Development Level

Tbio 8,644 | 10,625
Tdark 2,969 | 7,003
Tchem 1,557 | 1,890
Tclin 441 | 602

Collection

Eligible Kinase Proteins 123 | 134
Eligible Ion Channel Proteins 31 | 117
Eligible non-olfactory GPCR Proteins 15 | 143

IMPC Term

preweaning lethality, complete... 586 | 633
preweaning lethality, incomple... 220 | 260
abnormal behavior 188 | 226
embryonic lethality prior to t... 176 | 187
decreased lean body mass 164 | 195
decreased body weight 154 | 174
decreased total body fat amoun... 152 | 186
embryonic lethality prior to o... 144 | 148
decreased bone mineral content 136 | 157
abnormal bone structure 111 | 131
decreased bone mineral density 104 | 126
decreased grip strength 102 | 123
abnormal embryo size 101 | 112
decreased circulating glucose ... 101 | 121
increased or absent threshold ... 101 | 128
increased circulating alkaline... 99 | 119
decreased body length 93 | 108
abnormal retina morphology 89 | 100
increased lean body mass 87 | 107
hyperactivity 84 | 108
increased bone mineral content 79 | 92
hypoactivity 76 | 89
increased mean corpuscular vol... 76 | 91
decreased circulating choleste... 75 | 85
enlarged heart 75 | 111
increased mean corpuscular hem... 73 | 93
decreased circulating triglyce... 71 | 83
decreased circulating HDL chol... 70 | 77
increased grip strength 69 | 83
decreased circulating serum al... 65 | 79
short tibia 65 | 82
abnormal lens morphology 64 | 73
decreased circulating insulin ... 63 | 75
prenatal lethality prior to he... 59 | 64
increased circulating HDL chol... 55 | 63
increased circulating sodium l... 54 | 71
increased fasted circulating g... 51 | 68
decreased lumbar vertebrae num... 50 | 62
increased circulating choleste... 50 | 53
increased sacral vertebrae num... 50 | 62
abnormal retinal pigmentation 49 | 61
decreased mean corpuscular vol... 49 | 50
increased total body fat amoun... 49 | 57
abnormal sleep behavior 48 | 63
male infertility 48 | 62
abnormal bone mineralization 47 | 55
improved glucose tolerance 47 | 56
abnormal coat/hair pigmentatio... 46 | 54
decreased hemoglobin content 46 | 53
decreased rib number 46 | 59
decreased circulating alanine ... 44 | 53
decreased leukocyte cell numbe... 44 | 54
abnormal behavioral response t... 43 | 52
decreased prepulse inhibition 43 | 52
increased bone mineral density 43 | 52
decreased fasted circulating g... 42 | 49
abnormal gait 41 | 51
decreased startle reflex 41 | 48
impaired glucose tolerance 41 | 52
increased exploration in new e... 41 | 56
thrombocytopenia 40 | 46
decreased caudal vertebrae num... 37 | 49
decreased heart weight 37 | 44
increased body weight 37 | 42
increased circulating chloride... 37 | 43
abnormal seminal vesicle morph... 36 | 47
increased blood urea nitrogen ... 36 | 44
abnormal neural tube closure 34 | 37
decreased circulating alkaline... 34 | 41
decreased erythrocyte cell num... 34 | 43
increased hemoglobin content 34 | 45
abnormal heart morphology 33 | 51
decreased circulating LDL chol... 33 | 37
decreased eosinophil cell numb... 33 | 41
increased heart weight 33 | 37
abnormal eye morphology 32 | 38
decreased circulating free fat... 31 | 39
decreased circulating total pr... 31 | 41
increased rib number 31 | 41
increased startle reflex 31 | 38
cardiovascular system phenotyp... 30 | 35
increased leukocyte cell numbe... 30 | 37
decreased T cell number 29 | 31
decreased circulating calcium ... 29 | 33
decreased mean corpuscular hem... 29 | 34
tremors 29 | 34
abnormal kidney morphology 28 | 30
small testis 28 | 37
abnormal cranium morphology 27 | 32
abnormal spleen morphology 27 | 36
decreased blood urea nitrogen ... 27 | 31
decreased circulating fructosa... 27 | 31
embryonic growth retardation 27 | 28
limb grasping 27 | 35
abnormal rib morphology 26 | 28
decreased neutrophil cell numb... 26 | 37
increased hematocrit 26 | 36
decreased circulating aspartat... 25 | 27
female infertility 25 | 34
increased circulating creatini... 25 | 29

