Development Level

Tbio 760 | 11,651
Tdark 195 | 6,593
Tchem 105 | 1,388
Tclin 90 | 612

Collection

RFA-RM-18-021 5 | 328
Ion Channel: IDG Consortium (T... 2 | 99
Kinase: IDG Consortium (Target... 2 | 125
GPCR: IDG Consortium (Complete... 1 | 25

IMPC Phenotype

preweaning lethality, complete... 99 | 979
preweaning lethality, incomple... 33 | 499
embryonic lethality prior to o... 27 | 239
embryonic lethality prior to t... 26 | 278
abnormal behavior 23 | 298
decreased vertical activity 17 | 208
abnormal embryo size 16 | 220
decreased total body fat amoun... 16 | 207
increased lean body mass 16 | 172
increased total body fat amoun... 16 | 134
decreased body weight 15 | 161
enlarged heart 15 | 210
hyperactivity 14 | 148
decreased bone mineral content 13 | 151
decreased lean body mass 13 | 135
abnormal bone structure 12 | 187
abnormal heart morphology 11 | 162
hypoactivity 11 | 132
cataract 10 | 92
embryonic growth retardation 10 | 106
abnormal lens morphology 9 | 81
increased mean corpuscular hem... 9 | 96
increased startle reflex 9 | 112
male infertility 8 | 123
abnormal sleep behavior 7 | 70
decreased circulating HDL chol... 7 | 68
decreased circulating glucose ... 7 | 126
decreased hematocrit 7 | 46
decreased mean corpuscular vol... 7 | 79
increased circulating alkaline... 7 | 122
prenatal lethality prior to he... 7 | 87
abnormal gait 6 | 69
abnormal snout morphology 6 | 23
decreased body length 6 | 101
decreased circulating LDL chol... 6 | 38
decreased circulating alkaline... 6 | 46
decreased circulating choleste... 6 | 93
decreased grip strength 6 | 116
decreased hemoglobin content 6 | 68
increased circulating sodium l... 6 | 71
increased fasted circulating g... 6 | 76
pallor 6 | 34
thrombocytopenia 6 | 56
abnormal neural tube closure 5 | 46
abnormal skin morphology 5 | 50
decreased bone mineral density 5 | 126
decreased circulating insulin ... 5 | 76
decreased circulating serum al... 5 | 82
decreased heart weight 5 | 27
decreased lymphocyte cell numb... 5 | 83
edema 5 | 59
impaired glucose tolerance 5 | 75
improved glucose tolerance 5 | 79
increased bone mineral content 5 | 108
increased circulating HDL chol... 5 | 80
increased circulating choleste... 5 | 66
increased circulating phosphat... 5 | 26
increased heart weight 5 | 62
increased mean corpuscular vol... 5 | 92
increased monocyte cell number 5 | 63
increased red blood cell distr... 5 | 34
short tibia 5 | 97
abnormal coat-hair pigmentatio... 4 | 64
abnormal placenta size 4 | 20
abnormal seminal vesicle morph... 4 | 114
decreased circulating aspartat... 4 | 34
decreased circulating phosphat... 4 | 27
decreased circulating total pr... 4 | 49
decreased circulating triglyce... 4 | 79
decreased erythrocyte cell num... 4 | 62
decreased leukocyte cell numbe... 4 | 73
decreased mean corpuscular hem... 4 | 50
decreased total retina thickne... 4 | 17
female infertility 4 | 60
increased circulating calcium ... 4 | 34
increased prepulse inhibition 4 | 32
small superior vagus ganglion 4 | 74
small testis 4 | 58
small thymus 4 | 16
tremors 4 | 39
abnormal bone mineralization 3 | 38
abnormal cranium morphology 3 | 36
decreased caudal vertebrae num... 3 | 53
decreased circulating alanine ... 3 | 47
decreased circulating calcium ... 3 | 36
decreased circulating creatini... 3 | 39
decreased circulating iron lev... 3 | 32
decreased fasted circulating g... 3 | 65
decreased lactate dehydrogenas... 3 | 16
decreased prepulse inhibition 3 | 82
decreased red blood cell distr... 3 | 41
decreased startle reflex 3 | 75
increased anti-nuclear antigen... 3 | 19
increased bone mineral density 3 | 72
increased circulating bilirubi... 3 | 16
increased circulating chloride... 3 | 41
increased or absent threshold ... 3 | 101
pale yolk sac 3 | 25
persistence of hyaloid vascula... 3 | 33
prolonged QT interval 3 | 38

