Development Level

Tbio 104 | 11,445
Tclin 55 | 613
Tdark 20 | 6,588
Tchem 18 | 1,598

Collection

Kinase: IDG Consortium (Target... 2 | 125
RFA-RM-18-021 2 | 328

IMPC Phenotype

preweaning lethality, complete... 25 | 979
embryonic lethality prior to o... 8 | 239
embryonic lethality prior to t... 6 | 278
abnormal behavior 5 | 298
abnormal embryo size 4 | 220
cataract 4 | 92
hyperactivity 4 | 148
pallor 4 | 34
decreased bone mineral content 3 | 151
increased lean body mass 3 | 172
prenatal lethality prior to he... 3 | 87
preweaning lethality, incomple... 3 | 499
abnormal heart morphology 2 | 162
abnormal lens morphology 2 | 81
abnormal placenta size 2 | 20
abnormal skin coloration 2 | 25
decreased circulating LDL chol... 2 | 38
decreased lean body mass 2 | 135
decreased vertical activity 2 | 208
embryonic growth retardation 2 | 106
increased circulating glucose ... 2 | 24
increased circulating sodium l... 2 | 71
increased fasted circulating g... 2 | 76
increased heart weight 2 | 62
increased total body fat amoun... 2 | 134
abnormal allantois morphology 1 | 8
abnormal chorioallantoic fusio... 1 | 8
abnormal embryo development 1 | 7
abnormal embryo turning 1 | 31
abnormal embryonic autopod pla... 1 | 2
abnormal epididymis morphology 1 | 42
abnormal hindbrain development 1 | 16
abnormal kidney morphology 1 | 65
abnormal limb bud morphology 1 | 17
abnormal liver size 1 | 5
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal neural tube morpholog... 1 | 12
abnormal placenta development 1 | 1
abnormal placenta morphology 1 | 5
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal sensory capabilities-... 1 | 8
abnormal skin morphology 1 | 50
abnormal tail movements 1 | 12
abnormal visceral yolk sac mor... 1 | 6
abnormal vitelline vasculature... 1 | 6
absent startle reflex 1 | 24
absent testes 1 | 6
brachydactyly 1 | 19
decreased body weight 1 | 161
decreased cardiac stroke volum... 1 | 6
decreased circulating chloride... 1 | 30
decreased circulating choleste... 1 | 93
decreased circulating magnesiu... 1 | 13
decreased circulating phosphat... 1 | 27
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased food intake 1 | 13
decreased heart weight 1 | 27
decreased lactate dehydrogenas... 1 | 16
decreased mean platelet volume 1 | 25
decreased neutrophil cell numb... 1 | 42
decreased total body fat amoun... 1 | 207
decreased total retina thickne... 1 | 17
enlarged epididymis 1 | 31
enlarged heart 1 | 210
enlarged lymph nodes 1 | 37
hemorrhage 1 | 23
hypoactivity 1 | 132
increased blood uric acid leve... 1 | 5
increased bone mineral content 1 | 108
increased circulating alkaline... 1 | 122
increased circulating calcium ... 1 | 34
increased circulating chloride... 1 | 41
increased circulating phosphat... 1 | 26
increased granulocyte number 1 | 1
increased grip strength 1 | 41
increased heart rate 1 | 23
increased leukocyte cell numbe... 1 | 47
increased mean platelet volume 1 | 45
increased prepulse inhibition 1 | 32
male infertility 1 | 123
pale liver 1 | 6
pale yolk sac 1 | 25
prenatal lethality 1 | 28
shortened RR interval 1 | 17
syndactyly 1 | 23

