Development Level

Tbio 7,532 | 10,625
Tdark 2,447 | 7,003
Tchem 1,288 | 1,890
Tclin 350 | 602

Collection

Kinase: IDG Consortium (Targets) 85 | 125
Kinase: IDG Consortium (Complete/Control) 32 | 37
Ion Channel: IDG Consortium (Targets) 23 | 102
GPCR: IDG Consortium (Targets) 10 | 127
GPCR: IDG Consortium (Complete/Control) 3 | 26

IMPC Phenotype

preweaning lethality, complete... 534 | 633
preweaning lethality, incomple... 193 | 260
embryonic lethality prior to t... 163 | 187
abnormal behavior 160 | 226
decreased lean body mass 142 | 195
decreased body weight 135 | 174
decreased total body fat amoun... 133 | 186
embryonic lethality prior to o... 133 | 148
decreased bone mineral content 120 | 157
abnormal bone structure 96 | 131
decreased grip strength 93 | 123
abnormal embryo size 91 | 112
decreased bone mineral density 91 | 126
increased circulating alkaline... 90 | 119
decreased circulating glucose ... 85 | 121
increased or absent threshold ... 85 | 128
decreased body length 82 | 108
abnormal retina morphology 76 | 100
increased lean body mass 74 | 107
hyperactivity 71 | 108
decreased circulating choleste... 68 | 85
increased bone mineral content 67 | 92
hypoactivity 66 | 89
increased mean corpuscular vol... 66 | 91
enlarged heart 63 | 111
decreased circulating HDL chol... 62 | 77
increased mean corpuscular hem... 61 | 93
increased grip strength 59 | 83
abnormal lens morphology 58 | 73
decreased circulating triglyce... 57 | 83
short tibia 56 | 82
decreased circulating serum al... 55 | 79
prenatal lethality prior to he... 50 | 64
increased circulating sodium l... 49 | 71
decreased circulating insulin ... 48 | 75
increased fasted circulating g... 46 | 68
decreased lumbar vertebrae num... 45 | 62
increased circulating HDL chol... 43 | 63
increased sacral vertebrae num... 43 | 62
decreased mean corpuscular vol... 42 | 50
abnormal bone mineralization 41 | 55
increased total body fat amoun... 41 | 57
male infertility 41 | 62
abnormal retinal pigmentation 40 | 61
decreased circulating alanine ... 40 | 53
decreased leukocyte cell numbe... 40 | 54
increased circulating choleste... 40 | 53
abnormal coat-hair pigmentatio... 39 | 54
abnormal sleep behavior 39 | 63
decreased rib number 38 | 59
abnormal behavioral response t... 37 | 52
decreased hemoglobin content 37 | 53
increased bone mineral density 37 | 52
decreased fasted circulating g... 36 | 49
improved glucose tolerance 36 | 56
abnormal gait 35 | 51
impaired glucose tolerance 35 | 52
decreased prepulse inhibition 34 | 52
increased circulating chloride... 34 | 43
increased exploration in new e... 34 | 56
decreased caudal vertebrae num... 33 | 49
thrombocytopenia 33 | 46
abnormal neural tube closure 32 | 37
decreased heart weight 32 | 44
decreased circulating LDL chol... 31 | 37
abnormal seminal vesicle morph... 30 | 47
decreased erythrocyte cell num... 30 | 43
decreased startle reflex 30 | 48
increased blood urea nitrogen ... 30 | 44
increased body weight 30 | 42
increased heart weight 30 | 37
abnormal heart morphology 29 | 51
decreased circulating alkaline... 29 | 41
decreased circulating total pr... 29 | 41
increased hemoglobin content 29 | 45
abnormal eye morphology 28 | 38
increased startle reflex 28 | 38
decreased eosinophil cell numb... 27 | 41
decreased mean corpuscular hem... 26 | 34
tremors 26 | 34
embryonic growth retardation 25 | 28
increased leukocyte cell numbe... 25 | 37
limb grasping 25 | 35
abnormal kidney morphology 24 | 30
decreased T cell number 24 | 31
decreased circulating aspartat... 23 | 27
decreased circulating calcium ... 23 | 33
decreased circulating creatini... 23 | 31
decreased circulating fructosa... 23 | 31
increased circulating creatini... 23 | 29
increased hematocrit 23 | 36
small testis 23 | 37
abnormal cornea morphology 22 | 24
abnormal rib morphology 22 | 28
abnormal spleen morphology 22 | 36
cardiovascular system phenotyp... 22 | 35
decreased blood urea nitrogen ... 22 | 31
decreased circulating free fat... 22 | 39
female infertility 22 | 34
increased rib number 22 | 41

