Development Level

Tbio 6,899 | 10,625
Tdark 2,183 | 7,003
Tchem 1,207 | 1,890
Tclin 329 | 602

Collection

Kinase: IDG Consortium (Targets) 80 | 125
Kinase: IDG Consortium (Complete/Control) 27 | 37
Ion Channel: IDG Consortium (Targets) 18 | 102
GPCR: IDG Consortium (Targets) 10 | 127
GPCR: IDG Consortium (Complete/Control) 3 | 26

IMPC Phenotype

preweaning lethality, complete... 502 | 633
preweaning lethality, incomple... 166 | 260
embryonic lethality prior to t... 154 | 187
abnormal behavior 151 | 226
decreased lean body mass 130 | 195
embryonic lethality prior to o... 126 | 148
decreased body weight 123 | 174
decreased total body fat amoun... 119 | 186
decreased bone mineral content 105 | 157
abnormal bone structure 86 | 131
decreased grip strength 86 | 123
abnormal embryo size 83 | 112
increased circulating alkaline... 83 | 119
decreased bone mineral density 79 | 126
decreased circulating glucose ... 74 | 121
decreased body length 73 | 108
increased or absent threshold ... 73 | 128
abnormal retina morphology 70 | 100
increased lean body mass 67 | 107
hyperactivity 64 | 108
hypoactivity 62 | 89
increased bone mineral content 61 | 92
enlarged heart 60 | 111
decreased circulating choleste... 59 | 85
increased mean corpuscular vol... 59 | 91
increased mean corpuscular hem... 57 | 93
abnormal lens morphology 56 | 73
decreased circulating HDL chol... 56 | 77
increased grip strength 54 | 83
decreased circulating triglyce... 52 | 83
decreased circulating serum al... 51 | 79
short tibia 51 | 82
prenatal lethality prior to he... 47 | 64
increased circulating sodium l... 44 | 71
decreased circulating insulin ... 43 | 75
decreased lumbar vertebrae num... 41 | 62
increased fasted circulating g... 41 | 68
increased sacral vertebrae num... 40 | 62
increased circulating HDL chol... 39 | 63
increased total body fat amoun... 39 | 57
abnormal bone mineralization 38 | 55
abnormal coat-hair pigmentatio... 38 | 54
abnormal retinal pigmentation 38 | 61
decreased leukocyte cell numbe... 38 | 54
decreased mean corpuscular vol... 38 | 50
decreased circulating alanine ... 37 | 53
increased circulating choleste... 37 | 53
increased bone mineral density 36 | 52
decreased fasted circulating g... 35 | 49
decreased rib number 35 | 59
decreased hemoglobin content 34 | 53
impaired glucose tolerance 34 | 52
abnormal behavioral response t... 33 | 52
abnormal gait 33 | 51
decreased caudal vertebrae num... 33 | 49
decreased prepulse inhibition 33 | 52
thrombocytopenia 32 | 46
decreased heart weight 31 | 44
improved glucose tolerance 31 | 56
male infertility 31 | 62
abnormal neural tube closure 30 | 37
abnormal seminal vesicle morph... 30 | 47
abnormal sleep behavior 30 | 63
increased exploration in new e... 30 | 56
decreased circulating LDL chol... 29 | 37
increased circulating chloride... 29 | 43
abnormal heart morphology 28 | 51
decreased circulating alkaline... 28 | 41
decreased erythrocyte cell num... 28 | 43
increased blood urea nitrogen ... 28 | 44
increased startle reflex 27 | 38
abnormal eye morphology 26 | 38
decreased mean corpuscular hem... 26 | 34
increased hemoglobin content 26 | 45
decreased circulating total pr... 25 | 41
decreased startle reflex 25 | 48
tremors 25 | 34
decreased eosinophil cell numb... 24 | 41
increased heart weight 24 | 37
abnormal kidney morphology 23 | 30
increased body weight 23 | 42
increased leukocyte cell numbe... 23 | 37
decreased T cell number 22 | 31
decreased blood urea nitrogen ... 22 | 31
embryonic growth retardation 22 | 28
decreased circulating calcium ... 21 | 33
decreased circulating fructosa... 21 | 31
increased circulating creatini... 21 | 29
limb grasping 21 | 35
abnormal epididymis morphology 20 | 31
abnormal hindbrain development 20 | 24
abnormal rib morphology 20 | 28
abnormal spleen morphology 20 | 36
cardiovascular system phenotyp... 20 | 35
decreased circulating aspartat... 20 | 27
decreased hematocrit 20 | 25
decreased threshold for audito... 20 | 32
increased circulating serum al... 20 | 25
small testis 20 | 37
decreased circulating free fat... 19 | 39

