Development Level

Tbio 618 | 11,651
Tclin 108 | 612
Tchem 94 | 1,388
Tdark 63 | 6,593

Collection

Kinase: IDG Consortium (Target... 2 | 125
GPCR: IDG Consortium (Targets) 1 | 126

IMPC Phenotype

preweaning lethality, complete... 82 | 979
embryonic lethality prior to o... 33 | 239
embryonic lethality prior to t... 30 | 278
preweaning lethality, incomple... 22 | 499
abnormal embryo size 19 | 220
abnormal behavior 18 | 298
decreased total body fat amoun... 13 | 207
increased total body fat amoun... 12 | 134
decreased vertical activity 10 | 208
abnormal bone structure 9 | 187
enlarged heart 9 | 210
hyperactivity 9 | 148
increased lean body mass 9 | 172
increased startle reflex 9 | 112
cardiovascular system phenotyp... 8 | 36
decreased circulating glucose ... 8 | 126
decreased prepulse inhibition 8 | 82
increased bone mineral content 8 | 108
small superior vagus ganglion 8 | 74
abnormal heart morphology 7 | 162
abnormal seminal vesicle morph... 7 | 114
cataract 7 | 92
decreased body weight 7 | 161
decreased bone mineral content 7 | 151
decreased lymphocyte cell numb... 7 | 83
embryonic growth retardation 7 | 106
hypoactivity 7 | 132
increased circulating sodium l... 7 | 71
increased heart weight 7 | 62
increased monocyte cell number 7 | 63
abnormal kidney morphology 6 | 65
decreased bone mineral density 6 | 126
decreased circulating alkaline... 6 | 46
decreased circulating choleste... 6 | 93
hydrometra 6 | 53
increased circulating alkaline... 6 | 122
increased grip strength 6 | 41
increased neutrophil cell numb... 6 | 46
pallor 6 | 34
thrombocytopenia 6 | 56
abnormal lens morphology 5 | 81
abnormal retina morphology 5 | 71
abnormal sleep behavior 5 | 70
decreased circulating insulin ... 5 | 76
decreased circulating serum al... 5 | 82
decreased fasted circulating g... 5 | 65
decreased hemoglobin content 5 | 68
decreased lean body mass 5 | 135
decreased leukocyte cell numbe... 5 | 73
decreased mean corpuscular vol... 5 | 79
impaired glucose tolerance 5 | 75
increased circulating triglyce... 5 | 42
increased fasted circulating g... 5 | 76
increased leukocyte cell numbe... 5 | 47
increased or absent threshold ... 5 | 101
abnormal gait 4 | 69
abnormal testis morphology 4 | 43
decreased circulating HDL chol... 4 | 68
decreased circulating LDL chol... 4 | 38
decreased circulating triglyce... 4 | 79
decreased erythrocyte cell num... 4 | 62
decreased grip strength 4 | 116
decreased mean corpuscular hem... 4 | 50
edema 4 | 59
hemorrhage 4 | 23
increased blood urea nitrogen ... 4 | 48
increased bone mineral density 4 | 72
increased erythrocyte cell num... 4 | 39
increased hematocrit 4 | 46
increased lymphocyte cell numb... 4 | 32
increased mean corpuscular hem... 4 | 96
limb grasping 4 | 41
prenatal lethality prior to he... 4 | 87
short tibia 4 | 97
abnormal pericardium morpholog... 3 | 26
abnormal retinal blood vessel ... 3 | 26
abnormal sensory capabilities-... 3 | 8
abnormal skin coloration 3 | 25
abnormal spleen morphology 3 | 55
decreased circulating free fat... 3 | 31
decreased heart rate variabili... 3 | 13
decreased hematocrit 3 | 46
decreased large unstained cell... 3 | 11
increased circulating LDL chol... 3 | 13
increased mean corpuscular hem... 3 | 36
increased prepulse inhibition 3 | 32
increased spleen weight 3 | 10
male infertility 3 | 123
prenatal lethality 3 | 28
small testis 3 | 58
tremors 3 | 39
abnormal liver morphology 2 | 17
abnormal lung morphology 2 | 26
abnormal vibrissa morphology 2 | 25
decreased circulating creatini... 2 | 39
increased cardiac muscle contr... 2 | 8
increased circulating calcium ... 2 | 34
increased circulating chloride... 2 | 41
increased hemoglobin content 2 | 45
thrombocytosis 2 | 27

