Development Level

Tbio 6,899 | 10,625
Tdark 2,183 | 7,003
Tchem 1,208 | 1,890
Tclin 329 | 602

Collection

Eligible Kinase Proteins 86 | 134
Eligible Ion Channel Proteins 17 | 117
Eligible non-olfactory GPCR Proteins 10 | 143

IMPC Term

preweaning lethality, complete... 502 | 633
preweaning lethality, incomple... 166 | 260
embryonic lethality prior to t... 154 | 187
abnormal behavior 151 | 226
decreased lean body mass 130 | 195
embryonic lethality prior to o... 126 | 148
decreased body weight 123 | 174
decreased total body fat amoun... 119 | 186
decreased bone mineral content 105 | 157
abnormal bone structure 86 | 131
decreased grip strength 86 | 123
abnormal embryo size 83 | 112
increased circulating alkaline... 83 | 119
decreased bone mineral density 79 | 126
decreased circulating glucose ... 74 | 121
decreased body length 73 | 108
increased or absent threshold ... 73 | 128
abnormal retina morphology 70 | 100
increased lean body mass 67 | 107
hyperactivity 64 | 108
hypoactivity 62 | 89
increased bone mineral content 61 | 92
enlarged heart 60 | 111
decreased circulating choleste... 59 | 85
increased mean corpuscular vol... 59 | 91
increased mean corpuscular hem... 57 | 93
abnormal lens morphology 56 | 73
decreased circulating HDL chol... 56 | 77
increased grip strength 54 | 83
decreased circulating triglyce... 52 | 83
decreased circulating serum al... 51 | 79
short tibia 51 | 82
prenatal lethality prior to he... 47 | 64
increased circulating sodium l... 44 | 71
decreased circulating insulin ... 43 | 75
decreased lumbar vertebrae num... 41 | 62
increased fasted circulating g... 41 | 68
increased sacral vertebrae num... 40 | 62
increased circulating HDL chol... 39 | 63
increased total body fat amoun... 39 | 57
abnormal bone mineralization 38 | 55
abnormal coat/hair pigmentatio... 38 | 54
abnormal retinal pigmentation 38 | 61
decreased leukocyte cell numbe... 38 | 54
decreased mean corpuscular vol... 38 | 50
decreased circulating alanine ... 37 | 53
increased circulating choleste... 37 | 53
increased bone mineral density 36 | 52
decreased fasted circulating g... 35 | 49
decreased rib number 35 | 59
decreased hemoglobin content 34 | 53
impaired glucose tolerance 34 | 52
abnormal behavioral response t... 33 | 52
abnormal gait 33 | 51
decreased caudal vertebrae num... 33 | 49
decreased prepulse inhibition 33 | 52
thrombocytopenia 32 | 46
decreased heart weight 31 | 44
improved glucose tolerance 31 | 56
male infertility 31 | 62
abnormal neural tube closure 30 | 37
abnormal seminal vesicle morph... 30 | 47
abnormal sleep behavior 30 | 63
increased exploration in new e... 30 | 56
decreased circulating LDL chol... 29 | 37
increased circulating chloride... 29 | 43
abnormal heart morphology 28 | 51
decreased circulating alkaline... 28 | 41
decreased erythrocyte cell num... 28 | 43
increased blood urea nitrogen ... 28 | 44
increased startle reflex 27 | 38
abnormal eye morphology 26 | 38
decreased mean corpuscular hem... 26 | 34
increased hemoglobin content 26 | 45
decreased circulating total pr... 25 | 41
decreased startle reflex 25 | 48
tremors 25 | 34
decreased eosinophil cell numb... 24 | 41
increased heart weight 24 | 37
abnormal kidney morphology 23 | 30
increased body weight 23 | 42
increased leukocyte cell numbe... 23 | 37
decreased T cell number 22 | 31
decreased blood urea nitrogen ... 22 | 31
embryonic growth retardation 22 | 28
decreased circulating calcium ... 21 | 33
decreased circulating fructosa... 21 | 31
increased circulating creatini... 21 | 29
limb grasping 21 | 35
abnormal epididymis morphology 20 | 31
abnormal hindbrain development 20 | 24
abnormal rib morphology 20 | 28
abnormal spleen morphology 20 | 36
cardiovascular system phenotyp... 20 | 35
decreased circulating aspartat... 20 | 27
decreased hematocrit 20 | 25
decreased threshold for audito... 20 | 32
increased circulating serum al... 20 | 25
small testis 20 | 37
decreased circulating free fat... 19 | 39

