Development Level

Tbio 65 | 10,625
Tdark 16 | 7,003
Tchem 9 | 1,890

Collection

Ion Channel: IDG Consortium (Targets) 2 | 102

IMPC Phenotype

preweaning lethality, complete... 5 | 633
embryonic lethality prior to t... 4 | 187
preweaning lethality, incomple... 3 | 260
abnormal body wall morphology 2 | 7
abnormal craniofacial morpholo... 2 | 12
abnormal facial morphology 2 | 9
abnormal lens morphology 2 | 73
abnormal limb bud morphology 2 | 15
abnormal limb morphology 2 | 7
anophthalmia 2 | 20
cleft palate 2 | 6
decreased NK T cell number 2 | 28
decreased circulating alanine ... 2 | 53
decreased total body fat amoun... 2 | 186
edema 2 | 11
facial cleft 2 | 3
increased bone mineral content 2 | 92
increased circulating alkaline... 2 | 119
increased lean body mass 2 | 107
increased mean corpuscular hem... 2 | 93
male infertility 2 | 62
polydactyly 2 | 22
abnormal QRS complex 1 | 25
abnormal behavior 1 | 226
abnormal eye morphology 1 | 38
abnormal heart left ventricle ... 1 | 20
abnormal retinal vasculature m... 1 | 15
abnormal skin condition 1 | 6
abnormal sleep behavior 1 | 63
abnormal tail movements 1 | 12
decreased CD8-positive, alpha-... 1 | 26
decreased NK cell number 1 | 16
decreased T cell number 1 | 31
decreased bone mineral content 1 | 157
decreased circulating HDL chol... 1 | 77
decreased circulating LDL chol... 1 | 37
decreased circulating calcium ... 1 | 33
decreased circulating choleste... 1 | 85
decreased circulating free fat... 1 | 39
decreased circulating insulin ... 1 | 75
decreased circulating potassiu... 1 | 17
decreased circulating serum al... 1 | 79
decreased circulating triglyce... 1 | 83
decreased eosinophil cell numb... 1 | 41
decreased hemoglobin content 1 | 53
decreased lean body mass 1 | 195
decreased mean corpuscular hem... 1 | 34
embryonic lethality prior to o... 1 | 148
hydrops fetalis 1 | 22
immune system phenotype 1 | 17
impaired glucose tolerance 1 | 52
increased CD8-positive, alpha-... 1 | 11
increased circulating free fat... 1 | 17
increased circulating magnesiu... 1 | 10
increased effector memory CD8-... 1 | 14
increased exploration in new e... 1 | 56
increased fasted circulating g... 1 | 68
increased grip strength 1 | 83
increased mean platelet volume 1 | 19
increased prepulse inhibition 1 | 21
straub tail 1 | 26
thick ventricular wall 1 | 7
thrombocytopenia 1 | 46
tremors 1 | 34

Disease

ovarian cancer 57 | 8,491
osteosarcoma 40 | 7,933
psoriasis 37 | 6,685
glioblastoma 35 | 5,572
medulloblastoma, large-cell 32 | 6,234
lung cancer 22 | 4,473
atypical teratoid / rhabdoid tumor 21 | 4,369
intraductal papillary-mucinous carcinoma (IPMC) 21 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 20 | 2,956
intraductal papillary-mucinous neoplasm (IPMN) 17 | 3,289
group 4 medulloblastoma 16 | 1,875
lung adenocarcinoma 16 | 2,714
pancreatic cancer 16 | 2,300
pilocytic astrocytoma 15 | 3,086
ependymoma 14 | 2,514
Breast cancer 13 | 3,098
astrocytoma 13 | 1,493
malignant mesothelioma 13 | 3,163
pancreatic ductal adenocarcinoma liver metastasis 13 | 1,795
invasive ductal carcinoma 12 | 2,950
ulcerative colitis 12 | 2,087
adult high grade glioma 11 | 2,148
cystic fibrosis 11 | 1,670
oligodendroglioma 11 | 2,849
pediatric high grade glioma 11 | 2,712
Multiple myeloma 10 | 1,327
interstitial cystitis 10 | 2,299
pituitary cancer 10 | 1,972
astrocytic glioma 9 | 2,241
non-small cell lung cancer 9 | 2,798
posterior fossa group A ependymoma 9 | 1,511
primary pancreatic ductal adenocarcinoma 9 | 1,271
primitive neuroectodermal tumor 9 | 3,031
spina bifida 9 | 1,064
subependymal giant cell astrocytoma 9 | 2,287
tuberculosis 9 | 1,563
active Crohn's disease 8 | 918
atypical teratoid/rhabdoid tumor 8 | 1,095
Cancer 7 | 2,346
Pick disease 7 | 1,893
Waldenstrons macroglobulinemia 7 | 764
acute quadriplegic myopathy 7 | 1,157
dermatomyositis 7 | 966
diabetes mellitus 7 | 1,663
group 3 medulloblastoma 7 | 2,254
hereditary spastic paraplegia 7 | 313
juvenile dermatomyositis 7 | 1,189
lung carcinoma 7 | 2,844
esophageal adenocarcinoma 6 | 737
non primary Sjogren syndrome sicca 6 | 840
sonic hedgehog group medulloblastoma 6 | 1,482
Alzheimer's disease 5 | 644
Amyotrophic Lateral Sclerosis 5 | 432
breast carcinoma 5 | 1,614
pancreatic carcinoma 5 | 567
tuberculosis and treatment for 6 months 5 | 686
Carcinoma 4 | 2,147
IGA Glomerulonephritis 4 | 454
Neurodegenerative disease 4 | 383
Rheumatoid Arthritis 4 | 1,170
active ulcerative colitis 4 | 477
acute myeloid leukemia 4 | 785
aldosterone-producing adenoma 4 | 664
ductal carcinoma in situ 4 | 1,745
fibroadenoma 4 | 557
gastric carcinoma 4 | 832
medulloblastoma 4 | 1,524
mucosa-associated lymphoid tissue lymphoma 4 | 480
posterior fossa group B ependymoma 4 | 1,530
primary Sjogren syndrome 4 | 788
Congenital disorder of glycosylation 3 | 53
Desbuquois dysplasia 3 | 9
Duchenne muscular dystrophy 3 | 602
Hyperphosphatemia 3 | 32
Intellectual disability 3 | 573
Prostatic Neoplasms 3 | 471
autosomal dominant Emery-Dreifuss muscular dystrophy 3 | 499
cutaneous lupus erythematosus 3 | 1,056
nasopharyngeal carcinoma 3 | 1,056
periodontitis 3 | 269
progressive supranuclear palsy 3 | 674
Bipolar Disorder 2 | 266
Cardiovascular system disease 2 | 194
Cerebral palsy 2 | 28
Chylomicron retention disease 2 | 11
Craniofacial Abnormalities 2 | 147
Dementia 2 | 129
Diabetes Mellitus, Non-Insulin-Dependent 2 | 161
Down syndrome 2 | 548
Lipid metabolism disorder 2 | 102
Microcephaly 2 | 149
Neuroblastoma 2 | 78
Sclerocornea 2 | 16
Type 2 diabetes mellitus 2 | 192
adrenocortical carcinoma 2 | 1,427
chronic lymphocytic leukemia 2 | 244
chronic rhinosinusitis 2 | 512
colon cancer 2 | 1,475
hepatocellular carcinoma 2 | 550
tuberculosis and treatment for 3 months 2 | 327