Disease

ovarian cancer 109 | 8,520
Carcinoma 66 | 11,493
osteosarcoma 64 | 7,950
lung cancer 61 | 4,740
Multiple myeloma 59 | 1,332
psoriasis 51 | 6,694
Diabetes mellitus type 2 46 | 69
Treatment Refractory Type 2 Diabetes Mellitus 46 | 53
Autosomal recessive predisposition 44 | 1,442
medulloblastoma, large-cell 44 | 6,241
Cerebellar Ataxia 40 | 304
astrocytic glioma 39 | 2,597
ependymoma 39 | 4,679
atypical teratoid / rhabdoid tumor 38 | 5,112
pancreatic ductal adenocarcinoma liver metastasis 38 | 1,962
glioblastoma 37 | 5,792
Epilepsy 36 | 792
Dystonia 33 | 164
Seizures 32 | 596
Leigh disease 31 | 100
Blepharoptosis 30 | 231
Cognitive delay 30 | 608
Global developmental delay 30 | 608
Mental and motor retardation 30 | 608
Mitochondrial complex I deficiency 30 | 46
Acidosis, Lactic 29 | 97
Lactic acidemia 29 | 95
Muscle hypotonia 29 | 571
Breast cancer 28 | 3,578
oligodendroglioma 28 | 2,850
Hyperreflexia 27 | 209
Intellectual disability 27 | 1,016
Nystagmus 27 | 317
Parkinson's disease 27 | 392
Optic Atrophy 26 | 242
diabetes mellitus 26 | 1,728
Cancer 25 | 2,499
Schizophrenia 25 | 1,160
Alzheimer's disease 24 | 658
Dull intelligence 24 | 645
Low intelligence 24 | 645
Mental Retardation 24 | 645
Mental deficiency 24 | 645
Muscle Spasticity 24 | 195
Poor school performance 24 | 645
Sensorineural Hearing Loss (disorder) 24 | 284
Muscle Weakness 23 | 170
adult high grade glioma 23 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 23 | 3,291
Dystonic disease 22 | 106
Waldenstrons macroglobulinemia 22 | 765
Mitochondrial Complex 1 Deficiency 21 | 28
Developmental regression 20 | 95
Failure to gain weight 20 | 365
Highly variable clinical phenotype 20 | 150
Highly variable phenotype and severity 20 | 150
Highly variable phenotype, even within families 20 | 150
Loss of developmental milestones 20 | 95
Mental deterioration in childhood 20 | 95
Neurodevelopmental regression 20 | 95
Pediatric failure to thrive 20 | 365
Phenotypic variability 20 | 150
Psychomotor regression 20 | 95
Psychomotor regression beginning in infancy 20 | 95
Psychomotor regression in infants 20 | 95
Psychomotor regression, progressive 20 | 95
lung adenocarcinoma 20 | 2,716
Hypoglycemia 19 | 152
Strabismus 19 | 270
Abnormal mitochondria in muscle tissue 18 | 20
Babinski Reflex 18 | 100
CSF lactate increased 18 | 33
Depressive disorder 18 | 409
Increased serum lactate 18 | 60
Infantile onset 18 | 238
NADH:Q(1) Oxidoreductase deficiency 18 | 24
Respiratory Failure 18 | 104
Toxic encephalopathy 18 | 141
malignant mesothelioma 18 | 3,232
Bipolar Disorder 17 | 666
Feeding difficulties in infancy 17 | 175
Hypertrophic Cardiomyopathy 17 | 117
Leigh syndrome 17 | 28
Pick disease 17 | 1,894
Vomiting 17 | 116
non-small cell lung cancer 17 | 2,890
Ophthalmoplegia 16 | 106
breast carcinoma 16 | 1,638
invasive ductal carcinoma 16 | 2,951
Atrophy of cerebellum 15 | 103
Attention deficit hyperactivity disorder 15 | 278
Cerebellar degeneration 15 | 103
Cerebral Edema 15 | 30
Dysarthria 15 | 192
Impaired exercise tolerance 15 | 42
Infratentorial atrophy 15 | 103
Myopathy 15 | 185
Neurodegenerative disease 15 | 414
group 3 medulloblastoma 15 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 15 | 2,955

Tissue

Endocrine System 195 | 18,159
Female tissues 195 | 17,400
Blood and immune system 194 | 16,909
Digestive Tract 194 | 17,369
Liver and Pancreas 194 | 16,750
Male tissues 194 | 17,142
Skin and soft tissues 194 | 17,230
Urinary Tract 194 | 16,678
Nervous System 193 | 16,725
Cardiovascular System 191 | 15,192
Respiratory system 191 | 16,393

Target Family

Enzyme 131 | 4,145
Non-IDG 56 | 12,091
Kinase 5 | 634
Transporter 3 | 473
GPCR 1 | 408
Ion Channel 1 | 344

Compartment GO Term

GO:0098798 197 | 197
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,109 | 14,109
Intracellular part 13,972 | 13,972
Organelle 12,237 | 12,237
Intracellular organelle 12,023 | 12,023
membrane-bounded organelle 11,130 | 11,130
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,340 | 10,340
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,784 | 8,784
Membrane 8,531 | 8,531
Nucleus 7,561 | 7,561
Cytosol 6,686 | 6,686
Membrane part 6,554 | 6,554
Plasma membrane 5,830 | 5,830
Macromolecular complex 5,476 | 5,476
Intrinsic component of membran... 5,458 | 5,458
Cell periphery 5,382 | 5,382
Integral component of membrane 5,331 | 5,331
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,972 | 3,972
non-membrane-bounded organelle 3,972 | 3,972
Nuclear lumen 3,968 | 3,968
Protein complex 3,674 | 3,674
Organelle membrane 2,846 | 2,846
Extracellular region 2,732 | 2,732
Plasma membrane part 2,594 | 2,594
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,217 | 2,217
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,955 | 1,955
Golgi apparatus 1,932 | 1,932
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,641 | 1,641
Cytoskeletal part 1,637 | 1,637
Extracellular region part 1,628 | 1,628
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,547 | 1,547
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,123 | 1,123
Nuclear outer membrane-endopla... 1,121 | 1,121
Nucleoplasm part 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,040 | 1,040
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 967 | 967
Supramolecular complex 966 | 966
Cell junction 960 | 960
Supramolecular fiber 959 | 959
Golgi apparatus part 949 | 949
Nucleoli 942 | 942
Endosome 931 | 931
Nucleolus 926 | 926
Chromosomal part 889 | 889
GO:0098796 884 | 884
Ribonucleoprotein complex 864 | 864
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 849 | 849
Transferase complex 848 | 848
Cell surface 842 | 842
Plasma membrane region 841 | 841
Vesicle membrane 801 | 801
Cytoplasmic vesicle membrane 795 | 795
Polymeric cytoskeletal fiber 764 | 764
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 714 | 714
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

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