Disease

ovarian cancer 5,494 | 8,484
osteosarcoma 4,871 | 7,933
psoriasis 3,828 | 6,685
medulloblastoma, large-cell 3,751 | 6,234
glioblastoma 3,390 | 5,572
lung cancer 2,949 | 4,466
atypical teratoid / rhabdoid tumor 2,602 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 2,033 | 3,289
malignant mesothelioma 2,028 | 3,162
Breast cancer 1,927 | 3,094
primitive neuroectodermal tumor 1,833 | 3,031
Cancer 1,803 | 2,346
intraductal papillary-mucinous carcinoma (IPMC) 1,776 | 2,988
invasive ductal carcinoma 1,750 | 2,950
oligodendroglioma 1,697 | 2,849
pilocytic astrocytoma 1,693 | 3,086
intraductal papillary-mucinous adenoma (IPMA) 1,692 | 2,956
pediatric high grade glioma 1,648 | 2,712
non-small cell lung cancer 1,637 | 2,798
lung adenocarcinoma 1,561 | 2,713
ependymoma 1,501 | 2,514
group 3 medulloblastoma 1,454 | 2,254
lung carcinoma 1,444 | 2,844
pancreatic cancer 1,374 | 2,300
subependymal giant cell astrocytoma 1,315 | 2,287
astrocytic glioma 1,297 | 2,241
pancreatic ductal adenocarcinoma liver metastasis 1,211 | 1,795
Pick disease 1,203 | 1,893
ulcerative colitis 1,182 | 2,087
Carcinoma 1,175 | 2,147
group 4 medulloblastoma 1,160 | 1,875
interstitial cystitis 1,160 | 2,299
adult high grade glioma 1,144 | 2,148
pituitary cancer 1,107 | 1,972
Multiple myeloma 1,084 | 1,327
diabetes mellitus 1,042 | 1,663
ductal carcinoma in situ 1,009 | 1,745
astrocytoma 1,005 | 1,493
breast carcinoma 965 | 1,614
tuberculosis 937 | 1,557
medulloblastoma 922 | 1,524
cystic fibrosis 912 | 1,665
colon cancer 897 | 1,475
adrenocortical carcinoma 888 | 1,427
posterior fossa group A ependymoma 871 | 1,511
sonic hedgehog group medulloblastoma 868 | 1,482
Rheumatoid Arthritis 806 | 1,160
juvenile dermatomyositis 792 | 1,189
acute quadriplegic myopathy 777 | 1,157
primary pancreatic ductal adenocarcinoma 762 | 1,271
posterior fossa group B ependymoma 738 | 1,530
dermatomyositis 688 | 933
atypical teratoid/rhabdoid tumor 646 | 1,095
spina bifida 635 | 1,064
Waldenstrons macroglobulinemia 611 | 765
cutaneous lupus erythematosus 601 | 1,056
nasopharyngeal carcinoma 586 | 1,056
non primary Sjogren syndrome sicca 551 | 840
active Crohn's disease 541 | 918
acute myeloid leukemia 537 | 780
Atopic dermatitis 526 | 944
gastric carcinoma 485 | 832
primary Sjogren syndrome 473 | 789
esophageal adenocarcinoma 462 | 737
tuberculosis and treatment for 6 months 462 | 686
Alzheimer's disease 439 | 644
aldosterone-producing adenoma 432 | 664
progressive supranuclear palsy 428 | 674
Intellectual disability 407 | 573
Obesity 397 | 616
Down syndrome 368 | 548
pancreatic carcinoma 367 | 567
hepatocellular carcinoma 357 | 532
Duchenne muscular dystrophy 347 | 602
Prostatic Neoplasms 347 | 471
Endometriosis 335 | 535
Mammary Neoplasms 310 | 410
Neurodegenerative disease 309 | 383
IGA Glomerulonephritis 308 | 454
autosomal dominant Emery-Dreifuss muscular dystrophy 307 | 499
Schizophrenia 304 | 501
Amyotrophic Lateral Sclerosis 303 | 431
fibroadenoma 300 | 557
Multiple Sclerosis 295 | 498
Kidney disease 289 | 396
gastric cancer 280 | 430
active ulcerative colitis 269 | 477
inflammatory breast cancer 266 | 404
mucosa-associated lymphoid tissue lymphoma 256 | 480
Parkinson's disease 255 | 364
chronic rhinosinusitis 241 | 512
hereditary spastic paraplegia 239 | 313
Polycystic Ovary Syndrome 235 | 332
Stomach Neoplasms 220 | 282
non-small cell lung carcinoma 213 | 413
sarcoidosis 210 | 358
Epilepsy 209 | 346
Peripheral Neuropathy 209 | 303
Vascular disease 208 | 281
Heart disease 206 | 279

