Development Level

Tbio 537 | 10,625
Tdark 94 | 7,003
Tchem 72 | 1,890
Tclin 7 | 602

Collection

Eligible Kinase Proteins 4 | 134
Eligible Ion Channel Proteins 2 | 117

IMPC Term

preweaning lethality, complete... 28 | 633
embryonic lethality prior to t... 13 | 187
decreased total body fat amoun... 12 | 186
abnormal bone structure 11 | 131
decreased bone mineral content 11 | 157
decreased lean body mass 10 | 195
increased mean corpuscular hem... 9 | 93
preweaning lethality, incomple... 9 | 260
decreased circulating HDL chol... 8 | 77
decreased circulating choleste... 8 | 85
increased mean corpuscular vol... 8 | 91
abnormal behavior 7 | 226
decreased body length 7 | 108
decreased body weight 7 | 174
decreased bone mineral density 7 | 126
decreased circulating alanine ... 7 | 53
decreased circulating triglyce... 7 | 83
decreased grip strength 7 | 123
increased heart weight 7 | 37
abnormal bone mineralization 6 | 55
abnormal lens morphology 6 | 73
abnormal retina morphology 6 | 100
decreased circulating LDL chol... 6 | 37
embryonic lethality prior to o... 6 | 148
hypoactivity 6 | 89
increased bone mineral content 6 | 92
increased lean body mass 6 | 107
abnormal sleep behavior 5 | 63
decreased circulating serum al... 5 | 79
decreased fasted circulating g... 5 | 49
decreased prepulse inhibition 5 | 52
enlarged heart 5 | 111
male infertility 5 | 62
abnormal QRS complex 4 | 25
abnormal retinal pigmentation 4 | 61
cardiovascular system phenotyp... 4 | 35
decreased circulating glucose ... 4 | 121
decreased circulating insulin ... 4 | 75
increased circulating alkaline... 4 | 119
increased grip strength 4 | 83
increased or absent threshold ... 4 | 128
abnormal eye morphology 3 | 38
abnormal kidney morphology 3 | 30
abnormal testis morphology 3 | 30
cataract 3 | 26
decreased CD8-positive, alpha-... 3 | 26
decreased NK T cell number 3 | 28
decreased T cell number 3 | 31
decreased heart weight 3 | 44
decreased hemoglobin content 3 | 53
decreased lactate dehydrogenas... 3 | 14
decreased mean corpuscular hem... 3 | 34
decreased vertical activity 3 | 22
hydrops fetalis 3 | 22
hyperactivity 3 | 108
increased blood urea nitrogen ... 3 | 44
increased bone mineral density 3 | 52
increased circulating chloride... 3 | 43
straub tail 3 | 26
abnormal behavioral response t... 2 | 52
abnormal coat appearance 2 | 25
abnormal cranium morphology 2 | 32
abnormal embryo size 2 | 112
abnormal epididymis morphology 2 | 31
abnormal gait 2 | 51
abnormal heart morphology 2 | 51
abnormal spleen morphology 2 | 36
abnormal tail movements 2 | 12
abnormal vibrissa morphology 2 | 17
decreased caudal vertebrae num... 2 | 49
decreased circulating calcium ... 2 | 33
decreased circulating creatini... 2 | 31
decreased circulating free fat... 2 | 39
decreased circulating glycerol... 2 | 19
decreased circulating potassiu... 2 | 17
decreased eosinophil cell numb... 2 | 41
decreased hematocrit 2 | 25
decreased mean corpuscular vol... 2 | 50
decreased rib number 2 | 59
enlarged spleen 2 | 26
impaired glucose tolerance 2 | 52
increased CD5-positive Ly6C-po... 2 | 4
increased body weight 2 | 42
increased circulating glycerol... 2 | 11
increased circulating serum al... 2 | 25
increased circulating sodium l... 2 | 71
increased erythrocyte cell num... 2 | 26
increased exploration in new e... 2 | 56
increased fasted circulating g... 2 | 68
increased hematocrit 2 | 36
increased hemoglobin content 2 | 45
increased mean corpuscular hem... 2 | 25
increased prepulse inhibition 2 | 21
increased sacral vertebrae num... 2 | 62
limb grasping 2 | 35
short tibia 2 | 82
small testis 2 | 37
thrombocytopenia 2 | 46
thrombocytosis 2 | 23
tremors 2 | 34

