 17,958
Skin and soft tissues 12,960 | 18,115
Respiratory system 12,739 | 17,484

Target Family

Non-IDG 7,284 | 11,969
Enzyme 3,426 | 4,146
Transcription Factor 1,387 | 1,400
Kinase 578 | 634
Transporter 245 | 473
Epigenetic 226 | 242
Ion Channel 135 | 341
GPCR 109 | 408
Nuclear Receptor 47 | 48
TF/Epigenetic 37 | 38
oGPCR 1 | 421

Compartment GO Term

Intracellular part 13,475 | 13,475
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,612 | 13,612
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,353 | 10,353
Membrane 8,871 | 8,871
Organelle part 8,169 | 8,169
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,831 | 7,831
Nucleus 7,577 | 7,577
Membrane part 6,469 | 6,469
Cytosol 6,034 | 6,034
Plasma membrane 5,673 | 5,673
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,171 | 5,171
Cell periphery 5,146 | 5,146
Nucleoplasm 4,930 | 4,930
Extracellular region 4,607 | 4,607
Protein complex 4,439 | 4,439
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,874 | 3,874
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,592 | 2,592
Plasma membrane part 2,564 | 2,564
Cytoskeleton 2,046 | 2,046
Golgi apparatus 1,946 | 1,946
Endoplasmic reticulum 1,872 | 1,872
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Vesicles 1,625 | 1,625
Cytoskeletal part 1,568 | 1,568
Mitochondrion 1,530 | 1,530
Cell projection 1,425 | 1,425
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,234 | 1,234
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,092 | 1,092
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,084 | 1,084
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Mitochondria 1,003 | 1,003
Chromosome 999 | 999
Mitochondrial part 988 | 988
Nucleoli 950 | 950
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 815 | 815
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 781 | 781
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 739 | 739
Plasma membrane protein comple... 721 | 721
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Microtubule organizing center 680 | 680
Centrosome 676 | 676
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 656 | 656
Extracellular matrix 633 | 633
Synapse 594 | 594
Lytic vacuole 571 | 571

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA polymerase delta catalytic subunit POLD1 Tclin Enzyme -2.02098 96.6 198
V-type proton ATPase 116 kDa subunit a isoform 2 ATP6V0A2 Tbio Enzyme -2.43448 279.3 62
HLA class I histocompatibility antigen, alpha chain G HLA-G Tbio Non-IDG -3.07995 1275.9 729
cAMP-dependent protein kinase catalytic subunit alpha PRKACA Tchem Kinase -1.02404 9.59 274
Lysyl oxidase homolog 2 LOXL2 Tbio Enzyme -2.17984 142.0 237
Thioredoxin domain-containing protein 2 TXNDC2 Tbio Non-IDG -0.71996 6.88 13
GPI mannosyltransferase 4 PIGZ Tdark Enzyme -1.17375 14.4 26
Metal-response element-binding transcription factor 2 MTF2 Tbio Epigenetic -1.74028 52.0 101
Mitochondrial coenzyme A transporter SLC25A42 SLC25A42 Tbio Transporter -0.38872 3.06 24
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.49889 302.1 11