Development Level

Tbio 7,247 | 11,651
Tdark 1,868 | 6,593
Tchem 913 | 1,388
Tclin 313 | 612

Collection

RFA-RM-18-021 103 | 328
Kinase: IDG Consortium (Target... 76 | 125
Kinase: IDG Consortium (Comple... 27 | 37
Ion Channel: IDG Consortium (T... 16 | 99
GPCR: IDG Consortium (Targets) 12 | 126
GPCR: IDG Consortium (Complete... 2 | 25

IMPC Phenotype

preweaning lethality, complete... 775 | 979
preweaning lethality, incomple... 294 | 499
embryonic lethality prior to t... 229 | 278
embryonic lethality prior to o... 201 | 239
abnormal behavior 167 | 298
abnormal embryo size 166 | 220
decreased total body fat amoun... 133 | 207
abnormal bone structure 127 | 187
enlarged heart 121 | 210
decreased vertical activity 115 | 208
decreased body weight 114 | 161
increased lean body mass 104 | 172
abnormal heart morphology 98 | 162
decreased bone mineral content 98 | 151
decreased lean body mass 98 | 135
hypoactivity 97 | 132
increased total body fat amoun... 95 | 134
embryonic growth retardation 87 | 106
increased startle reflex 83 | 112
hyperactivity 80 | 148
decreased bone mineral density 79 | 126
decreased grip strength 79 | 116
increased circulating alkaline... 78 | 122
decreased circulating glucose ... 76 | 126
abnormal seminal vesicle morph... 71 | 114
increased bone mineral content 67 | 108
decreased circulating choleste... 66 | 93
male infertility 66 | 123
decreased body length 63 | 101
increased mean corpuscular vol... 61 | 92
increased mean corpuscular hem... 60 | 96
cataract 58 | 92
prenatal lethality prior to he... 58 | 87
decreased circulating serum al... 57 | 82
decreased lymphocyte cell numb... 57 | 83
decreased mean corpuscular vol... 55 | 79
increased or absent threshold ... 55 | 101
short tibia 55 | 97
abnormal lens morphology 54 | 81
decreased prepulse inhibition 54 | 82
decreased circulating triglyce... 53 | 79
increased bone mineral density 51 | 72
increased circulating HDL chol... 50 | 80
decreased circulating HDL chol... 49 | 68
decreased hemoglobin content 49 | 68
impaired glucose tolerance 49 | 75
increased fasted circulating g... 49 | 76
small superior vagus ganglion 48 | 74
increased circulating choleste... 47 | 66
decreased leukocyte cell numbe... 46 | 73
abnormal kidney morphology 45 | 65
abnormal gait 44 | 69
decreased fasted circulating g... 44 | 65
decreased circulating insulin ... 43 | 76
edema 43 | 59
improved glucose tolerance 42 | 79
increased heart weight 42 | 62
abnormal retina morphology 41 | 71
increased circulating sodium l... 41 | 71
abnormal coat-hair pigmentatio... 40 | 64
abnormal eye morphology 40 | 68
decreased erythrocyte cell num... 40 | 62
increased monocyte cell number 40 | 63
abnormal behavioral response t... 39 | 66
abnormal neural tube closure 38 | 46
decreased mean corpuscular hem... 38 | 50
decreased startle reflex 37 | 75
thrombocytopenia 37 | 56
decreased circulating alkaline... 36 | 46
female infertility 36 | 60
abnormal sleep behavior 35 | 70
decreased blood urea nitrogen ... 35 | 51
decreased caudal vertebrae num... 35 | 53
decreased circulating alanine ... 34 | 47
decreased circulating total pr... 34 | 49
small testis 34 | 58
abnormal spleen morphology 32 | 55
hydrometra 32 | 53
increased blood urea nitrogen ... 32 | 48
increased neutrophil cell numb... 32 | 46
decreased hematocrit 31 | 46
increased circulating triglyce... 31 | 42
decreased circulating LDL chol... 30 | 38
increased circulating chloride... 30 | 41
tremors 30 | 39
abnormal skin morphology 29 | 50
increased hemoglobin content 29 | 45
decreased circulating calcium ... 28 | 36
increased grip strength 28 | 41
increased mean platelet volume 28 | 45
abnormal testis morphology 27 | 43
increased circulating creatini... 27 | 38
increased leukocyte cell numbe... 27 | 47
abnormal bone mineralization 25 | 38
abnormal craniofacial morpholo... 25 | 33
abnormal embryo turning 25 | 31
decreased circulating creatini... 25 | 39
enlarged spleen 25 | 41
increased body length 25 | 32
increased red blood cell distr... 25 | 34

