Development Level

Tbio 74 | 10,625
Tchem 21 | 1,890
Tdark 12 | 7,003
Tclin 4 | 602

Collection

Kinase: IDG Consortium (Targets) 1 | 125

IMPC Phenotype

preweaning lethality, complete... 8 | 633
decreased body weight 4 | 174
embryonic lethality prior to o... 3 | 148
abnormal behavior 2 | 226
abnormal lens morphology 2 | 73
decreased T cell number 2 | 31
decreased bone mineral density 2 | 126
decreased circulating glucose ... 2 | 121
decreased leukocyte cell numbe... 2 | 54
embryonic lethality prior to t... 2 | 187
increased mean corpuscular vol... 2 | 91
abnormal bone mineralization 1 | 55
abnormal coping response 1 | 12
abnormal cornea morphology 1 | 24
abnormal gait 1 | 51
abnormal hair texture 1 | 4
abnormal iris morphology 1 | 12
abnormal maxilla morphology 1 | 16
abnormal placement of pupils 1 | 4
abnormal retinal blood vessel ... 1 | 18
abnormal snout morphology 1 | 18
abnormal tooth morphology 1 | 24
abnormal vertebral arch morpho... 1 | 9
decreased B cell number 1 | 30
decreased CD4-positive, alpha ... 1 | 19
decreased CD8-positive, alpha-... 1 | 26
decreased Ly6C high monocyte n... 1 | 18
decreased Ly6C low monocyte nu... 1 | 23
decreased NK cell number 1 | 16
decreased alpha-beta T cell nu... 1 | 12
decreased body length 1 | 108
decreased bone mineral content 1 | 157
decreased circulating alkaline... 1 | 41
decreased circulating insulin ... 1 | 75
decreased circulating potassiu... 1 | 17
decreased eosinophil cell numb... 1 | 41
decreased lactate dehydrogenas... 1 | 14
decreased lumbar vertebrae num... 1 | 62
decreased mature B cell number 1 | 25
decreased respiratory quotient 1 | 12
decreased rib number 1 | 59
decreased total body fat amoun... 1 | 186
decreased total retina thickne... 1 | 20
hyperactivity 1 | 108
increased CD4-positive, CD25-p... 1 | 18
increased Ly6C low monocyte nu... 1 | 8
increased bone mineral density 1 | 52
increased circulating choleste... 1 | 53
increased circulating creatine... 1 | 2
increased circulating magnesiu... 1 | 10
increased effector memory CD4-... 1 | 15
increased exploration in new e... 1 | 56
increased granulocyte number 1 | 8
increased lactate dehydrogenas... 1 | 3
increased monocyte cell number 1 | 27
increased or absent threshold ... 1 | 128
increased plasma cell number 1 | 5
increased respiratory quotient 1 | 12
increased sacral vertebrae num... 1 | 62
irregularly shaped pupil 1 | 7
narrow eye opening 1 | 15
prenatal lethality prior to he... 1 | 64
preweaning lethality, incomple... 1 | 260
short tibia 1 | 82
tremors 1 | 34

