Development Level

Tbio 709 | 10,625
Tchem 273 | 1,890
Tclin 240 | 602
Tdark 82 | 7,003

Collection

Eligible Ion Channel Proteins 62 | 117
Eligible Kinase Proteins 4 | 134

IMPC Term

preweaning lethality, complete... 79 | 633
embryonic lethality prior to t... 31 | 187
embryonic lethality prior to o... 29 | 148
abnormal behavior 25 | 226
abnormal embryo size 16 | 112
decreased total body fat amoun... 16 | 186
decreased body weight 14 | 174
hyperactivity 13 | 108
preweaning lethality, incomple... 13 | 260
decreased bone mineral content 12 | 157
decreased lean body mass 12 | 195
increased circulating sodium l... 12 | 71
abnormal bone mineralization 11 | 55
decreased circulating glucose ... 11 | 121
decreased grip strength 11 | 123
increased lean body mass 11 | 107
abnormal bone structure 10 | 131
decreased circulating choleste... 10 | 85
decreased circulating triglyce... 10 | 83
decreased bone mineral density 9 | 126
increased fasted circulating g... 9 | 68
cardiovascular system phenotyp... 8 | 35
decreased mean corpuscular vol... 8 | 50
enlarged heart 8 | 111
increased bone mineral content 8 | 92
increased circulating HDL chol... 8 | 63
increased total body fat amoun... 8 | 57
abnormal gait 7 | 51
abnormal lens morphology 7 | 73
abnormal retina morphology 7 | 100
decreased circulating HDL chol... 7 | 77
decreased circulating insulin ... 7 | 75
decreased circulating serum al... 7 | 79
decreased fasted circulating g... 7 | 49
decreased prepulse inhibition 7 | 52
hypoactivity 7 | 89
increased circulating alkaline... 7 | 119
increased circulating choleste... 7 | 53
increased exploration in new e... 7 | 56
increased grip strength 7 | 83
increased mean corpuscular hem... 7 | 93
increased mean corpuscular vol... 7 | 91
abnormal QRS complex 6 | 25
decreased circulating LDL chol... 6 | 37
decreased lumbar vertebrae num... 6 | 62
increased heart weight 6 | 37
increased or absent threshold ... 6 | 128
abnormal behavioral response t... 5 | 52
abnormal epididymis morphology 5 | 31
abnormal hindbrain development 5 | 24
abnormal midbrain development 5 | 22
abnormal neural tube closure 5 | 37
abnormal sleep behavior 5 | 63
decreased blood urea nitrogen ... 5 | 31
decreased circulating alanine ... 5 | 53
decreased circulating fructosa... 5 | 31
decreased erythrocyte cell num... 5 | 43
increased blood urea nitrogen ... 5 | 44
increased circulating LDL chol... 5 | 15
increased circulating chloride... 5 | 43
increased circulating free fat... 5 | 17
prenatal lethality prior to he... 5 | 64
thrombocytopenia 5 | 46
abnormal eye morphology 4 | 38
abnormal forebrain development 4 | 18
abnormal heart morphology 4 | 51
abnormal testis morphology 4 | 30
decreased body length 4 | 108
decreased circulating alkaline... 4 | 41
decreased circulating calcium ... 4 | 33
decreased circulating total pr... 4 | 41
decreased eosinophil cell numb... 4 | 41
decreased heart rate variabili... 4 | 11
decreased leukocyte cell numbe... 4 | 54
decreased startle reflex 4 | 48
decreased total retina thickne... 4 | 20
enlarged epididymis 4 | 27
enlarged lymph nodes 4 | 27
hydrops fetalis 4 | 22
increased body weight 4 | 42
increased circulating phosphat... 4 | 24
increased circulating triglyce... 4 | 24
increased hemoglobin content 4 | 45
increased leukocyte cell numbe... 4 | 37
limb grasping 4 | 35
prenatal lethality 4 | 16
small testis 4 | 37
tremors 4 | 34
vertebral fusion 4 | 23
abnormal skin coloration 3 | 18
abnormal spleen morphology 3 | 36
decreased NK T cell number 3 | 28
decreased T cell number 3 | 31
decreased caudal vertebrae num... 3 | 49
decreased circulating bilirubi... 3 | 14
impaired glucose tolerance 3 | 52
increased erythrocyte cell num... 3 | 26
increased hematocrit 3 | 36
short tibia 3 | 82
thrombocytosis 3 | 23

