Development Level

Tbio 2,978 | 10,625
Tdark 620 | 7,003
Tchem 605 | 1,890
Tclin 127 | 602

Collection

Kinase: IDG Consortium (Targets) 24 | 125
Kinase: IDG Consortium (Complete/Control) 9 | 37
GPCR: IDG Consortium (Targets) 3 | 127

IMPC Phenotype

preweaning lethality, complete... 264 | 633
embryonic lethality prior to o... 76 | 148
embryonic lethality prior to t... 76 | 187
preweaning lethality, incomple... 75 | 260
abnormal behavior 65 | 226
decreased body weight 57 | 174
decreased total body fat amoun... 55 | 186
decreased lean body mass 52 | 195
abnormal embryo size 45 | 112
decreased body length 40 | 108
abnormal bone structure 38 | 131
increased or absent threshold ... 37 | 128
abnormal retina morphology 36 | 100
decreased bone mineral content 35 | 157
decreased circulating glucose ... 35 | 121
enlarged heart 35 | 111
increased circulating alkaline... 34 | 119
increased lean body mass 34 | 107
decreased grip strength 32 | 123
increased bone mineral content 32 | 92
decreased bone mineral density 31 | 126
hyperactivity 31 | 108
abnormal lens morphology 28 | 73
decreased circulating choleste... 28 | 85
increased grip strength 28 | 83
decreased circulating HDL chol... 27 | 77
increased mean corpuscular hem... 26 | 93
increased mean corpuscular vol... 26 | 91
prenatal lethality prior to he... 26 | 64
short tibia 24 | 82
abnormal bone mineralization 22 | 55
decreased circulating serum al... 22 | 79
decreased circulating triglyce... 22 | 83
decreased hemoglobin content 21 | 53
increased sacral vertebrae num... 21 | 62
abnormal retinal pigmentation 20 | 61
decreased lumbar vertebrae num... 20 | 62
abnormal coat-hair pigmentatio... 19 | 54
decreased circulating insulin ... 19 | 75
decreased leukocyte cell numbe... 19 | 54
decreased rib number 19 | 59
hypoactivity 19 | 89
increased bone mineral density 19 | 52
increased circulating HDL chol... 19 | 63
abnormal heart morphology 18 | 51
decreased caudal vertebrae num... 18 | 49
decreased prepulse inhibition 17 | 52
increased fasted circulating g... 17 | 68
male infertility 17 | 62
decreased erythrocyte cell num... 16 | 43
decreased fasted circulating g... 16 | 49
increased circulating choleste... 16 | 53
decreased circulating LDL chol... 15 | 37
decreased mean corpuscular vol... 15 | 50
embryonic growth retardation 15 | 28
abnormal eye morphology 14 | 38
abnormal gait 14 | 51
impaired glucose tolerance 14 | 52
increased blood urea nitrogen ... 14 | 44
increased circulating sodium l... 14 | 71
abnormal seminal vesicle morph... 13 | 47
decreased heart weight 13 | 44
increased circulating creatini... 13 | 29
thrombocytopenia 13 | 46
abnormal behavioral response t... 12 | 52
abnormal sleep behavior 12 | 63
decreased circulating alanine ... 12 | 53
decreased circulating total pr... 12 | 41
decreased mean corpuscular hem... 12 | 34
decreased startle reflex 12 | 48
increased heart weight 12 | 37
increased hemoglobin content 12 | 45
increased total body fat amoun... 12 | 57
polydactyly 12 | 22
abnormal locomotor activation 11 | 26
abnormal neural tube closure 11 | 37
corneal opacity 11 | 25
decreased T cell number 11 | 31
decreased circulating alkaline... 11 | 41
decreased eosinophil cell numb... 11 | 41
decreased hematocrit 11 | 25
increased circulating triglyce... 11 | 24
increased mean corpuscular hem... 11 | 25
increased startle reflex 11 | 38
abnormal cornea morphology 10 | 24
abnormal kidney morphology 10 | 30
cataract 10 | 26
decreased Ly6C low monocyte nu... 10 | 23
decreased circulating fructosa... 10 | 31
decreased circulating iron lev... 10 | 25
female infertility 10 | 34
hydrops fetalis 10 | 22
improved glucose tolerance 10 | 56
increased exploration in new e... 10 | 56
small testis 10 | 37
tremors 10 | 34
anophthalmia 9 | 20
cardiovascular system phenotyp... 9 | 35
decreased circulating aspartat... 9 | 27
increased circulating chloride... 9 | 43