Disease

ovarian cancer 5,499 | 8,491
osteosarcoma 4,871 | 7,933
psoriasis 3,828 | 6,685
medulloblastoma, large-cell 3,751 | 6,234
glioblastoma 3,390 | 5,572
lung cancer 2,955 | 4,473
atypical teratoid / rhabdoid tumor 2,602 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 2,033 | 3,289
malignant mesothelioma 2,029 | 3,163
Breast cancer 1,930 | 3,098
primitive neuroectodermal tumor 1,833 | 3,031
Cancer 1,803 | 2,346
intraductal papillary-mucinous carcinoma (IPMC) 1,776 | 2,988
invasive ductal carcinoma 1,750 | 2,950
oligodendroglioma 1,697 | 2,849
pilocytic astrocytoma 1,693 | 3,086
intraductal papillary-mucinous adenoma (IPMA) 1,692 | 2,956
pediatric high grade glioma 1,648 | 2,712
non-small cell lung cancer 1,637 | 2,798
lung adenocarcinoma 1,562 | 2,714
ependymoma 1,501 | 2,514
group 3 medulloblastoma 1,454 | 2,254
lung carcinoma 1,444 | 2,844
pancreatic cancer 1,374 | 2,300
subependymal giant cell astrocytoma 1,315 | 2,287
astrocytic glioma 1,297 | 2,241
pancreatic ductal adenocarcinoma liver metastasis 1,211 | 1,795
Pick disease 1,203 | 1,893
ulcerative colitis 1,182 | 2,087
Carcinoma 1,175 | 2,147
group 4 medulloblastoma 1,160 | 1,875
interstitial cystitis 1,160 | 2,299
adult high grade glioma 1,144 | 2,148
pituitary cancer 1,107 | 1,972
Multiple myeloma 1,083 | 1,327
diabetes mellitus 1,042 | 1,663
ductal carcinoma in situ 1,009 | 1,745
astrocytoma 1,005 | 1,493
breast carcinoma 965 | 1,614
tuberculosis 941 | 1,563
medulloblastoma 922 | 1,524
cystic fibrosis 915 | 1,670
colon cancer 897 | 1,475
adrenocortical carcinoma 888 | 1,427
posterior fossa group A ependymoma 871 | 1,511
sonic hedgehog group medulloblastoma 868 | 1,482
Rheumatoid Arthritis 805 | 1,170
juvenile dermatomyositis 792 | 1,189
acute quadriplegic myopathy 777 | 1,157
primary pancreatic ductal adenocarcinoma 762 | 1,271
posterior fossa group B ependymoma 738 | 1,530
dermatomyositis 721 | 966
atypical teratoid/rhabdoid tumor 646 | 1,095
spina bifida 635 | 1,064
Waldenstrons macroglobulinemia 610 | 764
cutaneous lupus erythematosus 601 | 1,056
nasopharyngeal carcinoma 586 | 1,056
non primary Sjogren syndrome sicca 551 | 840
acute myeloid leukemia 542 | 785
active Crohn's disease 541 | 918
Atopic dermatitis 526 | 944
gastric carcinoma 485 | 832
primary Sjogren syndrome 472 | 788
esophageal adenocarcinoma 462 | 737
tuberculosis and treatment for 6 months 462 | 686
Alzheimer's disease 439 | 644
aldosterone-producing adenoma 432 | 664
progressive supranuclear palsy 428 | 674
Intellectual disability 407 | 573
Obesity 397 | 616
hepatocellular carcinoma 372 | 550
Down syndrome 368 | 548
pancreatic carcinoma 367 | 567
Duchenne muscular dystrophy 347 | 602
Prostatic Neoplasms 347 | 471
Endometriosis 335 | 535
Mammary Neoplasms 310 | 410
Neurodegenerative disease 309 | 383
IGA Glomerulonephritis 308 | 454
autosomal dominant Emery-Dreifuss muscular dystrophy 307 | 499
Schizophrenia 306 | 503
Amyotrophic Lateral Sclerosis 303 | 432
fibroadenoma 300 | 557
Multiple Sclerosis 295 | 498
Kidney disease 289 | 397
gastric cancer 285 | 436
active ulcerative colitis 269 | 477
inflammatory breast cancer 266 | 404
mucosa-associated lymphoid tissue lymphoma 256 | 480
Parkinson's disease 255 | 364
chronic rhinosinusitis 241 | 512
hereditary spastic paraplegia 239 | 313
Polycystic Ovary Syndrome 237 | 334
Stomach Neoplasms 220 | 282
non-small cell lung carcinoma 213 | 413
sarcoidosis 210 | 368
Epilepsy 209 | 346
Peripheral Neuropathy 209 | 303
Vascular disease 208 | 281
Heart disease 206 | 279