Disease

ovarian cancer 376 | 8,484
osteosarcoma 321 | 7,933
psoriasis 284 | 6,685
glioblastoma 257 | 5,572
medulloblastoma, large-cell 250 | 6,234
atypical teratoid / rhabdoid tumor 199 | 4,369
lung cancer 170 | 4,466
pilocytic astrocytoma 158 | 3,086
Cancer 151 | 2,346
intraductal papillary-mucinous adenoma (IPMA) 147 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 142 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 135 | 3,289
Breast cancer 132 | 3,094
invasive ductal carcinoma 129 | 2,950
lung carcinoma 126 | 2,844
diabetes mellitus 122 | 1,663
malignant mesothelioma 115 | 3,162
lung adenocarcinoma 114 | 2,713
pancreatic cancer 113 | 2,300
oligodendroglioma 107 | 2,849
adult high grade glioma 102 | 2,148
ependymoma 101 | 2,514
pediatric high grade glioma 100 | 2,712
group 4 medulloblastoma 99 | 1,875
primitive neuroectodermal tumor 99 | 3,031
pituitary cancer 97 | 1,972
Rheumatoid Arthritis 96 | 1,160
non-small cell lung cancer 93 | 2,798
pancreatic ductal adenocarcinoma liver metastasis 88 | 1,795
astrocytic glioma 87 | 2,241
interstitial cystitis 87 | 2,299
subependymal giant cell astrocytoma 85 | 2,287
Pick disease 77 | 1,893
astrocytoma 77 | 1,493
Carcinoma 74 | 2,147
posterior fossa group A ependymoma 73 | 1,511
Ankylosing spondylitis 72 | 138
Multiple myeloma 70 | 1,327
ductal carcinoma in situ 70 | 1,745
ulcerative colitis 69 | 2,087
Hypersensitivity reaction type II disease 68 | 235
group 3 medulloblastoma 65 | 2,254
breast carcinoma 64 | 1,614
tuberculosis 64 | 1,557
juvenile dermatomyositis 63 | 1,189
Arthritis 62 | 248
cystic fibrosis 62 | 1,665
Juvenile rheumatoid arthritis 61 | 104
Uveitis 59 | 103
Acquired immunodeficiency syndrome 58 | 164
active Crohn's disease 58 | 918
primary pancreatic ductal adenocarcinoma 58 | 1,271
Behcet's disease 56 | 74
medulloblastoma 56 | 1,524
posterior fossa group B ependymoma 56 | 1,530
Psoriatic arthritis 52 | 83
adrenocortical carcinoma 50 | 1,427
Multiple Sclerosis 48 | 498
acute quadriplegic myopathy 48 | 1,157
dermatomyositis 48 | 933
spina bifida 45 | 1,064
colon cancer 44 | 1,475
sonic hedgehog group medulloblastoma 44 | 1,482
primary Sjogren syndrome 40 | 789
Stevens-Johnson syndrome 39 | 78
non primary Sjogren syndrome sicca 38 | 840
Liver disease 37 | 219
cutaneous lupus erythematosus 37 | 1,056
tuberculosis and treatment for 6 months 37 | 686
Kidney disease 36 | 396
aldosterone-producing adenoma 36 | 664
atypical teratoid/rhabdoid tumor 36 | 1,095
pancreatic carcinoma 36 | 567
Congenital adrenal hyperplasia 35 | 74
Retinal vasculitis 35 | 36
Takayasu's arteritis 35 | 52
Alzheimer's disease 34 | 644
gastric carcinoma 34 | 832
nasopharyngeal carcinoma 33 | 1,056
active ulcerative colitis 32 | 477
Anemia 31 | 252
Down syndrome 31 | 548
Intellectual disability 31 | 573
esophageal adenocarcinoma 30 | 737
hepatocellular carcinoma 29 | 532
acute myeloid leukemia 28 | 780
Atopic dermatitis 27 | 944
Hepatitis B 27 | 103
progressive supranuclear palsy 26 | 674
Duchenne muscular dystrophy 25 | 602
Hemochromatosis 24 | 55
Leprosy 24 | 77
Neurodegenerative disease 24 | 383
Waldenstrons macroglobulinemia 24 | 765
IGA Glomerulonephritis 23 | 454
Prostatic Neoplasms 22 | 471
Skin disease 22 | 65
fibroadenoma 22 | 557
hereditary spastic paraplegia 21 | 313
sarcoidosis 21 | 358

Tissue

Nervous System 639 | 18,561
Digestive Tract 636 | 18,473
Endocrine System 636 | 18,512
Female tissues 635 | 18,647
Cardiovascular System 634 | 17,958
Liver and Pancreas 634 | 18,136
Blood and immune system 633 | 17,995
Male tissues 633 | 17,969
Urinary Tract 633 | 18,444
Respiratory system 627 | 17,484
Skin and soft tissues 623 | 18,115

Target Family

Non-IDG 371 | 11,971
Enzyme 283 | 4,146
Transporter 24 | 473
Kinase 11 | 634
Transcription Factor 8 | 1,400
Ion Channel 7 | 341
GPCR 6 | 406

Compartment GO Term

Golgi membrane 710 | 710
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,170 | 8,170
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,830 | 7,830
Nucleus 6,897 | 6,897
Membrane part 6,469 | 6,469
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,172 | 5,172
Cell periphery 5,145 | 5,145
Plasma membrane 5,059 | 5,059
Extracellular region 4,606 | 4,606
Protein complex 4,438 | 4,438
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Cytosol 3,352 | 3,352
Nucleoplasm 2,938 | 2,938
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,563 | 2,563
Cytoskeleton 2,045 | 2,045
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Endoplasmic reticulum 1,663 | 1,663
Cytoskeletal part 1,567 | 1,567
Mitochondrion 1,530 | 1,530
Cell projection 1,426 | 1,426
Golgi apparatus 1,402 | 1,402
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,233 | 1,233
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Chromosome 999 | 999
Mitochondrial part 989 | 989
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 780 | 780
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 738 | 738
Plasma membrane protein comple... 720 | 720
Mitochondrial envelope 716 | 716
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Microtubule organizing center 617 | 617
Synapse 594 | 594
Lysosome 571 | 571
Lytic vacuole 571 | 571
Vesicle membrane 559 | 559
cell-cell junction 557 | 557
Cytoplasmic vesicle membrane 552 | 552

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