Development Level

Tbio 9,646 | 11,651
Tdark 2,805 | 6,593
Tchem 1,191 | 1,388
Tclin 466 | 612

Collection

RFA-RM-18-021 166 | 328
Kinase: IDG Consortium (Target... 113 | 125
Kinase: IDG Consortium (Comple... 36 | 37
Ion Channel: IDG Consortium (T... 34 | 99
GPCR: IDG Consortium (Targets) 20 | 126
GPCR: IDG Consortium (Complete... 9 | 25

IMPC Phenotype

preweaning lethality, complete... 917 | 979
preweaning lethality, incomple... 425 | 499
embryonic lethality prior to t... 266 | 278
abnormal behavior 240 | 298
embryonic lethality prior to o... 231 | 239
abnormal embryo size 202 | 220
decreased total body fat amoun... 175 | 207
abnormal bone structure 162 | 187
decreased vertical activity 149 | 208
enlarged heart 149 | 210
increased lean body mass 143 | 172
decreased body weight 142 | 161
decreased bone mineral content 129 | 151
decreased lean body mass 119 | 135
hypoactivity 119 | 132
increased total body fat amoun... 118 | 134
hyperactivity 117 | 148
abnormal heart morphology 116 | 162
increased circulating alkaline... 105 | 122
male infertility 104 | 123
decreased bone mineral density 103 | 126
decreased circulating glucose ... 103 | 126
embryonic growth retardation 102 | 106
increased startle reflex 102 | 112
decreased grip strength 101 | 116
abnormal seminal vesicle morph... 88 | 114
increased bone mineral content 87 | 108
decreased circulating choleste... 86 | 93
decreased body length 83 | 101
increased or absent threshold ... 81 | 101
prenatal lethality prior to he... 80 | 87
cataract 79 | 92
increased mean corpuscular hem... 79 | 96
increased mean corpuscular vol... 79 | 92
short tibia 76 | 97
decreased mean corpuscular vol... 74 | 79
abnormal lens morphology 72 | 81
decreased circulating serum al... 72 | 82
decreased prepulse inhibition 72 | 82
decreased lymphocyte cell numb... 69 | 83
decreased circulating triglyce... 68 | 79
improved glucose tolerance 68 | 79
increased circulating HDL chol... 68 | 80
increased bone mineral density 66 | 72
decreased circulating HDL chol... 64 | 68
impaired glucose tolerance 64 | 75
increased fasted circulating g... 64 | 76
decreased circulating insulin ... 63 | 76
decreased hemoglobin content 63 | 68
decreased startle reflex 62 | 75
abnormal retina morphology 61 | 71
decreased leukocyte cell numbe... 60 | 73
small superior vagus ganglion 60 | 74
increased circulating choleste... 59 | 66
abnormal gait 57 | 69
edema 57 | 59
increased heart weight 57 | 62
decreased fasted circulating g... 56 | 65
increased circulating sodium l... 56 | 71
abnormal behavioral response t... 54 | 66
abnormal eye morphology 54 | 68
abnormal kidney morphology 54 | 65
abnormal sleep behavior 54 | 70
abnormal coat-hair pigmentatio... 53 | 64
increased monocyte cell number 52 | 63
decreased erythrocyte cell num... 51 | 62
female infertility 50 | 60
thrombocytopenia 49 | 56
decreased mean corpuscular hem... 47 | 50
small testis 47 | 58
abnormal spleen morphology 45 | 55
decreased caudal vertebrae num... 44 | 53
abnormal neural tube closure 43 | 46
decreased blood urea nitrogen ... 43 | 51
decreased circulating alanine ... 43 | 47
decreased circulating total pr... 43 | 49
decreased circulating alkaline... 41 | 46
decreased hematocrit 40 | 46
hydrometra 40 | 53
increased leukocyte cell numbe... 40 | 47
increased blood urea nitrogen ... 39 | 48
abnormal skin morphology 38 | 50
increased circulating chloride... 38 | 41
increased neutrophil cell numb... 38 | 46
increased hematocrit 37 | 46
increased hemoglobin content 37 | 45
increased mean platelet volume 37 | 45
decreased circulating LDL chol... 36 | 38
enlarged spleen 35 | 41
prolonged QT interval 35 | 38
abnormal bone mineralization 34 | 38
abnormal testis morphology 34 | 43
increased circulating creatini... 34 | 38
increased circulating triglyce... 34 | 42
increased grip strength 34 | 41
prolonged ST segment 34 | 36
tremors 34 | 39
abnormal cranium morphology 33 | 36
decreased circulating calcium ... 33 | 36
pallor 33 | 34

