Development Level

Tbio 666 | 10,625
Tdark 218 | 7,003
Tchem 123 | 1,890
Tclin 86 | 602

Collection

Kinase: IDG Consortium (Targets) 2 | 125
GPCR: IDG Consortium (Targets) 1 | 128
Ion Channel: IDG Consortium (Targets) 1 | 102

IMPC Phenotype

preweaning lethality, complete... 63 | 633
embryonic lethality prior to o... 23 | 148
embryonic lethality prior to t... 19 | 187
abnormal behavior 17 | 226
decreased body weight 17 | 174
preweaning lethality, incomple... 17 | 260
decreased lean body mass 13 | 195
decreased bone mineral content 12 | 157
decreased grip strength 11 | 123
decreased circulating glucose ... 10 | 121
hypoactivity 10 | 89
abnormal bone structure 9 | 131
decreased circulating choleste... 9 | 85
decreased total body fat amoun... 9 | 186
increased lean body mass 9 | 107
increased mean corpuscular hem... 9 | 93
abnormal embryo size 8 | 112
increased grip strength 8 | 83
abnormal lens morphology 7 | 73
decreased circulating HDL chol... 7 | 77
decreased rib number 7 | 59
increased circulating alkaline... 7 | 119
increased circulating sodium l... 7 | 71
increased mean corpuscular vol... 7 | 91
abnormal retina morphology 6 | 100
decreased body length 6 | 108
decreased leukocyte cell numbe... 6 | 54
enlarged heart 6 | 111
increased circulating choleste... 6 | 53
increased circulating phosphat... 6 | 24
increased heart weight 6 | 37
increased or absent threshold ... 6 | 128
prenatal lethality prior to he... 6 | 64
abnormal snout morphology 5 | 18
decreased caudal vertebrae num... 5 | 49
decreased circulating alkaline... 5 | 41
decreased circulating insulin ... 5 | 75
decreased heart weight 5 | 44
decreased lumbar vertebrae num... 5 | 62
decreased total retina thickne... 5 | 20
embryonic growth retardation 5 | 28
hyperactivity 5 | 108
increased blood urea nitrogen ... 5 | 44
increased sacral vertebrae num... 5 | 62
short tibia 5 | 82
thrombocytopenia 5 | 46
abnormal bone mineralization 4 | 55
abnormal locomotor activation 4 | 26
abnormal skin morphology 4 | 23
decreased circulating LDL chol... 4 | 37
decreased circulating serum al... 4 | 79
decreased circulating triglyce... 4 | 83
decreased mean corpuscular vol... 4 | 50
increased circulating HDL chol... 4 | 63
increased circulating creatini... 4 | 29
increased exploration in new e... 4 | 56
increased fasted circulating g... 4 | 68
increased total body fat amoun... 4 | 57
male infertility 4 | 62
abnormal clavicle morphology 3 | 5
abnormal femur morphology 3 | 14
abnormal heart left ventricle ... 3 | 20
abnormal heart morphology 3 | 51
abnormal limb bud morphology 3 | 15
abnormal neural tube closure 3 | 37
abnormal rib morphology 3 | 28
abnormal sleep behavior 3 | 63
abnormal tibia morphology 3 | 14
abnormal tooth morphology 3 | 24
decreased blood urea nitrogen ... 3 | 31
decreased bone mineral density 3 | 126
decreased circulating aspartat... 3 | 27
decreased circulating creatini... 3 | 31
decreased circulating glycerol... 3 | 19
decreased circulating iron lev... 3 | 25
decreased circulating total pr... 3 | 41
decreased fasted circulating g... 3 | 49
decreased hematocrit 3 | 25
decreased mean corpuscular hem... 3 | 34
decreased mean platelet volume 3 | 12
decreased startle reflex 3 | 48
female infertility 3 | 34
impaired glucose tolerance 3 | 52
improved glucose tolerance 3 | 56
increased bone mineral content 3 | 92
increased circulating aspartat... 3 | 17
increased startle reflex 3 | 38
pallor 3 | 13
persistence of hyaloid vascula... 3 | 22
small thymus 3 | 11
tremors 3 | 34
decreased circulating calcium ... 2 | 33
decreased hemoglobin content 2 | 53
increased body weight 2 | 42
increased circulating bilirubi... 2 | 16
increased circulating calcium ... 2 | 32
increased circulating chloride... 2 | 43
increased circulating potassiu... 2 | 31
increased erythrocyte cell num... 2 | 26
increased respiratory quotient 2 | 12

