Development Level

Tbio 100 | 10,625
Tclin 55 | 602
Tdark 28 | 7,003
Tchem 21 | 1,890

Collection

Eligible Kinase Proteins 1 | 134

IMPC Term

preweaning lethality, complete... 22 | 633
embryonic lethality prior to o... 9 | 148
embryonic lethality prior to t... 6 | 187
abnormal behavior 5 | 226
decreased lean body mass 4 | 195
increased fasted circulating g... 4 | 68
prenatal lethality prior to he... 4 | 64
abnormal embryo size 3 | 112
abnormal lens morphology 3 | 73
decreased body weight 3 | 174
decreased bone mineral content 3 | 157
increased circulating sodium l... 3 | 71
increased exploration in new e... 3 | 56
increased heart weight 3 | 37
increased lean body mass 3 | 107
pallor 3 | 13
abnormal skin coloration 2 | 18
decreased circulating LDL chol... 2 | 37
decreased circulating total pr... 2 | 41
decreased heart weight 2 | 44
decreased mean platelet volume 2 | 12
decreased total body fat amoun... 2 | 186
decreased total retina thickne... 2 | 20
embryonic growth retardation 2 | 28
hyperactivity 2 | 108
immune system phenotype 2 | 17
increased circulating chloride... 2 | 43
increased leukocyte cell numbe... 2 | 37
increased mean corpuscular vol... 2 | 91
prenatal lethality 2 | 16
preweaning lethality, incomple... 2 | 260
abnormal QRS complex 1 | 25
abnormal bone structure 1 | 131
abnormal embryo turning 1 | 15
abnormal epididymis morphology 1 | 31
abnormal gait 1 | 51
abnormal heart morphology 1 | 51
abnormal hindbrain development 1 | 24
abnormal kidney morphology 1 | 30
abnormal limb bud morphology 1 | 15
abnormal liver size 1 | 4
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal placenta development 1 | 1
abnormal placenta morphology 1 | 4
abnormal placenta size 1 | 10
abnormal retina morphology 1 | 100
abnormal retinal blood vessel ... 1 | 18
abnormal retinal outer nuclear... 1 | 5
abnormal retinal vasculature m... 1 | 15
abnormal rib morphology 1 | 28
abnormal skin appearance 1 | 8
abnormal skin morphology 1 | 23
abnormal tail movements 1 | 12
abnormal tooth morphology 1 | 24
absent teeth 1 | 4
absent testes 1 | 2
cardiovascular system phenotyp... 1 | 35
decreased blood urea nitrogen ... 1 | 31
decreased cardiac stroke volum... 1 | 3
decreased caudal vertebrae num... 1 | 49
decreased circulating HDL chol... 1 | 77
decreased circulating choleste... 1 | 85
decreased circulating fructosa... 1 | 31
decreased circulating glucose ... 1 | 121
decreased circulating magnesiu... 1 | 11
decreased circulating serum al... 1 | 79
decreased circulating sodium l... 1 | 18
decreased circulating triglyce... 1 | 83
decreased effector memory CD8-... 1 | 24
decreased eosinophil cell numb... 1 | 41
decreased grip strength 1 | 123
decreased lactate dehydrogenas... 1 | 14
decreased lumbar vertebrae num... 1 | 62
decreased rib number 1 | 59
decreased startle reflex 1 | 48
enlarged epididymis 1 | 27
enlarged lymph nodes 1 | 27
hypoactivity 1 | 89
increased CD4-positive, CD25-p... 1 | 18
increased CD5-positive Ly6C-po... 1 | 4
increased T cell number 1 | 15
increased alpha-beta T cell nu... 1 | 9
increased blood urea nitrogen ... 1 | 44
increased blood uric acid leve... 1 | 5
increased bone mineral content 1 | 92
increased circulating alkaline... 1 | 119
increased circulating aspartat... 1 | 17
increased circulating free fat... 1 | 17
increased circulating glucose ... 1 | 16
increased circulating phosphat... 1 | 24
increased granulocyte number 1 | 8
increased grip strength 1 | 83
increased mean corpuscular hem... 1 | 93
increased mean platelet volume 1 | 19
increased or absent threshold ... 1 | 128
increased sacral vertebrae num... 1 | 62
increased startle reflex 1 | 38
pale liver 1 | 5
short tibia 1 | 82

