Development Level

Tbio 189 | 11,651
Tdark 21 | 6,593
Tchem 15 | 1,388
Tclin 1 | 612

IMPC Phenotype

preweaning lethality, complete... 17 | 979
embryonic lethality prior to o... 7 | 239
preweaning lethality, incomple... 7 | 499
embryonic lethality prior to t... 6 | 278
enlarged heart 5 | 210
increased lean body mass 5 | 172
decreased blood urea nitrogen ... 4 | 51
decreased total body fat amoun... 4 | 207
embryonic growth retardation 4 | 106
abnormal bone structure 3 | 187
abnormal embryo size 3 | 220
decreased circulating choleste... 3 | 93
decreased circulating glucose ... 3 | 126
decreased lean body mass 3 | 135
abnormal bone mineralization 2 | 38
abnormal gait 2 | 69
abnormal heart morphology 2 | 162
abnormal retina morphology 2 | 71
abnormal seminal vesicle morph... 2 | 114
decreased circulating HDL chol... 2 | 68
decreased circulating alanine ... 2 | 47
decreased circulating triglyce... 2 | 79
decreased mean corpuscular vol... 2 | 79
decreased startle reflex 2 | 75
hydrometra 2 | 53
increased bone mineral content 2 | 108
increased circulating alkaline... 2 | 122
increased circulating amylase ... 2 | 25
increased circulating triglyce... 2 | 42
increased grip strength 2 | 41
increased prepulse inhibition 2 | 32
increased total body fat amoun... 2 | 134
limb grasping 2 | 41
small superior vagus ganglion 2 | 74
thrombocytopenia 2 | 56
abnormal behavior 1 | 298
abnormal coat-hair pigmentatio... 1 | 64
abnormal eye morphology 1 | 68
abnormal forebrain development 1 | 20
abnormal hair growth 1 | 10
abnormal hindbrain development 1 | 16
abnormal joint morphology 1 | 23
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal locomotor behavior 1 | 24
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal optic disc morphology 1 | 10
abnormal pericardium morpholog... 1 | 26
abnormal retinal blood vessel ... 1 | 26
abnormal skin morphology 1 | 50
abnormal sleep behavior 1 | 70
abnormal spinal cord morpholog... 1 | 9
abnormal testis morphology 1 | 43
abnormal vibrissa morphology 1 | 25
abnormal vocalization 1 | 21
brachydactyly 1 | 19
decreased IgG1 level 1 | 8
decreased T cell number 1 | 15
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased circulating alkaline... 1 | 46
decreased circulating amylase ... 1 | 28
decreased circulating aspartat... 1 | 34
decreased circulating fructosa... 1 | 30
decreased circulating insulin ... 1 | 76
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased eosinophil cell numb... 1 | 24
decreased fasted circulating g... 1 | 65
decreased lactate dehydrogenas... 1 | 16
decreased mean corpuscular hem... 1 | 50
decreased red blood cell distr... 1 | 41
decreased respiratory quotient 1 | 16
decreased vertical activity 1 | 208
enlarged kidney 1 | 14
hydroencephaly 1 | 14
hyperactivity 1 | 148
impaired glucose tolerance 1 | 75
increased T cell number 1 | 6
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased circulating magnesiu... 1 | 10
increased circulating total pr... 1 | 28
increased eosinophil cell numb... 1 | 11
increased fasted circulating g... 1 | 76
increased heart weight 1 | 62
increased mean corpuscular vol... 1 | 92
increased mean platelet volume 1 | 45
increased startle reflex 1 | 112
long tibia 1 | 25
male infertility 1 | 123
prenatal lethality prior to he... 1 | 87
prolonged PR interval 1 | 15
small adrenal glands 1 | 16
small testis 1 | 58
syndactyly 1 | 23
thin ventricular wall 1 | 24
tremors 1 | 39
vertebral fusion 1 | 23