Disease

Carcinoma 6,412 | 11,493
ovarian cancer 5,408 | 8,520
osteosarcoma 4,799 | 7,950
psoriasis 3,732 | 6,694
medulloblastoma, large-cell 3,610 | 6,241
glioblastoma 3,400 | 5,792
lung cancer 3,027 | 4,740
atypical teratoid / rhabdoid tumor 2,932 | 5,112
ependymoma 2,515 | 4,679
group 3 medulloblastoma 2,492 | 4,104
Breast cancer 2,155 | 3,578
malignant mesothelioma 2,018 | 3,232
adult high grade glioma 2,016 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 1,963 | 3,291
Cancer 1,841 | 2,499
primitive neuroectodermal tumor 1,753 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 1,738 | 2,989
invasive ductal carcinoma 1,699 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 1,643 | 2,955
non-small cell lung cancer 1,634 | 2,890
oligodendroglioma 1,618 | 2,850
Astrocytoma, Pilocytic 1,617 | 3,081
lung adenocarcinoma 1,501 | 2,716
astrocytic glioma 1,445 | 2,597
Kidney cancer 1,437 | 2,613
pancreatic cancer 1,385 | 2,398
lung carcinoma 1,367 | 2,843
pancreatic ductal adenocarcinoma liver metastasis 1,299 | 1,962
subependymal giant cell astrocytoma 1,269 | 2,287
tuberculosis 1,191 | 2,010
Pick disease 1,157 | 1,894
interstitial cystitis 1,106 | 2,312
group 4 medulloblastoma 1,104 | 1,855
pituitary cancer 1,081 | 1,972
Multiple myeloma 1,063 | 1,332
diabetes mellitus 1,056 | 1,728
ductal carcinoma in situ 985 | 1,745
ulcerative colitis 985 | 1,819
breast carcinoma 975 | 1,638
Autosomal recessive predisposition 969 | 1,442
adrenocortical carcinoma 883 | 1,428
cystic fibrosis 882 | 1,696
colon cancer 875 | 1,478
Rheumatoid arthritis 798 | 1,191
astrocytoma 781 | 1,146
juvenile dermatomyositis 778 | 1,187
acute quadriplegic myopathy 776 | 1,158
Intellectual disability 739 | 1,016
dermatomyositis 706 | 966
Schizophrenia 675 | 1,160
pediatric high grade glioma 673 | 1,064
primary pancreatic ductal adenocarcinoma 647 | 1,109
spina bifida 607 | 1,074
Waldenstrons macroglobulinemia 600 | 765
cutaneous lupus erythematosus 586 | 1,057
non primary Sjogren syndrome sicca 575 | 891
nasopharyngeal carcinoma 572 | 1,058
Epilepsy 557 | 792
active Crohn's disease 535 | 922
acute myeloid leukemia 530 | 783
Atopic dermatitis 517 | 952
Dull intelligence 483 | 645
Low intelligence 483 | 645
Mental Retardation 483 | 645
Mental deficiency 483 | 645
Poor school performance 483 | 645
Cognitive delay 479 | 608
Global developmental delay 479 | 608
Mental and motor retardation 479 | 608
Liver Cirrhosis, Experimental 465 | 769
Seizures 457 | 596
Obesity 451 | 678
esophageal adenocarcinoma 442 | 737
gastric carcinoma 440 | 807
Muscle hypotonia 438 | 571
Alzheimer's disease 437 | 658
active ulcerative colitis 432 | 764
primary Sjogren syndrome 430 | 735
aldosterone-producing adenoma 427 | 665
progressive supranuclear palsy 418 | 676
Short stature 410 | 531
medulloblastoma 409 | 720
Bipolar Disorder 390 | 666
hepatocellular carcinoma 367 | 547
Prostatic Neoplasms 356 | 495
Melanoma 354 | 711
pancreatic carcinoma 350 | 562
Breast Neoplasms 328 | 445
Duchenne muscular dystrophy 327 | 601
Neurodegenerative disease 324 | 414
Down syndrome 323 | 499
Endometriosis 322 | 540
Mammary Neoplasms 313 | 425
Amyotrophic lateral sclerosis 310 | 451
Liver cancer 309 | 604
Multiple Sclerosis 307 | 540
autosomal dominant Emery-Dreifuss muscular dystrophy 303 | 510
Small head 298 | 374
Kidney disease 296 | 430
gastric cancer 291 | 459

