Development Level

Tbio 6,365 | 11,445
Tdark 1,234 | 6,588
Tchem 890 | 1,598
Tclin 295 | 613

Collection

RFA-RM-18-021 78 | 328
Kinase: IDG Consortium (Target... 50 | 125
Kinase: IDG Consortium (Comple... 19 | 37
Ion Channel: IDG Consortium (T... 16 | 99
GPCR: IDG Consortium (Targets) 13 | 126
GPCR: IDG Consortium (Complete... 5 | 25

IMPC Phenotype

preweaning lethality, complete... 734 | 979
preweaning lethality, incomple... 273 | 499
embryonic lethality prior to t... 215 | 278
embryonic lethality prior to o... 190 | 239
abnormal behavior 157 | 298
abnormal embryo size 151 | 220
decreased total body fat amoun... 119 | 207
abnormal bone structure 103 | 187
decreased body weight 102 | 161
enlarged heart 98 | 210
increased lean body mass 95 | 172
decreased vertical activity 92 | 208
decreased bone mineral content 84 | 151
increased total body fat amoun... 84 | 134
abnormal heart morphology 82 | 162
decreased lean body mass 82 | 135
hypoactivity 79 | 132
embryonic growth retardation 77 | 106
hyperactivity 75 | 148
increased startle reflex 75 | 112
increased circulating alkaline... 73 | 122
decreased bone mineral density 70 | 126
decreased circulating glucose ... 65 | 126
decreased circulating choleste... 63 | 93
decreased grip strength 60 | 116
male infertility 60 | 123
cataract 59 | 92
abnormal seminal vesicle morph... 57 | 114
decreased body length 57 | 101
prenatal lethality prior to he... 56 | 87
short tibia 56 | 97
increased bone mineral content 55 | 108
increased mean corpuscular hem... 55 | 96
increased mean corpuscular vol... 55 | 92
abnormal lens morphology 51 | 81
decreased mean corpuscular vol... 51 | 79
decreased circulating serum al... 50 | 82
increased or absent threshold ... 50 | 101
increased bone mineral density 49 | 72
decreased lymphocyte cell numb... 48 | 83
decreased circulating HDL chol... 47 | 68
impaired glucose tolerance 45 | 75
abnormal retina morphology 43 | 71
decreased prepulse inhibition 43 | 82
edema 42 | 59
increased fasted circulating g... 42 | 76
decreased leukocyte cell numbe... 41 | 73
increased circulating HDL chol... 41 | 80
abnormal kidney morphology 40 | 65
decreased circulating triglyce... 40 | 79
decreased hemoglobin content 40 | 68
abnormal coat-hair pigmentatio... 39 | 64
decreased circulating insulin ... 39 | 76
increased circulating sodium l... 38 | 71
abnormal sleep behavior 37 | 70
decreased fasted circulating g... 37 | 65
increased circulating choleste... 36 | 66
abnormal eye morphology 35 | 68
abnormal gait 35 | 69
abnormal behavioral response t... 34 | 66
decreased mean corpuscular hem... 34 | 50
improved glucose tolerance 34 | 79
increased heart weight 34 | 62
abnormal neural tube closure 33 | 46
decreased erythrocyte cell num... 33 | 62
decreased startle reflex 32 | 75
increased monocyte cell number 32 | 63
small superior vagus ganglion 32 | 74
decreased circulating total pr... 31 | 49
decreased caudal vertebrae num... 30 | 53
decreased circulating LDL chol... 30 | 38
small testis 30 | 58
thrombocytopenia 30 | 56
decreased circulating alkaline... 29 | 46
decreased hematocrit 29 | 46
decreased circulating alanine ... 28 | 47
increased circulating chloride... 28 | 41
increased neutrophil cell numb... 28 | 46
increased circulating triglyce... 27 | 42
increased hemoglobin content 27 | 45
tremors 27 | 39
abnormal spleen morphology 26 | 55
increased grip strength 26 | 41
female infertility 25 | 60
increased blood urea nitrogen ... 25 | 48
pallor 25 | 34
abnormal bone mineralization 24 | 38
abnormal craniofacial morpholo... 24 | 33
abnormal embryo turning 24 | 31
abnormal skin morphology 24 | 50
decreased blood urea nitrogen ... 24 | 51
hydrometra 24 | 53
increased mean platelet volume 24 | 45
decreased circulating creatini... 23 | 39
increased leukocyte cell numbe... 23 | 47
abnormal cranium morphology 22 | 36
abnormal testis morphology 22 | 43
enlarged spleen 22 | 41
increased body length 22 | 32
increased circulating creatini... 22 | 38