Disease

Carcinoma 118 | 11,493
psoriasis 101 | 6,694
ovarian cancer 97 | 8,520
Cancer 91 | 2,499
diabetes mellitus 84 | 1,728
osteosarcoma 78 | 7,950
Ankylosing spondylitis 74 | 140
Behcet's disease 70 | 89
Hypersensitivity reaction type II disease 65 | 253
Juvenile rheumatoid arthritis 61 | 111
Arthritis 59 | 290
Uveitis 58 | 103
glioblastoma 58 | 5,792
Acquired immunodeficiency syndrome 57 | 197
Rheumatoid arthritis 57 | 1,191
Herpes zoster 56 | 68
Psoriatic arthritis 53 | 86
Stevens-Johnson syndrome 51 | 92
lung cancer 51 | 4,740
Human immunodeficiency virus infectious disease 50 | 138
dermatomyositis 50 | 966
medulloblastoma, large-cell 49 | 6,241
tuberculosis 47 | 2,010
Astrocytoma, Pilocytic 39 | 3,081
Synovitis 36 | 78
lung carcinoma 36 | 2,843
Behcet's syndrome 35 | 50
Congenital adrenal hyperplasia 35 | 73
Dermatitis 35 | 157
Nephritis 35 | 51
Retinal vasculitis 35 | 36
Spondyloarthropathy, Susceptibility To, 1 35 | 35
Takayasu's arteritis 35 | 53
atypical teratoid / rhabdoid tumor 35 | 5,112
drug-induced hepatitis 35 | 44
ependymoma 35 | 4,679
Breast cancer 34 | 3,578
Multiple Sclerosis 33 | 540
pancreatic ductal adenocarcinoma liver metastasis 32 | 1,962
adult high grade glioma 30 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 29 | 3,291
invasive ductal carcinoma 29 | 2,951
Multiple myeloma 28 | 1,332
juvenile dermatomyositis 28 | 1,187
Liver disease 27 | 237
interstitial cystitis 27 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 27 | 2,989
subependymal giant cell astrocytoma 27 | 2,287
Autosomal recessive predisposition 26 | 1,442
Hepatitis B 26 | 108
astrocytoma 26 | 1,146
Anemia 25 | 365
non-small cell lung cancer 25 | 2,890
Kidney disease 24 | 430
Leprosy 24 | 73
Hemochromatosis 23 | 54
active Crohn's disease 23 | 922
oligodendroglioma 22 | 2,850
Birdshot chorioretinopathy 21 | 23
Primary immunodeficiency disease 21 | 54
Skin disease 21 | 66
group 3 medulloblastoma 21 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 21 | 2,955
pituitary cancer 21 | 1,972
breast carcinoma 20 | 1,638
astrocytic glioma 19 | 2,597
malignant mesothelioma 19 | 3,232
pancreatic cancer 19 | 2,398
esophageal adenocarcinoma 18 | 737
active ulcerative colitis 17 | 764
group 4 medulloblastoma 16 | 1,855
lung adenocarcinoma 16 | 2,716
Duchenne muscular dystrophy 15 | 601
Epilepsy 15 | 792
Intellectual disability 15 | 1,016
Pick disease 15 | 1,894
Pre-Eclampsia 15 | 68
Schizophrenia 15 | 1,160
primary Sjogren syndrome 15 | 735
primitive neuroectodermal tumor 15 | 3,035
Human immunodeficiency virus type 1, susceptibility to 14 | 26
Neurodegenerative disease 14 | 414
Psoriasis susceptibility 1 14 | 14
adrenocortical carcinoma 14 | 1,428
non primary Sjogren syndrome sicca 13 | 891
Atopic dermatitis 12 | 952
Down syndrome 12 | 499
acute quadriplegic myopathy 12 | 1,158
cutaneous lupus erythematosus 12 | 1,057
cystic fibrosis 12 | 1,696
Dull intelligence 11 | 645
Low intelligence 11 | 645
Mental Retardation 11 | 645
Mental deficiency 11 | 645
Obesity 11 | 678
Poor school performance 11 | 645
Waldenstrons macroglobulinemia 11 | 765
ductal carcinoma in situ 11 | 1,745
Short stature 10 | 531
aldosterone-producing adenoma 10 | 665

Tissue

Endocrine System 152 | 18,159
Digestive Tract 151 | 17,369
Liver and Pancreas 151 | 16,750
Blood and immune system 149 | 16,909
Female tissues 149 | 17,400
Respiratory system 149 | 16,393
Skin and soft tissues 148 | 17,230
Urinary Tract 148 | 16,678
Male tissues 146 | 17,142
Nervous System 146 | 16,725
Cardiovascular System 145 | 15,192

Target Family

Non-IDG 154 | 12,091
Enzyme 52 | 4,145
Transporter 10 | 473
Transcription Factor 7 | 1,400
Kinase 2 | 634
Ion Channel 1 | 344

Compartment GO Term

Integral component of endoplas... 226 | 226
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,783 | 8,783
Membrane 8,530 | 8,530
Nucleus 7,563 | 7,563
Cytosol 6,686 | 6,686
Membrane part 6,553 | 6,553
Plasma membrane 5,829 | 5,829
Macromolecular complex 5,476 | 5,476
Intrinsic component of membran... 5,457 | 5,457
Cell periphery 5,381 | 5,381
Integral component of membrane 5,330 | 5,330
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,974 | 3,974
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,673 | 3,673
Organelle membrane 2,846 | 2,846
Extracellular region 2,731 | 2,731
Plasma membrane part 2,593 | 2,593
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,216 | 2,216
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,638 | 1,638
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 968 | 968
Supramolecular complex 967 | 967
Cell junction 960 | 960
Supramolecular fiber 960 | 960
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 931 | 931
Nucleolus 927 | 927
Chromosomal part 889 | 889
GO:0098796 883 | 883
Ribonucleoprotein complex 864 | 864
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 849 | 849
Transferase complex 849 | 849
Cell surface 841 | 841
Plasma membrane region 841 | 841
Vesicle membrane 800 | 800
Cytoplasmic vesicle membrane 794 | 794
Polymeric cytoskeletal fiber 765 | 765
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 713 | 713
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

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