Disease

ovarian cancer 2,553 | 8,491
osteosarcoma 2,114 | 7,933
psoriasis 1,619 | 6,685
medulloblastoma, large-cell 1,573 | 6,234
glioblastoma 1,420 | 5,572
lung cancer 1,419 | 4,473
atypical teratoid / rhabdoid tumor 1,074 | 4,369
Cancer 940 | 2,346
malignant mesothelioma 933 | 3,163
Breast cancer 880 | 3,098
intraductal papillary-mucinous neoplasm (IPMN) 860 | 3,289
primitive neuroectodermal tumor 795 | 3,031
non-small cell lung cancer 733 | 2,798
intraductal papillary-mucinous carcinoma (IPMC) 732 | 2,988
group 3 medulloblastoma 726 | 2,254
pediatric high grade glioma 723 | 2,712
invasive ductal carcinoma 713 | 2,950
oligodendroglioma 710 | 2,849
lung adenocarcinoma 678 | 2,714
intraductal papillary-mucinous adenoma (IPMA) 659 | 2,956
ependymoma 626 | 2,514
pilocytic astrocytoma 593 | 3,086
Multiple myeloma 586 | 1,327
pancreatic cancer 568 | 2,300
pancreatic ductal adenocarcinoma liver metastasis 540 | 1,795
Carcinoma 531 | 2,147
subependymal giant cell astrocytoma 516 | 2,287
astrocytic glioma 513 | 2,241
Pick disease 500 | 1,893
diabetes mellitus 468 | 1,663
lung carcinoma 466 | 2,844
ulcerative colitis 464 | 2,087
astrocytoma 455 | 1,493
group 4 medulloblastoma 449 | 1,875
adult high grade glioma 427 | 2,148
pituitary cancer 422 | 1,972
breast carcinoma 420 | 1,614
colon cancer 418 | 1,475
ductal carcinoma in situ 418 | 1,745
interstitial cystitis 404 | 2,299
sonic hedgehog group medulloblastoma 403 | 1,482
acute quadriplegic myopathy 401 | 1,157
adrenocortical carcinoma 390 | 1,427
juvenile dermatomyositis 383 | 1,189
tuberculosis 355 | 1,563
Waldenstrons macroglobulinemia 353 | 764
medulloblastoma 351 | 1,524
posterior fossa group A ependymoma 351 | 1,511
dermatomyositis 343 | 966
Rheumatoid Arthritis 328 | 1,170
primary pancreatic ductal adenocarcinoma 322 | 1,271
cystic fibrosis 319 | 1,670
atypical teratoid/rhabdoid tumor 282 | 1,095
acute myeloid leukemia 278 | 785
nasopharyngeal carcinoma 276 | 1,056
spina bifida 262 | 1,064
non primary Sjogren syndrome sicca 255 | 840
posterior fossa group B ependymoma 255 | 1,530
Atopic dermatitis 221 | 944
cutaneous lupus erythematosus 221 | 1,056
tuberculosis and treatment for 6 months 208 | 686
gastric carcinoma 203 | 832
Intellectual disability 198 | 573
active Crohn's disease 197 | 918
Alzheimer's disease 193 | 644
progressive supranuclear palsy 192 | 674
Mammary Neoplasms 188 | 410
primary Sjogren syndrome 187 | 788
Endometriosis 185 | 535
aldosterone-producing adenoma 180 | 664
esophageal adenocarcinoma 179 | 737
hepatocellular carcinoma 178 | 550
Prostatic Neoplasms 171 | 471
pancreatic carcinoma 158 | 567
Obesity 157 | 616
Amyotrophic Lateral Sclerosis 152 | 432
Down syndrome 148 | 548
IGA Glomerulonephritis 140 | 454
Neurodegenerative disease 137 | 383
autosomal dominant Emery-Dreifuss muscular dystrophy 134 | 499
Duchenne muscular dystrophy 130 | 602
Stomach Neoplasms 129 | 282
gastric cancer 127 | 436
Kidney disease 123 | 397
inflammatory breast cancer 120 | 404
Polycystic Ovary Syndrome 117 | 334
Vascular disease 112 | 281
Schizophrenia 105 | 503
fibroadenoma 105 | 557
Parkinson's disease 104 | 364
Liver carcinoma 100 | 217
mucosa-associated lymphoid tissue lymphoma 100 | 480
Atherosclerosis 96 | 275
Peripheral Neuropathy 95 | 303
active ulcerative colitis 94 | 477
hereditary spastic paraplegia 94 | 313
non-small cell lung carcinoma 94 | 413
Heart disease 93 | 279
Multiple Sclerosis 91 | 498
chronic rhinosinusitis 90 | 512

