Development Level

Tbio 2,778 | 11,445
Tdark 1,571 | 6,588
Tchem 583 | 1,598
Tclin 399 | 613

Collection

RFA-RM-18-021 200 | 328
GPCR: IDG Consortium (Targets) 124 | 126
Ion Channel: IDG Consortium (T... 90 | 99
GPCR: IDG Consortium (Complete... 25 | 25
Kinase: IDG Consortium (Target... 9 | 125
Kinase: IDG Consortium (Comple... 2 | 37

IMPC Phenotype

preweaning lethality, complete... 190 | 979
preweaning lethality, incomple... 131 | 499
abnormal behavior 87 | 298
decreased vertical activity 69 | 208
embryonic lethality prior to t... 68 | 278
enlarged heart 66 | 210
decreased total body fat amoun... 58 | 207
increased lean body mass 53 | 172
abnormal bone structure 51 | 187
embryonic lethality prior to o... 51 | 239
decreased bone mineral content 49 | 151
increased total body fat amoun... 49 | 134
abnormal embryo size 48 | 220
hyperactivity 46 | 148
abnormal heart morphology 44 | 162
decreased body weight 44 | 161
decreased lean body mass 40 | 135
abnormal seminal vesicle morph... 37 | 114
decreased bone mineral density 33 | 126
increased bone mineral content 33 | 108
decreased circulating glucose ... 31 | 126
hypoactivity 31 | 132
increased mean corpuscular vol... 30 | 92
increased circulating alkaline... 29 | 122
increased startle reflex 29 | 112
decreased grip strength 28 | 116
decreased lymphocyte cell numb... 28 | 83
improved glucose tolerance 27 | 79
abnormal gait 25 | 69
decreased body length 25 | 101
decreased prepulse inhibition 25 | 82
embryonic growth retardation 25 | 106
increased circulating sodium l... 25 | 71
increased or absent threshold ... 25 | 101
abnormal eye morphology 24 | 68
abnormal sleep behavior 24 | 70
increased monocyte cell number 24 | 63
decreased fasted circulating g... 23 | 65
increased mean corpuscular hem... 23 | 96
decreased circulating choleste... 22 | 93
decreased hemoglobin content 22 | 68
small superior vagus ganglion 22 | 74
decreased circulating insulin ... 21 | 76
decreased circulating serum al... 21 | 82
decreased erythrocyte cell num... 21 | 62
abnormal kidney morphology 20 | 65
cataract 20 | 92
decreased circulating HDL chol... 20 | 68
decreased mean corpuscular vol... 20 | 79
decreased startle reflex 20 | 75
increased circulating HDL chol... 20 | 80
limb grasping 20 | 41
short tibia 20 | 97
abnormal epididymis morphology 19 | 42
decreased circulating triglyce... 19 | 79
decreased leukocyte cell numbe... 19 | 73
impaired glucose tolerance 19 | 75
increased fasted circulating g... 18 | 76
male infertility 18 | 123
abnormal lens morphology 17 | 81
increased circulating calcium ... 17 | 34
abnormal behavioral response t... 16 | 66
abnormal retina morphology 16 | 71
decreased circulating alkaline... 16 | 46
decreased heart weight 16 | 27
enlarged epididymis 16 | 31
thrombocytopenia 16 | 56
hydrometra 15 | 53
increased circulating choleste... 15 | 66
increased circulating triglyce... 15 | 42
increased heart weight 15 | 62
increased neutrophil cell numb... 15 | 46
prenatal lethality prior to he... 15 | 87
tremors 15 | 39
abnormal coat-hair pigmentatio... 14 | 64
cardiovascular system phenotyp... 14 | 36
decreased circulating total pr... 14 | 49
edema 14 | 59
increased bone mineral density 14 | 72
increased leukocyte cell numbe... 14 | 47
abnormal skin morphology 13 | 50
decreased circulating calcium ... 13 | 36
decreased hematocrit 13 | 46
decreased red blood cell distr... 13 | 41
enlarged spleen 13 | 41
abnormal bone mineralization 12 | 38
abnormal lung morphology 12 | 26
abnormal neural tube closure 12 | 46
abnormal spleen morphology 12 | 55
decreased circulating LDL chol... 12 | 38
decreased circulating creatini... 12 | 39
decreased mean corpuscular hem... 12 | 50
increased circulating amylase ... 12 | 25
increased mean platelet volume 12 | 45
prolonged QT interval 12 | 38
abnormal vibrissa morphology 11 | 25
increased circulating chloride... 11 | 41
increased circulating iron lev... 11 | 30
prolonged ST segment 11 | 36
small testis 11 | 58