Disease

ovarian cancer 669 | 8,484
psoriasis 580 | 6,685
osteosarcoma 565 | 7,933
glioblastoma 512 | 5,572
Cancer 499 | 2,346
medulloblastoma, large-cell 462 | 6,234
lung cancer 409 | 4,466
atypical teratoid / rhabdoid tumor 347 | 4,369
lung carcinoma 312 | 2,844
pilocytic astrocytoma 308 | 3,086
diabetes mellitus 282 | 1,663
Breast cancer 256 | 3,094
oligodendroglioma 254 | 2,849
pediatric high grade glioma 253 | 2,712
invasive ductal carcinoma 251 | 2,950
intraductal papillary-mucinous neoplasm (IPMN) 247 | 3,289
malignant mesothelioma 244 | 3,162
subependymal giant cell astrocytoma 236 | 2,287
lung adenocarcinoma 234 | 2,713
intraductal papillary-mucinous adenoma (IPMA) 233 | 2,956
ependymoma 224 | 2,514
non-small cell lung cancer 223 | 2,798
interstitial cystitis 222 | 2,299
Carcinoma 221 | 2,147
intraductal papillary-mucinous carcinoma (IPMC) 221 | 2,988
primitive neuroectodermal tumor 215 | 3,031
ulcerative colitis 213 | 2,087
pancreatic cancer 188 | 2,300
Multiple myeloma 185 | 1,327
astrocytic glioma 184 | 2,241
Rheumatoid Arthritis 183 | 1,160
pancreatic ductal adenocarcinoma liver metastasis 176 | 1,795
pituitary cancer 174 | 1,972
astrocytoma 172 | 1,493
Pick disease 170 | 1,893
tuberculosis 168 | 1,557
adult high grade glioma 164 | 2,148
Kidney disease 155 | 396
Arthritis 149 | 248
cystic fibrosis 149 | 1,665
group 4 medulloblastoma 149 | 1,875
posterior fossa group A ependymoma 143 | 1,511
Multiple Sclerosis 142 | 498
Alzheimer's disease 139 | 644
Hypersensitivity reaction type II disease 139 | 235
breast carcinoma 138 | 1,614
ductal carcinoma in situ 138 | 1,745
colon cancer 135 | 1,475
medulloblastoma 131 | 1,524
cutaneous lupus erythematosus 118 | 1,056
juvenile dermatomyositis 118 | 1,189
primary pancreatic ductal adenocarcinoma 115 | 1,271
acute quadriplegic myopathy 113 | 1,157
group 3 medulloblastoma 110 | 2,254
Obesity 109 | 616
Epilepsy 105 | 346
adrenocortical carcinoma 104 | 1,427
dermatomyositis 104 | 933
Heart disease 103 | 279
Schizophrenia 103 | 501
Asthma 102 | 349
Anemia 101 | 252
Vascular disease 98 | 281
Waldenstrons macroglobulinemia 97 | 765
Liver disease 95 | 219
Hypertension 94 | 287
sonic hedgehog group medulloblastoma 91 | 1,482
Mammary Neoplasms 89 | 410
Acquired immunodeficiency syndrome 86 | 164
Ankylosing spondylitis 84 | 138
Atherosclerosis 83 | 275
Parkinson's disease 83 | 364
posterior fossa group B ependymoma 83 | 1,530
primary Sjogren syndrome 82 | 789
Duchenne muscular dystrophy 81 | 602
Neurodegenerative disease 79 | 383
Prostatic Neoplasms 79 | 471
Cerebrovascular disease 78 | 231
Down syndrome 78 | 548
gastric carcinoma 75 | 832
Uveitis 74 | 103
active Crohn's disease 73 | 918
Autistic Disorder 72 | 320
Juvenile rheumatoid arthritis 70 | 104
atypical teratoid/rhabdoid tumor 69 | 1,095
acute myeloid leukemia 68 | 780
non primary Sjogren syndrome sicca 68 | 840
Inflammatory bowel disease 67 | 142
Lung disease 67 | 132
nasopharyngeal carcinoma 66 | 1,056
Intellectual disability 65 | 573
Toxic encephalopathy 65 | 131
Atopic dermatitis 64 | 944
Coronary artery disease 64 | 240
Stomach Neoplasms 64 | 282
esophageal adenocarcinoma 63 | 737
spina bifida 63 | 1,064
Hypertensive disease 62 | 193
Endometriosis 61 | 535
non-small cell lung carcinoma 61 | 413

