Development Level

Tbio 767 | 11,651
Tdark 98 | 6,593
Tchem 74 | 1,388
Tclin 12 | 612

Collection

RFA-RM-18-021 9 | 328
Kinase: IDG Consortium (Target... 6 | 125
Ion Channel: IDG Consortium (T... 3 | 99
GPCR: IDG Consortium (Targets) 1 | 126

IMPC Phenotype

preweaning lethality, complete... 54 | 979
preweaning lethality, incomple... 35 | 499
embryonic lethality prior to t... 24 | 278
decreased total body fat amoun... 18 | 207
embryonic lethality prior to o... 18 | 239
abnormal bone structure 16 | 187
abnormal embryo size 14 | 220
increased lean body mass 14 | 172
decreased bone mineral content 13 | 151
abnormal behavior 12 | 298
abnormal sleep behavior 12 | 70
decreased vertical activity 12 | 208
enlarged heart 12 | 210
hypoactivity 11 | 132
increased bone mineral content 11 | 108
abnormal eye morphology 10 | 68
abnormal kidney morphology 10 | 65
decreased body weight 10 | 161
increased startle reflex 10 | 112
decreased circulating choleste... 9 | 93
decreased circulating serum al... 9 | 82
increased heart weight 9 | 62
increased mean corpuscular hem... 9 | 96
abnormal behavioral response t... 8 | 66
abnormal heart morphology 8 | 162
cataract 8 | 92
decreased bone mineral density 8 | 126
decreased grip strength 8 | 116
embryonic growth retardation 8 | 106
hyperactivity 8 | 148
increased mean corpuscular vol... 8 | 92
increased total body fat amoun... 8 | 134
abnormal retina morphology 7 | 71
abnormal seminal vesicle morph... 7 | 114
decreased body length 7 | 101
decreased circulating HDL chol... 7 | 68
decreased circulating alanine ... 7 | 47
decreased mean corpuscular vol... 7 | 79
edema 7 | 59
increased circulating alkaline... 7 | 122
abnormal lens morphology 6 | 81
abnormal limb bud morphology 6 | 17
abnormal limb morphology 6 | 13
decreased circulating LDL chol... 6 | 38
decreased circulating triglyce... 6 | 79
decreased lean body mass 6 | 135
increased bone mineral density 6 | 72
abnormal facial morphology 5 | 17
abnormal neural tube closure 5 | 46
abnormal spleen morphology 5 | 55
abnormal tail morphology 5 | 25
decreased circulating creatini... 5 | 39
decreased circulating insulin ... 5 | 76
decreased lymphocyte cell numb... 5 | 83
decreased mean corpuscular hem... 5 | 50
enlarged kidney 5 | 14
male infertility 5 | 123
abnormal craniofacial morpholo... 4 | 33
abnormal gait 4 | 69
anophthalmia 4 | 33
decreased circulating glucose ... 4 | 126
decreased fasted circulating g... 4 | 65
decreased hemoglobin content 4 | 68
decreased leukocyte cell numbe... 4 | 73
decreased prepulse inhibition 4 | 82
enlarged spleen 4 | 41
hydrometra 4 | 53
increased blood urea nitrogen ... 4 | 48
increased body weight 4 | 25
increased circulating chloride... 4 | 41
increased circulating serum al... 4 | 22
increased grip strength 4 | 41
increased monocyte cell number 4 | 63
tremors 4 | 39
abnormal body wall morphology 3 | 9
abnormal coat-hair pigmentatio... 3 | 64
abnormal cranium morphology 3 | 36
abnormal epididymis morphology 3 | 42
abnormal skin morphology 3 | 50
abnormal tail movements 3 | 12
abnormal vibrissa morphology 3 | 25
cardiovascular system phenotyp... 3 | 36
decreased caudal vertebrae num... 3 | 53
decreased circulating alkaline... 3 | 46
decreased circulating aspartat... 3 | 34
decreased circulating calcium ... 3 | 36
decreased lactate dehydrogenas... 3 | 16
decreased startle reflex 3 | 75
impaired glucose tolerance 3 | 75
impaired pupillary reflex 3 | 26
increased circulating sodium l... 3 | 71
increased circulating triglyce... 3 | 42
increased fasted circulating g... 3 | 76
increased or absent threshold ... 3 | 101
pale yolk sac 3 | 25
pallor 3 | 34
prenatal lethality 3 | 28
short tibia 3 | 97
small testis 3 | 58
thrombocytosis 3 | 27