Disease

ovarian cancer 488 | 8,520
Carcinoma 485 | 11,493
osteosarcoma 389 | 7,950
psoriasis 367 | 6,694
Cancer 355 | 2,499
glioblastoma 319 | 5,792
lung cancer 278 | 4,740
medulloblastoma, large-cell 275 | 6,241
atypical teratoid / rhabdoid tumor 230 | 5,112
ependymoma 228 | 4,679
Breast cancer 201 | 3,578
diabetes mellitus 199 | 1,728
lung carcinoma 183 | 2,843
Astrocytoma, Pilocytic 177 | 3,081
malignant mesothelioma 173 | 3,232
adult high grade glioma 170 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 170 | 3,291
invasive ductal carcinoma 166 | 2,951
non-small cell lung cancer 164 | 2,890
tuberculosis 154 | 2,010
Multiple myeloma 151 | 1,332
oligodendroglioma 151 | 2,850
intraductal papillary-mucinous carcinoma (IPMC) 146 | 2,989
astrocytic glioma 145 | 2,597
intraductal papillary-mucinous adenoma (IPMA) 145 | 2,955
interstitial cystitis 144 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 144 | 1,962
lung adenocarcinoma 142 | 2,716
group 3 medulloblastoma 134 | 4,104
Rheumatoid arthritis 133 | 1,191
Autosomal recessive predisposition 129 | 1,442
subependymal giant cell astrocytoma 129 | 2,287
pancreatic cancer 128 | 2,398
Kidney cancer 125 | 2,613
Hypersensitivity reaction type II disease 123 | 253
Arthritis 119 | 290
Schizophrenia 119 | 1,160
ulcerative colitis 119 | 1,819
primitive neuroectodermal tumor 112 | 3,035
dermatomyositis 106 | 966
Pick disease 104 | 1,894
Kidney disease 102 | 430
breast carcinoma 99 | 1,638
group 4 medulloblastoma 99 | 1,855
Anemia 97 | 365
pituitary cancer 97 | 1,972
Multiple Sclerosis 95 | 540
Alzheimer's disease 91 | 658
ductal carcinoma in situ 88 | 1,745
cystic fibrosis 87 | 1,696
Epilepsy 86 | 792
astrocytoma 84 | 1,146
colon cancer 81 | 1,478
Acquired immunodeficiency syndrome 80 | 197
Ankylosing spondylitis 78 | 140
Human immunodeficiency virus infectious disease 76 | 138
Intellectual disability 76 | 1,016
cutaneous lupus erythematosus 76 | 1,057
Liver disease 75 | 237
juvenile dermatomyositis 75 | 1,187
Liver Cirrhosis, Experimental 74 | 769
adrenocortical carcinoma 72 | 1,428
Waldenstrons macroglobulinemia 71 | 765
Behcet's disease 70 | 89
Uveitis 70 | 103
primary pancreatic ductal adenocarcinoma 70 | 1,109
Breast Neoplasms 68 | 445
acute quadriplegic myopathy 68 | 1,158
Seizures 67 | 596
Dermatitis 65 | 157
Juvenile rheumatoid arthritis 65 | 111
Mammary Neoplasms 65 | 425
Vascular disease 65 | 319
Heart disease 64 | 306
Cognitive delay 63 | 608
Global developmental delay 63 | 608
Mental and motor retardation 63 | 608
Bipolar Disorder 62 | 666
Herpes zoster 62 | 68
Obesity 62 | 678
pediatric high grade glioma 62 | 1,064
Stevens-Johnson syndrome 60 | 92
Asthma 56 | 385
Dull intelligence 56 | 645
Low intelligence 56 | 645
Mental Retardation 56 | 645
Mental deficiency 56 | 645
Muscle hypotonia 56 | 571
Neurodegenerative disease 56 | 414
Poor school performance 56 | 645
Psoriatic arthritis 55 | 86
Thrombocytopenia 53 | 197
Down syndrome 52 | 499
Duchenne muscular dystrophy 52 | 601
Hypertension 52 | 396
primary Sjogren syndrome 52 | 735
Failure to gain weight 51 | 365
Pediatric failure to thrive 51 | 365
Short stature 50 | 531
non primary Sjogren syndrome sicca 50 | 891

Tissue

Endocrine System 789 | 18,159
Digestive Tract 785 | 17,369
Skin and soft tissues 783 | 17,230
Liver and Pancreas 780 | 16,750
Blood and immune system 779 | 16,909
Female tissues 779 | 17,400
Male tissues 779 | 17,142
Urinary Tract 777 | 16,678
Nervous System 769 | 16,725
Respiratory system 767 | 16,393
Cardiovascular System 747 | 15,192

Target Family

Non-IDG 593 | 12,091
Enzyme 203 | 4,145
Kinase 37 | 634
Transcription Factor 21 | 1,400
Transporter 18 | 473
Ion Channel 7 | 344
GPCR 3 | 408
Nuclear Receptor 1 | 48

Compartment GO Term

GO:0098796 883 | 883
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,783 | 8,783
Membrane 8,530 | 8,530
Nucleus 7,563 | 7,563
Cytosol 6,686 | 6,686
Membrane part 6,553 | 6,553
Plasma membrane 5,829 | 5,829
Macromolecular complex 5,476 | 5,476
Intrinsic component of membran... 5,457 | 5,457
Cell periphery 5,381 | 5,381
Integral component of membrane 5,330 | 5,330
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,974 | 3,974
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,673 | 3,673
Organelle membrane 2,846 | 2,846
Extracellular region 2,731 | 2,731
Plasma membrane part 2,593 | 2,593
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,216 | 2,216
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,638 | 1,638
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 968 | 968
Supramolecular complex 967 | 967
Cell junction 960 | 960
Supramolecular fiber 960 | 960
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 931 | 931
Nucleolus 927 | 927
Chromosomal part 889 | 889
Ribonucleoprotein complex 864 | 864
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 849 | 849
Transferase complex 849 | 849
Cell surface 841 | 841
Plasma membrane region 841 | 841
Vesicle membrane 800 | 800
Cytoplasmic vesicle membrane 794 | 794
Polymeric cytoskeletal fiber 765 | 765
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 713 | 713
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Beta-secretase 2 BACE2 Tchem Enzyme -2.09709 114.0 418
Integrin alpha-11 ITGA11 Tbio Non-IDG -1.13736 14.3 76
Integrin alpha-2 ITGA2 Tbio Non-IDG -2.58423 335.9 895
Neuroendocrine secretory protein 55 GNAS Tbio Non-IDG -2.63356 1389.7 509
HLA class I histocompatibility antigen, A-25 alpha chain HLA-A Tbio Non-IDG -2.41667 4123.8 0
Tyrosine-protein kinase ZAP-70 ZAP70 Tchem Kinase -2.91589 798.2 1515
HLA class I histocompatibility antigen, B-51 alpha chain HLA-B Tbio Non-IDG -1.88752 1613.5 0
Thrombospondin-1 THBS1 Tbio Non-IDG -3.06622 1281.6 504
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 PLCB1 Tbio Enzyme -2.50444 332.8 190