Tissue

Female tissues 4,287 | 18,646
Nervous System 4,281 | 18,560
Digestive Tract 4,275 | 18,472
Endocrine System 4,272 | 18,511
Urinary Tract 4,270 | 18,443
Blood and immune system 4,268 | 17,994
Male tissues 4,268 | 17,968
Liver and Pancreas 4,267 | 18,135
Cardiovascular System 4,257 | 17,957
Skin and soft tissues 4,230 | 18,114
Respiratory system 4,222 | 17,483

Target Family

Non-IDG 2,267 | 11,969
Enzyme 1,171 | 4,146
Transcription Factor 434 | 1,400
Kinase 184 | 634
Epigenetic 168 | 242
Nuclear Receptor 46 | 48
TF/Epigenetic 26 | 38
Transporter 22 | 473
GPCR 7 | 408
Ion Channel 5 | 341

Compartment GO Term

Intracellular organelle lumen 4,330 | 4,330
cellular_component 18,237 | 18,237
Cell 15,806 | 15,806
Cell part 15,806 | 15,806
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,648 | 12,648
membrane-bounded organelle 11,793 | 11,793
Intracellular organelle 11,617 | 11,617
Intracellular membrane-bounded... 10,618 | 10,618
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,169 | 8,169
Intracellular organelle part 8,011 | 8,011
Cytoplasmic part 7,830 | 7,830
Nucleus 7,577 | 7,577
Membrane part 6,470 | 6,470
Cytosol 6,035 | 6,035
Plasma membrane 5,673 | 5,673
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,171 | 5,171
Cell periphery 5,146 | 5,146
Nucleoplasm 4,929 | 4,929
Extracellular region 4,606 | 4,606
Protein complex 4,439 | 4,439
Organelle lumen 4,330 | 4,330
membrane-enclosed lumen 4,330 | 4,330
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,839 | 3,839
non-membrane-bounded organelle 3,838 | 3,838
Nuclear part 3,807 | 3,807
Endomembrane system 3,720 | 3,720
Vesicle 3,666 | 3,666
membrane-bounded vesicle 3,494 | 3,494
Nuclear lumen 3,464 | 3,464
Extracellular organelle 2,849 | 2,849
Extracellular vesicle 2,848 | 2,848
Extracellular exosome 2,828 | 2,828
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,564 | 2,564
Cytoskeleton 2,046 | 2,046
Golgi apparatus 1,946 | 1,946
Endoplasmic reticulum 1,872 | 1,872
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Vesicles 1,625 | 1,625
Cytoskeletal part 1,568 | 1,568
Mitochondrion 1,531 | 1,531
Cell projection 1,426 | 1,426
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,305 | 1,305
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,234 | 1,234
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Mitochondria 1,003 | 1,003
Chromosome 999 | 999
Mitochondrial part 989 | 989
Nucleoli 952 | 952
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 793 | 793
Intracellular ribonucleoprotei... 789 | 789
Nucleoplasm part 781 | 781
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 739 | 739
Plasma membrane protein comple... 721 | 721
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Microtubule organizing center 680 | 680
Centrosome 676 | 676
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Synapse 594 | 594
Lytic vacuole 571 | 571

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Myeloma-overexpressed gene 2 protein COPS9 Tdark Non-IDG 0.21 0.67 12
Hydroxymethylglutaryl-CoA synthase, mitochondrial HMGCS2 Tbio Enzyme -1.69372 46.6 95
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 MAGI1 Tbio Enzyme -1.04868 9.00 130
Huntingtin HTT Tchem Non-IDG -3.32908 2140.8 521
Splicing regulatory glutamine/lysine-rich protein 1 SREK1 Tdark Non-IDG -0.37946 3.77 39
Protein Mpv17 MPV17 Tbio Non-IDG -1.63162 40.5 114
Isobutyryl-CoA dehydrogenase, mitochondrial ACAD8 Tbio Enzyme -1.14784 13.7 122
DNA-directed RNA polymerase II subunit RPB2 POLR2B Tbio Enzyme -2.47495 286.5 135
WD repeat-containing protein mio MIOS Tdark Non-IDG -1.44864 27.4 14
Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 DHX15 Tbio Enzyme -1.70052 49.6 108