Tissue

Female tissues 10,381 | 18,646
Nervous System 10,365 | 18,560
Endocrine System 10,358 | 18,511
Digestive Tract 10,341 | 18,472
Urinary Tract 10,312 | 18,443
Liver and Pancreas 10,272 | 18,135
Blood and immune system 10,264 | 17,994
Male tissues 10,255 | 17,968
Cardiovascular System 10,219 | 17,957
Skin and soft tissues 10,219 | 18,114
Respiratory system 10,058 | 17,483

Target Family

Non-IDG 5,385 | 11,969
Enzyme 2,751 | 4,146
Transcription Factor 1,379 | 1,400
Kinase 410 | 634
Transporter 221 | 473
Epigenetic 216 | 242
Ion Channel 94 | 341
GPCR 77 | 408
Nuclear Receptor 47 | 48
TF/Epigenetic 37 | 38
oGPCR 1 | 421

Compartment GO Term

Intracellular membrane-bounded... 10,618 | 10,618
cellular_component 18,237 | 18,237
Cell 15,806 | 15,806
Cell part 15,806 | 15,806
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,648 | 12,648
membrane-bounded organelle 11,793 | 11,793
Intracellular organelle 11,617 | 11,617
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,169 | 8,169
Intracellular organelle part 8,011 | 8,011
Cytoplasmic part 7,830 | 7,830
Nucleus 7,577 | 7,577
Membrane part 6,470 | 6,470
Cytosol 6,035 | 6,035
Plasma membrane 5,673 | 5,673
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,171 | 5,171
Cell periphery 5,146 | 5,146
Nucleoplasm 4,929 | 4,929
Extracellular region 4,606 | 4,606
Protein complex 4,439 | 4,439
Intracellular organelle lumen 4,330 | 4,330
Organelle lumen 4,330 | 4,330
membrane-enclosed lumen 4,330 | 4,330
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,839 | 3,839
non-membrane-bounded organelle 3,838 | 3,838
Nuclear part 3,807 | 3,807
Endomembrane system 3,720 | 3,720
Vesicle 3,666 | 3,666
membrane-bounded vesicle 3,494 | 3,494
Nuclear lumen 3,464 | 3,464
Extracellular organelle 2,849 | 2,849
Extracellular vesicle 2,848 | 2,848
Extracellular exosome 2,828 | 2,828
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,564 | 2,564
Cytoskeleton 2,046 | 2,046
Golgi apparatus 1,946 | 1,946
Endoplasmic reticulum 1,872 | 1,872
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Vesicles 1,625 | 1,625
Cytoskeletal part 1,568 | 1,568
Mitochondrion 1,531 | 1,531
Cell projection 1,426 | 1,426
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,305 | 1,305
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,234 | 1,234
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Mitochondria 1,003 | 1,003
Chromosome 999 | 999
Mitochondrial part 989 | 989
Nucleoli 952 | 952
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 793 | 793
Intracellular ribonucleoprotei... 789 | 789
Nucleoplasm part 781 | 781
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 739 | 739
Plasma membrane protein comple... 721 | 721
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Microtubule organizing center 680 | 680
Centrosome 676 | 676
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Synapse 594 | 594
Lytic vacuole 571 | 571

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.86495 767.9 361
F-box/LRR-repeat protein 3 FBXL3 Tbio Non-IDG -0.94799 9.59 158
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.29593 203.1 88
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.96873 85.2 108
Myeloma-overexpressed gene 2 protein COPS9 Tdark Non-IDG 0.21 0.67 12
Zinc finger protein Aiolos IKZF3 Tbio Transcription Factor -1.78743 55.0 277
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.47111 3.15 74
UDP-glucuronosyltransferase 2B15 UGT2B15 Tchem Enzyme -1.77071 60.2 66
Zinc finger protein 214 ZNF214 Tdark Transcription Factor -0.49369 2.48 88
Hydroxymethylglutaryl-CoA synthase, mitochondrial HMGCS2 Tbio Enzyme -1.69372 46.6 95