Disease

Carcinoma 610 | 11,493
ovarian cancer 511 | 8,520
osteosarcoma 424 | 7,950
psoriasis 387 | 6,694
glioblastoma 346 | 5,792
medulloblastoma, large-cell 331 | 6,241
atypical teratoid / rhabdoid tumor 283 | 5,112
lung cancer 254 | 4,740
ependymoma 253 | 4,679
Astrocytoma, Pilocytic 209 | 3,081
Breast cancer 209 | 3,578
Cancer 200 | 2,499
intraductal papillary-mucinous adenoma (IPMA) 200 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 196 | 3,291
adult high grade glioma 195 | 3,801
intraductal papillary-mucinous carcinoma (IPMC) 195 | 2,989
invasive ductal carcinoma 178 | 2,951
lung carcinoma 178 | 2,843
malignant mesothelioma 171 | 3,232
lung adenocarcinoma 161 | 2,716
diabetes mellitus 160 | 1,728
group 3 medulloblastoma 159 | 4,104
pancreatic cancer 159 | 2,398
oligodendroglioma 146 | 2,850
astrocytic glioma 144 | 2,597
Kidney cancer 143 | 2,613
non-small cell lung cancer 140 | 2,890
group 4 medulloblastoma 131 | 1,855
pituitary cancer 131 | 1,972
primitive neuroectodermal tumor 131 | 3,035
tuberculosis 128 | 2,010
pancreatic ductal adenocarcinoma liver metastasis 119 | 1,962
interstitial cystitis 118 | 2,312
Pick disease 116 | 1,894
subependymal giant cell astrocytoma 114 | 2,287
Rheumatoid arthritis 111 | 1,191
ductal carcinoma in situ 103 | 1,745
cystic fibrosis 98 | 1,696
breast carcinoma 97 | 1,638
dermatomyositis 93 | 966
ulcerative colitis 92 | 1,819
Autosomal recessive predisposition 91 | 1,442
Multiple myeloma 87 | 1,332
juvenile dermatomyositis 84 | 1,187
primary pancreatic ductal adenocarcinoma 79 | 1,109
pediatric high grade glioma 75 | 1,064
Hypersensitivity reaction type II disease 74 | 253
Ankylosing spondylitis 73 | 140
adrenocortical carcinoma 73 | 1,428
astrocytoma 73 | 1,146
Arthritis 71 | 290
Behcet's disease 70 | 89
active Crohn's disease 70 | 922
colon cancer 70 | 1,478
Intellectual disability 67 | 1,016
Schizophrenia 67 | 1,160
acute quadriplegic myopathy 66 | 1,158
Acquired immunodeficiency syndrome 65 | 197
Juvenile rheumatoid arthritis 61 | 111
active ulcerative colitis 61 | 764
Uveitis 59 | 103
spina bifida 58 | 1,074
Alzheimer's disease 56 | 658
Herpes zoster 56 | 68
Human immunodeficiency virus infectious disease 56 | 138
non primary Sjogren syndrome sicca 56 | 891
Multiple Sclerosis 54 | 540
Psoriatic arthritis 54 | 86
Stevens-Johnson syndrome 53 | 92
cutaneous lupus erythematosus 52 | 1,057
Kidney disease 51 | 430
Epilepsy 50 | 792
nasopharyngeal carcinoma 49 | 1,058
Liver disease 48 | 237
gastric carcinoma 48 | 807
aldosterone-producing adenoma 46 | 665
esophageal adenocarcinoma 46 | 737
Atopic dermatitis 45 | 952
Down syndrome 44 | 499
Anemia 41 | 365
Cognitive delay 41 | 608
Duchenne muscular dystrophy 41 | 601
Dull intelligence 41 | 645
Global developmental delay 41 | 608
Low intelligence 41 | 645
Mental Retardation 41 | 645
Mental and motor retardation 41 | 608
Mental deficiency 41 | 645
Neurodegenerative disease 41 | 414
Poor school performance 41 | 645
primary Sjogren syndrome 41 | 735
Dermatitis 40 | 157
Liver Cirrhosis, Experimental 40 | 769
Seizures 40 | 596
Liver cancer 39 | 604
Waldenstrons macroglobulinemia 39 | 765
pancreatic carcinoma 38 | 562
Melanoma 36 | 711
Muscle hypotonia 36 | 571
drug-induced hepatitis 36 | 44