Disease

Carcinoma 3,423 | 11,493
ovarian cancer 2,117 | 8,520
osteosarcoma 2,063 | 7,950
psoriasis 1,909 | 6,694
medulloblastoma, large-cell 1,707 | 6,241
glioblastoma 1,665 | 5,792
atypical teratoid / rhabdoid tumor 1,474 | 5,112
ependymoma 1,349 | 4,679
lung cancer 1,279 | 4,740
adult high grade glioma 1,143 | 3,801
Astrocytoma, Pilocytic 1,064 | 3,081
lung carcinoma 1,051 | 2,843
Breast cancer 991 | 3,578
group 3 medulloblastoma 981 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 930 | 3,291
invasive ductal carcinoma 895 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 884 | 2,955
non-small cell lung cancer 883 | 2,890
interstitial cystitis 867 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 861 | 2,989
malignant mesothelioma 840 | 3,232
lung adenocarcinoma 839 | 2,716
primitive neuroectodermal tumor 797 | 3,035
Cancer 788 | 2,499
oligodendroglioma 788 | 2,850
Kidney cancer 786 | 2,613
pancreatic cancer 760 | 2,398
astrocytic glioma 700 | 2,597
subependymal giant cell astrocytoma 688 | 2,287
tuberculosis 671 | 2,010
pituitary cancer 627 | 1,972
ulcerative colitis 621 | 1,819
diabetes mellitus 593 | 1,728
pancreatic ductal adenocarcinoma liver metastasis 570 | 1,962
cystic fibrosis 555 | 1,696
ductal carcinoma in situ 553 | 1,745
group 4 medulloblastoma 513 | 1,855
Pick disease 506 | 1,894
breast carcinoma 476 | 1,638
Autosomal recessive predisposition 465 | 1,442
Schizophrenia 457 | 1,160
colon cancer 401 | 1,478
cutaneous lupus erythematosus 394 | 1,057
Rheumatoid arthritis 389 | 1,191
adrenocortical carcinoma 388 | 1,428
primary pancreatic ductal adenocarcinoma 342 | 1,109
active Crohn's disease 340 | 922
astrocytoma 328 | 1,146
Epilepsy 313 | 792
pediatric high grade glioma 305 | 1,064
Multiple myeloma 300 | 1,332
active ulcerative colitis 295 | 764
juvenile dermatomyositis 282 | 1,187
Melanoma 273 | 711
Liver Cirrhosis, Experimental 272 | 769
Bipolar Disorder 270 | 666
nasopharyngeal carcinoma 269 | 1,058
Multiple Sclerosis 267 | 540
Obesity 264 | 678
acute quadriplegic myopathy 263 | 1,158
Atopic dermatitis 258 | 952
Intellectual disability 257 | 1,016
Alzheimer's disease 256 | 658
gastric carcinoma 256 | 807
spina bifida 248 | 1,074
non primary Sjogren syndrome sicca 244 | 891
dermatomyositis 243 | 966
primary Sjogren syndrome 239 | 735
esophageal adenocarcinoma 234 | 737
Kidney disease 218 | 430
Skin cancer 212 | 469
Seizures 204 | 596
Liver cancer 203 | 604
aldosterone-producing adenoma 203 | 665
mucosa-associated lymphoid tissue lymphoma 202 | 484
medulloblastoma 200 | 720
Hypertension 198 | 396
Duchenne muscular dystrophy 192 | 601
Asthma 185 | 385
Hypersensitivity reaction type II disease 185 | 253
Down syndrome 183 | 499
fibroadenoma 178 | 559
Depressive disorder 177 | 409
Arthritis 176 | 290
Anemia 175 | 365
acute myeloid leukemia 174 | 783
Dull intelligence 171 | 645
Low intelligence 171 | 645
Mental Retardation 171 | 645
Mental deficiency 171 | 645
Poor school performance 171 | 645
Muscle hypotonia 170 | 571
pancreatic carcinoma 166 | 562
progressive supranuclear palsy 166 | 676
Endometriosis 157 | 540
Prostatic Neoplasms 157 | 495
posterior fossa group A ependymoma 155 | 468
Cognitive delay 153 | 608
Global developmental delay 153 | 608
Mental and motor retardation 153 | 608