Disease

ovarian cancer 6,816 | 8,484
osteosarcoma 6,159 | 7,933
psoriasis 4,945 | 6,685
medulloblastoma, large-cell 4,804 | 6,234
glioblastoma 4,374 | 5,572
lung cancer 3,686 | 4,466
atypical teratoid / rhabdoid tumor 3,362 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 2,618 | 3,289
malignant mesothelioma 2,571 | 3,162
Breast cancer 2,468 | 3,094
primitive neuroectodermal tumor 2,393 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,339 | 2,988
invasive ductal carcinoma 2,298 | 2,950
pilocytic astrocytoma 2,289 | 3,086
intraductal papillary-mucinous adenoma (IPMA) 2,266 | 2,956
oligodendroglioma 2,216 | 2,849
non-small cell lung cancer 2,159 | 2,798
Cancer 2,123 | 2,346
pediatric high grade glioma 2,117 | 2,712
lung adenocarcinoma 2,039 | 2,713
lung carcinoma 2,022 | 2,844
ependymoma 1,963 | 2,514
group 3 medulloblastoma 1,813 | 2,254
pancreatic cancer 1,790 | 2,300
subependymal giant cell astrocytoma 1,759 | 2,287
astrocytic glioma 1,710 | 2,241
Carcinoma 1,616 | 2,147
interstitial cystitis 1,613 | 2,299
ulcerative colitis 1,576 | 2,087
adult high grade glioma 1,561 | 2,148
Pick disease 1,551 | 1,893
group 4 medulloblastoma 1,486 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,470 | 1,795
pituitary cancer 1,453 | 1,972
ductal carcinoma in situ 1,341 | 1,745
diabetes mellitus 1,267 | 1,663
breast carcinoma 1,266 | 1,614
cystic fibrosis 1,242 | 1,665
astrocytoma 1,239 | 1,493
Multiple myeloma 1,234 | 1,327
tuberculosis 1,204 | 1,557
colon cancer 1,187 | 1,475
medulloblastoma 1,185 | 1,524
sonic hedgehog group medulloblastoma 1,135 | 1,482
adrenocortical carcinoma 1,121 | 1,427
posterior fossa group A ependymoma 1,120 | 1,511
posterior fossa group B ependymoma 1,076 | 1,530
Rheumatoid Arthritis 988 | 1,160
juvenile dermatomyositis 988 | 1,189
primary pancreatic ductal adenocarcinoma 985 | 1,271
acute quadriplegic myopathy 975 | 1,157
spina bifida 847 | 1,064
atypical teratoid/rhabdoid tumor 845 | 1,095
dermatomyositis 834 | 933
cutaneous lupus erythematosus 798 | 1,056
nasopharyngeal carcinoma 794 | 1,056
Waldenstrons macroglobulinemia 709 | 765
Atopic dermatitis 691 | 944
active Crohn's disease 690 | 918
non primary Sjogren syndrome sicca 672 | 840
acute myeloid leukemia 658 | 780
gastric carcinoma 640 | 832
primary Sjogren syndrome 606 | 789
esophageal adenocarcinoma 604 | 737
tuberculosis and treatment for 6 months 567 | 686
progressive supranuclear palsy 561 | 674
aldosterone-producing adenoma 548 | 664
Alzheimer's disease 538 | 644
Intellectual disability 514 | 573
Obesity 507 | 616
pancreatic carcinoma 469 | 567
Duchenne muscular dystrophy 468 | 602
Down syndrome 452 | 548
hepatocellular carcinoma 448 | 532
Endometriosis 429 | 535
Prostatic Neoplasms 413 | 471
Schizophrenia 399 | 501
fibroadenoma 399 | 557
autosomal dominant Emery-Dreifuss muscular dystrophy 395 | 499
Multiple Sclerosis 386 | 498
Amyotrophic Lateral Sclerosis 383 | 431
IGA Glomerulonephritis 376 | 454
chronic rhinosinusitis 370 | 512
Mammary Neoplasms 367 | 410
Neurodegenerative disease 361 | 383
gastric cancer 355 | 430
mucosa-associated lymphoid tissue lymphoma 348 | 480
Kidney disease 347 | 396
active ulcerative colitis 346 | 477
inflammatory breast cancer 318 | 404
Parkinson's disease 313 | 364
non-small cell lung carcinoma 294 | 413
hereditary spastic paraplegia 290 | 313
Polycystic Ovary Syndrome 288 | 332
sarcoidosis 279 | 358
Asthma 277 | 349
Epilepsy 266 | 346
Peripheral Neuropathy 263 | 303
glioblastoma multiforme 262 | 347
Vascular disease 258 | 281

