Development Level

Tbio 2,577 | 10,625
Tdark 1,686 | 7,003
Tchem 661 | 1,890
Tclin 391 | 602

Collection

Eligible non-olfactory GPCR Proteins 136 | 145
Eligible Ion Channel Proteins 107 | 117
Eligible Kinase Proteins 8 | 134

IMPC Term

preweaning lethality, complete... 130 | 633
abnormal behavior 64 | 226
preweaning lethality, incomple... 61 | 260
decreased total body fat amoun... 56 | 186
decreased lean body mass 53 | 195
decreased bone mineral content 48 | 157
decreased body weight 44 | 174
embryonic lethality prior to t... 44 | 187
abnormal bone structure 36 | 131
decreased bone mineral density 35 | 126
increased circulating alkaline... 34 | 119
decreased grip strength 32 | 123
enlarged heart 31 | 111
hyperactivity 31 | 108
increased lean body mass 30 | 107
decreased circulating glucose ... 29 | 121
increased mean corpuscular vol... 28 | 91
increased or absent threshold ... 28 | 128
embryonic lethality prior to o... 26 | 148
abnormal retina morphology 25 | 100
increased bone mineral content 25 | 92
decreased circulating triglyce... 24 | 83
increased circulating sodium l... 24 | 71
increased mean corpuscular hem... 24 | 93
decreased circulating choleste... 22 | 85
hypoactivity 22 | 89
decreased body length 21 | 108
decreased circulating insulin ... 21 | 75
increased grip strength 21 | 83
abnormal embryo size 20 | 112
decreased circulating serum al... 20 | 79
abnormal gait 19 | 51
abnormal sleep behavior 19 | 63
decreased rib number 19 | 59
improved glucose tolerance 19 | 56
increased total body fat amoun... 19 | 57
decreased circulating HDL chol... 18 | 77
decreased fasted circulating g... 18 | 49
abnormal bone mineralization 17 | 55
decreased prepulse inhibition 17 | 52
increased circulating calcium ... 17 | 32
increased exploration in new e... 17 | 56
short tibia 17 | 82
decreased circulating alanine ... 16 | 53
decreased heart weight 16 | 44
decreased lumbar vertebrae num... 16 | 62
increased circulating potassiu... 16 | 31
increased fasted circulating g... 16 | 68
abnormal eye morphology 15 | 38
abnormal seminal vesicle morph... 15 | 47
cardiovascular system phenotyp... 15 | 35
enlarged epididymis 15 | 27
increased sacral vertebrae num... 15 | 62
tremors 15 | 34
abnormal lens morphology 14 | 73
abnormal retinal pigmentation 14 | 61
decreased eosinophil cell numb... 14 | 41
increased circulating HDL chol... 14 | 63
limb grasping 14 | 35
abnormal epididymis morphology 13 | 31
decreased leukocyte cell numbe... 13 | 54
impaired glucose tolerance 13 | 52
increased blood urea nitrogen ... 13 | 44
increased bone mineral density 13 | 52
thrombocytopenia 13 | 46
abnormal heart morphology 12 | 51
decreased hemoglobin content 12 | 53
decreased mean corpuscular vol... 12 | 50
decreased startle reflex 12 | 48
increased body weight 12 | 42
increased circulating choleste... 12 | 53
increased rib number 12 | 41
abnormal behavioral response t... 11 | 52
decreased NK T cell number 11 | 28
decreased caudal vertebrae num... 11 | 49
decreased circulating alkaline... 11 | 41
decreased circulating calcium ... 11 | 33
straub tail 11 | 26
abnormal neural tube closure 10 | 37
decreased erythrocyte cell num... 10 | 43
decreased monocyte cell number 10 | 28
increased circulating phosphat... 10 | 24
increased circulating serum al... 10 | 25
increased heart weight 10 | 37
increased hemoglobin content 10 | 45
increased leukocyte cell numbe... 10 | 37
abnormal coat appearance 9 | 25
abnormal coat/hair pigmentatio... 9 | 54
abnormal locomotor activation 9 | 26
decreased B cell number 9 | 30
decreased T cell number 9 | 31
decreased circulating LDL chol... 9 | 37
decreased circulating chloride... 9 | 32
decreased circulating free fat... 9 | 39
decreased circulating total pr... 9 | 41
increased hematocrit 9 | 36
increased prepulse inhibition 9 | 21
prenatal lethality prior to he... 9 | 64
increased circulating chloride... 8 | 43
small testis 8 | 37