Disease

Carcinoma 5,565 | 11,493
ovarian cancer 4,820 | 8,520
osteosarcoma 4,152 | 7,950
psoriasis 3,296 | 6,694
medulloblastoma, large-cell 3,162 | 6,241
glioblastoma 3,040 | 5,792
lung cancer 2,682 | 4,740
atypical teratoid / rhabdoid tumor 2,593 | 5,112
ependymoma 2,274 | 4,679
group 3 medulloblastoma 2,153 | 4,104
Breast cancer 1,940 | 3,578
malignant mesothelioma 1,819 | 3,232
adult high grade glioma 1,810 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 1,754 | 3,291
Cancer 1,669 | 2,499
intraductal papillary-mucinous carcinoma (IPMC) 1,542 | 2,989
primitive neuroectodermal tumor 1,525 | 3,035
invasive ductal carcinoma 1,508 | 2,951
non-small cell lung cancer 1,495 | 2,890
intraductal papillary-mucinous adenoma (IPMA) 1,466 | 2,955
Astrocytoma, Pilocytic 1,460 | 3,081
oligodendroglioma 1,425 | 2,850
lung adenocarcinoma 1,378 | 2,716
Kidney cancer 1,313 | 2,613
astrocytic glioma 1,265 | 2,597
lung carcinoma 1,257 | 2,843
pancreatic cancer 1,247 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 1,145 | 1,962
subependymal giant cell astrocytoma 1,127 | 2,287
Pick disease 1,054 | 1,894
tuberculosis 1,049 | 2,010
interstitial cystitis 1,002 | 2,312
diabetes mellitus 991 | 1,728
Multiple myeloma 972 | 1,332
group 4 medulloblastoma 945 | 1,855
pituitary cancer 924 | 1,972
Autosomal recessive predisposition 920 | 1,442
ulcerative colitis 880 | 1,819
ductal carcinoma in situ 873 | 1,745
breast carcinoma 863 | 1,638
colon cancer 790 | 1,478
adrenocortical carcinoma 783 | 1,428
cystic fibrosis 766 | 1,696
acute quadriplegic myopathy 721 | 1,158
juvenile dermatomyositis 713 | 1,187
Rheumatoid arthritis 701 | 1,191
astrocytoma 695 | 1,146
Intellectual disability 677 | 1,016
dermatomyositis 657 | 966
Schizophrenia 621 | 1,160
primary pancreatic ductal adenocarcinoma 603 | 1,109
pediatric high grade glioma 601 | 1,064
Waldenstrons macroglobulinemia 563 | 765
nasopharyngeal carcinoma 553 | 1,058
cutaneous lupus erythematosus 520 | 1,057
spina bifida 520 | 1,074
Epilepsy 519 | 792
non primary Sjogren syndrome sicca 509 | 891
acute myeloid leukemia 478 | 783
active Crohn's disease 463 | 922
Liver Cirrhosis, Experimental 461 | 769
Cognitive delay 458 | 608
Global developmental delay 458 | 608
Mental and motor retardation 458 | 608
Atopic dermatitis 454 | 952
Dull intelligence 447 | 645
Low intelligence 447 | 645
Mental Retardation 447 | 645
Mental deficiency 447 | 645
Poor school performance 447 | 645
Seizures 421 | 596
gastric carcinoma 415 | 807
Muscle hypotonia 413 | 571
Alzheimer's disease 402 | 658
esophageal adenocarcinoma 401 | 737
Short stature 392 | 531
Obesity 390 | 678
primary Sjogren syndrome 388 | 735
active ulcerative colitis 376 | 764
aldosterone-producing adenoma 376 | 665
progressive supranuclear palsy 367 | 676
medulloblastoma 355 | 720
Bipolar Disorder 341 | 666
Duchenne muscular dystrophy 340 | 601
Melanoma 336 | 711
Prostatic Neoplasms 313 | 495
Neurodegenerative disease 312 | 414
hepatocellular carcinoma 312 | 547
Breast Neoplasms 307 | 445
Endometriosis 307 | 540
pancreatic carcinoma 307 | 562
Liver cancer 303 | 604
autosomal dominant Emery-Dreifuss muscular dystrophy 298 | 510
Down syndrome 295 | 499
Mammary Neoplasms 293 | 425
Amyotrophic lateral sclerosis 290 | 451
Small head 290 | 374
Kidney disease 280 | 430
Anemia 272 | 365
Failure to gain weight 267 | 365