Disease

Carcinoma 8,809 | 11,493
ovarian cancer 7,035 | 8,520
osteosarcoma 6,371 | 7,950
psoriasis 5,159 | 6,694
medulloblastoma, large-cell 4,946 | 6,241
glioblastoma 4,669 | 5,792
atypical teratoid / rhabdoid tumor 4,060 | 5,112
lung cancer 3,970 | 4,740
ependymoma 3,624 | 4,679
group 3 medulloblastoma 3,321 | 4,104
adult high grade glioma 2,927 | 3,801
Breast cancer 2,909 | 3,578
malignant mesothelioma 2,713 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 2,687 | 3,291
primitive neuroectodermal tumor 2,449 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,415 | 2,989
Astrocytoma, Pilocytic 2,368 | 3,081
invasive ductal carcinoma 2,367 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 2,339 | 2,955
non-small cell lung cancer 2,298 | 2,890
Cancer 2,279 | 2,499
oligodendroglioma 2,260 | 2,850
lung adenocarcinoma 2,115 | 2,716
lung carcinoma 2,106 | 2,843
Kidney cancer 2,062 | 2,613
astrocytic glioma 2,052 | 2,597
pancreatic cancer 1,920 | 2,398
subependymal giant cell astrocytoma 1,822 | 2,287
interstitial cystitis 1,690 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 1,647 | 1,962
tuberculosis 1,628 | 2,010
Pick disease 1,588 | 1,894
group 4 medulloblastoma 1,506 | 1,855
pituitary cancer 1,502 | 1,972
ulcerative colitis 1,425 | 1,819
diabetes mellitus 1,398 | 1,728
ductal carcinoma in situ 1,381 | 1,745
breast carcinoma 1,329 | 1,638
cystic fibrosis 1,304 | 1,696
Autosomal recessive predisposition 1,261 | 1,442
Multiple myeloma 1,247 | 1,332
colon cancer 1,207 | 1,478
adrenocortical carcinoma 1,160 | 1,428
Rheumatoid arthritis 1,026 | 1,191
juvenile dermatomyositis 1,017 | 1,187
acute quadriplegic myopathy 1,005 | 1,158
astrocytoma 984 | 1,146
Intellectual disability 934 | 1,016
Schizophrenia 930 | 1,160
dermatomyositis 893 | 966
primary pancreatic ductal adenocarcinoma 889 | 1,109
spina bifida 878 | 1,074
pediatric high grade glioma 875 | 1,064
nasopharyngeal carcinoma 829 | 1,058
cutaneous lupus erythematosus 827 | 1,057
Atopic dermatitis 743 | 952
non primary Sjogren syndrome sicca 736 | 891
Waldenstrons macroglobulinemia 722 | 765
active Crohn's disease 711 | 922
Epilepsy 699 | 792
acute myeloid leukemia 681 | 783
gastric carcinoma 643 | 807
Liver Cirrhosis, Experimental 635 | 769
esophageal adenocarcinoma 630 | 737
Dull intelligence 600 | 645
Low intelligence 600 | 645
Mental Retardation 600 | 645
Mental deficiency 600 | 645
Poor school performance 600 | 645
primary Sjogren syndrome 596 | 735
active ulcerative colitis 587 | 764
Cognitive delay 583 | 608
Global developmental delay 583 | 608
Mental and motor retardation 583 | 608
Obesity 581 | 678
progressive supranuclear palsy 566 | 676
aldosterone-producing adenoma 562 | 665
Alzheimer's disease 561 | 658
medulloblastoma 560 | 720
Seizures 551 | 596
Bipolar Disorder 548 | 666
Melanoma 531 | 711
Muscle hypotonia 527 | 571
Duchenne muscular dystrophy 494 | 601
Short stature 491 | 531
pancreatic carcinoma 470 | 562
hepatocellular carcinoma 468 | 547
Liver cancer 457 | 604
Prostatic Neoplasms 442 | 495
Endometriosis 437 | 540
Multiple Sclerosis 430 | 540
autosomal dominant Emery-Dreifuss muscular dystrophy 422 | 510
Down syndrome 419 | 499
fibroadenoma 416 | 559
Amyotrophic lateral sclerosis 405 | 451
Breast Neoplasms 404 | 445
Neurodegenerative disease 395 | 414
Mammary Neoplasms 385 | 425
Kidney disease 384 | 430
gastric cancer 384 | 459

