Development Level

Tbio 76 | 11,445
Tchem 22 | 1,598
Tdark 6 | 6,588
Tclin 4 | 613

Collection

Kinase: IDG Consortium (Target... 1 | 125
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 15 | 979
decreased body weight 6 | 161
preweaning lethality, incomple... 5 | 499
abnormal lens morphology 4 | 81
embryonic lethality prior to o... 4 | 239
abnormal behavior 3 | 298
abnormal cornea morphology 3 | 31
cataract 3 | 92
decreased circulating glucose ... 3 | 126
decreased lean body mass 3 | 135
embryonic lethality prior to t... 3 | 278
increased circulating HDL chol... 3 | 80
increased lean body mass 3 | 172
abnormal eye morphology 2 | 68
abnormal retinal blood vessel ... 2 | 26
corneal opacity 2 | 32
decreased body length 2 | 101
decreased bone mineral content 2 | 151
decreased bone mineral density 2 | 126
increased circulating alkaline... 2 | 122
increased circulating choleste... 2 | 66
increased mean corpuscular vol... 2 | 92
increased total body fat amoun... 2 | 134
abnormal bone mineralization 1 | 38
abnormal coat-hair pigmentatio... 1 | 64
abnormal cranium morphology 1 | 36
abnormal embryo size 1 | 220
abnormal eye pigmentation 1 | 3
abnormal eye size 1 | 7
abnormal eyelid aperture 1 | 2
abnormal gait 1 | 69
abnormal hair texture 1 | 4
abnormal heart left ventricle ... 1 | 16
abnormal heart morphology 1 | 162
abnormal iris morphology 1 | 13
abnormal maxilla morphology 1 | 17
abnormal retinal outer nuclear... 1 | 3
abnormal retinal vasculature m... 1 | 27
abnormal tooth morphology 1 | 24
abnormal vertebral arch morpho... 1 | 9
cardiovascular system phenotyp... 1 | 36
corneal vascularization 1 | 6
decreased IgG2b level 1 | 4
decreased T cell number 1 | 15
decreased cardiac stroke volum... 1 | 6
decreased circulating alkaline... 1 | 46
decreased circulating insulin ... 1 | 76
decreased circulating potassiu... 1 | 20
decreased grip strength 1 | 116
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lactate dehydrogenas... 1 | 16
decreased leukocyte cell numbe... 1 | 73
decreased mean platelet volume 1 | 25
decreased startle reflex 1 | 75
decreased total body fat amoun... 1 | 207
decreased total retina thickne... 1 | 17
decreased vertical activity 1 | 208
enlarged heart 1 | 210
eyelids fail to open 1 | 3
female infertility 1 | 60
impaired glucose tolerance 1 | 75
increased circulating creatine... 1 | 5
increased circulating magnesiu... 1 | 10
increased circulating potassiu... 1 | 29
increased circulating sodium l... 1 | 71
increased erythrocyte cell num... 1 | 39
increased hemoglobin content 1 | 45
increased lactate dehydrogenas... 1 | 3
increased monocyte cell number 1 | 63
increased respiratory quotient 1 | 2
increased startle reflex 1 | 112
irregularly shaped pupil 1 | 7
male infertility 1 | 123
mammalian phenotype 1 | 17
mydriasis 1 | 6
prenatal lethality prior to he... 1 | 87
short tibia 1 | 97
thrombocytopenia 1 | 56
tremors 1 | 39