Tissue

Endocrine System 8,502 | 18,159
Digestive Tract 8,411 | 17,369
Female tissues 8,402 | 17,400
Skin and soft tissues 8,381 | 17,230
Male tissues 8,328 | 17,142
Blood and immune system 8,286 | 16,909
Liver and Pancreas 8,278 | 16,750
Urinary Tract 8,246 | 16,678
Nervous System 8,197 | 16,725
Respiratory system 8,157 | 16,393
Cardiovascular System 7,826 | 15,192

Target Family

Non-IDG 4,931 | 12,091
Enzyme 2,366 | 4,145
Transcription Factor 562 | 1,400
Kinase 319 | 634
Epigenetic 194 | 242
Transporter 192 | 473
Ion Channel 79 | 344
GPCR 61 | 408
Nuclear Receptor 47 | 48
TF/Epigenetic 28 | 38
oGPCR 5 | 421

Compartment GO Term

Intracellular organelle part 8,784 | 8,784
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,109 | 14,109
Intracellular part 13,972 | 13,972
Organelle 12,237 | 12,237
Intracellular organelle 12,023 | 12,023
membrane-bounded organelle 11,130 | 11,130
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,340 | 10,340
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Membrane 8,531 | 8,531
Nucleus 7,561 | 7,561
Cytosol 6,686 | 6,686
Membrane part 6,554 | 6,554
Plasma membrane 5,830 | 5,830
Macromolecular complex 5,476 | 5,476
Intrinsic component of membran... 5,458 | 5,458
Cell periphery 5,382 | 5,382
Integral component of membrane 5,331 | 5,331
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,972 | 3,972
non-membrane-bounded organelle 3,972 | 3,972
Nuclear lumen 3,968 | 3,968
Protein complex 3,674 | 3,674
Organelle membrane 2,846 | 2,846
Extracellular region 2,732 | 2,732
Plasma membrane part 2,594 | 2,594
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,217 | 2,217
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,955 | 1,955
Golgi apparatus 1,932 | 1,932
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,641 | 1,641
Cytoskeletal part 1,637 | 1,637
Extracellular region part 1,628 | 1,628
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,547 | 1,547
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,123 | 1,123
Nuclear outer membrane-endopla... 1,121 | 1,121
Nucleoplasm part 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,040 | 1,040
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 967 | 967
Supramolecular complex 966 | 966
Cell junction 960 | 960
Supramolecular fiber 959 | 959
Golgi apparatus part 949 | 949
Nucleoli 942 | 942
Endosome 931 | 931
Nucleolus 926 | 926
Chromosomal part 889 | 889
GO:0098796 884 | 884
Ribonucleoprotein complex 864 | 864
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 849 | 849
Transferase complex 848 | 848
Cell surface 842 | 842
Plasma membrane region 841 | 841
Vesicle membrane 801 | 801
Cytoplasmic vesicle membrane 795 | 795
Polymeric cytoskeletal fiber 764 | 764
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 714 | 714
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Endosomal/lysosomal potassium channel TMEM175 TMEM175 Tbio Non-IDG -0.65375 3.76 42
Transmembrane protein 170A TMEM170A Tdark Non-IDG 0.00000 1.18 3
Protein AF-9 MLLT3 Tbio Non-IDG -1.99555 93.8 210
Scm-like with four MBT domains protein 1 SFMBT1 Tbio Epigenetic -2.06810 112.0 113
ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 Tbio Transporter -0.85002 7.18 96
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial MCCC2 Tbio Enzyme -1.24396 15.5 189
Rab GTPase-activating protein 1 RABGAP1 Tbio Enzyme -0.72004 3.69 184
Lysosomal Pro-X carboxypeptidase PRCP Tchem Enzyme -1.87633 85.9 165
Y-box-binding protein 2 YBX2 Tbio Transcription Factor -1.99119 94.8 236
Glutaminase liver isoform, mitochondrial GLS2 Tbio Enzyme -3.14287 1343.1 167