Tissue

Female tissues 13,310 | 18,647
Nervous System 13,284 | 18,561
Endocrine System 13,271 | 18,512
Digestive Tract 13,251 | 18,473
Urinary Tract 13,202 | 18,444
Liver and Pancreas 13,150 | 18,136
Blood and immune system 13,130 | 17,995
Male tissues 13,121 | 17,969
Cardiovascular System 13,091 | 17,958
Skin and soft tissues 13,087 | 18,115
Respiratory system 12,866 | 17,484

Target Family

Non-IDG 7,348 | 11,971
Enzyme 3,440 | 4,146
Transcription Factor 1,387 | 1,400
Kinase 588 | 634
Transporter 259 | 473
Epigenetic 226 | 242
Ion Channel 145 | 341
GPCR 133 | 406
Nuclear Receptor 47 | 48
TF/Epigenetic 37 | 38
oGPCR 1 | 421

Compartment GO Term

Intracellular 13,611 | 13,611
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular part 13,474 | 13,474
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,170 | 8,170
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,830 | 7,830
Nucleus 6,897 | 6,897
Membrane part 6,469 | 6,469
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,172 | 5,172
Cell periphery 5,145 | 5,145
Plasma membrane 5,059 | 5,059
Extracellular region 4,606 | 4,606
Protein complex 4,438 | 4,438
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Cytosol 3,352 | 3,352
Nucleoplasm 2,938 | 2,938
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,563 | 2,563
Cytoskeleton 2,045 | 2,045
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Endoplasmic reticulum 1,663 | 1,663
Cytoskeletal part 1,567 | 1,567
Mitochondrion 1,530 | 1,530
Cell projection 1,426 | 1,426
Golgi apparatus 1,402 | 1,402
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,233 | 1,233
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Chromosome 999 | 999
Mitochondrial part 989 | 989
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 780 | 780
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 738 | 738
Plasma membrane protein comple... 720 | 720
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Microtubule organizing center 617 | 617
Synapse 594 | 594
Lysosome 571 | 571
Lytic vacuole 571 | 571
Vesicle membrane 559 | 559
cell-cell junction 557 | 557
Cytoplasmic vesicle membrane 552 | 552

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitochondrial 2-oxodicarboxylate carrier SLC25A21 Tbio Transporter -0.46900 2.68 102
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
RNA pseudouridylate synthase domain-containing protein 3 RPUSD3 Tdark Enzyme 0.42 34
D(2) dopamine receptor DRD2 Tclin GPCR -3.24474 1775.2 248
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Zinc finger protein 136 ZNF136 Tdark Transcription Factor 0.12 0.68 102
Syntaxin-1B STX1B Tbio Non-IDG -1.74488 52.6 27
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345