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Target Filters...

Development Level

Tbio 100 | 10,625
Tclin 55 | 602
Tdark 28 | 7,003
Tchem 21 | 1,890

Collection

Eligible Kinase Proteins 1 | 134

IMPC Term

preweaning lethality, complete... 22 | 633
embryonic lethality prior to o... 9 | 148
embryonic lethality prior to t... 6 | 187
abnormal behavior 5 | 226
decreased lean body mass 4 | 195
increased fasted circulating g... 4 | 68
prenatal lethality prior to he... 4 | 64
abnormal embryo size 3 | 112
abnormal lens morphology 3 | 73
decreased body weight 3 | 174
decreased bone mineral content 3 | 157
increased circulating sodium l... 3 | 71
increased exploration in new e... 3 | 56
increased heart weight 3 | 37
increased lean body mass 3 | 107
pallor 3 | 13
abnormal skin coloration 2 | 18
decreased circulating LDL chol... 2 | 37
decreased circulating total pr... 2 | 41
decreased heart weight 2 | 44
decreased mean platelet volume 2 | 12
decreased total body fat amoun... 2 | 186
decreased total retina thickne... 2 | 20
embryonic growth retardation 2 | 28
hyperactivity 2 | 108
immune system phenotype 2 | 17
increased circulating chloride... 2 | 43
increased leukocyte cell numbe... 2 | 37
increased mean corpuscular vol... 2 | 91
prenatal lethality 2 | 16
preweaning lethality, incomple... 2 | 260
abnormal QRS complex 1 | 25
abnormal bone structure 1 | 131
abnormal embryo turning 1 | 15
abnormal epididymis morphology 1 | 31
abnormal gait 1 | 51
abnormal heart morphology 1 | 51
abnormal hindbrain development 1 | 24
abnormal kidney morphology 1 | 30
abnormal limb bud morphology 1 | 15
abnormal liver size 1 | 4
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal placenta development 1 | 1
abnormal placenta morphology 1 | 4
abnormal placenta size 1 | 10
abnormal retina morphology 1 | 100
abnormal retinal blood vessel ... 1 | 18
abnormal retinal outer nuclear... 1 | 5
abnormal retinal vasculature m... 1 | 15
abnormal rib morphology 1 | 28
abnormal skin appearance 1 | 8
abnormal skin morphology 1 | 23
abnormal tail movements 1 | 12
abnormal tooth morphology 1 | 24
absent teeth 1 | 4
absent testes 1 | 2
cardiovascular system phenotyp... 1 | 35
decreased blood urea nitrogen ... 1 | 31
decreased cardiac stroke volum... 1 | 3
decreased caudal vertebrae num... 1 | 49
decreased circulating HDL chol... 1 | 77
decreased circulating choleste... 1 | 85
decreased circulating fructosa... 1 | 31
decreased circulating glucose ... 1 | 121
decreased circulating magnesiu... 1 | 11
decreased circulating serum al... 1 | 79
decreased circulating sodium l... 1 | 18
decreased circulating triglyce... 1 | 83
decreased effector memory CD8-... 1 | 24
decreased eosinophil cell numb... 1 | 41
decreased grip strength 1 | 123
decreased lactate dehydrogenas... 1 | 14
decreased lumbar vertebrae num... 1 | 62
decreased rib number 1 | 59
decreased startle reflex 1 | 48
enlarged epididymis 1 | 27
enlarged lymph nodes 1 | 27
hypoactivity 1 | 89
increased CD4-positive, CD25-p... 1 | 18
increased CD5-positive Ly6C-po... 1 | 4
increased T cell number 1 | 15
increased alpha-beta T cell nu... 1 | 9
increased blood urea nitrogen ... 1 | 44
increased blood uric acid leve... 1 | 5
increased bone mineral content 1 | 92
increased circulating alkaline... 1 | 119
increased circulating aspartat... 1 | 17
increased circulating free fat... 1 | 17
increased circulating glucose ... 1 | 16
increased circulating phosphat... 1 | 24
increased granulocyte number 1 | 8
increased grip strength 1 | 83
increased mean corpuscular hem... 1 | 93
increased mean platelet volume 1 | 19
increased or absent threshold ... 1 | 128
increased sacral vertebrae num... 1 | 62
increased startle reflex 1 | 38
pale liver 1 | 5
short tibia 1 | 82

