Development Level

Tbio 196 | 10,625
Tdark 56 | 7,003
Tchem 54 | 1,890
Tclin 19 | 602

Collection

Kinase: IDG Consortium (Targets) 2 | 125

IMPC Phenotype

preweaning lethality, complete... 6 | 633
preweaning lethality, incomple... 6 | 260
decreased circulating alkaline... 4 | 41
decreased circulating insulin ... 4 | 75
decreased grip strength 4 | 123
abnormal behavior 3 | 226
abnormal lens morphology 3 | 73
abnormal retina morphology 3 | 100
decreased lean body mass 3 | 195
decreased total body fat amoun... 3 | 186
embryonic lethality prior to t... 3 | 187
improved glucose tolerance 3 | 56
increased circulating alkaline... 3 | 119
increased or absent threshold ... 3 | 128
abnormal QRS complex 2 | 25
abnormal bone structure 2 | 131
abnormal coat appearance 2 | 25
abnormal sleep behavior 2 | 63
cataract 2 | 26
decreased body weight 2 | 174
decreased bone mineral content 2 | 157
decreased circulating calcium ... 2 | 33
decreased heart weight 2 | 44
decreased rib number 2 | 59
hyperactivity 2 | 108
increased circulating HDL chol... 2 | 63
increased circulating choleste... 2 | 53
increased exploration in new e... 2 | 56
increased heart rate 2 | 17
increased lean body mass 2 | 107
limb grasping 2 | 35
short tibia 2 | 82
shortened RR interval 2 | 19
tremors 2 | 34
abnormal anxiety-related respo... 1 | 1
abnormal bone mineralization 1 | 55
abnormal coat- hair morphology 1 | 18
abnormal coat-hair pigmentatio... 1 | 54
abnormal digit morphology 1 | 13
abnormal gait 1 | 51
abnormal head morphology 1 | 10
abnormal motor learning 1 | 4
abnormal optic disc morphology 1 | 10
abnormal retinal blood vessel ... 1 | 18
abnormal retinal vasculature m... 1 | 15
abnormal skin morphology 1 | 23
abnormal social-conspecific in... 1 | 3
abnormal spine curvature 1 | 7
abnormal spleen morphology 1 | 36
abnormal startle reflex 1 | 14
abnormal vocalization 1 | 21
abnormal whole-body plethysmog... 1 | 4
cardiovascular system phenotyp... 1 | 35
convulsive seizures 1 | 11
decreased CD8-positive, alpha-... 1 | 26
decreased T cell number 1 | 31
decreased blood urea nitrogen ... 1 | 31
decreased body length 1 | 108
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 77
decreased circulating free fat... 1 | 39
decreased circulating glucose ... 1 | 121
decreased circulating phosphat... 1 | 15
decreased circulating serum al... 1 | 79
decreased circulating triglyce... 1 | 83
decreased follicular B cell nu... 1 | 4
decreased heart rate variabili... 1 | 11
decreased leukocyte cell numbe... 1 | 54
decreased mean corpuscular vol... 1 | 50
decreased pulmonary respirator... 1 | 4
decreased total retina thickne... 1 | 20
decreased vertical activity 1 | 22
embryonic lethality prior to o... 1 | 148
enlarged heart 1 | 111
hydrops fetalis 1 | 22
increased blood uric acid leve... 1 | 5
increased body length 1 | 20
increased body weight 1 | 42
increased bone mineral density 1 | 52
increased circulating chloride... 1 | 43
increased circulating magnesiu... 1 | 10
increased circulating serum al... 1 | 25
increased granulocyte number 1 | 8
increased grip strength 1 | 83
increased heart weight 1 | 37
increased mean corpuscular hem... 1 | 93
increased mean corpuscular vol... 1 | 91
increased respiratory quotient 1 | 12
increased rib number 1 | 41
increased tidal volume 1 | 1
male infertility 1 | 62
persistence of hyaloid vascula... 1 | 22
polycystic kidney 1 | 9
shortened ST segment 1 | 9
straub tail 1 | 26