Disease

ovarian cancer 595 | 8,491
osteosarcoma 492 | 7,933
medulloblastoma, large-cell 372 | 6,234
psoriasis 359 | 6,685
lung cancer 348 | 4,473
glioblastoma 318 | 5,572
atypical teratoid / rhabdoid tumor 242 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 200 | 3,289
Breast cancer 196 | 3,098
pancreatic ductal adenocarcinoma liver metastasis 186 | 1,795
malignant mesothelioma 185 | 3,163
Cancer 178 | 2,346
Multiple myeloma 174 | 1,327
invasive ductal carcinoma 171 | 2,950
non-small cell lung cancer 170 | 2,798
intraductal papillary-mucinous carcinoma (IPMC) 167 | 2,988
pediatric high grade glioma 164 | 2,712
oligodendroglioma 157 | 2,849
ependymoma 156 | 2,514
primitive neuroectodermal tumor 156 | 3,031
intraductal papillary-mucinous adenoma (IPMA) 150 | 2,956
lung adenocarcinoma 146 | 2,714
astrocytic glioma 144 | 2,241
group 3 medulloblastoma 144 | 2,254
pilocytic astrocytoma 137 | 3,086
pancreatic cancer 126 | 2,300
Pick disease 125 | 1,893
lung carcinoma 124 | 2,844
subependymal giant cell astrocytoma 112 | 2,287
ulcerative colitis 112 | 2,087
diabetes mellitus 111 | 1,663
adult high grade glioma 104 | 2,148
breast carcinoma 101 | 1,614
group 4 medulloblastoma 101 | 1,875
ductal carcinoma in situ 93 | 1,745
astrocytoma 89 | 1,493
interstitial cystitis 89 | 2,299
colon cancer 86 | 1,475
medulloblastoma 86 | 1,524
tuberculosis 85 | 1,563
Rheumatoid Arthritis 83 | 1,170
pituitary cancer 81 | 1,972
non primary Sjogren syndrome sicca 80 | 840
Waldenstrons macroglobulinemia 79 | 764
acute quadriplegic myopathy 79 | 1,157
dermatomyositis 79 | 966
adrenocortical carcinoma 78 | 1,427
cystic fibrosis 78 | 1,670
Carcinoma 76 | 2,147
Alzheimer's disease 75 | 644
Neurodegenerative disease 74 | 383
acute myeloid leukemia 73 | 785
posterior fossa group A ependymoma 72 | 1,511
sonic hedgehog group medulloblastoma 72 | 1,482
primary pancreatic ductal adenocarcinoma 71 | 1,271
nasopharyngeal carcinoma 65 | 1,056
atypical teratoid/rhabdoid tumor 63 | 1,095
juvenile dermatomyositis 63 | 1,189
posterior fossa group B ependymoma 62 | 1,530
Obesity 61 | 616
Parkinson's disease 58 | 364
aldosterone-producing adenoma 58 | 664
Mammary Neoplasms 54 | 410
cutaneous lupus erythematosus 54 | 1,056
Diabetes mellitus type 2 52 | 69
Treatment Refractory Type 2 Diabetes Mellitus 51 | 53
tuberculosis and treatment for 6 months 47 | 686
Atopic dermatitis 46 | 944
Leigh disease 46 | 81
Vascular disease 44 | 281
primary Sjogren syndrome 44 | 788
Kidney disease 43 | 397
Toxic encephalopathy 43 | 131
Down syndrome 42 | 548
hereditary spastic paraplegia 42 | 313
Amyotrophic Lateral Sclerosis 41 | 432
gastric carcinoma 41 | 832
progressive supranuclear palsy 40 | 674
Schizophrenia 39 | 503
esophageal adenocarcinoma 39 | 737
spina bifida 38 | 1,064
Prostatic Neoplasms 36 | 471
Stomach Neoplasms 36 | 282
active Crohn's disease 36 | 918
pancreatic carcinoma 35 | 567
hepatocellular carcinoma 34 | 550
IGA Glomerulonephritis 33 | 454
Mitochondrial complex I deficiency 32 | 37
Atherosclerosis 31 | 275
Diabetes Mellitus, Experimental 31 | 106
Heart disease 31 | 279
Multiple Sclerosis 31 | 498
Neuropathy 31 | 210
Duchenne muscular dystrophy 30 | 602
Endometriosis 30 | 535
Brain disease 29 | 84
Liver carcinoma 29 | 217
Polycystic Ovary Syndrome 29 | 334
Asthma 28 | 349
Epilepsy 28 | 346