Tissue

Digestive Tract 845 | 17,369
Endocrine System 844 | 18,159
Female tissues 842 | 17,400
Skin and soft tissues 836 | 17,230
Liver and Pancreas 825 | 16,750
Blood and immune system 823 | 16,909
Male tissues 823 | 17,142
Nervous System 823 | 16,725
Urinary Tract 822 | 16,678
Respiratory system 812 | 16,393
Cardiovascular System 765 | 15,192

Target Family

Non-IDG 536 | 12,091
Enzyme 339 | 4,145
Transporter 31 | 473
Kinase 18 | 634
Transcription Factor 11 | 1,400
GPCR 8 | 408
Ion Channel 8 | 344

Compartment GO Term

Golgi apparatus part 951 | 951
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,783 | 8,783
Membrane 8,530 | 8,530
Nucleus 7,563 | 7,563
Cytosol 6,686 | 6,686
Membrane part 6,553 | 6,553
Plasma membrane 5,829 | 5,829
Macromolecular complex 5,476 | 5,476
Intrinsic component of membran... 5,457 | 5,457
Cell periphery 5,381 | 5,381
Integral component of membrane 5,330 | 5,330
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,974 | 3,974
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,673 | 3,673
Organelle membrane 2,846 | 2,846
Extracellular region 2,731 | 2,731
Plasma membrane part 2,593 | 2,593
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,216 | 2,216
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,638 | 1,638
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 968 | 968
Supramolecular complex 967 | 967
Cell junction 960 | 960
Supramolecular fiber 960 | 960
Nucleoli 942 | 942
Endosome 931 | 931
Nucleolus 927 | 927
Chromosomal part 889 | 889
GO:0098796 883 | 883
Ribonucleoprotein complex 864 | 864
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 849 | 849
Transferase complex 849 | 849
Cell surface 841 | 841
Plasma membrane region 841 | 841
Vesicle membrane 800 | 800
Cytoplasmic vesicle membrane 794 | 794
Polymeric cytoskeletal fiber 765 | 765
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 713 | 713
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
UbiA prenyltransferase domain-containing protein 1 UBIAD1 Tbio Enzyme -1.59893 42.5 50
Atlastin-1 ATL1 Tbio Non-IDG -2.07795 119.7 164
Ras-related protein Rab-21 RAB21 Tbio Enzyme -1.33715 23.1 275
Beta-1,3-galactosyltransferase 1 B3GALT1 Tbio Enzyme -0.68296 3.85 66
Sphingomyelin phosphodiesterase 4 SMPD4 Tbio Enzyme -0.89678 7.05 66
GTP-binding protein SAR1b SAR1B Tbio Enzyme -1.91051 79.7 184
Neuroendocrine secretory protein 55 GNAS Tbio Non-IDG -2.63356 1389.7 509
HLA class I histocompatibility antigen, A-25 alpha chain HLA-A Tbio Non-IDG -2.41667 4123.8 0
Proprotein convertase subtilisin/kexin type 6 PCSK6 Tchem Enzyme -2.33983 216.4 239