Tissue

Endocrine System 13,570 | 18,159
Digestive Tract 13,261 | 17,369
Female tissues 13,241 | 17,400
Skin and soft tissues 13,226 | 17,230
Male tissues 13,097 | 17,142
Blood and immune system 12,993 | 16,909
Liver and Pancreas 12,930 | 16,750
Nervous System 12,899 | 16,725
Urinary Tract 12,892 | 16,678
Respiratory system 12,716 | 16,393
Cardiovascular System 12,060 | 15,192

Target Family

Non-IDG 7,726 | 12,091
Enzyme 3,508 | 4,145
Transcription Factor 1,384 | 1,400
Kinase 592 | 634
Transporter 269 | 473
Epigenetic 227 | 242
GPCR 159 | 408
Ion Channel 154 | 344
Nuclear Receptor 47 | 48
TF/Epigenetic 37 | 38
oGPCR 5 | 421

Compartment GO Term

Intracellular 14,108 | 14,108
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,783 | 8,783
Membrane 8,530 | 8,530
Nucleus 7,563 | 7,563
Cytosol 6,686 | 6,686
Membrane part 6,553 | 6,553
Plasma membrane 5,829 | 5,829
Macromolecular complex 5,476 | 5,476
Intrinsic component of membran... 5,457 | 5,457
Cell periphery 5,381 | 5,381
Integral component of membrane 5,330 | 5,330
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,974 | 3,974
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,673 | 3,673
Organelle membrane 2,846 | 2,846
Extracellular region 2,731 | 2,731
Plasma membrane part 2,593 | 2,593
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,216 | 2,216
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,638 | 1,638
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 968 | 968
Supramolecular complex 967 | 967
Cell junction 960 | 960
Supramolecular fiber 960 | 960
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 931 | 931
Nucleolus 927 | 927
Chromosomal part 889 | 889
GO:0098796 883 | 883
Ribonucleoprotein complex 864 | 864
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 849 | 849
Transferase complex 849 | 849
Cell surface 841 | 841
Plasma membrane region 841 | 841
Vesicle membrane 800 | 800
Cytoplasmic vesicle membrane 794 | 794
Polymeric cytoskeletal fiber 765 | 765
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 713 | 713
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.51747 3.15 91
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.99271 91.8 122
Paralemmin-3 PALM3 Tbio Non-IDG -0.66901 5.71 76
COP9 signalosome complex subunit 9 COPS9 Tbio Non-IDG 0.21 0.92 14
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
Pyrin domain-containing protein 1 PYDC1 Tbio Non-IDG -2.88567 750.0 115
UDP-glucuronosyltransferase 2B15 UGT2B15 Tbio Enzyme -1.79589 61.5 83