Disease

Carcinoma 76 | 11,493
ovarian cancer 71 | 8,520
osteosarcoma 61 | 7,950
psoriasis 36 | 6,694
Cancer 35 | 2,499
lung cancer 32 | 4,740
Breast cancer 31 | 3,578
group 3 medulloblastoma 30 | 4,104
medulloblastoma, large-cell 29 | 6,241
glioblastoma 26 | 5,792
malignant mesothelioma 26 | 3,232
atypical teratoid / rhabdoid tumor 24 | 5,112
Kidney cancer 22 | 2,613
Multiple myeloma 21 | 1,332
Intellectual disability 18 | 1,016
intraductal papillary-mucinous neoplasm (IPMN) 18 | 3,291
primitive neuroectodermal tumor 18 | 3,035
ependymoma 17 | 4,679
subependymal giant cell astrocytoma 16 | 2,287
oligodendroglioma 15 | 2,850
intraductal papillary-mucinous carcinoma (IPMC) 14 | 2,989
invasive ductal carcinoma 14 | 2,951
lung adenocarcinoma 14 | 2,716
pancreatic cancer 14 | 2,398
Rheumatoid arthritis 13 | 1,191
Schizophrenia 13 | 1,160
astrocytoma 13 | 1,146
dermatomyositis 13 | 966
intraductal papillary-mucinous adenoma (IPMA) 13 | 2,955
Pick disease 12 | 1,894
tuberculosis 12 | 2,010
adult high grade glioma 11 | 3,801
diabetes mellitus 11 | 1,728
group 4 medulloblastoma 11 | 1,855
non-small cell lung cancer 11 | 2,890
pancreatic ductal adenocarcinoma liver metastasis 11 | 1,962
Waldenstrons macroglobulinemia 10 | 765
acute myeloid leukemia 10 | 783
colon cancer 10 | 1,478
Muscle hypotonia 9 | 571
Small head 9 | 374
Spinocerebellar ataxia type 7 9 | 13
ductal carcinoma in situ 9 | 1,745
juvenile dermatomyositis 9 | 1,187
lung carcinoma 9 | 2,843
spina bifida 9 | 1,074
Adenoid Cystic Carcinoma 8 | 99
Astrocytoma, Pilocytic 8 | 3,081
Autosomal recessive predisposition 8 | 1,442
Carcinoma, Adenoid Cystic 8 | 99
Dull intelligence 8 | 645
Epilepsy 8 | 792
Low intelligence 8 | 645
Mental Retardation 8 | 645
Mental deficiency 8 | 645
Neurodegenerative disease 8 | 414
Poor school performance 8 | 645
Seizures 8 | 596
astrocytic glioma 8 | 2,597
Acquired scoliosis 7 | 281
Curvature of spine 7 | 282
Liver cancer 7 | 604
Short stature 7 | 531
pediatric high grade glioma 7 | 1,064
Alzheimer's disease 6 | 658
Cognitive delay 6 | 608
Cryptorchidism 6 | 296
Endometrial cancer 6 | 311
Global developmental delay 6 | 608
Mental and motor retardation 6 | 608
adrenocortical carcinoma 6 | 1,428
breast carcinoma 6 | 1,638
Atrial Septal Defects 5 | 85
Bipolar Disorder 5 | 666
Blepharoptosis 5 | 231
Breast Neoplasms 5 | 445
Carcinoma, Squamous Cell 5 | 110
Endometriosis 5 | 540
Feeding difficulties in infancy 5 | 175
Immune system cancer 5 | 140
Low set ears 5 | 181
Mood Disorders 5 | 184
Parkinson's disease 5 | 392
Squamous cell carcinoma 5 | 129
Strabismus 5 | 270
acute quadriplegic myopathy 5 | 1,158
hepatocellular carcinoma 5 | 547
pituitary cancer 5 | 1,972
primary pancreatic ductal adenocarcinoma 5 | 1,109
progressive supranuclear palsy 5 | 676
Broad flat nasal bridge 4 | 236
Byzanthine arch palate 4 | 194
Failure to gain weight 4 | 365
Kidney disease 4 | 430
Nasal bridge wide 4 | 236
Pediatric failure to thrive 4 | 365
Prostatic Neoplasms 4 | 495
Ventricular Septal Defects 4 | 119
cystic fibrosis 4 | 1,696
medulloblastoma 4 | 720

Tissue

Blood and immune system 107 | 16,909
Digestive Tract 107 | 17,369
Female tissues 107 | 17,400
Liver and Pancreas 107 | 16,750
Skin and soft tissues 107 | 17,230
Urinary Tract 107 | 16,678
Endocrine System 106 | 18,159
Male tissues 106 | 17,142
Nervous System 106 | 16,725
Respiratory system 105 | 16,393
Cardiovascular System 104 | 15,192

Target Family

Non-IDG 52 | 12,091
Epigenetic 32 | 242
Enzyme 12 | 4,145
Kinase 8 | 634
Transcription Factor 3 | 1,400
TF/Epigenetic 1 | 38

Compartment GO Term

Histone acetyltransferase comp... 108 | 108
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,109 | 14,109
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,975 | 8,975
Intracellular organelle part 8,783 | 8,783
Membrane 8,531 | 8,531
Nucleus 7,562 | 7,562
Cytosol 6,686 | 6,686
Membrane part 6,554 | 6,554
Plasma membrane 5,830 | 5,830
Macromolecular complex 5,475 | 5,475
Intrinsic component of membran... 5,458 | 5,458
Cell periphery 5,382 | 5,382
Integral component of membrane 5,331 | 5,331
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,975 | 3,975
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,674 | 3,674
Organelle membrane 2,846 | 2,846
Extracellular region 2,732 | 2,732
Plasma membrane part 2,594 | 2,594
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,217 | 2,217
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,637 | 1,637
Extracellular region part 1,628 | 1,628
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 967 | 967
Supramolecular complex 966 | 966
Cell junction 960 | 960
Supramolecular fiber 959 | 959
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 930 | 930
Nucleolus 926 | 926
Chromosomal part 889 | 889
GO:0098796 884 | 884
Ribonucleoprotein complex 865 | 865
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 850 | 850
Transferase complex 849 | 849
Cell surface 842 | 842
Plasma membrane region 841 | 841
Vesicle membrane 801 | 801
Cytoplasmic vesicle membrane 795 | 795
Polymeric cytoskeletal fiber 764 | 764
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 714 | 714
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 663 | 663
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Probable global transcription activator SNF2L1 SMARCA1 Tbio Non-IDG -2.20560 145.6 116
Bromodomain and PHD finger-containing protein 3 BRPF3 Tchem Epigenetic -0.46982 2.70 64
Inhibitor of growth protein 3 ING3 Tbio Epigenetic -2.33680 199.4 175
Serine/threonine-protein kinase 24 STK24 Tchem Kinase -2.24110 132.9 243
Adenylate kinase isoenzyme 6 AK6 Tbio Kinase -2.18859 223.1 91
Transcription initiation factor TFIID subunit 9B TAF9B Tbio Non-IDG -1.38372 23.5 105
Histone deacetylase 8 HDAC8 Tclin Epigenetic -2.41838 263.5 487
Inhibitor of growth protein 4 ING4 Tbio Epigenetic -1.76632 69.3 193
STAGA complex 65 subunit gamma SUPT7L Tdark Non-IDG -0.46246 2.75 76
YEATS domain-containing protein 2 YEATS2 Tbio Non-IDG -0.51547 3.19 61