Disease

ovarian cancer 113 | 8,484
osteosarcoma 69 | 7,933
lung cancer 60 | 4,466
Multiple myeloma 57 | 1,327
psoriasis 56 | 6,685
Diabetes mellitus type 2 46 | 69
Treatment Refractory Type 2 Diabetes Mellitus 46 | 53
medulloblastoma, large-cell 42 | 6,234
pancreatic ductal adenocarcinoma liver metastasis 42 | 1,795
glioblastoma 38 | 5,572
astrocytic glioma 34 | 2,241
atypical teratoid / rhabdoid tumor 33 | 4,369
Leigh disease 29 | 81
Parkinson's disease 28 | 364
ependymoma 28 | 2,514
Breast cancer 27 | 3,094
intraductal papillary-mucinous neoplasm (IPMN) 27 | 3,289
oligodendroglioma 27 | 2,849
Alzheimer's disease 23 | 644
MITOCHONDRIAL COMPLEX I DEFICIENCY 23 | 37
Waldenstrons macroglobulinemia 23 | 765
diabetes mellitus 22 | 1,663
lung adenocarcinoma 21 | 2,713
Cancer 20 | 2,346
invasive ductal carcinoma 20 | 2,950
Pick disease 18 | 1,893
malignant mesothelioma 18 | 3,162
non-small cell lung cancer 18 | 2,798
Toxic encephalopathy 17 | 131
intraductal papillary-mucinous adenoma (IPMA) 17 | 2,956
ulcerative colitis 17 | 2,087
NADH:Q(1) Oxidoreductase deficiency 15 | 20
astrocytoma 15 | 1,493
tuberculosis 15 | 1,557
Dystonia 14 | 77
Neurodegenerative disease 14 | 383
Schizophrenia 14 | 501
intraductal papillary-mucinous carcinoma (IPMC) 14 | 2,988
medulloblastoma 14 | 1,524
pancreatic cancer 14 | 2,300
pediatric high grade glioma 14 | 2,712
Parkinson Disease 13 | 102
breast carcinoma 13 | 1,614
interstitial cystitis 13 | 2,299
non primary Sjogren syndrome sicca 13 | 840
pilocytic astrocytoma 13 | 3,086
sonic hedgehog group medulloblastoma 13 | 1,482
Myopathy 12 | 128
Obesity 12 | 616
adult high grade glioma 12 | 2,148
aldosterone-producing adenoma 12 | 664
colon cancer 12 | 1,475
lung carcinoma 11 | 2,844
pituitary cancer 11 | 1,972
primitive neuroectodermal tumor 11 | 3,031
subependymal giant cell astrocytoma 11 | 2,287
Brain disease 10 | 83
LEIGH SYNDROME DUE TO MITOCHONDRIAL COMPLEX I DEFICIENCY 10 | 14
acute myeloid leukemia 10 | 780
Attention deficit hyperactivity disorder 9 | 156
Leber hereditary optic neuropathy 9 | 17
Nerve Degeneration 9 | 73
acute quadriplegic myopathy 9 | 1,157
ductal carcinoma in situ 9 | 1,745
3-methylglutaconic aciduria 8 | 29
Autistic Disorder 8 | 320
Cerebrovascular disease 8 | 231
Mitochondrial myopathy 8 | 23
Neuropathy 8 | 210
Optic Atrophy, Hereditary, Leber 8 | 14
cystic fibrosis 8 | 1,665
group 4 medulloblastoma 8 | 1,875
hereditary spastic paraplegia 8 | 313
juvenile dermatomyositis 8 | 1,189
posterior fossa group A ependymoma 8 | 1,511
Bipolar Disorder 7 | 266
Dementia 7 | 129
Epilepsy 7 | 346
Huntington's disease 7 | 72
Lactic acidosis 7 | 42
Parkinsonian Disorders 7 | 23
Pheochromocytoma 7 | 22
Pneumonia 7 | 133
primary pancreatic ductal adenocarcinoma 7 | 1,271
Brain Ischemia 6 | 87
Deafness dystonia syndrome 6 | 20
Down syndrome 6 | 548
Heart disease 6 | 279
Intellectual disability 6 | 573
Kidney disease 6 | 396
Peripheral Neuropathy 6 | 303
Rheumatoid Arthritis 6 | 1,160
adrenocortical carcinoma 6 | 1,427
gastric carcinoma 6 | 832
hepatocellular carcinoma 6 | 532
nervous system disorder 6 | 53
progressive supranuclear palsy 6 | 674
spina bifida 6 | 1,064
Prostatic Neoplasms 5 | 471
cutaneous lupus erythematosus 5 | 1,056