Tissue

Nervous System 88 | 18,560
Digestive Tract 87 | 18,472
Male tissues 87 | 17,968
Blood and immune system 86 | 17,994
Cardiovascular System 86 | 17,957
Endocrine System 86 | 18,511
Female tissues 86 | 18,646
Liver and Pancreas 86 | 18,135
Respiratory system 86 | 17,483
Urinary Tract 86 | 18,443
Skin and soft tissues 85 | 18,114

Target Family

Enzyme 54 | 4,146
Non-IDG 34 | 11,969
Ion Channel 2 | 341

Compartment GO Term

Golgi cisterna 90 | 90
cellular_component 18,237 | 18,237
Cell 15,806 | 15,806
Cell part 15,806 | 15,806
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,648 | 12,648
membrane-bounded organelle 11,793 | 11,793
Intracellular organelle 11,617 | 11,617
Intracellular membrane-bounded... 10,618 | 10,618
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,169 | 8,169
Intracellular organelle part 8,011 | 8,011
Cytoplasmic part 7,830 | 7,830
Nucleus 7,577 | 7,577
Membrane part 6,470 | 6,470
Cytosol 6,035 | 6,035
Plasma membrane 5,673 | 5,673
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,171 | 5,171
Cell periphery 5,146 | 5,146
Nucleoplasm 4,929 | 4,929
Extracellular region 4,606 | 4,606
Protein complex 4,439 | 4,439
Intracellular organelle lumen 4,330 | 4,330
Organelle lumen 4,330 | 4,330
membrane-enclosed lumen 4,330 | 4,330
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,839 | 3,839
non-membrane-bounded organelle 3,838 | 3,838
Nuclear part 3,807 | 3,807
Endomembrane system 3,720 | 3,720
Vesicle 3,666 | 3,666
membrane-bounded vesicle 3,494 | 3,494
Nuclear lumen 3,464 | 3,464
Extracellular organelle 2,849 | 2,849
Extracellular vesicle 2,848 | 2,848
Extracellular exosome 2,828 | 2,828
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,564 | 2,564
Cytoskeleton 2,046 | 2,046
Golgi apparatus 1,946 | 1,946
Endoplasmic reticulum 1,872 | 1,872
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Vesicles 1,625 | 1,625
Cytoskeletal part 1,568 | 1,568
Mitochondrion 1,531 | 1,531
Cell projection 1,426 | 1,426
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,305 | 1,305
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,234 | 1,234
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Mitochondria 1,003 | 1,003
Chromosome 999 | 999
Mitochondrial part 989 | 989
Nucleoli 952 | 952
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 793 | 793
Intracellular ribonucleoprotei... 789 | 789
Nucleoplasm part 781 | 781
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 739 | 739
Plasma membrane protein comple... 721 | 721
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Microtubule organizing center 680 | 680
Centrosome 676 | 676
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Synapse 594 | 594
Lytic vacuole 571 | 571

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