Tissue

Endocrine System 9,996 | 18,159
Digestive Tract 9,804 | 17,369
Female tissues 9,764 | 17,400
Skin and soft tissues 9,762 | 17,230
Male tissues 9,699 | 17,142
Blood and immune system 9,618 | 16,909
Liver and Pancreas 9,599 | 16,750
Urinary Tract 9,580 | 16,678
Nervous System 9,578 | 16,725
Respiratory system 9,450 | 16,393
Cardiovascular System 9,055 | 15,192

Target Family

Non-IDG 5,190 | 12,091
Enzyme 2,704 | 4,145
Transcription Factor 1,375 | 1,400
Kinase 404 | 634
Epigenetic 218 | 242
Transporter 212 | 473
Ion Channel 83 | 344
GPCR 71 | 408
Nuclear Receptor 47 | 48
TF/Epigenetic 37 | 38

Compartment GO Term

Intracellular membrane-bounded... 10,341 | 10,341
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,783 | 8,783
Membrane 8,530 | 8,530
Nucleus 7,563 | 7,563
Cytosol 6,686 | 6,686
Membrane part 6,553 | 6,553
Plasma membrane 5,829 | 5,829
Macromolecular complex 5,476 | 5,476
Intrinsic component of membran... 5,457 | 5,457
Cell periphery 5,381 | 5,381
Integral component of membrane 5,330 | 5,330
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,974 | 3,974
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,673 | 3,673
Organelle membrane 2,846 | 2,846
Extracellular region 2,731 | 2,731
Plasma membrane part 2,593 | 2,593
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,216 | 2,216
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,638 | 1,638
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 968 | 968
Supramolecular complex 967 | 967
Cell junction 960 | 960
Supramolecular fiber 960 | 960
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 931 | 931
Nucleolus 927 | 927
Chromosomal part 889 | 889
GO:0098796 883 | 883
Ribonucleoprotein complex 864 | 864
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 849 | 849
Transferase complex 849 | 849
Cell surface 841 | 841
Plasma membrane region 841 | 841
Vesicle membrane 800 | 800
Cytoplasmic vesicle membrane 794 | 794
Polymeric cytoskeletal fiber 765 | 765
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 713 | 713
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.51747 3.15 91
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.99271 91.8 122
COP9 signalosome complex subunit 9 COPS9 Tbio Non-IDG 0.21 0.92 14
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
Pyrin domain-containing protein 1 PYDC1 Tbio Non-IDG -2.88567 750.0 115
UDP-glucuronosyltransferase 2B15 UGT2B15 Tbio Enzyme -1.79589 61.5 83
Calcium uptake protein 3, mitochondrial MICU3 Tdark Non-IDG -0.21085 1.14 50
UbiA prenyltransferase domain-containing protein 1 UBIAD1 Tbio Enzyme -1.59893 42.5 50
DNA-binding death effector domain-containing protein 2 DEDD2 Tbio Non-IDG -0.55115 3.37 164