Tissue

Blood and immune system 203 | 17,995
Cardiovascular System 203 | 17,958
Digestive Tract 203 | 18,473
Endocrine System 203 | 18,512
Female tissues 203 | 18,647
Liver and Pancreas 203 | 18,136
Male tissues 203 | 17,969
Nervous System 203 | 18,561
Respiratory system 203 | 17,484
Urinary Tract 203 | 18,444
Skin and soft tissues 201 | 18,115

Target Family

Enzyme 134 | 4,146
Non-IDG 58 | 11,971
Kinase 7 | 634
Transporter 3 | 473
GPCR 1 | 406
Ion Channel 1 | 341

Compartment GO Term

GO:0098798 204 | 204
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,170 | 8,170
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,830 | 7,830
Nucleus 6,897 | 6,897
Membrane part 6,469 | 6,469
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,172 | 5,172
Cell periphery 5,145 | 5,145
Plasma membrane 5,059 | 5,059
Extracellular region 4,606 | 4,606
Protein complex 4,438 | 4,438
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Cytosol 3,352 | 3,352
Nucleoplasm 2,938 | 2,938
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,563 | 2,563
Cytoskeleton 2,045 | 2,045
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Endoplasmic reticulum 1,663 | 1,663
Cytoskeletal part 1,567 | 1,567
Mitochondrion 1,530 | 1,530
Cell projection 1,426 | 1,426
Golgi apparatus 1,402 | 1,402
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,233 | 1,233
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Chromosome 999 | 999
Mitochondrial part 989 | 989
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 780 | 780
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 738 | 738
Plasma membrane protein comple... 720 | 720
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Microtubule organizing center 617 | 617
Synapse 594 | 594
Lysosome 571 | 571
Lytic vacuole 571 | 571
Vesicle membrane 559 | 559
cell-cell junction 557 | 557
Cytoplasmic vesicle membrane 552 | 552

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
ATP synthase F(0) complex subunit C3, mitochondrial ATP5G3 Tdark Enzyme -1.10871 11.9 27
ADP/ATP translocase 3 SLC25A6 Tbio Transporter -2.06581 118.3 193
Glial cell line-derived neurotrophic factor GDNF Tbio Non-IDG -3.30206 2301.5 303
Taste receptor type 1 member 1 TAS1R1 Tbio GPCR -1.71516 50.8 165
ATP synthase protein 8 MT-ATP8 Tbio Enzyme -2.30895 191.4 20
Cytochrome c oxidase subunit 6A1, mitochondrial COX6A1 Tbio Enzyme -1.00384 11.8 165
Small nuclear ribonucleoprotein E SNRPE Tbio Non-IDG -2.70963 540.8 230
Cytochrome c oxidase subunit 7C, mitochondrial COX7C Tdark Enzyme -0.99133 9.67 34
Cytochrome b MT-CYB Tbio Non-IDG -3.74473 5676.0 122
Calcium uniporter protein, mitochondrial MCU Tbio Ion Channel -2.59256 408.9 18