Disease

ovarian cancer 2,104 | 8,492
osteosarcoma 2,049 | 7,933
psoriasis 1,905 | 6,685
medulloblastoma, large-cell 1,709 | 6,234
glioblastoma 1,605 | 5,572
atypical teratoid / rhabdoid tumor 1,246 | 4,369
lung cancer 1,167 | 4,473
pilocytic astrocytoma 1,068 | 3,086
lung carcinoma 1,052 | 2,844
intraductal papillary-mucinous neoplasm (IPMN) 932 | 3,289
invasive ductal carcinoma 896 | 2,950
intraductal papillary-mucinous adenoma (IPMA) 883 | 2,956
interstitial cystitis 859 | 2,299
intraductal papillary-mucinous carcinoma (IPMC) 859 | 2,988
non-small cell lung cancer 847 | 2,798
Breast cancer 845 | 3,099
lung adenocarcinoma 839 | 2,714
pediatric high grade glioma 825 | 2,712
malignant mesothelioma 819 | 3,163
primitive neuroectodermal tumor 796 | 3,031
oligodendroglioma 789 | 2,849
Cancer 738 | 2,346
pancreatic cancer 720 | 2,300
ulcerative colitis 718 | 2,087
ependymoma 711 | 2,514
Carcinoma 698 | 2,147
subependymal giant cell astrocytoma 689 | 2,287
pituitary cancer 627 | 1,972
adult high grade glioma 623 | 2,148
astrocytic glioma 608 | 2,241
diabetes mellitus 564 | 1,663
ductal carcinoma in situ 556 | 1,745
cystic fibrosis 547 | 1,670
group 4 medulloblastoma 531 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 527 | 1,795
tuberculosis 519 | 1,563
posterior fossa group A ependymoma 512 | 1,511
Pick disease 506 | 1,893
group 3 medulloblastoma 491 | 2,254
breast carcinoma 468 | 1,614
astrocytoma 422 | 1,493
medulloblastoma 420 | 1,524
colon cancer 400 | 1,475
cutaneous lupus erythematosus 391 | 1,056
adrenocortical carcinoma 387 | 1,427
primary pancreatic ductal adenocarcinoma 384 | 1,271
posterior fossa group B ependymoma 382 | 1,530
Rheumatoid Arthritis 378 | 1,171
sonic hedgehog group medulloblastoma 378 | 1,482
active Crohn's disease 338 | 918
atypical teratoid/rhabdoid tumor 326 | 1,095
Multiple myeloma 305 | 1,328
juvenile dermatomyositis 283 | 1,189
nasopharyngeal carcinoma 268 | 1,056
gastric carcinoma 266 | 832
acute quadriplegic myopathy 264 | 1,157
primary Sjogren syndrome 260 | 789
Atopic dermatitis 256 | 944
Multiple Sclerosis 254 | 498
Obesity 249 | 616
Alzheimer's disease 246 | 644
dermatomyositis 246 | 967
spina bifida 243 | 1,064
esophageal adenocarcinoma 228 | 737
non primary Sjogren syndrome sicca 220 | 840
Schizophrenia 216 | 503
aldosterone-producing adenoma 205 | 664
Kidney disease 202 | 397
Down syndrome 201 | 548
mucosa-associated lymphoid tissue lymphoma 201 | 480
Duchenne muscular dystrophy 192 | 602
Epilepsy 192 | 346
active ulcerative colitis 185 | 477
Asthma 181 | 349
fibroadenoma 177 | 557
acute myeloid leukemia 173 | 785
Hypersensitivity reaction type II disease 172 | 235
pancreatic carcinoma 169 | 567
progressive supranuclear palsy 165 | 674
Arthritis 158 | 248
Endometriosis 156 | 535
tuberculosis and treatment for 6 months 152 | 686
Hypertension 151 | 293
IGA Glomerulonephritis 150 | 454
Prostatic Neoplasms 150 | 471
non-small cell lung carcinoma 145 | 413
Intellectual disability 144 | 573
Waldenstrons macroglobulinemia 144 | 765
autosomal dominant Emery-Dreifuss muscular dystrophy 141 | 499
Autistic Disorder 138 | 320
Anemia 134 | 252
Parkinson's disease 134 | 364
Atherosclerosis 133 | 275
Liver disease 132 | 219
Neurodegenerative disease 132 | 383
hepatocellular carcinoma 131 | 550
Heart disease 130 | 279
sarcoidosis 125 | 368
nephrosclerosis 124 | 329
Cerebrovascular disease 120 | 231