Tissue

Nervous System 1,079 | 18,560
Female tissues 1,078 | 18,646
Male tissues 1,078 | 17,968
Blood and immune system 1,077 | 17,994
Urinary Tract 1,077 | 18,443
Liver and Pancreas 1,076 | 18,135
Digestive Tract 1,075 | 18,472
Endocrine System 1,075 | 18,511
Cardiovascular System 1,073 | 17,957
Skin and soft tissues 1,065 | 18,114
Respiratory system 1,063 | 17,483

Target Family

Non-IDG 556 | 11,969
Enzyme 362 | 4,146
Transporter 71 | 473
Kinase 40 | 634
Transcription Factor 27 | 1,400
Ion Channel 16 | 341
Epigenetic 9 | 242
GPCR 8 | 408
Nuclear Receptor 3 | 48
TF/Epigenetic 1 | 38

Compartment GO Term

GO:0031975 1,093 | 1,093
cellular_component 18,237 | 18,237
Cell 15,806 | 15,806
Cell part 15,806 | 15,806
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,648 | 12,648
membrane-bounded organelle 11,793 | 11,793
Intracellular organelle 11,617 | 11,617
Intracellular membrane-bounded... 10,618 | 10,618
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,169 | 8,169
Intracellular organelle part 8,011 | 8,011
Cytoplasmic part 7,830 | 7,830
Nucleus 7,577 | 7,577
Membrane part 6,470 | 6,470
Cytosol 6,035 | 6,035
Plasma membrane 5,673 | 5,673
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,171 | 5,171
Cell periphery 5,146 | 5,146
Nucleoplasm 4,929 | 4,929
Extracellular region 4,606 | 4,606
Protein complex 4,439 | 4,439
Intracellular organelle lumen 4,330 | 4,330
Organelle lumen 4,330 | 4,330
membrane-enclosed lumen 4,330 | 4,330
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,839 | 3,839
non-membrane-bounded organelle 3,838 | 3,838
Nuclear part 3,807 | 3,807
Endomembrane system 3,720 | 3,720
Vesicle 3,666 | 3,666
membrane-bounded vesicle 3,494 | 3,494
Nuclear lumen 3,464 | 3,464
Extracellular organelle 2,849 | 2,849
Extracellular vesicle 2,848 | 2,848
Extracellular exosome 2,828 | 2,828
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,564 | 2,564
Cytoskeleton 2,046 | 2,046
Golgi apparatus 1,946 | 1,946
Endoplasmic reticulum 1,872 | 1,872
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Vesicles 1,625 | 1,625
Cytoskeletal part 1,568 | 1,568
Mitochondrion 1,531 | 1,531
Cell projection 1,426 | 1,426
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,305 | 1,305
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,234 | 1,234
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Mitochondria 1,003 | 1,003
Chromosome 999 | 999
Mitochondrial part 989 | 989
Nucleoli 952 | 952
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 793 | 793
Intracellular ribonucleoprotei... 789 | 789
Nucleoplasm part 781 | 781
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 739 | 739
Plasma membrane protein comple... 721 | 721
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Microtubule organizing center 680 | 680
Centrosome 676 | 676
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Synapse 594 | 594
Lytic vacuole 571 | 571

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.29593 203.1 88
Protein Mpv17 MPV17 Tbio Non-IDG -1.63162 40.5 114
Long-chain-fatty-acid--CoA ligase 6 ACSL6 Tbio Enzyme -1.84683 72.3 120
Galectin-3 LGALS3 Tchem Non-IDG -3.33005 2249.5 911
Mitochondrial 2-oxoglutarate/malate carrier protein SLC25A11 Tbio Transporter -1.36706 24.8 148
28S ribosomal protein S18a, mitochondrial MRPS18A Tdark Non-IDG 0.32 0.72 46
Putative nuclear envelope pore membrane protein POM 121B POM121B Tdark Non-IDG 0.00000 0
Mitochondrial ribosome-associated GTPase 1 MTG1 Tdark Enzyme -0.54103 1.85 75
Aquaporin-1 AQP1 Tbio Non-IDG -3.06090 1040.5 321
Cytochrome b5 type B CYB5B Tbio Non-IDG -0.89834 7.51 36