Development Level

Tbio 171 | 10,625
Tchem 19 | 1,890
Tdark 17 | 7,003
Tclin 1 | 602

IMPC Term

preweaning lethality, complete... 10 | 633
decreased lean body mass 4 | 195
abnormal bone structure 3 | 131
decreased bone mineral content 3 | 157
decreased circulating alanine ... 3 | 53
decreased circulating insulin ... 3 | 75
embryonic lethality prior to t... 3 | 187
increased total body fat amoun... 3 | 57
abnormal bone mineralization 2 | 55
abnormal gait 2 | 51
abnormal retina morphology 2 | 100
abnormal retinal pigmentation 2 | 61
decreased T cell number 2 | 31
decreased mean corpuscular vol... 2 | 50
decreased startle reflex 2 | 48
decreased total body fat amoun... 2 | 186
embryonic lethality prior to o... 2 | 148
enlarged heart 2 | 111
hyperactivity 2 | 108
increased circulating alkaline... 2 | 119
increased grip strength 2 | 83
increased lean body mass 2 | 107
increased or absent threshold ... 2 | 128
limb grasping 2 | 35
preweaning lethality, incomple... 2 | 260
thrombocytopenia 2 | 46
abnormal behavior 1 | 226
abnormal coat/hair pigmentatio... 1 | 54
abnormal eye morphology 1 | 38
abnormal eye size 1 | 11
abnormal hair growth 1 | 8
abnormal retinal blood vessel ... 1 | 18
abnormal seminal vesicle morph... 1 | 47
abnormal vocalization 1 | 21
absent vibrissae 1 | 14
convulsive seizures 1 | 11
decreased B cell number 1 | 30
decreased CD8-positive, alpha-... 1 | 26
decreased IgG1 level 1 | 4
decreased NK T cell number 1 | 28
decreased NK cell number 1 | 16
decreased blood urea nitrogen ... 1 | 31
decreased body weight 1 | 174
decreased bone mineral density 1 | 126
decreased circulating alkaline... 1 | 41
decreased circulating aspartat... 1 | 27
decreased circulating choleste... 1 | 85
decreased circulating fructosa... 1 | 31
decreased circulating glucose ... 1 | 121
decreased circulating serum al... 1 | 79
decreased circulating total pr... 1 | 41
decreased circulating triglyce... 1 | 83
decreased granulocyte number 1 | 8
decreased heart weight 1 | 44
decreased lactate dehydrogenas... 1 | 14
decreased mean corpuscular hem... 1 | 34
hydroencephaly 1 | 6
increased KLRG1-positive NK ce... 1 | 9
increased T cell number 1 | 15
increased bone mineral content 1 | 92
increased circulating HDL chol... 1 | 63
increased circulating choleste... 1 | 53
increased circulating magnesiu... 1 | 10
increased effector memory CD8-... 1 | 14
increased mean corpuscular vol... 1 | 91
increased mean platelet volume 1 | 19
male infertility 1 | 62
microphthalmia 1 | 15
mydriasis 1 | 9
persistence of hyaloid vascula... 1 | 22
prenatal lethality prior to he... 1 | 64
small adrenal glands 1 | 15
thin ventricular wall 1 | 5
tremors 1 | 34
vertebral fusion 1 | 23