Tissue

Female tissues 5,065 | 18,647
Urinary Tract 5,028 | 18,444
Nervous System 5,002 | 18,561
Endocrine System 4,992 | 18,512
Digestive Tract 4,962 | 18,473
Skin and soft tissues 4,867 | 18,115
Liver and Pancreas 4,818 | 18,136
Cardiovascular System 4,758 | 17,958
Blood and immune system 4,755 | 17,995
Male tissues 4,711 | 17,969
Respiratory system 4,635 | 17,484

Target Family

Non-IDG 2,682 | 11,969
Enzyme 927 | 4,146
Transporter 456 | 473
GPCR 399 | 408
oGPCR 380 | 421
Ion Channel 326 | 341
Kinase 105 | 634
Transcription Factor 34 | 1,400
Epigenetic 3 | 242
Nuclear Receptor 3 | 48

Compartment GO Term

Integral component of membrane 5,315 | 5,315
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,612 | 13,612
Intracellular part 13,475 | 13,475
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,353 | 10,353
Membrane 8,871 | 8,871
Organelle part 8,169 | 8,169
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,831 | 7,831
Nucleus 7,577 | 7,577
Membrane part 6,469 | 6,469
Cytosol 6,034 | 6,034
Plasma membrane 5,673 | 5,673
Intrinsic component of membran... 5,445 | 5,445
Macromolecular complex 5,171 | 5,171
Cell periphery 5,146 | 5,146
Nucleoplasm 4,930 | 4,930
Extracellular region 4,607 | 4,607
Protein complex 4,439 | 4,439
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,874 | 3,874
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,592 | 2,592
Plasma membrane part 2,564 | 2,564
Cytoskeleton 2,046 | 2,046
Golgi apparatus 1,946 | 1,946
Endoplasmic reticulum 1,872 | 1,872
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Vesicles 1,625 | 1,625
Cytoskeletal part 1,568 | 1,568
Mitochondrion 1,530 | 1,530
Cell projection 1,425 | 1,425
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,234 | 1,234
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,092 | 1,092
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,084 | 1,084
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Mitochondria 1,003 | 1,003
Chromosome 999 | 999
Mitochondrial part 988 | 988
Nucleoli 950 | 950
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 815 | 815
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 781 | 781
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 739 | 739
Plasma membrane protein comple... 721 | 721
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Microtubule organizing center 680 | 680
Centrosome 676 | 676
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 656 | 656
Extracellular matrix 633 | 633
Synapse 594 | 594
Lytic vacuole 571 | 571

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
V-type proton ATPase 116 kDa subunit a isoform 2 ATP6V0A2 Tbio Enzyme -2.43448 279.3 62
HLA class I histocompatibility antigen, alpha chain G HLA-G Tbio Non-IDG -3.07995 1275.9 729
cAMP-dependent protein kinase catalytic subunit alpha PRKACA Tchem Kinase -1.02404 9.59 274
GPI mannosyltransferase 4 PIGZ Tdark Enzyme -1.17375 14.4 26
Mitochondrial coenzyme A transporter SLC25A42 SLC25A42 Tbio Transporter -0.38872 3.06 24
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.25741 172.1 240
Equilibrative nucleoside transporter 1 SLC29A1 Tclin Transporter -2.59024 397.3 363
Transmembrane 9 superfamily member 2 TM9SF2 Tdark Non-IDG -0.27748 1.00 57
Solute carrier family 25 member 33 SLC25A33 Tbio Transporter -0.28165 1.49 35
ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 Tbio Transporter -0.85002 7.01 82