Disease

psoriasis 159 | 6,685
Cancer 157 | 2,346
ovarian cancer 150 | 8,491
osteosarcoma 118 | 7,933
glioblastoma 112 | 5,572
lung cancer 110 | 4,473
medulloblastoma, large-cell 100 | 6,234
Breast cancer 87 | 3,098
atypical teratoid / rhabdoid tumor 83 | 4,369
malignant mesothelioma 78 | 3,163
pilocytic astrocytoma 77 | 3,086
non-small cell lung cancer 71 | 2,798
intraductal papillary-mucinous neoplasm (IPMN) 70 | 3,289
lung carcinoma 70 | 2,844
oligodendroglioma 70 | 2,849
lung adenocarcinoma 69 | 2,714
diabetes mellitus 68 | 1,663
invasive ductal carcinoma 68 | 2,950
intraductal papillary-mucinous adenoma (IPMA) 66 | 2,956
Carcinoma 62 | 2,147
pancreatic cancer 62 | 2,300
cystic fibrosis 61 | 1,670
interstitial cystitis 61 | 2,299
intraductal papillary-mucinous carcinoma (IPMC) 59 | 2,988
primitive neuroectodermal tumor 59 | 3,031
pediatric high grade glioma 58 | 2,712
ulcerative colitis 55 | 2,087
Alzheimer's disease 52 | 644
breast carcinoma 51 | 1,614
pituitary cancer 51 | 1,972
subependymal giant cell astrocytoma 50 | 2,287
ductal carcinoma in situ 48 | 1,745
posterior fossa group A ependymoma 48 | 1,511
colon cancer 46 | 1,475
Kidney disease 45 | 397
adrenocortical carcinoma 45 | 1,427
ependymoma 45 | 2,514
Pick disease 43 | 1,893
adult high grade glioma 43 | 2,148
Down syndrome 40 | 548
sonic hedgehog group medulloblastoma 40 | 1,482
Cerebrovascular disease 39 | 231
Mammary Neoplasms 38 | 410
group 3 medulloblastoma 38 | 2,254
Adenoma 37 | 165
Toxic encephalopathy 37 | 131
astrocytoma 37 | 1,493
esophageal adenocarcinoma 37 | 737
primary pancreatic ductal adenocarcinoma 37 | 1,271
Endometriosis 36 | 535
Heart disease 36 | 279
Neuropathy 36 | 210
astrocytic glioma 36 | 2,241
atypical teratoid/rhabdoid tumor 36 | 1,095
Vascular disease 35 | 281
tuberculosis 35 | 1,563
posterior fossa group B ependymoma 34 | 1,530
Multiple Sclerosis 33 | 498
Rheumatoid Arthritis 33 | 1,170
cutaneous lupus erythematosus 33 | 1,056
Amyotrophic Lateral Sclerosis 31 | 432
Liver disease 31 | 219
Neurodegenerative disease 31 | 383
Parkinson's disease 31 | 364
acute quadriplegic myopathy 31 | 1,157
group 4 medulloblastoma 31 | 1,875
nasopharyngeal carcinoma 31 | 1,056
Schizophrenia 30 | 503
dermatomyositis 30 | 966
Hypertension 29 | 293
Stomach Neoplasms 29 | 282
medulloblastoma 29 | 1,524
Arthritis 28 | 248
Atopic dermatitis 28 | 944
Neoplasm Metastasis 28 | 138
spina bifida 28 | 1,064
Duchenne muscular dystrophy 27 | 602
Obesity 27 | 616
Prostatic Neoplasms 27 | 471
Asthma 26 | 349
Hypersensitivity reaction type II disease 26 | 235
Multiple myeloma 26 | 1,327
Neoplasm Invasiveness 26 | 127
autosomal dominant Emery-Dreifuss muscular dystrophy 26 | 499
Inflammatory bowel disease 25 | 142
gastric carcinoma 25 | 832
Brain disease 24 | 84
Lung disease 24 | 136
Myopathy 24 | 128
Neoplastic Cell Transformation 24 | 81
pancreatic ductal adenocarcinoma liver metastasis 24 | 1,795
Liver carcinoma 23 | 217
Dementia 22 | 129
Epilepsy 21 | 346
Lung Neoplasms 21 | 171
Waldenstrons macroglobulinemia 21 | 764
juvenile dermatomyositis 21 | 1,189
non-small cell lung carcinoma 21 | 413
Atherosclerosis 20 | 275
Brain Ischemia 20 | 87