Disease

ovarian cancer 74 | 8,491
osteosarcoma 62 | 7,933
psoriasis 38 | 6,685
Cancer 34 | 2,346
lung cancer 30 | 4,473
medulloblastoma, large-cell 29 | 6,234
malignant mesothelioma 26 | 3,163
Breast cancer 25 | 3,098
glioblastoma 25 | 5,572
atypical teratoid / rhabdoid tumor 23 | 4,369
Multiple myeloma 21 | 1,327
Carcinoma 20 | 2,147
primitive neuroectodermal tumor 20 | 3,031
group 3 medulloblastoma 18 | 2,254
intraductal papillary-mucinous neoplasm (IPMN) 18 | 3,289
group 4 medulloblastoma 17 | 1,875
oligodendroglioma 16 | 2,849
subependymal giant cell astrocytoma 16 | 2,287
Intellectual disability 15 | 573
intraductal papillary-mucinous carcinoma (IPMC) 15 | 2,988
lung adenocarcinoma 15 | 2,714
astrocytoma 14 | 1,493
dermatomyositis 14 | 966
intraductal papillary-mucinous adenoma (IPMA) 14 | 2,956
invasive ductal carcinoma 14 | 2,950
Pick disease 13 | 1,893
ependymoma 13 | 2,514
Rheumatoid Arthritis 12 | 1,170
non-small cell lung cancer 12 | 2,798
pancreatic cancer 12 | 2,300
pediatric high grade glioma 12 | 2,712
Waldenstrons macroglobulinemia 11 | 764
diabetes mellitus 11 | 1,663
pancreatic ductal adenocarcinoma liver metastasis 11 | 1,795
tuberculosis 11 | 1,563
acute myeloid leukemia 10 | 785
spina bifida 10 | 1,064
Spinocerebellar ataxia type 7 9 | 13
colon cancer 9 | 1,475
ductal carcinoma in situ 9 | 1,745
juvenile dermatomyositis 9 | 1,189
lung carcinoma 9 | 2,844
pilocytic astrocytoma 9 | 3,086
Adenoid Cystic Carcinoma 8 | 99
astrocytic glioma 8 | 2,241
Neurodegenerative disease 7 | 383
medulloblastoma 7 | 1,524
Alzheimer's disease 6 | 644
adrenocortical carcinoma 6 | 1,427
adult high grade glioma 6 | 2,148
pituitary cancer 6 | 1,972
primary pancreatic ductal adenocarcinoma 6 | 1,271
sonic hedgehog group medulloblastoma 6 | 1,482
Endometriosis 5 | 535
Kidney cancer 5 | 121
Parkinson's disease 5 | 364
Schizophrenia 5 | 503
acute quadriplegic myopathy 5 | 1,157
breast carcinoma 5 | 1,614
hepatocellular carcinoma 5 | 550
posterior fossa group A ependymoma 5 | 1,511
progressive supranuclear palsy 5 | 674
Bladder Neoplasm 4 | 109
Cockayne syndrome 4 | 54
Epidermodysplasia verruciformis 4 | 21
Gaucher disease type 1 4 | 171
Huntington's disease 4 | 72
Kidney disease 4 | 397
Melanoma 4 | 261
Peripheral T-cell lymphoma 4 | 24
Primary cutaneous T-cell lymphoma 4 | 29
Prostatic Neoplasms 4 | 471
Small cell carcinoma of lung 4 | 45
active Crohn's disease 4 | 918
atypical teratoid/rhabdoid tumor 4 | 1,095
cystic fibrosis 4 | 1,670
glioblastoma multiforme 4 | 347
pancreatic carcinoma 4 | 567
posterior fossa group B ependymoma 4 | 1,530
tuberculosis and treatment for 6 months 4 | 686
Asthma 3 | 349
Carcinoma, Transitional Cell 3 | 31
Cleft palate 3 | 125
Dystonia 3 | 77
IGA Glomerulonephritis 3 | 454
Leishmaniasis 3 | 49
Lung Neoplasms 3 | 171
Lupus erythematosus 3 | 80
Mammary Neoplasms 3 | 410
Obesity 3 | 616
Polycystic Ovary Syndrome 3 | 334
Sezary Syndrome 3 | 26
Squamous cell carcinoma 3 | 96
Squamous cell carcinoma of esophagus 3 | 82
Vascular disease 3 | 281
active ulcerative colitis 3 | 477
aldosterone-producing adenoma 3 | 664
gastric cancer 3 | 436
non-small cell lung carcinoma 3 | 413
ulcerative colitis 3 | 2,087