Tissue

Female tissues 10,382 | 18,647
Nervous System 10,366 | 18,561
Endocrine System 10,359 | 18,512
Digestive Tract 10,342 | 18,473
Urinary Tract 10,313 | 18,444
Liver and Pancreas 10,273 | 18,136
Blood and immune system 10,265 | 17,995
Male tissues 10,256 | 17,969
Cardiovascular System 10,220 | 17,958
Skin and soft tissues 10,220 | 18,115
Respiratory system 10,059 | 17,484

Target Family

Non-IDG 5,385 | 11,971
Enzyme 2,752 | 4,146
Transcription Factor 1,379 | 1,400
Kinase 410 | 634
Transporter 221 | 473
Epigenetic 216 | 242
Ion Channel 94 | 341
GPCR 77 | 406
Nuclear Receptor 47 | 48
TF/Epigenetic 37 | 38
oGPCR 1 | 421

Compartment GO Term

Intracellular membrane-bounded... 10,619 | 10,619
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,170 | 8,170
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,830 | 7,830
Nucleus 6,897 | 6,897
Membrane part 6,469 | 6,469
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,172 | 5,172
Cell periphery 5,145 | 5,145
Plasma membrane 5,059 | 5,059
Extracellular region 4,606 | 4,606
Protein complex 4,438 | 4,438
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Cytosol 3,352 | 3,352
Nucleoplasm 2,938 | 2,938
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,563 | 2,563
Cytoskeleton 2,045 | 2,045
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Endoplasmic reticulum 1,663 | 1,663
Cytoskeletal part 1,567 | 1,567
Mitochondrion 1,530 | 1,530
Cell projection 1,426 | 1,426
Golgi apparatus 1,402 | 1,402
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,233 | 1,233
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Chromosome 999 | 999
Mitochondrial part 989 | 989
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 780 | 780
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 738 | 738
Plasma membrane protein comple... 720 | 720
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Microtubule organizing center 617 | 617
Synapse 594 | 594
Lysosome 571 | 571
Lytic vacuole 571 | 571
Vesicle membrane 559 | 559
cell-cell junction 557 | 557
Cytoplasmic vesicle membrane 552 | 552

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitochondrial 2-oxodicarboxylate carrier SLC25A21 Tbio Transporter -0.46900 2.68 102
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
RNA pseudouridylate synthase domain-containing protein 3 RPUSD3 Tdark Enzyme 0.42 34
D(2) dopamine receptor DRD2 Tclin GPCR -3.24474 1775.2 248