Tissue

Endocrine System 4,799 | 18,159
Digestive Tract 4,568 | 17,369
Female tissues 4,564 | 17,400
Skin and soft tissues 4,483 | 17,230
Male tissues 4,482 | 17,142
Nervous System 4,412 | 16,725
Blood and immune system 4,399 | 16,909
Liver and Pancreas 4,383 | 16,750
Urinary Tract 4,382 | 16,678
Respiratory system 4,230 | 16,393
Cardiovascular System 3,858 | 15,192

Target Family

Non-IDG 2,684 | 12,091
Enzyme 939 | 4,145
Transporter 455 | 473
GPCR 397 | 408
oGPCR 380 | 421
Ion Channel 328 | 344
Kinase 108 | 634
Transcription Factor 34 | 1,400
Epigenetic 3 | 242
Nuclear Receptor 3 | 48

Compartment GO Term

Integral component of membrane 5,331 | 5,331
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,109 | 14,109
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,975 | 8,975
Intracellular organelle part 8,783 | 8,783
Membrane 8,531 | 8,531
Nucleus 7,562 | 7,562
Cytosol 6,686 | 6,686
Membrane part 6,554 | 6,554
Plasma membrane 5,830 | 5,830
Macromolecular complex 5,475 | 5,475
Intrinsic component of membran... 5,458 | 5,458
Cell periphery 5,382 | 5,382
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,975 | 3,975
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,674 | 3,674
Organelle membrane 2,846 | 2,846
Extracellular region 2,732 | 2,732
Plasma membrane part 2,594 | 2,594
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,217 | 2,217
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,637 | 1,637
Extracellular region part 1,628 | 1,628
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 967 | 967
Supramolecular complex 966 | 966
Cell junction 960 | 960
Supramolecular fiber 959 | 959
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 930 | 930
Nucleolus 926 | 926
Chromosomal part 889 | 889
GO:0098796 884 | 884
Ribonucleoprotein complex 865 | 865
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 850 | 850
Transferase complex 849 | 849
Cell surface 842 | 842
Plasma membrane region 841 | 841
Vesicle membrane 801 | 801
Cytoplasmic vesicle membrane 795 | 795
Polymeric cytoskeletal fiber 764 | 764
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 714 | 714
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 663 | 663
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C Tbio Non-IDG -2.61667 619.4 0
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.27709 182.9 314
Serine incorporator 5 SERINC5 Tbio Non-IDG -1.50535 34.0 11
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.55550 343.3 205
UPF0606 protein KIAA1549 KIAA1549 Tbio Non-IDG -1.67668 47.8 19
GPI mannosyltransferase 4 PIGZ Tdark Enzyme -1.18571 13.8 39
Mitochondrial coenzyme A transporter SLC25A42 SLC25A42 Tbio Transporter -0.53750 4.06 29
Mitochondrial uncoupling protein 3 UCP3 Tbio Non-IDG -2.74050 585.4 181
Post-GPI attachment to proteins factor 6 TMEM8A Tdark Non-IDG -0.56820 3.55 16
HLA class I histocompatibility antigen, B-35 alpha chain HLA-B Tbio Non-IDG -1.88752 1613.5 0