Disease

ovarian cancer 5,951 | 8,491
osteosarcoma 5,301 | 7,933
psoriasis 4,213 | 6,685
medulloblastoma, large-cell 4,128 | 6,234
glioblastoma 3,756 | 5,572
lung cancer 3,200 | 4,473
atypical teratoid / rhabdoid tumor 2,888 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 2,239 | 3,289
malignant mesothelioma 2,231 | 3,163
Breast cancer 2,137 | 3,098
primitive neuroectodermal tumor 2,046 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 1,968 | 2,988
invasive ductal carcinoma 1,939 | 2,950
pilocytic astrocytoma 1,917 | 3,086
Cancer 1,909 | 2,346
oligodendroglioma 1,891 | 2,849
intraductal papillary-mucinous adenoma (IPMA) 1,888 | 2,956
pediatric high grade glioma 1,842 | 2,712
non-small cell lung cancer 1,816 | 2,798
lung adenocarcinoma 1,713 | 2,714
ependymoma 1,683 | 2,514
lung carcinoma 1,638 | 2,844
group 3 medulloblastoma 1,584 | 2,254
pancreatic cancer 1,522 | 2,300
subependymal giant cell astrocytoma 1,458 | 2,287
astrocytic glioma 1,440 | 2,241
Carcinoma 1,366 | 2,147
Pick disease 1,322 | 1,893
interstitial cystitis 1,309 | 2,299
ulcerative colitis 1,291 | 2,087
group 4 medulloblastoma 1,278 | 1,875
adult high grade glioma 1,272 | 2,148
pancreatic ductal adenocarcinoma liver metastasis 1,271 | 1,795
pituitary cancer 1,224 | 1,972
ductal carcinoma in situ 1,132 | 1,745
Multiple myeloma 1,124 | 1,327
diabetes mellitus 1,120 | 1,663
astrocytoma 1,097 | 1,493
breast carcinoma 1,075 | 1,614
tuberculosis 1,028 | 1,563
medulloblastoma 1,019 | 1,524
cystic fibrosis 1,016 | 1,670
colon cancer 1,014 | 1,475
adrenocortical carcinoma 978 | 1,427
sonic hedgehog group medulloblastoma 966 | 1,482
posterior fossa group A ependymoma 955 | 1,511
posterior fossa group B ependymoma 886 | 1,530
juvenile dermatomyositis 872 | 1,189
acute quadriplegic myopathy 862 | 1,157
Rheumatoid Arthritis 857 | 1,170
primary pancreatic ductal adenocarcinoma 849 | 1,271
dermatomyositis 779 | 966
atypical teratoid/rhabdoid tumor 725 | 1,095
spina bifida 709 | 1,064
nasopharyngeal carcinoma 668 | 1,056
cutaneous lupus erythematosus 658 | 1,056
Waldenstrons macroglobulinemia 642 | 764
active Crohn's disease 600 | 918
non primary Sjogren syndrome sicca 595 | 840
Atopic dermatitis 586 | 944
acute myeloid leukemia 585 | 785
gastric carcinoma 532 | 832
primary Sjogren syndrome 506 | 788
esophageal adenocarcinoma 501 | 737
tuberculosis and treatment for 6 months 494 | 686
Alzheimer's disease 475 | 644
progressive supranuclear palsy 470 | 674
aldosterone-producing adenoma 467 | 664
Intellectual disability 455 | 573
Obesity 446 | 616
Duchenne muscular dystrophy 413 | 602
Down syndrome 400 | 548
hepatocellular carcinoma 400 | 550
pancreatic carcinoma 400 | 567
Endometriosis 372 | 535
Prostatic Neoplasms 362 | 471
autosomal dominant Emery-Dreifuss muscular dystrophy 349 | 499
Schizophrenia 342 | 503
Amyotrophic Lateral Sclerosis 341 | 432
fibroadenoma 334 | 557
Neurodegenerative disease 331 | 383
IGA Glomerulonephritis 329 | 454
Mammary Neoplasms 327 | 410
Multiple Sclerosis 318 | 498
Kidney disease 313 | 397
gastric cancer 309 | 436
chronic rhinosinusitis 307 | 512
active ulcerative colitis 294 | 477
inflammatory breast cancer 281 | 404
mucosa-associated lymphoid tissue lymphoma 277 | 480
Parkinson's disease 273 | 364
hereditary spastic paraplegia 259 | 313
Polycystic Ovary Syndrome 256 | 334
non-small cell lung carcinoma 236 | 413
Stomach Neoplasms 234 | 282
glioblastoma multiforme 228 | 347
Asthma 227 | 349
Epilepsy 227 | 346
Heart disease 227 | 279
Peripheral Neuropathy 224 | 303