Disease

ovarian cancer 629 | 8,520
Carcinoma 587 | 11,493
osteosarcoma 524 | 7,950
medulloblastoma, large-cell 398 | 6,241
psoriasis 382 | 6,694
lung cancer 373 | 4,740
glioblastoma 350 | 5,792
atypical teratoid / rhabdoid tumor 307 | 5,112
ependymoma 267 | 4,679
group 3 medulloblastoma 241 | 4,104
Breast cancer 227 | 3,578
adult high grade glioma 221 | 3,801
pancreatic ductal adenocarcinoma liver metastasis 212 | 1,962
intraductal papillary-mucinous neoplasm (IPMN) 211 | 3,291
malignant mesothelioma 208 | 3,232
Cancer 198 | 2,499
Multiple myeloma 188 | 1,332
invasive ductal carcinoma 185 | 2,951
non-small cell lung cancer 179 | 2,890
intraductal papillary-mucinous carcinoma (IPMC) 178 | 2,989
astrocytic glioma 167 | 2,597
oligodendroglioma 164 | 2,850
intraductal papillary-mucinous adenoma (IPMA) 160 | 2,955
primitive neuroectodermal tumor 160 | 3,035
lung adenocarcinoma 154 | 2,716
Astrocytoma, Pilocytic 146 | 3,081
Autosomal recessive predisposition 144 | 1,442
pancreatic cancer 131 | 2,398
tuberculosis 130 | 2,010
diabetes mellitus 129 | 1,728
lung carcinoma 128 | 2,843
Pick disease 126 | 1,894
group 4 medulloblastoma 119 | 1,855
subependymal giant cell astrocytoma 116 | 2,287
breast carcinoma 115 | 1,638
ulcerative colitis 109 | 1,819
Schizophrenia 102 | 1,160
ductal carcinoma in situ 100 | 1,745
Kidney cancer 95 | 2,613
colon cancer 94 | 1,478
interstitial cystitis 93 | 2,312
Epilepsy 91 | 792
Rheumatoid arthritis 91 | 1,191
Waldenstrons macroglobulinemia 88 | 765
acute quadriplegic myopathy 87 | 1,158
cystic fibrosis 87 | 1,696
non primary Sjogren syndrome sicca 87 | 891
pituitary cancer 86 | 1,972
Alzheimer's disease 85 | 658
adrenocortical carcinoma 85 | 1,428
dermatomyositis 85 | 966
Cognitive delay 79 | 608
Global developmental delay 79 | 608
Mental and motor retardation 79 | 608
astrocytoma 79 | 1,146
Seizures 78 | 596
acute myeloid leukemia 78 | 783
Neurodegenerative disease 77 | 414
Obesity 75 | 678
Intellectual disability 74 | 1,016
juvenile dermatomyositis 73 | 1,187
Muscle hypotonia 72 | 571
nasopharyngeal carcinoma 70 | 1,058
pediatric high grade glioma 66 | 1,064
Cerebellar Ataxia 65 | 304
Liver Cirrhosis, Experimental 63 | 769
Parkinson's disease 63 | 392
primary pancreatic ductal adenocarcinoma 61 | 1,109
Bipolar Disorder 60 | 666
Mammary Neoplasms 60 | 425
aldosterone-producing adenoma 60 | 665
Breast Neoplasms 59 | 445
Failure to gain weight 59 | 365
Pediatric failure to thrive 59 | 365
Dull intelligence 56 | 645
Low intelligence 56 | 645
Mental Retardation 56 | 645
Mental deficiency 56 | 645
Poor school performance 56 | 645
cutaneous lupus erythematosus 56 | 1,057
Leigh disease 55 | 100
Optic Atrophy 55 | 242
Toxic encephalopathy 54 | 141
Dystonia 53 | 164
Diabetes mellitus type 2 52 | 69
Treatment Refractory Type 2 Diabetes Mellitus 51 | 53
Amyotrophic lateral sclerosis 50 | 451
Depressive disorder 50 | 409
Hyperreflexia 49 | 209
Nystagmus 49 | 317
Vascular disease 49 | 319
Atopic dermatitis 48 | 952
Blepharoptosis 48 | 231
Acidosis, Lactic 47 | 97
Lactic acidemia 47 | 95
Prostatic Neoplasms 46 | 495
Stomach Neoplasms 45 | 300
Neuropathy 44 | 261
hereditary spastic paraplegia 44 | 318
primary Sjogren syndrome 44 | 735