Disease

ovarian cancer 115 | 8,492
osteosarcoma 69 | 7,933
lung cancer 61 | 4,473
Multiple myeloma 57 | 1,328
psoriasis 56 | 6,685
Diabetes mellitus type 2 46 | 69
Treatment Refractory Type 2 Diabetes Mellitus 46 | 53
medulloblastoma, large-cell 42 | 6,234
pancreatic ductal adenocarcinoma liver metastasis 42 | 1,795
glioblastoma 38 | 5,572
astrocytic glioma 34 | 2,241
atypical teratoid / rhabdoid tumor 33 | 4,369
Leigh disease 29 | 81
Parkinson's disease 28 | 364
ependymoma 28 | 2,514
Breast cancer 27 | 3,099
intraductal papillary-mucinous neoplasm (IPMN) 27 | 3,289
oligodendroglioma 27 | 2,849
Alzheimer's disease 23 | 644
Mitochondrial complex I deficiency 23 | 37
Waldenstrons macroglobulinemia 23 | 765
diabetes mellitus 22 | 1,663
Mitochondrial Complex 1 Deficiency 21 | 28
lung adenocarcinoma 21 | 2,714
Cancer 20 | 2,346
invasive ductal carcinoma 20 | 2,950
Leigh syndrome 19 | 34
Pick disease 18 | 1,893
malignant mesothelioma 18 | 3,163
non-small cell lung cancer 18 | 2,798
Toxic encephalopathy 17 | 131
intraductal papillary-mucinous adenoma (IPMA) 17 | 2,956
ulcerative colitis 17 | 2,087
NADH:Q(1) Oxidoreductase deficiency 15 | 20
astrocytoma 15 | 1,493
tuberculosis 15 | 1,563
Dystonia 14 | 77
Neurodegenerative disease 14 | 383
Schizophrenia 14 | 503
intraductal papillary-mucinous carcinoma (IPMC) 14 | 2,988
medulloblastoma 14 | 1,524
pancreatic cancer 14 | 2,300
pediatric high grade glioma 14 | 2,712
Parkinson Disease 13 | 105
breast carcinoma 13 | 1,614
interstitial cystitis 13 | 2,299
non primary Sjogren syndrome sicca 13 | 840
pilocytic astrocytoma 13 | 3,086
sonic hedgehog group medulloblastoma 13 | 1,482
Myopathy 12 | 128
Obesity 12 | 616
adult high grade glioma 12 | 2,148
aldosterone-producing adenoma 12 | 664
colon cancer 12 | 1,475
lung carcinoma 11 | 2,844
pituitary cancer 11 | 1,972
primitive neuroectodermal tumor 11 | 3,031
subependymal giant cell astrocytoma 11 | 2,287
Brain disease 10 | 84
LEIGH SYNDROME DUE TO MITOCHONDRIAL COMPLEX I DEFICIENCY 10 | 14
acute myeloid leukemia 10 | 785
Attention deficit hyperactivity disorder 9 | 156
Leber hereditary optic neuropathy 9 | 17
Nerve Degeneration 9 | 73
acute quadriplegic myopathy 9 | 1,157
ductal carcinoma in situ 9 | 1,745
3-methylglutaconic aciduria 8 | 29
Autistic Disorder 8 | 320
Cerebrovascular disease 8 | 231
Leber's optic atrophy 8 | 10
Mitochondrial myopathy 8 | 24
Neuropathy 8 | 210
Optic Atrophy, Hereditary, Leber 8 | 14
cystic fibrosis 8 | 1,670
group 4 medulloblastoma 8 | 1,875
hereditary spastic paraplegia 8 | 313
juvenile dermatomyositis 8 | 1,189
posterior fossa group A ependymoma 8 | 1,511
Bipolar Disorder 7 | 266
Dementia 7 | 129
Epilepsy 7 | 346
Huntington's disease 7 | 72
Lactic acidosis 7 | 43
Parkinsonian Disorders 7 | 23
Pheochromocytoma 7 | 22
Pneumonia 7 | 133
primary pancreatic ductal adenocarcinoma 7 | 1,271
Brain Ischemia 6 | 87
Down syndrome 6 | 548
Heart disease 6 | 279
Intellectual disability 6 | 573
Kidney disease 6 | 397
Peripheral Neuropathy 6 | 303
Rheumatoid Arthritis 6 | 1,171
adrenocortical carcinoma 6 | 1,427
gastric carcinoma 6 | 832
hepatocellular carcinoma 6 | 550
nervous system disorder 6 | 53
progressive supranuclear palsy 6 | 674
spina bifida 6 | 1,064