Tissue

Female tissues 312 | 18,646
Endocrine System 306 | 18,511
Nervous System 306 | 18,560
Digestive Tract 304 | 18,472
Skin and soft tissues 302 | 18,114
Urinary Tract 298 | 18,443
Liver and Pancreas 295 | 18,135
Cardiovascular System 294 | 17,957
Male tissues 292 | 17,968
Blood and immune system 288 | 17,994
Respiratory system 283 | 17,483

Target Family

Non-IDG 232 | 11,969
Enzyme 34 | 4,146
Transcription Factor 32 | 1,400
Kinase 15 | 634
GPCR 3 | 408
Transporter 3 | 473
Epigenetic 2 | 242
Ion Channel 2 | 341
Nuclear Receptor 2 | 48

Compartment GO Term

Intermediate filament cytoskel... 325 | 325
cellular_component 18,237 | 18,237
Cell 15,806 | 15,806
Cell part 15,806 | 15,806
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,648 | 12,648
membrane-bounded organelle 11,793 | 11,793
Intracellular organelle 11,617 | 11,617
Intracellular membrane-bounded... 10,618 | 10,618
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,169 | 8,169
Intracellular organelle part 8,011 | 8,011
Cytoplasmic part 7,830 | 7,830
Nucleus 7,577 | 7,577
Membrane part 6,470 | 6,470
Cytosol 6,035 | 6,035
Plasma membrane 5,673 | 5,673
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,171 | 5,171
Cell periphery 5,146 | 5,146
Nucleoplasm 4,929 | 4,929
Extracellular region 4,606 | 4,606
Protein complex 4,439 | 4,439
Intracellular organelle lumen 4,330 | 4,330
Organelle lumen 4,330 | 4,330
membrane-enclosed lumen 4,330 | 4,330
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,839 | 3,839
non-membrane-bounded organelle 3,838 | 3,838
Nuclear part 3,807 | 3,807
Endomembrane system 3,720 | 3,720
Vesicle 3,666 | 3,666
membrane-bounded vesicle 3,494 | 3,494
Nuclear lumen 3,464 | 3,464
Extracellular organelle 2,849 | 2,849
Extracellular vesicle 2,848 | 2,848
Extracellular exosome 2,828 | 2,828
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,564 | 2,564
Cytoskeleton 2,046 | 2,046
Golgi apparatus 1,946 | 1,946
Endoplasmic reticulum 1,872 | 1,872
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Vesicles 1,625 | 1,625
Cytoskeletal part 1,568 | 1,568
Mitochondrion 1,531 | 1,531
Cell projection 1,426 | 1,426
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,305 | 1,305
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,234 | 1,234
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Mitochondria 1,003 | 1,003
Chromosome 999 | 999
Mitochondrial part 989 | 989
Nucleoli 952 | 952
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 793 | 793
Intracellular ribonucleoprotei... 789 | 789
Nucleoplasm part 781 | 781
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 739 | 739
Plasma membrane protein comple... 721 | 721
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Microtubule organizing center 680 | 680
Centrosome 676 | 676
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Synapse 594 | 594
Lytic vacuole 571 | 571

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Receptor tyrosine-protein kinase erbB-2 ERBB2 Tclin Kinase -4.25806 19000.3 3336
High affinity nerve growth factor receptor NTRK1 Tchem Kinase -3.03552 1003.4 1000
Paired box protein Pax-2 PAX2 Tbio Transcription Factor -2.66256 471.8 306
Trichoplein keratin filament-binding protein TCHP Tbio Non-IDG -2.30520 126.7 92
E3 ubiquitin-protein ligase Praja-2 PJA2 Tbio Enzyme -0.64427 2.59 159
Cyclin-dependent kinase inhibitor 2A CDKN2A Tbio Enzyme -3.70375 8561.3 896
Alpha-1-antichymotrypsin SERPINA3 Tchem Non-IDG -2.94207 803.8 261
Alpha-1-antitrypsin SERPINA1 Tbio Non-IDG -3.73976 5495.0 809
Prominin-1 PROM1 Tbio Non-IDG -3.27144 1922.5 226
NSFL1 cofactor p47 NSFL1C Tbio Non-IDG -0.96009 8.42 54