Disease

psoriasis 94 | 6,685
Cancer 88 | 2,346
ovarian cancer 88 | 8,484
diabetes mellitus 81 | 1,663
Ankylosing spondylitis 72 | 138
osteosarcoma 65 | 7,933
Hypersensitivity reaction type II disease 62 | 235
Juvenile rheumatoid arthritis 60 | 104
Acquired immunodeficiency syndrome 56 | 164
Arthritis 56 | 248
Behcet's disease 56 | 74
Uveitis 56 | 103
Rheumatoid Arthritis 53 | 1,160
glioblastoma 53 | 5,572
Psoriatic arthritis 52 | 83
medulloblastoma, large-cell 46 | 6,234
lung cancer 42 | 4,466
Stevens-Johnson syndrome 38 | 78
Congenital adrenal hyperplasia 35 | 74
Retinal vasculitis 35 | 36
Takayasu's arteritis 35 | 52
pilocytic astrocytoma 35 | 3,086
Multiple Sclerosis 33 | 498
Breast cancer 32 | 3,094
atypical teratoid / rhabdoid tumor 32 | 4,369
lung carcinoma 30 | 2,844
astrocytoma 28 | 1,493
pancreatic ductal adenocarcinoma liver metastasis 28 | 1,795
Multiple myeloma 27 | 1,327
Liver disease 25 | 219
intraductal papillary-mucinous neoplasm (IPMN) 25 | 3,289
invasive ductal carcinoma 25 | 2,950
juvenile dermatomyositis 25 | 1,189
Leprosy 24 | 77
Hepatitis B 23 | 103
Kidney disease 23 | 396
intraductal papillary-mucinous carcinoma (IPMC) 23 | 2,988
Hemochromatosis 22 | 55
interstitial cystitis 22 | 2,299
non-small cell lung cancer 22 | 2,798
Anemia 21 | 252
Primary immunodeficiency disease 21 | 52
Skin disease 21 | 65
oligodendroglioma 21 | 2,849
subependymal giant cell astrocytoma 21 | 2,287
active Crohn's disease 20 | 918
ependymoma 20 | 2,514
tuberculosis 20 | 1,557
dermatomyositis 19 | 933
intraductal papillary-mucinous adenoma (IPMA) 18 | 2,956
malignant mesothelioma 17 | 3,162
pancreatic cancer 17 | 2,300
pediatric high grade glioma 17 | 2,712
pituitary cancer 17 | 1,972
breast carcinoma 16 | 1,614
group 4 medulloblastoma 16 | 1,875
posterior fossa group A ependymoma 16 | 1,511
Pick disease 15 | 1,893
adult high grade glioma 15 | 2,148
esophageal adenocarcinoma 15 | 737
lung adenocarcinoma 15 | 2,713
pre-eclampsia 15 | 67
primitive neuroectodermal tumor 15 | 3,031
Human immunodeficiency virus infectious disease 14 | 92
Neurodegenerative disease 14 | 383
astrocytic glioma 14 | 2,241
primary Sjogren syndrome 14 | 789
ulcerative colitis 13 | 2,087
Duchenne muscular dystrophy 12 | 602
Atopic dermatitis 11 | 944
acute quadriplegic myopathy 11 | 1,157
group 3 medulloblastoma 11 | 2,254
adrenocortical carcinoma 10 | 1,427
cystic fibrosis 10 | 1,665
Down syndrome 9 | 548
Waldenstrons macroglobulinemia 9 | 765
active ulcerative colitis 9 | 477
cutaneous lupus erythematosus 9 | 1,056
ductal carcinoma in situ 9 | 1,745
progressive supranuclear palsy 9 | 674
Obesity 8 | 616
aldosterone-producing adenoma 8 | 664
autosomal dominant Emery-Dreifuss muscular dystrophy 8 | 499
hereditary spastic paraplegia 8 | 313
medulloblastoma 8 | 1,524
non primary Sjogren syndrome sicca 8 | 840
primary pancreatic ductal adenocarcinoma 8 | 1,271
Intellectual disability 7 | 573
acute myeloid leukemia 7 | 780
colon cancer 7 | 1,475
sarcoidosis 7 | 358
spina bifida 7 | 1,064
tuberculosis and treatment for 6 months 7 | 686
Alzheimer's disease 6 | 644
Asthma 6 | 349
Carcinoma 6 | 2,147
limb girdle muscular dystrophy 2I 6 | 56
posterior fossa group B ependymoma 6 | 1,530
Becker muscular dystrophy 5 | 187
sonic hedgehog group medulloblastoma 5 | 1,482

Tissue

Cardiovascular System 145 | 17,958
Digestive Tract 144 | 18,473
Endocrine System 144 | 18,512
Female tissues 144 | 18,647
Liver and Pancreas 144 | 18,136
Nervous System 144 | 18,561
Urinary Tract 144 | 18,444
Blood and immune system 143 | 17,995
Male tissues 143 | 17,969
Respiratory system 143 | 17,484
Skin and soft tissues 137 | 18,115

Target Family

Non-IDG 145 | 11,971
Enzyme 44 | 4,146
Transporter 10 | 473
Transcription Factor 6 | 1,400
Kinase 2 | 634
Ion Channel 1 | 341

Compartment GO Term

Integral component of endoplas... 208 | 208
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,170 | 8,170
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,830 | 7,830
Nucleus 6,897 | 6,897
Membrane part 6,469 | 6,469
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,172 | 5,172
Cell periphery 5,145 | 5,145
Plasma membrane 5,059 | 5,059
Extracellular region 4,606 | 4,606
Protein complex 4,438 | 4,438
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Cytosol 3,352 | 3,352
Nucleoplasm 2,938 | 2,938
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,563 | 2,563
Cytoskeleton 2,045 | 2,045
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Endoplasmic reticulum 1,663 | 1,663
Cytoskeletal part 1,567 | 1,567
Mitochondrion 1,530 | 1,530
Cell projection 1,426 | 1,426
Golgi apparatus 1,402 | 1,402
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,233 | 1,233
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Chromosome 999 | 999
Mitochondrial part 989 | 989
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 780 | 780
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 738 | 738
Plasma membrane protein comple... 720 | 720
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Microtubule organizing center 617 | 617
Synapse 594 | 594
Lysosome 571 | 571
Lytic vacuole 571 | 571
Vesicle membrane 559 | 559
cell-cell junction 557 | 557
Cytoplasmic vesicle membrane 552 | 552

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