Tissue

Nervous System 1,226 | 18,561
Endocrine System 1,224 | 18,512
Female tissues 1,223 | 18,647
Digestive Tract 1,220 | 18,473
Urinary Tract 1,220 | 18,444
Liver and Pancreas 1,216 | 18,136
Blood and immune system 1,215 | 17,995
Cardiovascular System 1,208 | 17,958
Skin and soft tissues 1,204 | 18,115
Male tissues 1,202 | 17,969
Respiratory system 1,201 | 17,484

Target Family

Non-IDG 683 | 11,971
Enzyme 257 | 4,146
Ion Channel 199 | 341
Kinase 78 | 634
Transcription Factor 33 | 1,400
Transporter 31 | 473
GPCR 18 | 406
Nuclear Receptor 3 | 48
Epigenetic 1 | 242
TF/Epigenetic 1 | 38

Compartment GO Term

GO:0098796 1,304 | 1,304
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,170 | 8,170
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,830 | 7,830
Nucleus 6,897 | 6,897
Membrane part 6,469 | 6,469
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,172 | 5,172
Cell periphery 5,145 | 5,145
Plasma membrane 5,059 | 5,059
Extracellular region 4,606 | 4,606
Protein complex 4,438 | 4,438
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Cytosol 3,352 | 3,352
Nucleoplasm 2,938 | 2,938
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,563 | 2,563
Cytoskeleton 2,045 | 2,045
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Endoplasmic reticulum 1,663 | 1,663
Cytoskeletal part 1,567 | 1,567
Mitochondrion 1,530 | 1,530
Cell projection 1,426 | 1,426
Golgi apparatus 1,402 | 1,402
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,233 | 1,233
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Chromosome 999 | 999
Mitochondrial part 989 | 989
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 780 | 780
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 738 | 738
Plasma membrane protein comple... 720 | 720
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Microtubule organizing center 617 | 617
Synapse 594 | 594
Lysosome 571 | 571
Lytic vacuole 571 | 571
Vesicle membrane 559 | 559
cell-cell junction 557 | 557
Cytoplasmic vesicle membrane 552 | 552

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Syntaxin-1B STX1B Tbio Non-IDG -1.74488 52.6 27
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
ATP synthase F(0) complex subunit C3, mitochondrial ATP5G3 Tdark Enzyme -1.10871 11.9 27
ADP/ATP translocase 3 SLC25A6 Tbio Transporter -2.06581 118.3 193
Apolipoprotein E APOE Tbio Non-IDG -4.17470 15380.4 788
Glial cell line-derived neurotrophic factor GDNF Tbio Non-IDG -3.30206 2301.5 303
Charged multivesicular body protein 2b CHMP2B Tbio Non-IDG -1.65708 53.0 166