Tissue

Female tissues 11,363 | 18,646
Nervous System 11,341 | 18,560
Endocrine System 11,330 | 18,511
Digestive Tract 11,313 | 18,472
Urinary Tract 11,278 | 18,443
Liver and Pancreas 11,232 | 18,135
Blood and immune system 11,216 | 17,994
Male tissues 11,214 | 17,968
Cardiovascular System 11,180 | 17,957
Skin and soft tissues 11,177 | 18,114
Respiratory system 10,998 | 17,483

Target Family

Non-IDG 6,202 | 11,969
Enzyme 2,863 | 4,146
Transcription Factor 1,382 | 1,400
Kinase 443 | 634
Transporter 226 | 473
Epigenetic 220 | 242
Ion Channel 112 | 341
GPCR 84 | 408
Nuclear Receptor 47 | 48
TF/Epigenetic 37 | 38
oGPCR 1 | 421

Compartment GO Term

Intracellular organelle 11,617 | 11,617
cellular_component 18,237 | 18,237
Cell 15,806 | 15,806
Cell part 15,806 | 15,806
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,648 | 12,648
membrane-bounded organelle 11,793 | 11,793
Intracellular membrane-bounded... 10,618 | 10,618
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,169 | 8,169
Intracellular organelle part 8,011 | 8,011
Cytoplasmic part 7,830 | 7,830
Nucleus 7,577 | 7,577
Membrane part 6,470 | 6,470
Cytosol 6,035 | 6,035
Plasma membrane 5,673 | 5,673
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,171 | 5,171
Cell periphery 5,146 | 5,146
Nucleoplasm 4,929 | 4,929
Extracellular region 4,606 | 4,606
Protein complex 4,439 | 4,439
Intracellular organelle lumen 4,330 | 4,330
Organelle lumen 4,330 | 4,330
membrane-enclosed lumen 4,330 | 4,330
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,839 | 3,839
non-membrane-bounded organelle 3,838 | 3,838
Nuclear part 3,807 | 3,807
Endomembrane system 3,720 | 3,720
Vesicle 3,666 | 3,666
membrane-bounded vesicle 3,494 | 3,494
Nuclear lumen 3,464 | 3,464
Extracellular organelle 2,849 | 2,849
Extracellular vesicle 2,848 | 2,848
Extracellular exosome 2,828 | 2,828
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,564 | 2,564
Cytoskeleton 2,046 | 2,046
Golgi apparatus 1,946 | 1,946
Endoplasmic reticulum 1,872 | 1,872
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Vesicles 1,625 | 1,625
Cytoskeletal part 1,568 | 1,568
Mitochondrion 1,531 | 1,531
Cell projection 1,426 | 1,426
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,305 | 1,305
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,234 | 1,234
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Mitochondria 1,003 | 1,003
Chromosome 999 | 999
Mitochondrial part 989 | 989
Nucleoli 952 | 952
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 793 | 793
Intracellular ribonucleoprotei... 789 | 789
Nucleoplasm part 781 | 781
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 739 | 739
Plasma membrane protein comple... 721 | 721
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Microtubule organizing center 680 | 680
Centrosome 676 | 676
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Synapse 594 | 594
Lytic vacuole 571 | 571

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.86495 767.9 361
F-box/LRR-repeat protein 3 FBXL3 Tbio Non-IDG -0.94799 9.59 158
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.29593 203.1 88
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.96873 85.2 108
Myeloma-overexpressed gene 2 protein COPS9 Tdark Non-IDG 0.21 0.67 12
Zinc finger protein Aiolos IKZF3 Tbio Transcription Factor -1.78743 55.0 277
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.47111 3.15 74
UDP-glucuronosyltransferase 2B15 UGT2B15 Tchem Enzyme -1.77071 60.2 66
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.29669 19.6 50
Zinc finger protein 214 ZNF214 Tdark Transcription Factor -0.49369 2.48 88