Tissue

Endocrine System 1,125 | 18,159
Digestive Tract 1,115 | 17,369
Female tissues 1,111 | 17,400
Male tissues 1,108 | 17,142
Liver and Pancreas 1,106 | 16,750
Skin and soft tissues 1,106 | 17,230
Blood and immune system 1,102 | 16,909
Nervous System 1,098 | 16,725
Urinary Tract 1,098 | 16,678
Respiratory system 1,088 | 16,393
Cardiovascular System 1,067 | 15,192

Target Family

Non-IDG 592 | 12,091
Enzyme 372 | 4,145
Transporter 71 | 473
Kinase 40 | 634
Transcription Factor 32 | 1,400
Ion Channel 17 | 344
Epigenetic 12 | 242
GPCR 10 | 408
Nuclear Receptor 3 | 48
TF/Epigenetic 1 | 38

Compartment GO Term

GO:0031975 1,150 | 1,150
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,783 | 8,783
Membrane 8,530 | 8,530
Nucleus 7,563 | 7,563
Cytosol 6,686 | 6,686
Membrane part 6,553 | 6,553
Plasma membrane 5,829 | 5,829
Macromolecular complex 5,476 | 5,476
Intrinsic component of membran... 5,457 | 5,457
Cell periphery 5,381 | 5,381
Integral component of membrane 5,330 | 5,330
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,974 | 3,974
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,673 | 3,673
Organelle membrane 2,846 | 2,846
Extracellular region 2,731 | 2,731
Plasma membrane part 2,593 | 2,593
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,216 | 2,216
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,638 | 1,638
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 968 | 968
Supramolecular complex 967 | 967
Cell junction 960 | 960
Supramolecular fiber 960 | 960
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 931 | 931
Nucleolus 927 | 927
Chromosomal part 889 | 889
GO:0098796 883 | 883
Ribonucleoprotein complex 864 | 864
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 849 | 849
Transferase complex 849 | 849
Cell surface 841 | 841
Plasma membrane region 841 | 841
Vesicle membrane 800 | 800
Cytoplasmic vesicle membrane 794 | 794
Polymeric cytoskeletal fiber 765 | 765
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 713 | 713
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Calcium uptake protein 3, mitochondrial MICU3 Tdark Non-IDG -0.21085 1.14 50
UbiA prenyltransferase domain-containing protein 1 UBIAD1 Tbio Enzyme -1.59893 42.5 50
28S ribosomal protein S14, mitochondrial MRPS14 Tdark Non-IDG 0.30 0.11 22
39S ribosomal protein L40, mitochondrial MRPL40 Tbio Non-IDG -0.92179 8.33 105
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 PLCB1 Tbio Enzyme -2.50444 332.8 190
Lamina-associated polypeptide 2, isoform alpha TMPO Tbio Non-IDG -2.11834 246.0 283
Macrophage receptor MARCO MARCO Tbio Non-IDG -2.37206 210.3 189
Protein KASH5 CCDC155 Tdark Non-IDG -0.58600 3.79 39
Serine/threonine-protein kinase PAK 1 PAK1 Tchem Kinase -2.29299 237.8 1060