Tissue

Cardiovascular System 111 | 17,957
Female tissues 111 | 18,646
Nervous System 111 | 18,560
Blood and immune system 110 | 17,994
Digestive Tract 110 | 18,472
Endocrine System 110 | 18,511
Liver and Pancreas 110 | 18,135
Male tissues 110 | 17,968
Respiratory system 109 | 17,483
Skin and soft tissues 109 | 18,114
Urinary Tract 109 | 18,443

Target Family

Non-IDG 53 | 11,969
Epigenetic 32 | 242
Enzyme 14 | 4,146
Kinase 8 | 634
Transcription Factor 3 | 1,400
TF/Epigenetic 1 | 38

Compartment GO Term

Histone acetyltransferase comp... 111 | 111
cellular_component 18,237 | 18,237
Cell 15,806 | 15,806
Cell part 15,806 | 15,806
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,648 | 12,648
membrane-bounded organelle 11,793 | 11,793
Intracellular organelle 11,617 | 11,617
Intracellular membrane-bounded... 10,618 | 10,618
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,169 | 8,169
Intracellular organelle part 8,011 | 8,011
Cytoplasmic part 7,830 | 7,830
Nucleus 7,577 | 7,577
Membrane part 6,470 | 6,470
Cytosol 6,035 | 6,035
Plasma membrane 5,673 | 5,673
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,171 | 5,171
Cell periphery 5,146 | 5,146
Nucleoplasm 4,929 | 4,929
Extracellular region 4,606 | 4,606
Protein complex 4,439 | 4,439
Intracellular organelle lumen 4,330 | 4,330
Organelle lumen 4,330 | 4,330
membrane-enclosed lumen 4,330 | 4,330
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,839 | 3,839
non-membrane-bounded organelle 3,838 | 3,838
Nuclear part 3,807 | 3,807
Endomembrane system 3,720 | 3,720
Vesicle 3,666 | 3,666
membrane-bounded vesicle 3,494 | 3,494
Nuclear lumen 3,464 | 3,464
Extracellular organelle 2,849 | 2,849
Extracellular vesicle 2,848 | 2,848
Extracellular exosome 2,828 | 2,828
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,564 | 2,564
Cytoskeleton 2,046 | 2,046
Golgi apparatus 1,946 | 1,946
Endoplasmic reticulum 1,872 | 1,872
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Vesicles 1,625 | 1,625
Cytoskeletal part 1,568 | 1,568
Mitochondrion 1,531 | 1,531
Cell projection 1,426 | 1,426
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,305 | 1,305
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,234 | 1,234
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Mitochondria 1,003 | 1,003
Chromosome 999 | 999
Mitochondrial part 989 | 989
Nucleoli 952 | 952
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 793 | 793
Intracellular ribonucleoprotei... 789 | 789
Nucleoplasm part 781 | 781
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 739 | 739
Plasma membrane protein comple... 721 | 721
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Microtubule organizing center 680 | 680
Centrosome 676 | 676
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Synapse 594 | 594
Lytic vacuole 571 | 571

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
YEATS domain-containing protein 2 YEATS2 Tdark Non-IDG -0.35735 2.19 56
Histone deacetylase 8 HDAC8 Tclin Epigenetic -2.36549 229.4 425
PHD finger protein 20 PHF20 Tbio Epigenetic -2.83402 660.7 91
Inhibitor of growth protein 5 ING5 Tbio Epigenetic -1.23809 15.9 138
Histone acetyltransferase KAT6B KAT6B Tchem Epigenetic -2.27196 178.8 53
Mitogen-activated protein kinase kinase kinase 7 MAP3K7 Tchem Kinase -1.41371 28.0 678
Inhibitor of growth protein 4 ING4 Tbio Epigenetic -1.73436 63.9 143
STAGA complex 65 subunit gamma SUPT7L Tdark Non-IDG -0.44863 2.75 64
DNA polymerase epsilon subunit 3 POLE3 Tbio Enzyme -0.73319 5.86 173
E1A-binding protein p400 EP400 Tbio Non-IDG -1.45388 26.7 53