Tissue

Blood and immune system 203 | 17,995
Cardiovascular System 203 | 17,958
Digestive Tract 203 | 18,473
Endocrine System 203 | 18,512
Female tissues 203 | 18,647
Liver and Pancreas 203 | 18,136
Male tissues 203 | 17,969
Nervous System 203 | 18,561
Respiratory system 203 | 17,484
Urinary Tract 203 | 18,444
Skin and soft tissues 201 | 18,115

Target Family

Enzyme 134 | 4,146
Non-IDG 58 | 11,969
Kinase 7 | 634
Transporter 3 | 473
GPCR 1 | 408
Ion Channel 1 | 341

Compartment GO Term

GO:0098798 204 | 204
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,612 | 13,612
Intracellular part 13,475 | 13,475
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,353 | 10,353
Membrane 8,871 | 8,871
Organelle part 8,169 | 8,169
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,831 | 7,831
Nucleus 7,577 | 7,577
Membrane part 6,469 | 6,469
Cytosol 6,034 | 6,034
Plasma membrane 5,673 | 5,673
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,171 | 5,171
Cell periphery 5,146 | 5,146
Nucleoplasm 4,930 | 4,930
Extracellular region 4,607 | 4,607
Protein complex 4,439 | 4,439
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,874 | 3,874
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,592 | 2,592
Plasma membrane part 2,564 | 2,564
Cytoskeleton 2,046 | 2,046
Golgi apparatus 1,946 | 1,946
Endoplasmic reticulum 1,872 | 1,872
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Vesicles 1,625 | 1,625
Cytoskeletal part 1,568 | 1,568
Mitochondrion 1,530 | 1,530
Cell projection 1,425 | 1,425
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,234 | 1,234
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,092 | 1,092
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,084 | 1,084
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Mitochondria 1,003 | 1,003
Chromosome 999 | 999
Mitochondrial part 988 | 988
Nucleoli 950 | 950
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 815 | 815
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 781 | 781
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 739 | 739
Plasma membrane protein comple... 721 | 721
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Microtubule organizing center 680 | 680
Centrosome 676 | 676
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 656 | 656
Extracellular matrix 633 | 633
Synapse 594 | 594
Lytic vacuole 571 | 571

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ubiquitin-associated domain-containing protein 1 UBAC1 Tbio Non-IDG -2.56341 358.4 116
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial MCCC2 Tbio Enzyme -1.23140 15.5 156
MICOS complex subunit MIC25 CHCHD6 Tbio Non-IDG -1.52785 31.8 140
Cytochrome b-c1 complex subunit 1, mitochondrial UQCRC1 Tbio Enzyme -1.42607 27.2 143
Putative peripheral benzodiazepine receptor-related protein TSPO Tbio Non-IDG -3.04986 2078.3 186
Nucleolar complex protein 2 homolog NOC2L Tbio Non-IDG -2.51263 334.5 79
Succinate dehydrogenase cytochrome b560 subunit, mitochondrial SDHC Tbio Enzyme -2.71429 399.0 110
AMP deaminase 3 AMPD3 Tchem Enzyme -1.84398 66.0 113
Complex I intermediate-associated protein 30, mitochondrial NDUFAF1 Tclin Non-IDG -1.09656 12.3 82
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 Tbio Enzyme -2.31226 190.9 412